杨华丽｜沈阳药科大学｜学者主页

2025

3-氨基苯并[d]异噁唑类大环ALK抑制剂的设计、合成及活性评价

周振，刘耀阳，黎瑶，华炫智，刘洋，杨华丽，程卯生

《沈阳药科大学学报》

DOI

2024

Corrigendum to "Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease" [Eur. J. Med. Chem. 163 (2019), 307-319. DOI: 10.1016/j.ejmech.2018.11.040].

Yan-Wei Tang, Cunjian Shi, Huali Yang, Pei Cai, Qiaohong Liu, Xuelian Yang, Ling-Yi Kong, Xiaobing Wang

European journal of medicinal chemistry

DOI

2022

Design, synthesis and antitumor activity evaluation of novel indole acrylamide derivatives as IMPDH inhibitors.

Hongxiang Jia, Huali Yang, Zhijun Xiong, Ming-hui Deng, Tong-Min Wang, Yang Liu, M. Cheng

Bioorganic chemistry (Print)

DOI

2020

阿尔茨海默病多功能治疗药物及近红外荧光诊断探针的设计、合成及生物活性研究

杨华丽

《沈阳药科大学》

2020

Design and SAR of withangulatin A analogs that act as covalent TrxR inhibitors through Michael addition reaction showing potential in cancer treatment.

Cheng Wang, Shun-Jie Li, Jin-Hua Zhao, Huali Yang, Fucheng Yin, Ming Ding, Jian-Guang Luo, Xiaobing Wang, Ling-Yi Kong

Journal of Medicinal Chemistry

DOI

2020

Development of a Tau-Targeted Drug Delivery System using a Multifunctional Nanoscale Metal-Organic Framework for Alzheimer's Disease Therapy.

Jin-Hua Zhao, Fucheng Yin, Limei Ji, Cheng Wang, Cunjian Shi, Xingchen Liu, Huali Yang, Xiaobing Wang, Ling-Yi Kong

ACS Applied Materials and Interfaces

DOI

2020

Identification and optimization of piperlongumine analogues as potential antioxidant and anti-inflammatory agents via activation of Nrf2.

Limei Ji, Lailiang Qu, Cheng Wang, Wan Peng, Shun-Jie Li, Huali Yang, Heng Luo, Fucheng Yin, Dehua Lu, Xingchen Liu, Ling-Yi Kong, Xiaobing Wang

European journal of medicinal chemistry

DOI

2020

Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer.

Huali Yang, Xiaobing Wang, Cheng Wang, Fucheng Yin, Lailiang Qu, Cunjian Shi, Jin-Hua Zhao, Shun-Jie Li, Limei Ji, Wan Peng, Heng Luo, Mao-Sheng Cheng, Ling-Yi Kong

European journal of medicinal chemistry

DOI

2019

Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors.

Cunjian Shi, Wan Peng, Jin-Hua Zhao, Huali Yang, Lailiang Qu, Cheng Wang, Ling-Yi Kong, Xiaobing Wang

European journal of medicinal chemistry

DOI

2019

A hemicyanine derivative for near-infrared imaging of β-amyloid plaques in Alzheimer's disease.

Huali Yang, Siqiang Fang, Yan-Wei Tang, Cheng Wang, Heng Luo, Lailiang Qu, Jin-Hua Zhao, Cunjian Shi, Fucheng Yin, Xiaobing Wang, Ling-Yi Kong

European journal of medicinal chemistry

DOI

2019

Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease.

Yan-Wei Tang, Cunjian Shi, Huali Yang, Pei Cai, Qiaohong Liu, Xuelian Yang, Ling-Yi Kong, Xiaobing Wang

European journal of medicinal chemistry

DOI

2018

Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.

Pei Cai, Siqiang Fang, Huali Yang, Xuelian Yang, Qiaohong Liu, Ling-Yi Kong, Xiaobing Wang

European journal of medicinal chemistry

DOI

2017

Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease.

Huali Yang, Pei Cai, Qiaohong Liu, Xuelian Yang, Siqiang Fang, Yan-Wei Tang, Cheng Wang, Xiaobing Wang, Ling-Yi Kong

Bioorganic & Medicinal Chemistry

DOI

2017

Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-β aggregation for the treatment of Alzheimer's disease.

Huali Yang, Pei Cai, Qiaohong Liu, Xuelian Yang, Fan Li, Jin Wang, Jia-Jia Wu, Xiaobing Wang, Ling-Yi Kong

European journal of medicinal chemistry

DOI

杨华丽

精选作品

期刊论文

3-氨基苯并[d]异噁唑类大环ALK抑制剂的设计、合成及活性评价

Corrigendum to "Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease" [Eur. J. Med. Chem. 163 (2019), 307-319. DOI: 10.1016/j.ejmech.2018.11.040].

Design, synthesis and antitumor activity evaluation of novel indole acrylamide derivatives as IMPDH inhibitors.

阿尔茨海默病多功能治疗药物及近红外荧光诊断探针的设计、合成及生物活性研究

Design and SAR of withangulatin A analogs that act as covalent TrxR inhibitors through Michael addition reaction showing potential in cancer treatment.

Development of a Tau-Targeted Drug Delivery System using a Multifunctional Nanoscale Metal-Organic Framework for Alzheimer's Disease Therapy.

Identification and optimization of piperlongumine analogues as potential antioxidant and anti-inflammatory agents via activation of Nrf2.

Optimization of WZ4003 as NUAK inhibitors against human colorectal cancer.

Usnic acid derivatives as tau-aggregation and neuroinflammation inhibitors.

A hemicyanine derivative for near-infrared imaging of β-amyloid plaques in Alzheimer's disease.

Synthesis and evaluation of isoprenylation-resveratrol dimer derivatives against Alzheimer's disease.

Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.

Design, synthesis, and evaluation of salicyladimine derivatives as multitarget-directed ligands against Alzheimer's disease.

Design, synthesis and evaluation of coumarin-pargyline hybrids as novel dual inhibitors of monoamine oxidases and amyloid-β aggregation for the treatment of Alzheimer's disease.

研究方向