张翔南｜浙江大学药理毒理研究所｜学者主页

期刊论文

2026

A Non-Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Xiangnan Zhang, Xingxian Zhang, Xinlei Mo, Xinyu Zhou, Xiaoliang Liu, Guizhi Li, Songhui Hu, Yangyang Lu, Chenze Zhu, Jinxi Feng, Zhitong Chen, Weiwei Hu, Yihui Cui, Zhong Chen

Advanced Science

DOI

2026

Therapeutic potential of tanshinones in ischaemia-reperfusion injury: Bioactive analogues, pharmacology and mechanisms

Xiangnan Zhang, Meijie Dai, Yimu Zhang, Chenze Zhu, Yuyan Yang, Sunliang Cui

British Journal of Pharmacology

DOI

2026

Lemborexant produces antidepressant- and anxiolytic-like effects with sleep-wake regulation compared with fluoxetine in male mice with comorbid depression and insomnia

Xiangnan Zhang, Nanxi Lai, Jie Wang, Jinfang Lou, Lei Miao, Ruqin Zhou, Xinyu Fan, Yi Wang

Neuropharmacology

DOI

2026

Microglial IRF7-induced lipophagy impairment aggravates lipid droplet overload and impedes neurological recovery after ischemic stroke

Xiangnan Zhang, Jing Yin, Yan Li, Yu-Lu Miao, Xue-Fang Song, Yao Cheng, Yu-Jie Zhai, Jia Ren, Cai-Hong Yang, Hui-Feng Zhang, Li-Jun Yang, Yan-Ying Fan

Journal of Neuroinflammation

DOI

2026

Neuronal mitochondrial dynamics: roles in brain disorders and therapeutic potential

Xiangnan Zhang, Xing-Xian Zhang, Jia-Min Du, Shen-Zhan Wang, Xin-Lei Mo

Acta Pharmacologica Sinica

DOI

2026

Powering Up the Brain: Intercellular Mitochondrial Quality Control and Its Implication in Stroke

Xiangnan Zhang, Xinyu Zhou, Shenzhe Wu, Tianxi Huang, Yue Li, Jianhong Yang, Zhen Gu

Current Neuropharmacology

DOI

2026

A switchable role of neuronal BNIP3L/NIX in mitochondrial fate: fission or finish

Xiangnan Zhang, Xinlei Mo, Xingxian Zhang

Autophagy

DOI

2026

Sevoflurane-induced disruption of critical period Arc signaling drives aberrant microglial synaptic pruning and cognitive deficits

Xiangnan Zhang, Bai-Hui Chen, Ye-Ru Chen, Liang-Yu Zheng, Hua-Jing Cai, Xin-Long Ke, Shi-Yu Li, Zheng-Jie Chen, Feng-Quan Zhou, Gang Chen

Acta Pharmacologica Sinica

DOI

2026

A tau-NLRP3 neuroimmune loop in the lateral septum drives chronic pain and anxiety comorbidity

Shuxia Zhang, Yeru Chen, Junwei Su, Huajing Cai, Fangla Luo, Jiao Liu, Hongyan Li, Xinlong Ke, Xiangnan Zhang, Yongjie Wang, Gang Chen

Journal of Neuroinflammation

DOI

2025

Pterostilbene mitigates the senescence of human dermal fibroblast cells by enhancing mitochondrial quality

Xiangnan Zhang, Xinyu Zhou, Ning Wang, Jihua Wei, Guizhi Li, Zhengwei Lue, Chang Liu, Qi Bao, Zhe Feng, Minjie Zhang, Hu Huang, Yue Li, Jing Wang

Frontiers in Pharmacology

DOI

2025

Discovery of adamantyl derivatives as potent and selective TRPM2 inhibitors with significantly reduced hERG liability

Xiangnan Zhang, Tinghao Lu, MeiJie Dai, Kaiyue Ying, Xianhao Dong, Wanglin Qu, Peichen Pan, Wei Yang, Peilin Yu, Hongbin Zou

European Journal of Medicinal Chemistry

DOI

2025

Low-density electrospun fibrous network promotes mechanotransduction and matrix remodeling in fibroblasts

Xiangnan Zhang, Han Tang, Xiaoli Wang, Sha Qiu, Yuying Wang, Yanzhong Zhang

Biomaterials Advances

DOI

2025

Dihydromyricetin restores lysosomal function in Schwann cells to alleviate bortezomib-induced peripheral neuropathy via ERK/TFEB signaling

Xiangnan Zhang, Xiaoliang Liu, Xingxian Zhang, Xinhang Li, Chen Zhang, Huajing Cai, Jiayu Qi, Ke Wang, Xuyun Li, Xiuhua Wu, Ziqi Ye, Gang Chen, Jiaying Wu

Archives of Toxicology

DOI

2025

Gallic acid relieved bortezomib-induced peripheral neurotoxicity by restoring Schwann cell lysosomal activity

Xiangnan Zhang, Xiaoliang Liu, Ke Wang, Xingxian Zhang, Jiayu Qi, Danyan Zhu, Zechao Wang, Zhi He, Jianbiao Yao, Jiaying Wu

Toxicological Sciences

DOI

2025

Modulation of autophagy by melatonin and its receptors: implications in brain disorders

Xiangnan Zhang, Chen-Ze Zhu, Gui-Zhi Li, Hai-Feng Lyu, Yang-Yang Lu, Yue Li

Acta Pharmacologica Sinica

DOI

2025

Mussel Foot Protein Membrane-Enclosed Crystalline Drug with Zero-Order Release Kinetics for Long-Acting Therapy

Xiangnan Zhang, Leihao Lu, Jianchang Xu, Xuehui Huang, Leyi Hu, Kangfan Ji, Chuhuan Jiang, Yanfang Wang, Yue Qin, Yang Zhang, Juan Zhang, Jiahao Hu, Shenxi Qian, Yingqi Huang, Hongzhen Bai, Fuyao Liu, Zhen Gu, Jinqiang Wang

Angewandte Chemie International Edition

DOI

2025

TRPC4 Mediates Trigeminal Neuropathic Pain via Ca2+-ERK/P38-ATF2 Pathway in the Trigeminal Ganglion of Mice

Xiangnan Zhang, Xinlong Ke, Huajing Cai, Fangla Luo, Xing Zheng, Qian Hu, Youfa Zhou, Yongjie Wang, Yeru Chen, Gang Chen

CNS Neuroscience & Therapeutics

DOI

2025

Indolizine Derivatives Inhibit TRPM2 and Protect against Ischemic Brain Injury with an Extended Treatment Window

Xiangnan Zhang, Tinghao Lu, Yi Zhang, Jinbiao Li, MeiJie Dai, Huan Liu, Huajian Zhu, Shaozi Fu, Xianhao Dong, Fenghao Sun, Hongwei Lin, Wei Yang, Peilin Yu, Hongbin Zou

Journal of Medicinal Chemistry

DOI

2025

Stress dynamically modulates neuronal autophagy to gate depression onset

Liang Yang, Guo Chen, Zhiwei Zheng, Yiyan Dong, Qifeng Xie, Zijian Lv, Min Li, Yangyang Lu, Xiaonan Guo, Rongshan Deng, Yiqin Liu, Yirong Feng, Ruiqi Mu, Xuliang Zhang, Xuliang Zhang, Huan Ma, Zhong Chen, Zhijun Zhang, Zhaoqi Dong, Wei Yang, Xiangnan Zhang, Xiangnan Zhang, Yihui Cui

Nature

DOI

2025

基质金属蛋白酶在缺血性脑白质损伤中的作用及药物干预研究进展

王泽超，刘晓亮，王申湛，何治，张翔南

《中国细胞生物学学报》

2025

蓝布正提取物改善脑缺血后神经功能损伤作用及机制研究

刘苏亚，王泽超，陆阳洋，吕政伟，何治，张翔南

《中国现代应用药学》

DOI

2024

Deletion of histamine H2 receptor in VTA dopaminergic neurons of mice induces behavior reminiscent of mania

Xiangnan Zhang, Shijia Ma, Qianyi Ma, Songhui Hu, Xinlei Mo, Chenze Zhu, Xingxian Zhang, Zetao Jia, Lingjie Tang, Lei Jiang, Yihui Cui, Zhong Chen, Weiwei Hu

Cell Reports

DOI

2024

Nervonic acid protects against oligodendrocytes injury following chronic cerebral hypoperfusion in mice

Xiangnan Zhang, Zheng W, Xu G, Lue Z, Zhou X, Wang N, Ma Y, Yuan W, Yu L, Zhu D

European Journal of Pharmacology

DOI

2024

The autophagic regulation of rosiglitazone-promoted adipocyte browning

Xiangnan Zhang, Li Y, Zheng W, Li X, Lue Z, Liu Y, Wu J

Frontiers in Pharmacology

DOI

2024

Cell-specific IL-1R1 regulates the regional heterogeneity of microglial displacement of GABAergic synapses and motor learning ability

Xiangnan Zhang, You Y, An DD, Wan YS, Zheng BX, Dai HB, Zhang SH, Wang RR, Shi P, Jin M, Wang Y, Jiang L, Chen Z, Hu WW

Cellular and Molecular Life Sciences

DOI

2024

Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke

Xiangnan Zhang, Tang T, Hu LB, Ding C, Zhang Z, Wang N, Wang T, Zhou H, Xia S, Fan L, Fu XJ, Yan F, Chen G, Li J

Stroke and Vascular Neurology

DOI

2024

恩格列净通过抑制小胶质细胞激活改善小鼠缺血性脑损伤

曹明，周心雨，刘苏亚，刘芸，郑婉晴，张翔南

《中国现代应用药学》

2024

Nervonic acid improves depression like behaviors and demyelination of medial prefrontal cortex in chronic restraint stress mice

Shijia Ma, Zhengwei Lue, Genghua Xu, Yun Ma, Wenyue Yuan, Zhenhui Huang, Songhui Hu, Lu-shan Yu, Xiangnan Zhang

Biochemical and Biophysical Research Communications

DOI

2023

Lysosomal dysfunction in Schwann cells is involved in bortezomib-induced peripheral neurotoxicity

Xiangnan Zhang, Wu Z, Yan W, Wang K, Xu G, Zhu D, Li X, Wang H, Yang M, Wu J

Archives of Toxicology

DOI

2023

The engagement of autophagy in maniac disease

Xiangnan Zhang, Yidong Yang, Renxiang Yuan, Yangyang Lu, Chenze Zhu, Chen Zhang, Haifeng Lue

CNS Neuroscience & Therapeutics

DOI

2023

Targeting neuronal mitophagy in ischemic stroke: an update

Xiangnan Zhang, Jun Li, Jiaying Wu, Xinyu Zhou, Yangyang Lu, Yuyang Ge

Burns & Trauma

DOI

2023

Postsynaptic histamine H3 receptors in ventral basal forebrain cholinergic neurons modulate contextual fear memory

Xiangnan Zhang, Yanrong Zheng, Lishi Fan, Zhuowen Fang, Zonghan Liu, Jiahui Chen, Yi Wang, Yan Zhang, Lei Jiang, Zhong Chen, Weiwei Hu

Cell Reports

DOI

2023

Microglial pyroptosis in hippocampus mediates sevolfurane-induced cognitive impairment in aged mice via ROS-NLRP3 inflammasome pathway

Xiangnan Zhang, Zhou Y, Zhang Y, Wang H, Chen Y, Chen G

International Immunopharmacology

DOI

2023

腹侧被盖区多巴胺能神经元上组胺H2受体在躁狂样行为中的作用及其机制

马史佳，马倩怡，胡薇薇，陈忠，张翔南

《中国药理学与毒理学杂志》

2023

自噬在缺血性脑卒中过程中的作用及其调节机制研究进展

李玥，郑婉晴，潘玲，刘孟茹，周心雨，陈忠，张翔南

《中国科学:生命科学》

2023

Baicalein-corrected gut microbiota may underlie the amelioration of memory and cognitive deficits in APP/PS1 mice

Jing Shi, Jie Chen, Xinyun Xie, Yuanyuan Li, Wenjing Ye, Jianbiao Yao, Xiangnan Zhang, Tianyuan Zhang, Jianqing Gao

Frontiers in Pharmacology

DOI

2023

BNIP3L/NIX-mediated mitophagy alleviates passive stress-coping behaviors induced by tumor necrosis factor-α

Jia-Jing Lu, Pengfei Wu, Jin‐Gang He, Yu-Ke Li, Li‐Hong Long, Xia-Ping Yao, Jia-Hao Yang, Hong-Sheng Chen, Xiangnan Zhang, Zhuang‐Li Hu, Zhong Chen, Fang Wang, Jianguo Chen

Molecular Psychiatry

DOI

2023

Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy

Jianchen Fan, Xinyan Dong, Yejiao Tang, Xuehui Wang, Donghui Lin, Lifen Gong, Chen Chen, Jie Jiang, Weida Shen, Anyu Xu, Xiangnan Zhang, Yicheng Xie, Xin Huang, Linghui Zeng

CNS Neuroscience & Therapeutics

DOI

2023

Hybrid stem cell-derived bioresponsive vesicles for effective inflamed blood-brain barrier targeting delivery

Honghui Wu, Xinchi Jiang, Yaosheng Li, Yunfei Dong, Juanjuan Zheng, Lu Li, Ying Li, Jinqiang Wang, Xianming Lin, Xiangnan Zhang, Tianyuan Zhang, Zhen Gu, Jianqing Gao

Nano Today

DOI

2023

Biological nano agent produced by hypoxic preconditioning stem cell for stroke treatment

Xinchi Jiang, Honghui Wu, Tianyuan Zhang, Yun-Fei Dong, Yao-Sheng Li, Ting Huang, An-Hao Tian, Peng-Xiang Chen, Xianming Lin, Yingzhi Huang, Chong Liu, Xiangnan Zhang, Zhong Chen, Yasuhiko Tabata, Jianqing Gao

Nano Research

DOI

2023

Histamine H 2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia

Qianyi Ma, Lei Jiang, Han Chen, Dadao An, Yiting Ping, Yujia Wang, Haibin Dai, Xiangnan Zhang, Yi Wang, Zhong Chen, Weiwei Hu

Proceedings of the National Academy of Sciences

DOI

2022

TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner

Xiangnan Zhang, Mengru Liu, Xinyu Zhou, Yue Li, Shijia Ma, Ling Pan, Xingxian Zhang, Wanqing Zheng, Zhanxun Wu, Ke Wang, Anil Ahsan, Jiaying Wu, Lei Jiang, Yangyang Lu, Weiwei Hu, Zhenghong Qin, Zhong Chen

Redox Biology

DOI

2022

Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window

Xiangnan Zhang, Pan L, Tang WD, Wang K, Fang QF, Liu MR, Wu ZX, Wang Y, Cui SL, Hu G, Hou TJ, Hu WW, Chen Z

Acta Pharmacologica Sinica

DOI

2022

Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia

Lishi Fan, You-chao Chen, Rujia Liao, Yanyan Zhao, Xiangnan Zhang, Zhong Chen, Lei Jiang, Weiwei Hu

Acta Pharmacologica Sinica

DOI

2022

Egr2 contributes to age-dependent vulnerability to sevoflurane-induced cognitive deficits in mice

Yeru Chen, Shuxia Zhang, Man Fang, Piao Zhang, Youfa Zhou, Xin Yu, Xiangnan Zhang, Gang Chen

Acta Pharmacologica Sinica

DOI

2022

Activation of glutamatergic neurons in the somatosensory cortex promotes remyelination in ischemic vascular dementia

Yiting Zhou, Da-Dao An, Yixin Xu, Ying Zhou, Qingqing Li, Haibin Dai, Xiangnan Zhang, Yi Wang, Min Lou, Zhong Chen, Weiwei Hu

Fundamental Research

DOI

2021

BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains

Xiangnan Zhang, Xiaoli Wu, Yanrong Zheng, Mengru Liu, Shijia Ma, Weidong Tang, Wenping Yan, Ming Cao, Wanqing Zheng, Lei Jiang, Jiaying Wu, Feng Han, Zhenghong Qin, Liang Fang, Wei-wei Hu, Zhong Chen

Autophagy

DOI

2021

Natural compounds modulate the autophagy with potential implication of stroke

Ahsan A, Liu M, Zheng Y, Yan W, Pan L, Li Y, Ma S, Zhang X, Cao M, Wu Z, Hu W, Chen Z

Acta Pharmaceutica Sinica B

DOI

2021

BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease

Li Y, Zheng W, Lu Y, Zheng Y, Pan L, Wu X, Yuan Y, Shen Z, Ma S, Zhang X, Wu J, Chen Z

Cell Death and Disease

DOI

2021

Baicalein Ameliorates Aβ-Induced Memory Deficits and Neuronal Atrophy via Inhibition of PDE2 and PDE4

Xiangnan Zhang, Shi J, Li Y, Zhang Y, Chen J, Gao J, Zhang T, Shang X

Frontiers in Pharmacology

DOI

2021

The molecular and cellular insight into the toxicology of bortezomib-induced peripheral neuropathy

Xiangnan Zhang, Yan W, Wu Z, Zhang Y, Hong D, Dong X, Liu L, Rao Y, Huang L, Wu J

Biomedicine & Pharmacotherapy

DOI

2021

Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury

Xiangnan Zhang, Jiang L, Cheng L, Chen H, Dai H, An D, Ma Q, Zheng Y, Hu W, Chen Z

The Journal of Experimental Medicine

DOI

2021

Histamine H 1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice

Xiangnan Zhang, Cheng L, Xu C, Wang L, An D, Jiang L, Zheng Y, Xu Y, Wang Y, Wang Y, Zhang K, Wang X, Bao A, Zhou Y, Yang J, Duan S, Swaab DF, Hu W, Chen Z

Nature Communications

DOI

2021

Privileged Biorenewable Secologanin‐Based Diversity‐Oriented Synthesis for Pseudo‐Natural Alkaloids: Uncovering Novel Neuroprotective and Antimalarial Frameworks

Huajian Zhu, Yun‐Rui Cai, Shijia Ma, Yushi Futamura, Jinbiao Li, Wen Zhong, Xiangnan Zhang, Hiroyuki Osada, Hongbin Zou

ChemSusChem

DOI

2021

Tomatidine provides mitophagy‐independent neuroprotection after ischemic injury

Yuting Wang, Li‐na Zhang, Xiao‐cui Lyu, Yue Li, Anil Ahsan, Zikai Feng, Xiangnan Zhang

FEBS Open Bio

DOI

2020

Melatonin Receptor Agonist Ramelteon Attenuates Mouse Acute and Chronic Ischemic Brain Injury

Xiangnan Zhang, Xiao-Li Wu, Shou-Sheng Lu, Meng-Ru Liu, Wei-Dong Tang, Jun-Zi Chen, Yan-Rong Zheng, Anil Ahsan, Ming Cao, Lei Jiang, Wei-Wei Hu, Jia-Ying Wu, Zhong Chen

Acta Pharmacologica Sinica

DOI

2020

Tomatidine protects against ischemic neuronal injury by improving lysosomal function

Xiangnan Zhang, Anil Ahsan, Yanrong Zheng, Shijia Ma, Mengru Liu, Ming Cao, Yue Li, Wanqing Zheng, Xinyu Zhou, Minhang Xin, Wei-Wei Hu, Zhong Chen

European Journal of Pharmacology

DOI

2019

Somatic autophagy of axonal mitochondria in ischemic neurons

Xiangnan Zhang, Yanrong Zheng, Xiaoli Wu, Lei Jiang, Anil Ahsan, Shijia Ma, Ziyu Xiao, Feng Han, Zhenghong Qin, Weiwei Hu, Zhong Chen

The Journal of Cell Biology

DOI

2019

Come and eat: mitochondrial transport guides mitophagy in ischemic neuronal axons

Xiangnan Zhang, Yanrong Zheng, Xiaoli Wu, Zhong Chen

Autophagy

DOI

2019

MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration

Xiangnan Zhang, Qiong Feng, Yu Luo, Xi-Fei Yang, Xiao-Yue Hong, Dong-Shen Sun, Xia-Chun Li, Yu Hu, Xiao-Guang Li, Jun-Fei Zhang, Xiao Li, Ying Yang, Qun Wang, Gong-Ping Liu, Jian-Zhi Wang

Autophagy

DOI

2019

Histamine H1 Receptors in Neural Stem Cells Are Required for the Promotion of Neurogenesis Conferred by H3 Receptor Antagonism following Traumatic Brain Injury

Xiangnan Zhang, Rujia Liao, Youchao Chen, Li Cheng, Lishi Fan, Han Chen, Yushan Wan, Yi You, Yanrong Zheng, Lei Jiang, Zhong Chen, Weiwei Hu

Stem Cell Reports

DOI

2019

Urolithin A-activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo

Xiangnan Zhang, Anil Ahsan, Yan-Rong Zheng, Xiao-Li Wu, Wei-Dong Tang, Meng-Ru Liu, Shi-Jia Ma, Lei Jiang, Wei-Wei Hu, Zhong Chen

CNS Neuroscience & Therapeutics

DOI

2019

Corrigendum to ‘Interleukin-1β impedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion’ [Brain Behav. Immun. 60 (2017) 93–105]

Yiting Zhou, Jing Zhang, Lu Wang, Ying Chen, Yushan Wan, Yang He, Lei Jiang, Jing Ma, Rujia Liao, Xiangnan Zhang, Liyun Shi, Zheng‐Hong Qin, Yudong Zhou, Zhong Chen, Weiwei Hu

Brain Behavior and Immunity

DOI

2019

Mitochondrial transport serves as a mitochondrial quality control strategy in axons: Implications for central nervous system disorders

Yan-Rong Zheng, Xiangnan Zhang, Zhong Chen

CNS Neuroscience & Therapeutics

DOI

2018

The Prophylactic and Therapeutic Effects of Fermented Cordyceps sinensis Powder, Cs-C-Q80, on Subcortical Ischemic Vascular Dementia in Mice

Xiangnan Zhang, Ying Chen, Lifeng Fu, Min Han, Meiying Jin, Jiaying Wu, Li Tan, Zhong Chen

Evidence-based Complementary and Alternative Medicine

DOI

2018

缺血神经元轴突线粒体逆向转运回胞体后被自噬清除

郑艳榕，张翔南，陈忠

《中国药理学与毒理学杂志》

2018

抑制Bnip3l二聚体降解的抗脑缺血损伤作用研究

吴晓丽，张翔南，陈忠

《中国药理学与毒理学杂志》

2017

BNIP3L/NIX-mediated mitophagy protects against ischemic brain injury independent of PARK2

Xiangnan Zhang, Yang Yuan, Yanrong Zheng, Ying Chen, Xiaoli Wu, Jiaying Wu, Zhe Shen, Lei Jiang, Lu Wang, Wei Yang, Jianhong Luo, Zhenghong Qin, Weiwei Hu, Zhong Chen

Autophagy

DOI

2017

PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window

Xiangnan Zhang, Zhe Shen, Yanrong Zheng, Jiaying Wu, Ying Chen, Xiaoli Wu, Yiting Zhou, Yang Yuan, Shousheng Lu, Lei Jiang, Zhenghong Qin, Zhong Chen, Weiwei Hu

Autophagy

DOI

2017

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Xiangnan Zhang, Yanrong Zheng, Zhe Shen, Xiaoli Wu, Lei Jiang, Wei-wei Hu, Zhong Chen

Journal of Visualized Experiments

DOI

2017

PD-1 inhibitors increase the incidence and risk of pneumonitis in cancer patients in a dose-independent manner: a meta-analysis

Xiangnan Zhang, Jiaying Wu, Dongsheng Hong, Xiaoyang Lu, Jing Miao

Scientific Reports

DOI

2017

大学生科研训练计划在研究型药学人才培养中的作用——以我院2017届本科毕业生为例

张翔南，汪仪，徐层林，朱卡林

《科教导刊》

2017

Nix介导的线粒体自噬机制的研究进展

郑艳榕，张翔南，陈忠

《浙江大学学报(医学版)》

2017

[Research progress on mechanism of Nix-mediated mitophagy].

Yanrong Zheng, Xiangnan Zhang, Zhong Chen

PubMed

DOI

2017

NaHS Protects against the Impairments Induced by Oxygen-Glucose Deprivation in Different Ages of Primary Hippocampal Neurons

Qian Yu, Binrong Wang, Tian-Zhi Zhao, Xiangnan Zhang, Lei Tao, Jinshan Shi, Xu-De Sun, Qian Ding

Frontiers in Cellular Neuroscience

DOI

2016

Interleukin-1β impedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion

Xiangnan Zhang, Yiting Zhou, Jing Zhang, Lu Wang, Ying Chen, Yushan Wan, Yang He, Lei Jiang, Jing Ma, Rujia Liao, Liyun Shi, Zhenghong Qin, Yudong Zhou, Zhong Chen, Weiwei Hu

Brain Behavior And Immunity，Vol. 60

DOI

2016

Pre-stroke Metformin Treatment is Neuroprotective Involving AMPK Reduction

Xiangnan Zhang, Tian Deng, Yan-Rong Zheng, Wei-Wei Hou, Yang Yuan, Zhe Shen, Xiao-Li Wu, Ying Chen, Li-San Zhang, Wei-Wei Hu, Zhong Chen

Neurochemical Research

DOI

2016

Tau accumulation impairs mitophagy via increasing mitochondrial membrane potential and reducing mitochondrial Parkin

Xiangnan Zhang, Yu Hu, Xia-Chun Li, Zhi-hao Wang, Yu Luo, Xiu-Ping Liu, Qiong Feng, Qun Wang, Zhenyu Yue, Zhong Chen, Keqiang Ye, Jian-Zhi Wang, Gong-Ping Liu

Oncotarget

DOI

2016

Entorhinal Principal Neurons Mediate Brain-stimulation Treatments for Epilepsy

Zhenghao Xu, Yi Wang, Bin Chen, Cenglin Xu, Xiaohua Wu, Ying Wang, Shihong Zhang, Weiwei Hu, Shuang Wang, Yi Chen Guo, Xiangnan Zhang, Jianhong Luo, Shumin Duan, Zhong Chen

EBioMedicine

DOI

2015

Inhibition of G-Protein-Coupled Receptor 81 (GPR81) Protects Against Ischemic Brain Injury

Xiangnan Zhang, Zhe Shen, Lei Jiang, Yang Yuan, Tian Deng, Yan-Rong Zheng, Wen-Lu Li, Jia-Ying Wu, Jian-Qing Gao, Wei-Wei-Hu, Zhong Chen

CNS Neuroscience & Therapeutics

DOI

2015

Regulation of mitophagy in ischemic brain injury

Xiangnan Zhang, Yang Yuan, Chen Zhong

Neuroscience Bulletin

DOI

2015

Histamine Promotes Locomotion Recovery After Spinal Cord Hemisection via Inhibiting Astrocytic Scar Formation

Xiangnan Zhang, Yan-Yan Zhao, Yang Yuan, Ying Chen, Lei Jiang, Ru-Jia Liao, Lu Wang, Hiroshi Ohtsu, Wei-Wei Hu, Zhong Chen

CNS Neuroscience & Therapeutics

DOI

2015

Histidine provides long-term neuroprotection after cerebral ischemia through promoting astrocyte migration

Xiangnan Zhang, Ru-jia Liao, Lei Jiang, Rong-rong Wang, Hua-wei Zhao, Ying Chen, Ya Li, Lu Wang, Li-Yong Jie, Yu-dong Zhou, Zhong Chen, Wei-wei Hu

Scientific Reports

DOI

2015

Early treatment of minocycline alleviates white matter and cognitive impairments after chronic cerebral hypoperfusion

Xiangnan Zhang, Jing Ma, Jing Zhang, Wei-wei Hou, Xiao-Hua Wu, Ru-Jia Liao, Ying Chen, Zhe Wang, Li-San Zhang, Yu-Dong Zhou, Zhong Chen, Wei-wei Hu

Scientific Reports

DOI

2015

自噬：生物学与疾病（第2版）临床卷

张翔南

《科学出版社》

2014

Morphology and functions of astrocytes cultured on water-repellent fractal tripalmitin surfaces

Xiangnan Zhang, Wei-wei Hu, Zhe Wang, Shan-shan Zhang, Lei Jiang, Jing Zhang, Qun-fang Lei, Hyun-Joo Park, Wen-jun Fang, Zhong Chen

Biomaterials

DOI

2014

A novel neuroprotective strategy for ischemic stroke: transient mild acidosis treatment by CO2 inhalation at reperfusion

Xiangnan Zhang, Yan-ying Fan, Zhe Shen, Ping He, Lei Jiang, Wei-wei Hou, Yao Shen, Wei-wei Hu, Zhong Chen

Journal of Cerebral Blood Flow & Metabolism

DOI

2014

TRPM2 channel deficiency prevents delayed cytosolic Zn2+ accumulation and CA1 pyramidal neuronal death after transient global ischemia

M Ye, W Yang, J F Ainscough, X-P Hu, X Li, A Sedo, X-H Zhang, Z Chen, X-M Li, D J Beech, A Sivaprasadarao, J-H Luo, L-H Jiang

Cell Death and Disease

DOI

2014

Dysfunction of thermoregulation contributes to the generation of hyperthermia-induced seizures

Xiangnan Zhang, Bo Feng, Yang-Shun Tang, Bin Chen, Yun-Jian Dai, Ceng-Lin Xu, Zheng-Hao Xu, Shi-Hong Zhang, Wei-Wei Hu, Zhong Chen

Neuroscience Letters

DOI

2014

Endoplasmic reticulum stress induced by tunicamycin and thapsigargin protects against transient ischemic brain injury

Xiangnan Zhang, Yang Yuan, Lei Jiang, Jingying Zhang, Jieqiong Gao, Zhe Shen, Yanrong Zheng, Tian Deng, Haijing Yan, Wenlu Li, Weiwei Hou, Jianxin Lü, Yao Shen, Haibing Dai, Weiwei Hu, Zhuohua Zhang, Zhong Chen

Autophagy

DOI

2014

Histamine H3 receptors aggravate cerebral ischaemic injury by histamine-independent mechanisms

Haijing Yan, Xiangnan Zhang, Weiwei Hu, Jing Ma, Weiwei Hou, Xingzhou Zhang, Xiaofen Wang, Jieqiong Gao, Yao Shen, Jianxin Lv, Hiroshi Ohtsu, Feng Han, Guanghui Wang, Zhong Chen

Nature Communications

DOI

2014

缺血性脑损伤中的自噬——研究进展与挑战

张翔南，陈忠

《中国科学:生命科学》

2014

Autophagy in Cerebral Ischemia: Progress and Challenge

Xiangnan Zhang, Zhong Chen

DOI

2013

Transient Lack of Glucose but not O2 is Involved in Ischemic Postconditioning-induced Neuroprotection

Xiangnan Zhang, Yan-Ying Fan, Ping He, Zhe Shen, Yao Shen, Xiao-Fen Wang, Wei-Wei Hu, Zhong Chen

CNS Neuroscience & Therapeutics

DOI

2013

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

Xiangnan Zhang, Haijing Yan, Yang Yuan, Jieqiong Gao, Zhe Shen, Yun Cheng, Yao Shen, Rongrong Wang, Xiaofen Wang, Weiwei Hu, Guanghui Wang, Zhong Chen

Autophagy

DOI

2013

肌肽对小鼠闭合性脑损伤的保护作用

裴旭颖，倪康欣，周优，应琨，张翔南，厉旭云，陆源，陈忠

《浙江大学学报(医学版)》

2013

[Protective effects of carnosine against closed head injury in mice].

Xuying Pei, Kang-Xin Ni, You Zhou, Kun Ying, Xiangnan Zhang, Xu-Yun Li, Yuan Lu, Zhong Chen

Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences

2012

Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis

Xiangnan Zhang, Jiaying Wu, Yuan Dou, Binbin Xia, Weibo Rong, Gerald Rimbach, Yijia Lou

European Journal of Pharmacology

DOI

2012

Oxygen-Glucose Deprivation Induced Glial Scar-Like Change in Astrocytes

Xiangnan Zhang, Rongrong Wang, Jianxiang Zhang, Yanying Fan, Yao Shen, Weiwei Hu, Zhong Chen

PLoS ONE

DOI

2012

Acidic preconditioning protects against ischemia-induced brain injury

Xiangnan Zhang, Chen-hui Zhang, Yan-ying Fan, Xiao-fen Wang, Jia-yan Xiong, Ying-ying Tang, Jie-qiong Gao, Zhe Shen, Xiao-hui Song, Jing-ying Zhang, Yao Shen, Qing Li, Zhong Chen

Neuroscience Letters

DOI

2012

Lanthionine Synthetase C-like Protein 1 Interacts with and Inhibits Cystathionine β-Synthase

Wei-Xia Zhong, Yu-bin Wang, Lin Peng, X. Ge, Jie Zhang, Shuang Liu, Xiangnan Zhang, Zheng-Hao Xu, Zhong Chen, Jian-hong Luo

Journal of Biological Chemistry

DOI

2012

Chronic H1‐Antihistamine Treatment Increases Seizure Susceptibility After Withdrawal by Impairing Glutamine Synthetase

Weiwei Hu, Qi Fang, Zheng-Hao Xu, Hai-jing Yan, P. He, Kai Zhong, Yan-Ying Fan, Ying Yang, Xiangnan Zhang, Chun-yang Zhang, H. Ohtsu, Tian-Le Xu, Zhong Chen

CNS Neuroscience & Therapeutics

DOI

2012

H1-antihistamines induce vacuolation in astrocytes through macroautophagy

Weiwei Hu, Ying Yang, Zhe Wang, Zhe Shen, Xiangnan Zhang, Guanghui Wang, Zhong Chen

Toxicology and Applied Pharmacology

DOI

2010

Synthesis, biological evaluation, and structure-activity relationship study of novel cytotoxic aza-caffeic acid derivatives

Xiangnan Zhang, Hongbin Zou, Hao Wu, Yu Zhao, Joachim Stoekigt, Yijia Lou, Yongping Yu

Bioorganic & Medicinal Chemistry

DOI

2010

LPS腹腔注射诱发大鼠脑内炎症致皮层与海马病理改变及相关机制研究

张翔南

《浙江大学》

2009

Dietary vitamin E, brain redox status and expression of Alzheimer’s disease relevant genes in rats

Xiangnan Zhang, Sonja Gaedicke, Patricia Huebbe, Christine Boesch-Saadatmandi, Yijia Lou, Ingrid Wiswedel, Andreas Gardemann, Jan Frank, Gerald Rimbach

British Journal Of Nutrition

DOI

2009

Ochratoxin A induces apoptosis in neuronal cells

Xiangnan Zhang, Christine Boesch, Yijia Lou, Siegfried Wolffram, Patricia Huebbe, Gerald H Rimbach

Genes & Nutrition

DOI

2009

Balb/c小鼠静脉注射刀豆蛋白A致大脑皮层内MAPEG基因表达变化及环孢素影响

张翔南，齐罗扬，朱丹雁，楼宜嘉

《浙江大学学报(医学版)》

2009

[Effect of concanavalin A on expression of MAPEG mRNA in Balb/c mouse brain].

Xiangnan Zhang, Lou-Yang Qi, Danyan Zhu, Yijia Lou

PubMed

DOI

2008

Vitamin E dependent microRNA regulation in rat liver

Xiangnan Zhang, Sonja Gaedicke, Constance Schmelzer, Yijia Lou, Frank Doering, Jan Frank, Gerald Rimbach

FEBS Letters

DOI

2008

Enhanced co-expression of β-tubulin III and choline acetyltransferase in neurons from mouse embryonic stem cells promoted by icaritin in an estrogen receptor-independent manner

Zhiqiang Wang, Huanhuan Wang, Jiaying Wu, Danyan Zhu, Xiangnan Zhang, Lili Ou, Yongping Yu, Yijia Lou

Chemico-Biological Interactions

DOI

2007

Neuroprotective effects of icaritin against beta amyloid-induced neurotoxicity in primary cultured rat neuronal cells via estrogen-dependent pathway

Xiangnan Zhang, Zhiqiang Wang, Luoyang Qi, Huanhuan Wang, Yijia Lou

Neuroscience

DOI

2007

淫羊藿素诱导小鼠胚胎干细胞体外定向分化为神经细胞

朱丹雁，张翔南，杜悦，陈燕，王志强，楼宜嘉

《浙江大学学报(医学版)》

2007

淫羊藿素抗Aβ肽致大鼠原代培养神经细胞凋亡作用

张翔南，王欢欢，王志强，吴佳莹，朱丹雁，楼宜嘉

《浙江大学学报(医学版)》

会议论文

2018

The regulations of mitophagy in ischemic neurons

ZHENG Yan-Rong, 张翔南, CHEN Zhong

《2018年药理学前沿国际研讨会暨浙江省药理学会浙江省药学会药理专业委员会学术年会摘要集》

2018

卡非佐米抑制Bnip3L二聚体降解发挥抗脑缺血损伤作用

吴晓丽，张翔南，陈忠

《2018年药理学前沿国际研讨会暨浙江省药理学会浙江省药学会药理专业委员会学术年会摘要集》

2017

氧糖剥夺-再灌诱导的小鼠大脑皮层神经元轴突线粒体逆向转运促进线粒体自噬

郑艳榕，张翔南，陈忠

《第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会论文集》

DOI

2017

Parkin-dependent mitophagy induced by acidic postconditioning extends reperfusion window in focal cerebral ischemia

Yanrong Zheng, Xiangnan Zhang, Zhong Chen

《EMBO Workshop 2017-“线粒体质量控制”国际研讨会》

2015

Histamine H3 receptor aggravates cerebral ischemic injury mediated by regulating autophagy

Xiangnan Zhang, Weiwei Hu, Haijing Yan, Zhong Chen

《第六届亚太神经科学联合会学术会议暨中国神经科学学会第十一届全国学术会议论文集》

2013

大鼠腹腔注射脂多糖致大鼠学习记忆能力损伤

张艺瀚，窦沅，张翔南，刘琰，何良艳，朱丹雁，楼宜嘉

《中国毒理学会第六届全国毒理学大会》

2013

Rescuing the Ischemic Brains by ER Stress-induced Autophagy

Yang Yuan, Jieqiong Gao, Jingying Zhang, Xiangnan Zhang, Zhong Chen

《中国药理通讯(2013年第三十卷第三期)》

2012

酸后处理对脑缺血再灌注损伤的保护作用

沈哲，范彦英，张翔南，陈忠

《第十五届中国神经精神药理学学术会议论文摘要》

2012

内质网应激在脑缺血复灌中的作用研究

袁扬，张翔南，陈忠

《第十五届中国神经精神药理学学术会议》

2011

自噬在组胺H3受体拮抗剂对脑缺血的神经保护中的作用

闫海静，张翔南，马婧，范彦英，张晨晖，王融溶，胡薇薇，陈忠

《中国神经科学学会第九届全国学术会议暨第五次会员代表大会论文摘要集》

2008

人参皂苷Rgl对Aβ 25-35 致大鼠原代皮层神经细胞损伤保护作用

吴佳莹，张翔南，许敏华，梅宇钦，朱丹雁，崔荣，林嘉贞，苏毅，楼宜嘉

《中国药学会应用药理专业委员会第三届学术会议、中国药理学会制药工业专业委员会第十三届学术会议暨2008生物医药学术论坛论文汇编》

书籍章节

2021

Monitoring Autophagy by Optical Microscopy

Xiangnan Zhang, Zheng Y, Chen Z

Advances in experimental medicine and biology

DOI

2020

Autophagy and Mitochondrial Encephalomyopathies

Xiangnan Zhang, Yanrong Zheng, Zhong Chen

Advances in experimental medicine and biology

DOI

个人简介

教育与工作经历

工作经历

教育经历

精选作品

期刊论文

A Non-Mitophagy Activity of BNIP3L/NIX in Amygdala Glutamatergic Neurons is Essential for Contextual Fear Memory Formation

Therapeutic potential of tanshinones in ischaemia-reperfusion injury: Bioactive analogues, pharmacology and mechanisms

Lemborexant produces antidepressant- and anxiolytic-like effects with sleep-wake regulation compared with fluoxetine in male mice with comorbid depression and insomnia

Microglial IRF7-induced lipophagy impairment aggravates lipid droplet overload and impedes neurological recovery after ischemic stroke

Neuronal mitochondrial dynamics: roles in brain disorders and therapeutic potential

Powering Up the Brain: Intercellular Mitochondrial Quality Control and Its Implication in Stroke

A switchable role of neuronal BNIP3L/NIX in mitochondrial fate: fission or finish

Sevoflurane-induced disruption of critical period Arc signaling drives aberrant microglial synaptic pruning and cognitive deficits

A tau-NLRP3 neuroimmune loop in the lateral septum drives chronic pain and anxiety comorbidity

Pterostilbene mitigates the senescence of human dermal fibroblast cells by enhancing mitochondrial quality

Discovery of adamantyl derivatives as potent and selective TRPM2 inhibitors with significantly reduced hERG liability

Low-density electrospun fibrous network promotes mechanotransduction and matrix remodeling in fibroblasts

Dihydromyricetin restores lysosomal function in Schwann cells to alleviate bortezomib-induced peripheral neuropathy via ERK/TFEB signaling

Gallic acid relieved bortezomib-induced peripheral neurotoxicity by restoring Schwann cell lysosomal activity

Modulation of autophagy by melatonin and its receptors: implications in brain disorders

Mussel Foot Protein Membrane-Enclosed Crystalline Drug with Zero-Order Release Kinetics for Long-Acting Therapy

TRPC4 Mediates Trigeminal Neuropathic Pain via Ca2+-ERK/P38-ATF2 Pathway in the Trigeminal Ganglion of Mice

Indolizine Derivatives Inhibit TRPM2 and Protect against Ischemic Brain Injury with an Extended Treatment Window

Stress dynamically modulates neuronal autophagy to gate depression onset

基质金属蛋白酶在缺血性脑白质损伤中的作用及药物干预研究进展

蓝布正提取物改善脑缺血后神经功能损伤作用及机制研究

Deletion of histamine H2 receptor in VTA dopaminergic neurons of mice induces behavior reminiscent of mania

Nervonic acid protects against oligodendrocytes injury following chronic cerebral hypoperfusion in mice

The autophagic regulation of rosiglitazone-promoted adipocyte browning

Cell-specific IL-1R1 regulates the regional heterogeneity of microglial displacement of GABAergic synapses and motor learning ability

Src inhibition rescues FUNDC1-mediated neuronal mitophagy in ischaemic stroke

恩格列净通过抑制小胶质细胞激活改善小鼠缺血性脑损伤

Nervonic acid improves depression like behaviors and demyelination of medial prefrontal cortex in chronic restraint stress mice

Lysosomal dysfunction in Schwann cells is involved in bortezomib-induced peripheral neurotoxicity

The engagement of autophagy in maniac disease

Targeting neuronal mitophagy in ischemic stroke: an update

Postsynaptic histamine H3 receptors in ventral basal forebrain cholinergic neurons modulate contextual fear memory

Microglial pyroptosis in hippocampus mediates sevolfurane-induced cognitive impairment in aged mice via ROS-NLRP3 inflammasome pathway

腹侧被盖区多巴胺能神经元上组胺H2受体在躁狂样行为中的作用及其机制

自噬在缺血性脑卒中过程中的作用及其调节机制研究进展

Baicalein-corrected gut microbiota may underlie the amelioration of memory and cognitive deficits in APP/PS1 mice

BNIP3L/NIX-mediated mitophagy alleviates passive stress-coping behaviors induced by tumor necrosis factor-α

Preferential pruning of inhibitory synapses by microglia contributes to alteration of the balance between excitatory and inhibitory synapses in the hippocampus in temporal lobe epilepsy

Hybrid stem cell-derived bioresponsive vesicles for effective inflamed blood-brain barrier targeting delivery

Biological nano agent produced by hypoxic preconditioning stem cell for stroke treatment

Histamine H 2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia

TIGAR alleviates oxidative stress in brain with extended ischemia via a pentose phosphate pathway-independent manner

Novel Caspase-1 inhibitor CZL80 improves neurological function in mice after progressive ischemic stroke within a long therapeutic time-window

Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia

Egr2 contributes to age-dependent vulnerability to sevoflurane-induced cognitive deficits in mice

Activation of glutamatergic neurons in the somatosensory cortex promotes remyelination in ischemic vascular dementia

BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains

Natural compounds modulate the autophagy with potential implication of stroke

BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease

Baicalein Ameliorates Aβ-Induced Memory Deficits and Neuronal Atrophy via Inhibition of PDE2 and PDE4

The molecular and cellular insight into the toxicology of bortezomib-induced peripheral neuropathy

Histamine H2 receptor negatively regulates oligodendrocyte differentiation in neonatal hypoxic-ischemic white matter injury

Histamine H 1 receptor deletion in cholinergic neurons induces sensorimotor gating ability deficit and social impairments in mice

Privileged Biorenewable Secologanin‐Based Diversity‐Oriented Synthesis for Pseudo‐Natural Alkaloids: Uncovering Novel Neuroprotective and Antimalarial Frameworks

Tomatidine provides mitophagy‐independent neuroprotection after ischemic injury

Melatonin Receptor Agonist Ramelteon Attenuates Mouse Acute and Chronic Ischemic Brain Injury

Tomatidine protects against ischemic neuronal injury by improving lysosomal function

Somatic autophagy of axonal mitochondria in ischemic neurons

Come and eat: mitochondrial transport guides mitophagy in ischemic neuronal axons

MAPT/Tau accumulation represses autophagy flux by disrupting IST1-regulated ESCRT-III complex formation: a vicious cycle in Alzheimer neurodegeneration

Histamine H1 Receptors in Neural Stem Cells Are Required for the Promotion of Neurogenesis Conferred by H3 Receptor Antagonism following Traumatic Brain Injury

Urolithin A-activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo

Corrigendum to ‘Interleukin-1β impedes oligodendrocyte progenitor cell recruitment and white matter repair following chronic cerebral hypoperfusion’ [Brain Behav. Immun. 60 (2017) 93–105]

Mitochondrial transport serves as a mitochondrial quality control strategy in axons: Implications for central nervous system disorders

The Prophylactic and Therapeutic Effects of Fermented Cordyceps sinensis Powder, Cs-C-Q80, on Subcortical Ischemic Vascular Dementia in Mice

缺血神经元轴突线粒体逆向转运回胞体后被自噬清除

抑制Bnip3l二聚体降解的抗脑缺血损伤作用研究

BNIP3L/NIX-mediated mitophagy protects against ischemic brain injury independent of PARK2

PARK2-dependent mitophagy induced by acidic postconditioning protects against focal cerebral ischemia and extends the reperfusion window

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

PD-1 inhibitors increase the incidence and risk of pneumonitis in cancer patients in a dose-independent manner: a meta-analysis

大学生科研训练计划在研究型药学人才培养中的作用——以我院2017届本科毕业生为例

Nix介导的线粒体自噬机制的研究进展

[Research progress on mechanism of Nix-mediated mitophagy].

自噬：生物学与疾病（第2版）临床卷