姜世勃

2026

From injection to inhalation: A STING‐activating mucosal adjuvant reprograms vaccination

Clinical and Translational Medicine

DOI

2026

FabI-targeting pentacyclic triterpenoid celastrol resensitizes multidrug-resistant Gram-negative bacteria to polymyxins

Phytomedicine

DOI

2026

Intranasal gold nanoparticle-antigen induces mucosal and systemic immunity against β-coronaviruses

hLife

DOI

2026

Current advances in the development of Nipah virus vaccines

Current Research in Microbial Sciences

DOI

2026

Pygenic acid A, a small-molecule PD-1/SHP-2 inhibitor, enhances efficacy of therapeutic melanoma vaccines and prophylactic influenza vaccines

Virologica Sinica

DOI

2026

Peptide-based henipavirus entry inhibitors as pandemic countermeasures

hLife

DOI

2026

Advances in human respiratory organoid models for studying the pathogenesis and intervention strategies of COVID-19

Virologica Sinica

DOI

2026

Chikungunya in 2025: Comprehensive Insights into Virology, Diagnostics, Vaccines, and Antiviral Therapies

Viruses

DOI

2026

A VLP-based mRNA vaccine elicits potent humoral and cellular immunity against Oropouche virus

mBio

DOI

2026

Antiviral potential of black tea and blueberry extracts against monkeypox virus by targeting orthopoxvirus surface proteins

Current Research in Microbial Sciences

DOI

2025

RYBP promotes HIV-1 latency through promoting H2AK119ub and decreasing H3K4me3

Cell Communication and Signaling

DOI

2025

Early fusion intermediate of ACE2-using coronavirus spike acting as an antiviral target

Cell

DOI

2025

Screening and discovery of an antiviral candidate inhibiting the SARS-CoV-2 envelope (2-E) channel

Current Research in Microbial Sciences

DOI

2025

Orphan broadly RBD-binding antibodies annotate three remaining conserved RBD epitopes along SARS-CoV-2 evolution

Nature Communications

DOI

2025

Antisera and antivirals targeting the conserved domains in SARS-CoV-2 S2 subunit are effective against ACE2-using MERSr-CoVs with spillover potential

Virologica Sinica

DOI

2025

Predicted early fusion intermediates in the spike of ACE2‐utilising bat coronavirus unveil broad‐spectrum antiviral mechanisms

Clinical and Translational Medicine

DOI

2025

Dual-targeting strategy enables extremely potent and broad inhibition of emerging MERS-related coronaviruses

Cell Discovery

DOI

2025

Potent Inhibition of Human Betacoronaviruses by a Short Double-Stapled Peptide Mimicking the HR2 Core Region in Viral Spike Protein

Journal of Medicinal Chemistry

DOI

2025

MERS-related coronavirus circulating in pangolins exhibits strong fusogenicity in human cells and high sensitivity to fusion inhibitors

Cell Reports Medicine

DOI

2025

Leveraged Vaccination to Alleviate Original Antigenic Sin for Enhancing Broad‐Neutralizing Antibody Response against SARS‐CoV‐2 Omicron Subvariants

MedComm

DOI

2025

Design, synthesis and biological evaluation of novel triarylmethane analogues as HIV-1 entry inhibitors

European Journal of Medicinal Chemistry

DOI

2025

STING agonist-based ER-targeting molecules boost antigen cross-presentation

Nature

DOI

2025

Correction: Fan et al. A Human DPP4-Knockin Mouse’s Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV. Viruses 2018, 10, 448

Viruses

DOI

2025

Frontiers in combating emerging infectious diseases: An editorial perspective

Current Research in Microbial Sciences

DOI

2024

基于重组人Ⅲ型胶原蛋白的三聚体抗原疫苗策略在新冠和流感疫苗中的应用

《合成生物学》

2024

针对逃逸中和抗体的新冠突变体开发基于T细胞抗原的人类冠状病毒疫苗（英文）

Science Bulletin

2024

合成生物学驱动下的疫苗创制策略

《合成生物学》

2024

A clinically used anti‐human papilloma virus agent (3‐hydroxyphthalic anhydride‐modified bovine β‐lactoglobulin) has a potential for topical application to prevent sexual transmission of monkeypox virus

MedComm

DOI

2024

Fully human single-domain antibody targeting a highly conserved cryptic epitope on the Nipah virus G protein

Nature Communications

DOI

2024

Discovery of a Double-Stapled Short Peptide as a Long-Acting HIV-1 Inactivator with Potential for Oral Bioavailability

Journal of Medicinal Chemistry

DOI

2024

Development of T cell antigen-based human coronavirus vaccines against nAb-escaping SARS-CoV-2 variants

《中国科学通报：英文版》

DOI

2024

Lineage Replacement and Genetic Changes of Four HR-HPV Types during the Period of Vaccine Coverage: A Six-Year Retrospective Study in Eastern China

Vaccines

DOI

2024

Inhibition of influenza A virus and SARS-CoV-2 infection or co-infection by griffithsin and griffithsin-based bivalent entry inhibitor

mBio

DOI

2024

Strong cross immune responses against sarbecoviruses but not merbecoviruses in SARS-CoV-2 BA.5/BF.7-infected individuals with or without inactivated COVID-19 vaccination

Journal of Infection

DOI

2024

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

Signal Transduction and Targeted Therapy

DOI

2024

gp120-derived amyloidogenic peptides form amyloid fibrils that increase HIV-1 infectivity

Cellular and Molecular Immunology

DOI

2024

Neutralization of SARS-CoV-2 BA.2.86 and JN.1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD

Cell Reports Medicine

DOI

2024

A subunit‐based influenza/SARS‐CoV‐2 Omicron combined vaccine induced potent protective immunity in BALB/c mice

Journal of Medical Virology

DOI

2024

Asialoglycoprotein receptor 1 promotes SARS-CoV-2 infection of human normal hepatocytes

Signal Transduction and Targeted Therapy

DOI

2024

SARS-CoV-2 evolution from the BA.2.86 to JN.1 variants: unexpected consequences

Trends in Immunology

DOI

2024

Receptor-binding domain-associated serotypes of SARS-CoV-2

Emerging Microbes & Infections

DOI

2024

Fusogenicity of SARS-CoV-2 BA.2.86 subvariant and its sensitivity to the prokaryotic recombinant EK1 peptide

Cell Discovery

DOI

2024

Alpaca-derived nanobody targeting the hydrophobic pocket of the HIV-1 gp41 NHR broadly neutralizes HIV-1 by blocking six-helix bundle formation

Current Research in Microbial Sciences

DOI

2023

流感-新冠混合疫苗的研究进展及展望

《病毒学报》

2023

蛋白类病毒感染失活剂:“遇敌即杀”的利器

《中国科学:生命科学》

2023

基于“以不变应万变”的策略研发泛β属冠状病毒疫苗

《中国食品药品监管》

2023

Enhanced neutralization of SARS-CoV-2 variant BA.2.86 and XBB sub-lineages by a tetravalent COVID-19 vaccine booster

Cell Host & Microbe

DOI

2023

Multiple-cohort study of the elderly to determine the immunological characteristics and pathogenic mechanisms of severe community-acquired pneumonia caused by the low-virulence virus SARS-CoV-2 Omicron variant

Cell Discovery

DOI

2023

Clinical development of antivirals against SARS-CoV-2 and its variants

Current Research in Microbial Sciences

DOI

2023

SARS-CoV-2 Omicron subvariant BA.2.86: limited potential for global spread

Signal Transduction and Targeted Therapy

DOI

2023

Design of MERS-CoV entry inhibitory short peptides based on helix-stabilizing strategies

Bioorganic & Medicinal Chemistry Letters

DOI

2023

Cross-reactive antibody response to Monkeypox virus surface proteins in a small proportion of individuals with and without Chinese smallpox vaccination history

BMC Biology

DOI

2023

Repurposing Navitoclax to block SARS‐CoV‐2 fusion and entry by targeting heptapeptide repeat sequence 1 in S2 protein

Journal of Medical Virology

DOI

2023

Rational Design of Sulfonyl-γ-AApeptides as Highly Potent HIV-1 Fusion Inhibitors with Broad-Spectrum Activity

Journal of Medicinal Chemistry

DOI

2023

IgG Fc-Binding Peptide-Conjugated Pan-CoV Fusion Inhibitor Exhibits Extended In Vivo Half-Life and Synergistic Antiviral Effect When Combined with Neutralizing Antibodies

Biomolecules

DOI

2023

An engineered recombinant protein containing three structural domains in SARS-CoV-2 S2 protein has potential to act as a pan-human coronavirus entry inhibitor or vaccine antigen

Emerging Microbes & Infections

DOI

2023

Potential cross-species transmission of highly pathogenic avian influenza H5 subtype (HPAI H5) viruses to humans calls for the development of H5-specific and universal influenza vaccines

Cell Discovery

DOI

2023

A dePEGylated Lipopeptide-Based Pan-Coronavirus Fusion Inhibitor Exhibits Potent and Broad-Spectrum Anti-HIV-1 Activity without Eliciting Anti-PEG Antibodies

International Journal of Molecular Sciences

DOI

2023

Diterpenoids from Euphorbia lactea and their anti-HIV-1 activity

Phytochemistry

DOI

2023

A spike-targeting bispecific T cell engager strategy provides dual layer protection against SARS-CoV-2 infection in vivo

Communications Biology

DOI

2023

25‐hydroxycholesterol inhibits human papillomavirus infection in cervical epithelial cells by perturbing cytoskeletal remodeling

Journal of Medical Virology

DOI

2023

An HR2-Mimicking Sulfonyl-γ-AApeptide Is a Potent Pan-coronavirus Fusion Inhibitor with Strong Blood–Brain Barrier Permeability, Long Half-Life, and Promising Oral Bioavailability

ACS Central Science

DOI

2023

An Artificial Peptide-Based Bifunctional HIV-1 Entry Inhibitor That Interferes with Viral Glycoprotein-41 Six-Helix Bundle Formation and Antagonizes CCR5 on the Host Cell Membrane

Viruses

DOI

2023

Human airway and nasal organoids reveal escalating replicative fitness of SARS-CoV-2 emerging variants

Proceedings of the National Academy of Sciences

DOI

2023

Editorial: AIDS 40th Year

Frontiers in Microbiology

DOI

2023

High-throughput screening of mutations affecting SARS-CoV-2 spike functions

Trends in Immunology

DOI

2023

Multitargeted drug design strategy for discovery of short-peptide-based HIV-1 entry inhibitors with high potency

European Journal of Medicinal Chemistry

DOI

2023

Application of “B+1” heterologous boosting strategy for preventing infection of SARS-CoV-2 variants with resistance to broad-spectrum coronavirus vaccines

Emerging Microbes & Infections

DOI

2023

Potential recombination between SARS-CoV-2 and MERS-CoV: calls for the development of Pan-CoV vaccines

Signal Transduction and Targeted Therapy

DOI

2023

A pan-sarbecovirus vaccine based on RBD of SARS-CoV-2 original strain elicits potent neutralizing antibodies against XBB in non-human primates

Proceedings of the National Academy of Sciences

DOI

2023

SARS‐CoV‐2 Omicron XBB subvariants exhibit enhanced fusogenicity and substantial immune evasion in elderly population, but high sensitivity to pan‐coronavirus fusion inhibitors

Journal of Medical Virology

DOI

2023

Development and validation of a prognostic model based on immune variables to early predict severe cases of SARS-CoV-2 Omicron variant infection

Frontiers in Immunology

DOI

2023

Lymphocyte integrins mediate entry and dysregulation of T cells by SARS-CoV-2

Signal Transduction and Targeted Therapy

DOI

2023

SARS-CoV-2 Omicron subvariants exhibit distinct fusogenicity, but similar sensitivity, to pan-CoV fusion inhibitors

Emerging Microbes & Infections

DOI

2023

Nasal mucosa is much more susceptible than oral mucosa to infection of SARS‐CoV‐2 Omicron subvariants: Wearing nasal masks where facial masks cannot be used

Journal of Medical Virology

DOI

2022

新型冠状病毒疫苗的研究策略及应对奥密克戎等变异株的挑战

《病毒学报》

2022

以不变应万变：高效广谱抗新冠病毒疫苗和药物防控现在和未来的冠状病毒疫情

《中国科学基金》

2022

A gossypol derivative effectively protects against Zika and dengue virus infection without toxicity

BMC Biology

DOI

2022

Characterization of cross‐reactive monoclonal antibodies against SARS‐CoV‐1 and SARS‐CoV‐2: Implication for rational design and development of pan‐sarbecovirus vaccines and neutralizing antibodies

Journal of Medical Virology

DOI

2022

Analogous comparison unravels heightened antiviral defense and boosted viral infection upon immunosuppression in bat organoids

Signal Transduction and Targeted Therapy

DOI

2022

Sertraline Is an Effective SARS-CoV-2 Entry Inhibitor Targeting the Spike Protein

Journal of Virology

DOI

2022

A variant-proof SARS-CoV-2 vaccine targeting HR1 domain in S2 subunit of spike protein

Cell Research

DOI

2022

FBXO34 promotes latent HIV-1 activation by post-transcriptional modulation

Emerging Microbes & Infections

DOI

2022

Neutralization of five SARS-CoV-2 variants of concern by convalescent and BBIBP-CorV vaccinee serum

Virologica Sinica

DOI

2022

A core epitope targeting antibody of SARS-CoV-2

Protein & Cell

DOI

2022

Broadly neutralizing antibodies to SARS-CoV-2 and other human coronaviruses

Nature reviews. Immunology

DOI

2022

Development of variant‐proof severe acute respiratory syndrome coronavirus 2, pan‐sarbecovirus, and pan‐β‐coronavirus vaccines

Journal of Medical Virology

DOI

2022

The current emergence of monkeypox: The recurrence of another smallpox?

Biosafety and Health

DOI

2022

Chemically Modified Bovine β-Lactoglobulin as a Broad-Spectrum Influenza Virus Entry Inhibitor with the Potential to Combat Influenza Outbreaks

Viruses

DOI

2022

Pan‐coronavirus fusion inhibitors to combat COVID‐19 and other emerging coronavirus infectious diseases

Journal of Medical Virology

DOI

2022

A novel cyclic γ-AApeptide-based long-acting pan-coronavirus fusion inhibitor with potential oral bioavailability by targeting two sites in spike protein

Cell Discovery

DOI

2022

The neutralization of B.1.617.1 and B.1.1.529 sera from convalescent patients and BBIBP-CorV vaccines

iScience

DOI

2022

Corrigendum: Advancement in the development of therapeutics against Zika virus infection

Frontiers in Cellular and Infection Microbiology

DOI

2022

Corrigendum to “Nelfinavir, an HIV protease inhibitor, induces apoptosis and cell cycle arrest in human cervical cancer cells via the ROS-dependent mitochondrial pathway” [Cancer Letters 364 (2015) 79–88]

Cancer Letters

DOI

2022

Neutralization of distinct Omicron sublineages by longitudinal vaccination sera

Journal of Medical Virology

DOI

2022

Network Pharmacology and Molecular Docking Elucidate the Underlying Pharmacological Mechanisms of the Herb Houttuynia cordata in Treating Pneumonia Caused by SARS-CoV-2

Viruses

DOI

2022

Origin, virological features, immune evasion and intervention of SARS-CoV-2 Omicron sublineages

Signal Transduction and Targeted Therapy

DOI

2022

Advancement in the Development of Therapeutics Against Zika Virus Infection

Frontiers in Cellular and Infection Microbiology

DOI

2022

Rock1 is a novel host dependency factor of human enterovirus A71: Implication as a drug target

Journal of Medical Virology

DOI

2022

A bipotential organoid model of respiratory epithelium recapitulates high infectivity of SARS-CoV-2 Omicron variant

Cell Discovery

DOI

2022

Sensitivity to Vaccines, Therapeutic Antibodies, and Viral Entry Inhibitors and Advances To Counter the SARS-CoV-2 Omicron Variant

Clinical Microbiology Reviews

DOI

2022

Renaming the SARS‐CoV‐2 Omicron sublineages as SARS‐CoV‐3 is contrary to nomenclature standards based on evolutionary and serological evidence

Clinical and Translational Medicine

DOI

2022

Up or down: where comes Omicron?

Cell Research

DOI

2022

Disease of influenza virus and SARS‐CoV‐2 coinfection: Flurona or Flucovid?

Journal of Medical Virology

DOI

2022

The putative mechanism of lymphopenia in COVID-19 patients

Journal of Molecular Cell Biology

DOI

2022

Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses

Cell Discovery

DOI

2022

Design of artificial α-helical peptides targeting both gp41 deep pocket and subpocket as potent HIV-1 fusion inhibitors

European Journal of Medicinal Chemistry

DOI

2022

A Protein-Based, Long-Acting HIV-1 Fusion Inhibitor with an Improved Pharmacokinetic Profile

Pharmaceuticals

DOI

2022

Small-molecule HIV-1 entry inhibitors targeting the epitopes of broadly neutralizing antibodies

Cell chemical biology

DOI

2022

A Modified Fibronectin Type III Domain-Conjugated, Long-Acting Pan-Coronavirus Fusion Inhibitor with Extended Half-Life

Viruses

DOI

2022

Neutralization Sensitivity of HIV-1 CRF07_BC From an Untreated Patient With a Focus on Evolution Over Time

Frontiers in Cellular and Infection Microbiology

DOI

2022

A Five-Helix-Based SARS-CoV-2 Fusion Inhibitor Targeting Heptad Repeat 2 Domain against SARS-CoV-2 and Its Variants of Concern

Viruses

DOI

2022

Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody

Cell

DOI

2021

广谱抗冠状病毒疫苗及抗冠状病毒多肽的研究进展

《微生物与感染》

2021

基于gp41近膜端外部区域中和表位天然构象的人类免疫缺陷病毒1型疫苗的设计

《微生物与感染》

2021

一种非洲猪瘟病毒假病毒细胞感染模型的建立及应用

《微生物与感染》

2020

抗新型冠状病毒2019-nCoV新药的研发

《中国临床药理学与治疗学》

2020

2020-2021年度新型冠状病毒肺炎疫情发展趋势分析与应对

《疾病监测》

2020

关于新型冠状病毒命名的思考与建议

《中国科技术语》

2020

新冠疫苗的有效性、安全性和广谱性的商榷

《中国科学基金》

DOI

2020

Development of oncolytic virotherapy: from genetic modification to combination therapy

Frontiers of Medicine

DOI

2019

利用I-Mutant2.0辅助设计与优化中东呼吸综合征冠状病毒融合抑制多肽

《微生物与感染》

2019

Real-time imaging of individual virion-triggered cortical actin dynamics for human immunodeficiency virus entry into resting CD4 T cells

Nanoscale

DOI

2019

A pan-coronavirus fusion inhibitor targeting the HR1 domain of human coronavirus spike

Science Advances

DOI

2019

Metformin combined with nelfinavir induces SIRT3/mROS-dependent autophagy in human cervical cancer cells and xenograft in nude mice

European Journal of Pharmacology

DOI

2019

Virtual screening and identification of potential HIV-1 inhibitors based on the cross-reactive neutralizing antibody N6

Doklady of the National Academy of Sciences of Belarus

DOI

2019

Design and Biological Evaluation of m-Xylene Thioether-Stapled Short Helical Peptides Targeting the HIV-1 gp41 Hexameric Coiled–Coil Fusion Complex

Journal of Medicinal Chemistry

DOI

2019

Long-Acting HIV-1 Fusion Inhibitory Peptides and their Mechanisms of Action

Viruses

DOI

2019

Crystal Structure of Refolding Fusion Core of Lassa Virus GP2 and Design of Lassa Virus Fusion Inhibitors

Frontiers in Microbiology

DOI

2019

In Silico Identification of Novel Aromatic Compounds as Potential HIV-1 Entry Inhibitors Mimicking Cellular Receptor CD4

Viruses

DOI

2019

N-Substituted Pyrrole Derivative 12m Inhibits HIV-1 Entry by Targeting Gp41 of HIV-1 Envelope Glycoprotein

Frontiers in Pharmacology

DOI

2019

Development of Protein- and Peptide-Based HIV Entry Inhibitors Targeting gp120 or gp41

Viruses

DOI

2019

Rapid Elimination of Broadly Neutralizing Antibodies Correlates with Treatment Failure in the Acute Phase of Simian-Human Immunodeficiency Virus Infection

Journal of Virology

DOI

2019

P848 Revisiting enfuvirtide’s mechanism and designing its analog with improved activity by targeting triple sites in gp41

Poster presentations

DOI

2019

P839 A chemically modified β-lactoglobulin (JB01) is effective in treating HPV infection and preventing sexual transmission of HIV

Poster presentations

DOI

2019

Revisiting the mechanism of enfuvirtide and designing an analog with improved fusion inhibitory activity by targeting triple sites in gp41

AIDS

DOI

2019

A Peptide-Based HIV-1 Fusion Inhibitor with Two Tail-Anchors and Palmitic Acid Exhibits Substantially Improved In Vitro and Ex Vivo Anti-HIV-1 Activity and Prolonged In Vivo Half-Life

Molecules

DOI

2019

Sin1/mTORC2 regulate B cell growth and metabolism by activating mTORC1 and Myc

Cellular and Molecular Immunology

DOI

2019

Transfusion-Transmitted Zika Virus Infection in Pregnant Mice Leads to Broad Tissue Tropism With Severe Placental Damage and Fetal Demise

Frontiers in Microbiology

DOI

2019

Potent MERS-CoV Fusion Inhibitory Peptides Identified from HR2 Domain in Spike Protein of Bat Coronavirus HKU4

Viruses

DOI

2019

Combining a Fusion Inhibitory Peptide Targeting the MERS-CoV S2 Protein HR1 Domain and a Neutralizing Antibody Specific for the S1 Protein Receptor-Binding Domain (RBD) Showed Potent Synergism against Pseudotyped MERS-CoV with or without Mutations in RBD

Viruses

DOI

2018

De Novo Design of α-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery

Journal of Medicinal Chemistry

DOI

2018

Combining New Non-Nucleoside Reverse Transcriptase Inhibitors (RTIs) with AZT Results in Strong Synergism against Multi-RTI-Resistant HIV-1 Strains

Molecules

DOI

2018

Development of Small-Molecule MERS-CoV Inhibitors

Viruses

DOI

2018

Characterization by high-resolution crystal structure analysis of a triple-helix region of human collagen type III with potent cell adhesion activity

Biochemical and Biophysical Research Communications

DOI

2018

The Antihistamine Drugs Carbinoxamine Maleate and Chlorpheniramine Maleate Exhibit Potent Antiviral Activity Against a Broad Spectrum of Influenza Viruses

Frontiers in Microbiology

DOI

2018

Topical Application of a Vitamin A Derivative and Its Combination With Non-ablative Fractional Laser Potentiates Cutaneous Influenza Vaccination

Frontiers in Microbiology

DOI

2018

A Human DPP4-Knockin Mouse’s Susceptibility to Infection by Authentic and Pseudotyped MERS-CoV

Viruses

DOI

2018

Prospects for a MERS-CoV spike vaccine

Expert Review of Vaccines

DOI

2018

Reply to ‘Trace N-glycans including sulphated species may originate from various plasma glycoproteins and not necessarily IgG’

Nature Communications

DOI

2018

3-Hydroxyphthalic Anhydride- Modified Rabbit Anti-PAP IgG as a Potential Bifunctional HIV-1 Entry Inhibitor

Frontiers in Microbiology

DOI

2018

Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza

Nature Communications

DOI

2018

Advances in the research and development of therapeutic antibodies against the Zika virus

Cellular and Molecular Immunology

DOI

2018

A defucosylated bispecific multivalent molecule exhibits broad HIV-1-neutralizing activity and enhanced antibody-dependent cellular cytotoxicity against reactivated HIV-1 latently infected cells

AIDS

DOI

2018

Blockade of the C5a–C5aR axis alleviates lung damage in hDPP4 -transgenic mice infected with MERS-CoV

Emerging Microbes & Infections

DOI

2018

The development of HIV vaccines targeting gp41 membrane-proximal external region (MPER): challenges and prospects

Protein & Cell

DOI

2018

Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen

Vaccine

DOI

2018

A CCR5 antagonist-based HIV entry inhibitor exhibited potent spermicidal activity: Potential application for contraception and prevention of HIV sexual transmission

European Journal of Pharmaceutical Sciences

DOI

2018

Discovery of Hydrocarbon-Stapled Short α-Helical Peptides as Promising Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Fusion Inhibitors

Journal of Medicinal Chemistry

DOI

2018

Peptide-Based Membrane Fusion Inhibitors Targeting HCoV-229E Spike Protein HR1 and HR2 Domains

International Journal of Molecular Sciences

DOI

2018

In-Depth Analysis of Human Neonatal and Adult IgM Antibody Repertoires

Frontiers in Immunology

DOI

2018

Critical neutralizing fragment of Zika virus EDIII elicits cross-neutralization and protection against divergent Zika viruses

Emerging Microbes & Infections

DOI

2018

Fusion

Springer eBooks

DOI

2017

酸酐修饰蛋白防控性传播疾病的研究进展

《中国实用妇科与产科杂志》

2017

“御敌于国门之外”——病毒入侵抑制剂的研究进展

《复旦学报(医学版)》

2017

Combining metformin and nelfinavir exhibits synergistic effects against the growth of human cervical cancer cells and xenograft in nude mice

Scientific Reports

DOI

2017

Advancements in Developing Strategies for Sterilizing and Functional HIV Cures

BioMed Research International

DOI

2017

A Potent Germline-like Human Monoclonal Antibody Targets a pH-Sensitive Epitope on H7N9 Influenza Hemagglutinin

Cell Host & Microbe

DOI

2017

Single-Domain Antibodies As Therapeutics against Human Viral Diseases

Frontiers in Immunology

DOI

2017

Development of small-molecule viral inhibitors targeting various stages of the life cycle of emerging and re-emerging viruses

Frontiers of Medicine

DOI

2017

Prevention and treatment of respiratory viral infections: Presentations on antivirals, traditional therapies and host-directed interventions at the 5th ISIRV Antiviral Group conference

Antiviral Research

DOI

2017

Adding an Artificial Tail—Anchor to a Peptide-Based HIV-1 Fusion Inhibitor for Improvement of Its Potency and Resistance Profile

Molecules

DOI

2017

Cross-neutralization of SARS coronavirus-specific antibodies against bat SARS-like coronaviruses

Science China Life Sciences

DOI

2017

Chidamide, a histone deacetylase inhibitor-based anticancer drug, effectively reactivates latent HIV-1 provirus

Microbes and Infection

DOI

2017

Combating flu in China

Microbes and Infection

DOI

2017

A Degraded Fragment of HIV-1 Gp120 in Rat Hepatocytes Forms Fibrils and Enhances HIV-1 Infection

Biophysical Journal

DOI

2017

A method to identify trace sulfated IgG N-glycans as biomarkers for rheumatoid arthritis

Nature Communications

DOI

2017

Genomic signature analysis of the recently emerged highly pathogenic A(H5N8) avian influenza virus: implying an evolutionary trend for bird-to-human transmission

Microbes and Infection

DOI

2017

The latest advancements in Zika virus vaccine development

Expert Review of Vaccines

DOI

2017

A peptide-based viral inactivator inhibits Zika virus infection in pregnant mice and fetuses

Nature Communications

DOI

2017

Escape from humoral immunity is associated with treatment failure in HIV-1-infected patients receiving long-term antiretroviral therapy

Scientific Reports

DOI

2017

Visual and Motor Deficits in Grown-up Mice with Congenital Zika Virus Infection

EBioMedicine

DOI

2017

Anti-HIV antibody and drug combinations exhibit synergistic activity against drug-resistant HIV-1 strains

Journal of Infection

DOI

2017

Receptor-binding domain of MERS-CoV with optimal immunogen dosage and immunization interval protects human transgenic mice from MERS-CoV infection

Human Vaccines & Immunotherapeutics

DOI

2017

Chemically Modified Human Serum Albumin Potently Blocks Entry of Ebola Pseudoviruses and Viruslike Particles

Antimicrobial Agents and Chemotherapy

DOI

2017

Small-molecule HIV-1 entry inhibitors targeting gp120 and gp41: a patent review (2010-2015)

Expert Opinion on Therapeutic Patents

DOI

2017

Neutralization of Zika virus by germline-like human monoclonal antibodies targeting cryptic epitopes on envelope domain III

Emerging Microbes & Infections

DOI

2017

HIV-1 gp41-targeting fusion inhibitory peptides enhance the gp120-targeting protein-mediated inactivation of HIV-1 virions

Emerging Microbes & Infections

DOI

2017

HIV-1 Env DNA prime plus gp120 and gp70-V1V2 boosts induce high level of V1V2-specific IgG and ADCC responses and low level of Env-specific IgA response: implication for improving RV144 vaccine regimen

Emerging Microbes & Infections

DOI

2016

人类高致病性冠状病毒SARS-CoV和MERS-CoV的流行与突变——共性与个性特征的启示

《生命科学》

2016

Site-specific Isopeptide Bridge Tethering of Chimeric gp41 N-terminal Heptad Repeat Helical Trimers for the Treatment of HIV-1 Infection

Scientific Reports

DOI

2016

MERS-CoV spike protein: a key target for antivirals

Expert Opinion on Therapeutic Targets

DOI

2016

Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines

Nature Communications

DOI

2016

Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants

Journal of Virology

DOI

2016

Creating an Artificial Tail Anchor as a Novel Strategy To Enhance the Potency of Peptide-Based HIV Fusion Inhibitors

Journal of Virology

DOI

2016

A recombinant receptor-binding domain of MERS-CoV in trimeric form protects human dipeptidyl peptidase 4 (hDPP4) transgenic mice from MERS-CoV infection

Virology

DOI

2016

Cell Entry of Porcine Epidemic Diarrhea Coronavirus Is Activated by Lysosomal Proteases

Journal of Biological Chemistry

DOI

2016

Rational improvement of gp41-targeting HIV-1 fusion inhibitors: an innovatively designed Ile-Asp-Leu tail with alternative conformations

Scientific Reports

DOI

2016

From therapeutic antibodies to chimeric antigen receptors (CARs): making better CARs based on antigen-binding domain

Expert Opinion on Biological Therapy

DOI

2016

A novel bispecific peptide HIV-1 fusion inhibitor targeting the N-terminal heptad repeat and fusion peptide domains in gp41

Amino Acids

DOI

2016

Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus

Journal of Medicinal Chemistry

DOI

2016

A new role of neuraminidase (NA) in the influenza virus life cycle: implication for developing NA inhibitors with novel mechanism of action

Reviews in Medical Virology

DOI

2016

Vaccines for the prevention against the threat of MERS-CoV

Expert Review of Vaccines

DOI

2016

Improving the CH1-CK heterodimerization and pharmacokinetics of 4Dm2m, a novel potent CD4-antibody fusion protein against HIV-1

mAbs

DOI

2016

Erratum to: Immunogenicity and antigenic relationships among spike proteins of porcine epidemic diarrhea virus subtypes G1 and G2

Archives of Virology

DOI

2016

An immunogen containing four tandem 10E8 epitope repeats with exposed key residues induces antibodies that neutralize HIV-1 and activates an ADCC reporter gene

Emerging Microbes & Infections

DOI

2016

Intranasal application of polyethyleneimine suppresses influenza virus infection in mice

Emerging Microbes & Infections

DOI

2015

多肽类中东呼吸系统综合征冠状病毒进入抑制剂的研究进展

《药学学报》

DOI

2015

抗MERS-CoV小分子化合物的研究进展

《药学学报》

2015

分析及预测治愈艾滋病的策略

《微生物与感染》

2015

An effective strategy for recapitulating N-terminal heptad repeat trimers in enveloped virus surface glycoproteins for therapeutic applications

Chemical Science

DOI

2015

De novo design of isopeptide bond-tethered triple-stranded coiled coils with exceptional resistance to unfolding and proteolysis: implication for developing antiviral therapeutics

Chemical Science

DOI

2015

Quercetin as an Antiviral Agent Inhibits Influenza A Virus (IAV) Entry

Viruses

DOI

2015

Multi-Organ Damage in Human Dipeptidyl Peptidase 4 Transgenic Mice Infected with Middle East Respiratory Syndrome-Coronavirus

PLoS ONE

DOI

2015

A Peptide Derived from the HIV-1 gp120 Coreceptor-Binding Region Promotes Formation of PAP248-286 Amyloid Fibrils to Enhance HIV-1 Infection

PLoS ONE

DOI

2015

Development of Small-molecule HIV Entry Inhibitors Specifically Targeting gp120 or gp41

Current Topics in Medicinal Chemistry

DOI

2015

Putative suppressing effect of IgG Fc-conjugated haemagglutinin (HA) stalk of influenza virus H7N9 on the neutralizing immunogenicity of Fc-conjugated HA head: implication for rational design of HA-based influenza vaccines

Journal of General Virology

DOI

2015

A stereo configuration-activity study of 3-iodo-4-(2-methylcyclohexyloxy)-6-phenethylpyridin-2(2H)-ones as potency inhibitors of HIV-1 variants

Organic & Biomolecular Chemistry

DOI

2015

Safety evaluation of chemically modified beta‐lactoglobulin administered intravaginally

Journal of Medical Virology

DOI

2015

Immunogenicity and antigenic relationships among spike proteins of porcine epidemic diarrhea virus subtypes G1 and G2

Archives of Virology

DOI

2015

Co-delivery of HIV-1 entry inhibitor and nonnucleoside reverse transcriptase inhibitor shuttled by nanoparticles

AIDS

DOI

2015

A randomized open-label clinical trial of an anti-HPV biological dressing (JB01-BD) administered intravaginally to treat high-risk HPV infection

Microbes and Infection

DOI

2015

Intranasally administered peptidic viral fusion inhibitor protected hDPP4 transgenic mice from MERS-CoV infection

The Lancet

DOI

2015

Middle East respiratory syndrome: current status and future prospects for vaccine development

Expert Opinion on Biological Therapy

DOI

2015

Normal human sera contain heat-sensitive factor(s) to enhance H7N9 influenza virus infection

Journal of Infection

DOI

2015

Junctional and allele-specific residues are critical for MERS-CoV neutralization by an exceptionally potent germline-like antibody

Nature Communications

DOI

2015

Up-regulation of human cervical cancer proto-oncogene contributes to hepatitis B virus-induced malignant transformation of hepatocyte by down-regulating E-cadherin

Oncotarget

DOI

2015

No evidence for a superior platform to develop therapeutic antibodies rapidly in response to MERS-CoV and other emerging viruses

Proceedings of the National Academy of Sciences

DOI

2015

Improved Pharmacological and Structural Properties of HIV Fusion Inhibitor AP3 over Enfuvirtide: Highlighting Advantages of Artificial Peptide Strategy

Scientific Reports

DOI

2015

Intranasal vaccination of recombinant H5N1 HA1 proteins fused with foldon and Fc induces strong mucosal immune responses with neutralizing activity: Implication for developing novel mucosal influenza vaccines

Human Vaccines & Immunotherapeutics

DOI

2015

Two Mutations Were Critical for Bat-to-Human Transmission of Middle East Respiratory Syndrome Coronavirus

Journal of Virology

DOI

2015

ADS-J1 Inhibits Semen-Derived Amyloid Fibril Formation and Blocks Fibril-Mediated Enhancement of HIV-1 Infection

Antimicrobial Agents and Chemotherapy

DOI

2015

The HEPT Analogue WPR-6 Is Active against a Broad Spectrum of Nonnucleoside Reverse Transcriptase Drug-Resistant HIV-1 Strains of Different Serotypes

Antimicrobial Agents and Chemotherapy

DOI

2015

Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection

The Journal of Infectious Diseases

DOI

2015

Enhancement of endocytic uptake of HIV-1 virions into CD4-negative epithelial cells by HIV-1 gp41 via its interaction with POB1

Cellular and Molecular Immunology

DOI

2015

An Artificial Peptide-Based HIV-1 Fusion Inhibitor Containing M-T Hook Structure Exhibiting Improved Antiviral Potency and Drug Resistance Profile

Future Virology

DOI

2015

Nonneutralizing Antibodies Induced by the HIV-1 gp41 NHR Domain Gain Neutralizing Activity in the Presence of the HIV Fusion Inhibitor Enfuvirtide: a Potential Therapeutic Vaccine Strategy

Journal of Virology

DOI

2015

Optimization of antigen dose for a receptor-binding domain-based subunit vaccine against MERS coronavirus

Human Vaccines & Immunotherapeutics

DOI

2015

Upregulation of MicroRNA-146a by Hepatitis B Virus X Protein Contributes to Hepatitis Development by Downregulating Complement Factor H

mBio

DOI

2015

Receptor Usage and Cell Entry of Porcine Epidemic Diarrhea Coronavirus

Journal of Virology

DOI

2015

A truncated fragment of Ov-ASP-1 consisting of the core pathogenesis-related-1 (PR-1) domain maintains adjuvanticity as the full-length protein

Vaccine

DOI

2015

Intranasal Administration of Maleic Anhydride-Modified Human Serum Albumin for Pre-Exposure Prophylaxis of Respiratory Syncytial Virus Infection

Viruses

DOI

2015

Identification of an ideal adjuvant for receptor-binding domain-based subunit vaccines against Middle East respiratory syndrome coronavirus

Cellular and Molecular Immunology

DOI

2015

Urgent development of effective therapeutic and prophylactic agents to control the emerging threat of Middle East respiratory syndrome (MERS)

Emerging Microbes & Infections

DOI

2015

Receptor Binding Domain Based HIV Vaccines

BioMed Research International

DOI

2014

HIV进入抑制多肽VIR576可抑制抗原特异性CD4+T细胞的体外活化:一种潜在的双功能杀微生物剂（英文）

《南方医科大学学报》

2014

CXCR4 HIV-1抑制剂的设计合成及活性研究

《军事医学》

2014

以HA2为基础的流感病毒候选疫苗同时与H5N1、H1N1和H3N2亚型毒株产生交叉反应

《中山大学学报(医学科学版)》

2014

Conjugation of a Nonspecific Antiviral Sapogenin with a Specific HIV Fusion Inhibitor: A Promising Strategy for Discovering New Antiviral Therapeutics

Journal of Medicinal Chemistry

DOI

2014

HIV-1 impairs human retinal pigment epithelial barrier function: possible association with the pathogenesis of HIV-associated retinopathy

Laboratory Investigation

DOI

2014

Studying the Nucleated Mammalian Cell Membrane by Single Molecule Approaches

PLoS ONE

DOI

2014

Advancements in the development of subunit influenza vaccines

Microbes and Infection

DOI

2014

Combating the emerging viral infectious diseases

Microbes and Infection

DOI

2014

Development of therapeutics for treatment of Ebola virus infection

Microbes and Infection

DOI

2014

Adenovirus-based vaccines against avian-origin H5N1 influenza viruses

Microbes and Infection

DOI

2014

Development of human neutralizing monoclonal antibodies for prevention and therapy of MERS-CoV infections

Microbes and Infection

DOI

2014

Treatment With Anti-C5a Antibody Improves the Outcome of H7N9 Virus Infection in African Green Monkeys

Clinical Infectious Diseases

DOI

2014

Peptide fusion inhibitors targeting the HIV-1 gp41: a patent review (2009 – 2014)

Expert Opinion on Therapeutic Patents

DOI

2014

Receptor-binding domain-based subunit vaccines against MERS-CoV

Virus Research

DOI

2014

Development of a heat-stable and orally delivered recombinant M2e-expressing B. subtilis spore-based influenza vaccine

Human Vaccines & Immunotherapeutics

DOI

2014

Testing of Middle East Respiratory Syndrome Coronavirus Replication Inhibitors for the Ability To Block Viral Entry

Antimicrobial Agents and Chemotherapy

DOI

2014

A Nanoparticle-Encapsulated Non-Nucleoside Reverse-Transcriptase Inhibitor with Enhanced Anti-HIV-1 Activity and Prolonged Circulation Time in Plasma

Current Pharmaceutical Design

DOI

2014

Middle East respiratory syndrome coronavirus (MERS-CoV) entry inhibitors targeting spike protein

Virus Research

DOI

2014

Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments—The importance of immunofocusing in subunit vaccine design

Vaccine

DOI

2014

Receptor usage and cell entry of bat coronavirus HKU4 provide insight into bat-to-human transmission of MERS coronavirus

Proceedings of the National Academy of Sciences

DOI

2014

Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors

Bioorganic & Medicinal Chemistry Letters

DOI

2014

Synergistic Effect Resulting From Combinations of a Bifunctional HIV-1 Antagonist With Antiretroviral Drugs

JAIDS Journal of Acquired Immune Deficiency Syndromes

DOI

2014

Calling for rapid development of a safe and effective MERS vaccine

Microbes and Infection

DOI

2014

Optimization of the Antiviral Potency and Lipophilicity of Halogenated 2,6‐Diarylpyridinamines as a Novel Class of HIV‐1 NNRTIS

ChemMedChem

DOI

2014

Exceptionally Potent Neutralization of Middle East Respiratory Syndrome Coronavirus by Human Monoclonal Antibodies

Journal of Virology

DOI

2014

Current advancements and potential strategies in the development of MERS-CoV vaccines

Expert Review of Vaccines

DOI

2014

Identification of the Critical Sites of NNRTI-Resistance in Reverse Transcriptase of HIV-1 CRF_BC Strains

PLoS ONE

DOI

2014

A Conformation-Dependent Neutralizing Monoclonal Antibody Specifically Targeting Receptor-Binding Domain in Middle East Respiratory Syndrome Coronavirus Spike Protein

Journal of Virology

DOI

2014

FbaA- and M protein-based multi-epitope vaccine elicits strong protective immune responses against group A streptococcus in mouse model

Microbes and Infection

DOI

2014

CorMut: an R/Bioconductor package for computing correlated mutations based on selection pressure

Bioinformatics

DOI

2014

Peptides derived from HIV‐1 gp120 co‐receptor binding domain form amyloid fibrils and enhance HIV‐1 infection

FEBS Letters

DOI

2014

Hydrophobic mutations in buried polar residues enhance HIV-1 gp41 N-terminal heptad repeat–C-terminal heptad repeat interactions and C-peptides’ anti-HIV activity

AIDS

DOI

2014

Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines

Vaccine

DOI

2014

Possible pandemic threat from new reassortment of influenza A(H7N9) virus in China

Eurosurveillance

DOI

2014

Artificial peptides conjugated with cholesterol and pocket-specific small molecules potently inhibit infection by laboratory-adapted and primary HIV-1 isolates and enfuvirtide-resistant HIV-1 strains

Journal of Antimicrobial Chemotherapy

DOI

2014

Structure-based discovery of Middle East respiratory syndrome coronavirus fusion inhibitor

Nature Communications

DOI

2014

Correction: HIV-1 Fusion Is Blocked through Binding of GB Virus C E2D Peptides to the HIV-1 gp41 Disulfide Loop

PLoS ONE

DOI

2014

ADS-J1 inhibits HIV-1 infection and membrane fusion by targeting the highly conserved pocket in the gp41 NHR-trimer

Biochimica et Biophysica Acta (BBA) - Biomembranes

DOI

2013

作用于HIV-1gp120小分子HIV进入抑制剂NC-2的虚拟筛选及其作用机制

《南方医科大学学报》

2013

An engineered HIV-1 gp41 trimeric coiled coil with increased stability and anti-HIV-1 activity: implication for developing anti-HIV microbicides

Journal of Antimicrobial Chemotherapy

DOI

2013

Mutation covariation of HIV-1 CRF07_BC reverse transcriptase during antiretroviral therapy

Journal of Antimicrobial Chemotherapy

DOI

2013

Tactics used by HIV-1 to evade host innate, adaptive, and intrinsic immunities

Chinese Medical Journal

DOI

2013

Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate

Human Vaccines & Immunotherapeutics

DOI

2013

A Truncated Receptor-Binding Domain of MERS-CoV Spike Protein Potently Inhibits MERS-CoV Infection and Induces Strong Neutralizing Antibody Responses: Implication for Developing Therapeutics and Vaccines

PLoS ONE

DOI

2013

Simultaneous Expression of Displayed and Secreted Antibodies for Antibody Screen

PLoS ONE

DOI

2013

F(ab′)2 fragment of a gp41 NHR-trimer-induced IgM monoclonal antibody neutralizes HIV-1 infection and blocks viral fusion by targeting the conserved gp41 pocket

Microbes and Infection

DOI

2013

A safe and convenient pseudovirus-based inhibition assay to detect neutralizing antibodies and screen for viral entry inhibitors against the novel human coronavirus MERS-CoV

Virology Journal

DOI

2013

PA-356R is a unique signature of the avian influenza A (H7N9) viruses with bird-to-human transmissibility: Potential implication for animal surveillances

Journal of Infection

DOI

2013

Highly Pathogenic Avian Influenza A(H5N1) Mutants Transmissible by Air Are Susceptible to Human and Animal Neutralizing Antibodies

The Journal of Infectious Diseases

DOI

2013

Identification of a Receptor-Binding Domain in the S Protein of the Novel Human Coronavirus Middle East Respiratory Syndrome Coronavirus as an Essential Target for Vaccine Development

Journal of Virology

DOI

2013

Middle East respiratory syndrome coronavirus (MERS-CoV): challenges in identifying its source and controlling its spread

Microbes and Infection

DOI

2013

Serological Investigation of Subclinical Influenza A(H7H9) Infection Among Healthcare and Non-Healthcare Workers in Zhejiang Province, China

Clinical Infectious Diseases

DOI

2013

Identification of a Human Protein-Derived HIV-1 Fusion Inhibitor Targeting the gp41 Fusion Core Structure

PLoS ONE

DOI

2013

3-Hydroxyphthalic Anhydride-Modified Human Serum Albumin as a Microbicide Candidate Against HIV Type 1 Entry by Targeting Both Viral Envelope Glycoprotein gp120 and Cellular Receptor CD4

AIDS Research and Human Retroviruses

DOI

2013

Antibodies induced by receptor-binding domain in spike protein of SARS-CoV do not cross-neutralize the novel human coronavirus hCoV-EMC

Journal of Infection

DOI

2013

Genomic signature and protein sequence analysis of a novel influenza A (H7N9) virus that causes an outbreak in humans in China

Microbes and Infection

DOI

2013

Small molecule fusion inhibitors: Design, synthesis and biological evaluation of (Z)-3-(5-(3-benzyl-4-oxo-2-thioxothiazolidinylidene)methyl)-N-(3-carboxy-4-hydroxy)phenyl-2,5-dimethylpyrroles and related derivatives targeting HIV-1 gp41

Bioorganic & Medicinal Chemistry

DOI

2013

Putative conformations of the receptor-binding domain in S protein of hCoV-EMC in complex with its receptor dipeptidyl peptidase-4

Journal of Infection

DOI

2013

Novel Pyridinone Derivatives As Non-Nucleoside Reverse Transcriptase Inhibitors (NNRTIs) with High Potency against NNRTI-Resistant HIV-1 Strains

Journal of Medicinal Chemistry

DOI

2013

ST103 HIV-1 variants with mutations in the gp41 pocket region are resistant to HIV fusion inhibitors with pocket-binding domain, but sensitive to T20

JAIDS Journal of Acquired Immune Deficiency Syndromes

DOI

2013

Polyanionic Candidate Microbicides Accelerate the Formation of Semen-Derived Amyloid Fibrils to Enhance HIV-1 Infection

PLoS ONE

DOI

2013

Inhibition of Complement Activation Alleviates Acute Lung Injury Induced by Highly Pathogenic Avian Influenza H5N1 Virus Infection

American Journal of Respiratory Cell and Molecular Biology

DOI

2013

Chemically modified bovine beta-lactoglobulin inhibits human papillomavirus infection

Microbes and Infection

DOI

2013

Design, Synthesis, and Biological Evaluation of Highly Potent Small Molecule–Peptide Conjugates as New HIV-1 Fusion Inhibitors

Journal of Medicinal Chemistry

DOI

2013

HIV-1 Fusion Is Blocked through Binding of GB Virus C E2D Peptides to the HIV-1 gp41 Disulfide Loop

PLoS ONE

DOI

2013

Respiratory Syncytial Virus Entry Inhibitors Targeting the F Protein

Viruses

DOI

2013

Approaches for Identification of HIV-1 Entry Inhibitors Targeting gp41 Pocket

Viruses

DOI

2013

A Critical HA1 Neutralizing Domain of H5N1 Influenza in an Optimal Conformation Induces Strong Cross-Protection

PLoS ONE

DOI

2013

Neutralization sensitivity of HIV-1 subtype B’ clinical isolates from former plasma donors in China

Virology Journal

DOI

2013

Receptor binding and transmission studies of H5N1 influenza virus in mammals

Emerging Microbes & Infections

DOI

2013

Controlling HIV sexual transmission: a major challenge for China's new leadership

Cell & Bioscience

DOI

2013

Fusion

Springer eBooks

DOI

2012

杀微生物剂——预防艾滋病病毒传播的新思路

《科学》

2012

基于中国HIV-1 CRF01AE重组亚型gp41 NHR结构域亚单位疫苗的研究

《细胞与分子免疫学杂志》

2012

艾滋病疫苗研发领域的投资趋势

《中国医药工业杂志》

2012

HIV-1 CRF07BC毒株gp41 NHR结构域N51的表达及结构分析

《南方医科大学学报》

2012

Biosecurity and biosafety in research on emerging pathogens

Emerging Microbes & Infections

DOI

2012

A predicted receptor-binding and critical neutralizing domain in S protein of the novel human coronavirus HCoV-EMC

Journal of Infection

DOI

2012

Development of SARS Vaccines and Therapeutics is Still Needed

Future Virology

DOI

2012

Isolation of Anti-HIV Components fromCanarium albumFruits by High-Speed Counter-Current Chromatography

Analytical Letters

DOI

2012

3-Hydroxyphthalic anhydride-modified human serum albumin as a microbicide candidate inhibits HIV infection by blocking viral entry

Journal of Antimicrobial Chemotherapy

DOI

2012

Identification and Structural Characterization of a Broadly Neutralizing Antibody Targeting a Novel Conserved Epitope on the Influenza Virus H5N1 Hemagglutinin

Journal of Virology

DOI

2012

Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome

Expert Review of Vaccines

DOI

2012

A bivalent recombinant protein inactivates HIV-1 by targeting the gp41 prehairpin fusion intermediate induced by CD4 D1D2 domains

Retrovirology

DOI

2012

Potential strategies and biosafety protocols used for dual‐use research on highly pathogenic influenza viruses

Reviews in Medical Virology

DOI

2012

The Conserved Residue Arg46 in the N-Terminal Heptad Repeat Domain of HIV-1 gp41 Is Critical for Viral Fusion and Entry

PLoS ONE

DOI

2012

Vaginal Gel Formulation Based on Theaflavin Derivatives As a Microbicide to Prevent HIV Sexual Transmission

AIDS Research and Human Retroviruses

DOI

2012

HIV-1 variants with a single-point mutation in the gp41 pocket region exhibiting different susceptibility to HIV fusion inhibitors with pocket- or membrane-binding domain

Biochimica et Biophysica Acta (BBA) - Biomembranes

DOI

2012

Salmonella typhi Ty21a bacterial ghost vector augments HIV-1 gp140 DNA vaccine-induced peripheral and mucosal antibody responses via TLR4 pathway

Vaccine

DOI

2012

Receptor-binding domains of spike proteins of emerging or re-emerging viruses as targets for development of antiviral vaccines

Emerging Microbes & Infections

DOI

2012

Biorisk Management in Studies of Highly Pathogenic H5N1 Viruses

Future Virology

DOI

2012

Phylogenetic and biological analysis of a laboratory-generated gammaretrovirus xenotropic murine leukemia virus-related virus (XMRV)

Virus Genes

DOI

2012

Efficacy, Stability, and Biosafety of Sifuvirtide Gel as a Microbicide Candidate against HIV-1

PLoS ONE

DOI

2012

Design, synthesis, and biological activity of novel 1,4-disubstituted piperidine/piperazine derivatives as CCR5 antagonist-based HIV-1 entry inhibitors

Bioorganic & Medicinal Chemistry Letters

DOI

2012

L-Selectin and P-Selectin Are Novel Biomarkers of Cervicovaginal Inflammation for Preclinical Mucosal Safety Assessment of Anti-HIV-1 Microbicide

Antimicrobial Agents and Chemotherapy

DOI

2012

Short cyclic peptides derived from the C-terminal sequence of α1-antitrypsin exhibit significant anti-HIV-1 activity

Bioorganic & Medicinal Chemistry Letters

DOI

2012

What can academia learn from XMRV studies?

Nature Reviews Urology

DOI

2012

Design, Synthesis, and Biological Evaluation of 1-[(2-Benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with an Improved Drug Resistance Profile

Journal of Medicinal Chemistry

DOI

2012

Design of highly potent HIV fusion inhibitors based on artificial peptide sequences

Chemical Communications

DOI

2011

基于gp41的HIV亚单位疫苗研究进展

《细胞与分子免疫学杂志》

2011

HIV相关痴呆的发病机制及药物治疗靶点

《中国病理生理杂志》

2011

含双环哌啶结构HIV-1抑制剂的设计合成及生物活性研究

《中国药物化学杂志》

2011

哺乳动物细胞表面展示人源HIV特异性全长抗体库的构建

《中国医药指南》

2011

Susceptibility of HIV-1 Subtypes B′, CRF07_BC and CRF01_AE that Are Predominantly Circulating in China to HIV-1 Entry Inhibitors

PLoS ONE

DOI

2011

Discovery of a potent peptidic cyclophilin A inhibitor Trp-Gly-Pro

European Journal of Medicinal Chemistry

DOI

2011

A Recombinant Vaccine of H5N1 HA1 Fused with Foldon and Human IgG Fc Induced Complete Cross-Clade Protection against Divergent H5N1 Viruses

PLoS ONE

DOI

2011

Identification of HBsAg-specific antibodies from a mammalian cell displayed full-length human antibody library of healthy immunized donor

Cellular and Molecular Immunology

DOI

2011

A natural theaflavins preparation inhibits HIV-1 infection by targeting the entry step: Potential applications for preventing HIV-1 infection

Fitoterapia

DOI

2011

Interactions between different generation HIV‐1 fusion inhibitors and the putative mechanism underlying the synergistic anti‐HIV‐1 effect resulting from their combination

The FASEB Journal

DOI

2011

HIV-1 Glycoprotein 41 Ectodomain Induces Activation of the CD74 Protein-mediated Extracellular Signal-regulated Kinase/Mitogen-activated Protein Kinase Pathway to Enhance Viral Infection

Journal of Biological Chemistry

DOI

2011

Mutations of Gln64 in the HIV-1 gp41 N-Terminal Heptad Repeat Render Viruses Resistant to Peptide HIV Fusion Inhibitors Targeting the gp41 Pocket

Journal of Virology

DOI

2011

Design, synthesis and biological evaluation of 3-substituted 2,5-dimethyl-N-(3-(1H-tetrazol-5-yl)phenyl)pyrroles as novel potential HIV-1 gp41 inhibitors

Bioorganic & Medicinal Chemistry

DOI

2011

Heteromeric Assembled Polypeptidic Artificial Hydrolases with a Six‐Helical Bundle Scaffold

ChemBioChem

DOI

2011

HIV-1 gp41 ectodomain enhances Cryptococcus neoformans binding to human brain microvascular endothelial cells via gp41 core-induced membrane activities

Biochemical Journal

DOI

2011

A Novel Chimeric Protein-based HIV-1 Fusion Inhibitor Targeting gp41 Glycoprotein with High Potency and Stability

Journal of Biological Chemistry

DOI

2011

Pathogenesis and Treatment of Human Immunodeficiency Virus-Associated Cytomegalovirus Retinitis

Future Virology

DOI

2011

HIV-1 gp41 Core with Exposed Membrane-Proximal External Region Inducing Broad HIV-1 Neutralizing Antibodies

PLoS ONE

DOI

2010

来源于马尾树树皮的化合物蜡果杨梅酸B抑制HIV进入的机制研究

《中国药理学通报》

2010

酸性天然凝胶电泳法研究HIV进入抑制剂ADS-J1的作用机制

《中国药理学通报》

2010

预防HIV感染的生物医学技术研究领域的投资趋势

《中国医药工业杂志》

2010

靶向血凝素的流感病毒进入抑制剂研究进展

《中国药学杂志》

2010

EGCG乙酸酯的HIV融合抑制活性及其作用机制研究

《中国新药杂志》

2010

靶向包膜蛋白的HIV进入抑制剂非感染性定量筛选方法的研究

《南方医科大学学报》

2010

日本蛇菰中咖啡酰基葡萄糖类化合物抑制HIV-1进入的机制

《南方医科大学学报》

2010

A 219-mer CHO-Expressing Receptor-Binding Domain of SARS-CoV S Protein Induces Potent Immune Responses and Protective Immunity

Viral Immunology

DOI

2009

与HIV感染相关的宿主细胞蛋白

《细胞与分子免疫学杂志》

2009

非核苷类HIV-1逆转录酶抑制剂——二芳烃取代苯并咪唑类衍生物的设计、合成和活性评价

《药学学报》

2009

HIV包膜蛋白的结构及其相应的病毒进入抑制剂

《中国药理学通报》

2009

艾滋病和眼部并发症(英文)

《国际眼科杂志》

2009

VIR576通过与TCR跨膜区结合抑制抗原特异性T细胞活化

《南方医科大学学报》

2008

三没食子酰吡喃葡糖作用于gp41抑制HIV与靶细胞的融合

《南方医科大学学报》

2008

预防HIV性传播的杀微生物剂

《中国计划生育学杂志》

2007

脱氧胆酰酪氨酸的体外杀精和抗HIV活性研究

《中华生殖与避孕杂志》

2006

HIV-1 gp41 NHR结合性环肽的研究

《免疫学杂志》

2006

合成环肽抑制HIV-1病毒介导的细胞融合的初步研究

《热带医学杂志》

2005

新型抗艾滋病药物——HIV进入抑制剂的研究进展

《中国药理学通报》

2004

HIV-1gp41 C-螺旋模拟位的筛选和鉴定

《中国免疫学杂志》

2004

HIV-1囊膜糖蛋白gp41三聚体结构域基因的表达及其单克隆抗体的制备

《中国免疫学杂志》

2004

SARS冠状病毒S蛋白S1区多肽与SARS病人血清的免疫反应

《南方医科大学学报》

2003

作用于HIV包膜蛋白亚基gp41的多肽类融合抑制剂

《中国药理学通报》

2003

HIV-1gp41核心结构模拟位的筛选与鉴定

《中国免疫学杂志》

2003

HIV-1 gp120 V3区的结构特征及其生物学功能

《自然科学进展》

2002

作用于gp41的HIV融合抑制剂高通量筛选方法的研究

《中国药理学通报》

2001

HIV-1 gp41基因的分段克隆和表达

《细胞与分子免疫学杂志》

2001

针对HIV-1进入细胞过程的抑制剂研究进展

《细胞与分子免疫学杂志》

1995

抗AIDS药物研究的最新进展

《国外医学(微生物学分册)》

1995

杀伤性淋巴细胞杀伤靶细胞并保护自身的分子机制

《南方医科大学学报》

1994

土贝母苷甲在体外对人免疫缺陷病毒核心蛋白p24的产生和细胞病变的作用(英文)

Acta Pharmacologica Sinica

1987

Influence of Ehrlich Ascitic Carcinoma on Immune System:Inhibition of Host Response to Thymus-dependent Antigen

Military Medical Research

1987

单篇文献分析作为研究生教学内容的尝试

《中华医学教育杂志》

1986

Ehrlich腹水癌对宿主胸腺细胞亚群的影响

《生物化学与生物物理进展》

1986

艾氏腹水癌带瘤鼠胸腺结构与功能的变化

《南方医科大学学报》

1986

Changes of Thymic Structure and Functions of Ehrlich Ascites Carcinoma-bearing Mice

Military Medical Research

1984

胸腺萎缩及其对免疫系统的影响

《国际免疫学杂志》

1980

细胞溶解性T淋巴细胞与靶细胞相互作用后的超微结构改变

《国际免疫学杂志》

2016

A Chemically Modified Protein JBOl for Preventing HIV Sexual Transmission and Treating HPV Infection

《2016第十四届国际新药发明科技年会——2016首届国际现代中医药大会、2016第三届国际高科技针灸与中西医结合大会、2016第九届国际癌症免疫治疗研讨会、2016第十届国际再生医学与干细胞大会、2016第六届世界微生物大会会刊》

2014

联合使用抗MERS-CoV的疫苗和多肽预防MERS-CoV感染

《第九届全国免疫学学术大会论文集》

2014

抗玛斯冠状病毒(MERS-Cov)疫苗和药物的研究

《中华医学会2014全国微生物学与免疫学学术年会》

2011

Studies on the structure - activity relationship of 1,4-disubstituted piperidine/piperazine embodied CCR5 receptor antagonists

《2011年全国药物化学学术会议——药物的源头创新》

2010

NHR三聚体作为艾滋病亚单位疫苗的研究

《第十届全国抗炎免疫药理学学术会议论文集》

2010

乙酰化EGCG作为前药抑制HIV的感染

《第十届全国抗炎免疫药理学学术会议论文集》

2010

HIV进入抑制剂ADS-J1作为杀微生物剂的研究

《第十届全国抗炎免疫药理学学术会议论文集》

2010

HIV-1 gp41 N-末端重复序列基因(N63)的克隆、表达与功能研究

《第十届全国抗炎免疫药理学学术会议论文集》

2010

中国流行的HIV-1毒株的药物敏感性研究

《第十届全国抗炎免疫药理学学术会议》

2010

酸酐修饰卵清蛋白HP-OVA与抗HIV药物协同作用预防HIV性传播的研究

《第十届全国抗炎免疫药理学学术会议》

2010

酸性凝胶电泳法检测NB-64作为HIV-1进入抑制剂的作用机制

《第十届全国抗炎免疫药理学学术会议》

2010

茶黄素衍生物作为候选杀微生物剂预防HIV的性传播

《第十届全国抗炎免疫药理学学术会议》

2010

新型艾滋病融和抑制剂的作用机制研究

《中国化学会第27届学术年会第03分会场摘要集》

2007

基于细胞-细胞融合的HIV进入抑制剂非感染性筛选方法的研究

《第七届全国病毒学学术研讨会暨第二届武汉现代病毒学国际研讨会论文集》

2000

针对HIV gp41核心结构的抗艾滋病药物高通量筛选方法

《第七届中国抗炎免疫药理学术会议》