沈立新｜西北大学｜学者主页

2025

Isoliquiritigenin targets las, rhl, and Pqs quorum sensing systems to mitigate the virulence and infection of Pseudomonas aeruginosa

Wenxu Song, Zhiying Tian, Yan‐Hong Wang, Yanjie Yin, Haixiang Zhang, Cuixiang Xu, Lixin Shen

BMC Microbiology

DOI

2025

Identification and characterization of alternative homologs of histidinol-phosphate phosphatase in Pseudomonas aeruginosa

Wei’an Guo, Xintong Duan, Chaoni Xiao, Songzhe Fu, Lixin Shen

BMC Microbiology

DOI

2025

A Unique Amino Acid, Se-Met, Regulates Autophagy and Inflammation in Pseudomonas aeruginosa Infection in Mice through the PAK1/Akt1/mTOR and NF-κB Signaling Pathway

Qihang Nie, Ziqi Fang, Jiaoxia Qin, Menghui Wu, Menghui Wu, Yanyan Zhang, Liumei Ye, Ruoyang Zhao, Yuying Li, Lixin Shen, Min Wu, Min Wu

ACS Infectious Diseases

DOI

2024

咖啡酸对铜绿假单胞菌群体感应抑制探究

宋文旭，冯玉琦，韩啸枫，王世伟，徐翠香，张海祥，沈立新

《西北大学学报(自然科学版)》

2024

Veratryl Alcohol Attenuates the Virulence and Pathogenicity of Pseudomonas aeruginosa Mainly via Targeting las Quorum-Sensing System

Songzhe Fu, Wenxu Song, Xiaofeng Han, Lin Chen, Lixin Shen

Microorganisms

DOI

2023

A novel culture-enriched metagenomic sequencing strategy effectively guarantee the microbial safety of drinking water by uncovering the low abundance pathogens

Songzhe Fu, Yixiang Zhang, Rui Wang, Zhiguang Qiu, Weizhi Song, Qian Yang, Lixin Shen

Journal Of Environmental Management，Vol. 345

DOI

2023

STING strengthens host anti-hantaviral immunity through an interferon-independent pathway

Kerong Wang, Jian Zhang, Yongheng Yang, Yue Si, Ziqing Zhou, Xudong Zhu, Sushan Wu, He Liu, Hui Zhang, Liang Zhang, Linfeng Cheng, Wei Ye, Xin Lv, Yingfeng Lei, Xijing Zhang, Shilin Cheng, Lixin Shen, Fanglin Zhang, Hongwei Ma

Virologica Sinica

DOI

2023

Advance on Engineering of Bacteriophages by Synthetic Biology

Qingqing Sun, Lixin Shen, Bailing Zhang, Jiaoyang Yu, Fu Xiang Wei, Yanmei Sun, Wei Chen, Shiwei Wang

Infection and Drug Resistance

DOI

2022

中药抗细菌感染相关研究进展

冯玉琦，李源睿，沈立新

《中华中医药杂志》

2022

Sennoside A inhibits quorum sensing system to attenuate its regulated virulence and pathogenicity via targeting LasR in Pseudomonas aeruginosa

Xiaofeng Han, Mengyue Nan, Xinyu Cai, Boling Qiao, Lin Chen, Lixin Shen

Frontiers in Microbiology

DOI

2022

LncRNA NEAT1 Potentiates SREBP2 Activity to Promote Inflammatory Macrophage Activation and Limit Hantaan Virus Propagation

Yongheng Yang, Mengyun Li, Yongtao Ma, Wei Ye, Yue Si, Xuyang Zheng, He Liu, Linfeng Cheng, Liang Zhang, Hui Zhang, Xijing Zhang, Yingfeng Lei, Lixin Shen, Fanglin Zhang, Hongwei Ma

Frontiers in Microbiology

DOI

2021

Inhibition of Virulence Factors and Biofilm Formation by Wogonin Attenuates Pathogenicity of Pseudomonas aeruginosa PAO1 via Targeting pqs Quorum-Sensing System

Shiwei Wang, Yuqi Feng, Xiaofeng Han, Xinyu Cai, Yang Liu, Chaolan Liu, Lixin Shen

International Journal of Molecular Sciences

DOI

2021

Axl−/− neurons promote JEV infection by dampening the innate immunity

Jiali Yang, Mengyuan Li, Mingcheng Yuan, Peiyu Bian, Yangchao Dong, Haijun Zhang, Chuanyu Luo, Zhifeng Xue, Yuan Wang, Fanglin Zhang, Lixin Shen, Yingfeng Lei

Virus Research

DOI

2021

Deletion of the PA4427-PA4431 Operon of Pseudomonas aeruginosa PAO1 Increased Antibiotics Resistance and Reduced Virulence and Pathogenicity by Affecting Quorum Sensing and Iron Uptake

Lixin Shen, Lang Gao, Mengjiao Yang, Jian Zhang, Yulu Wang, Yuqi Feng, Liping Wang, Shiwei Wang

Microorganisms

DOI

2021

Subunit Vaccine ESAT-6:c-di-AMP Delivered by Intranasal Route Elicits Immune Responses and Protects Against Mycobacterium tuberculosis Infection

Huanhuan Ning, Wei Zhang, Jian Kang, Tianbing Ding, Xuan Liang, Yanzhi Lu, Chengxuan Guo, Wenjie Sun, Huapeng Wang, Yinlan Bai, Lixin Shen

Frontiers in Cellular and Infection Microbiology

DOI

2019

细菌铁离子摄取系统与宿主免疫

刘芳彤，樊浩楠，沈立新，李博

《微生物学通报》

DOI

2019

PA0335, a Gene Encoding Histidinol Phosphate Phosphatase, Mediates Histidine Auxotrophy in Pseudomonas aeruginosa

Yulu Wang, Liyue Wang, Jian Zhang, Xintong Duan, Yuqi Feng, Shiwei Wang, Lixin Shen

Applied and Environmental Microbiology

DOI

2019

Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous Adjuvant Induces Elevated Immune Responses After Mycobacterium tuberculosis Infection

Huanhuan Ning, Lifei Wang, Jie Zhou, Yanzhi Lu, Jian Kang, Tianbing Ding, Lixin Shen, Zhikai Xu, Yinlan Bai

Frontiers in Immunology

DOI

2019

The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses

Kerong Wang, Hongwei Ma, He Liu, Wei Ye, Zhuo Li, Linfeng Cheng, Liang Zhang, Yingfeng Lei, Lixin Shen, Fanglin Zhang

Cell Reports

DOI

2019

Regulatory Effect of DNA Topoisomerase I on T3SS Activity, Antibiotic Susceptibility and Quorum- Sensing-Independent Pyocyanin Synthesis in Pseudomonas aeruginosa

Rong Yan, Shikun Hu, Ning Ma, Peiqing Song, Qingqing Liang, Huiqun Zhang, Yanqi Li, Lixin Shen, Kangmin Duan, Lin Chen

International Journal of Molecular Sciences

DOI

2017

The Two-Operon-Coded ABC Transporter Complex FpvWXYZCDEF is Required for Pseudomonas aeruginosa Growth and Virulence Under Iron-Limiting Conditions

Lang Gao, Zisheng Guo, Yue Wang, Yulu Wang, Kerong Wang, Бо Ли, Lixin Shen

The Journal of Membrane Biology

DOI

2017

Inhibition of Pseudomonas aeruginosa Biofilm Formation by Traditional Chinese Medicinal Herb Herba patriniae

Bo Fu, Qiaolian Wu, Minyan Dang, Dangdang Bai, Qiao Guo, Lixin Shen, Kangmin Duan

BioMed Research International

DOI

2016

细菌锌离子调控体系与感染

李博，李晶，沈立新

《微生物学报》

2016

The role of the temperature-regulated acyltransferase (PA3242) on growth, antibiotic resistance and virulence in Pseudomonas aeruginosa

Ying Shi Liang, Zisheng Guo, Lang Gao, Qianqian Guo, Liyue Wang, Yan Han, Kangmin Duan, Lixin Shen

Microbial Pathogenesis

DOI

2016

Identification of Genes that Regulate rsmA and Phenotypes Affected

HuiQun ZHANG, Rong Yan, Yao Yu, Mengmeng Dong, Lin CHEN, Kangmin Duan, Lixin Shen

Scientia Sinica Vitae

DOI

2015

病原菌耐药组的研究进展

王严，宁唤唤，梁鹰，杨赛，高浪，沈立新

《基因组学与应用生物学》

2015

细菌耐药性的起源与演变

王严，宁唤唤，梁鹰，王波波，李博，沈立新

《基因组学与应用生物学》

2015

铜绿假单胞菌耐药性与致病性共选择机制研究进展

宁唤唤，李晶，王严，李博，王波波，张悦，陈林，沈立新

《中国抗生素杂志》

2015

Pleiotropic effects of temperature-regulated 2-OH-lauroytransferase (PA0011) on Pseudomonas aeruginosa antibiotic resistance, virulence and type III secretion system

Bobo Wang, Бо Ли, Ying Shi Liang, Jing Li, Lang Gao, Lin Chen, Kangmin Duan, Lixin Shen

Microbial Pathogenesis

DOI

2014

铜绿假单胞菌对碳青霉烯类抗生素耐药相关基因的筛选

张悦，梁文，祁婧，宁唤唤，郭俏，陈林，段康民，沈立新

《中国科学:生命科学》

2014

PA2580基因与铜绿假单胞菌环境压力耐受性相关

赵琳，李娟，陈林，沈立新，段康民

《微生物学报》

2014

半枝莲对铜绿假单胞菌群体感应系统的抑制作用

肖骏，沈立新，赵琳，武玉婷，段康民，郭俏

《中国抗生素杂志》

2013

沙门菌致病相关毒力因子概述

韩妍，梁文，李博，魏昊辰，赵鑫，沈立新

《中国抗生素杂志》

2013

铜绿假单胞菌对碳青霉烯类抗生素耐药机制研究进展

梁文，李博，董萌萌，李晶，沈立新

《中国抗生素杂志》

2013

Construction of a tightly-controlled expression system for use in Pseudomonas

Liang Yang, Lin Chen, Lixin Shen, Kangmin Duan

Biotechnology Letters

DOI

2013

Hybrid sensor kinase PA 1611 in P seudomonas aeruginosa regulates transitions between acute and chronic infection through direct interaction with RetS

Weina Kong, Lin Chen, Jieqiong Zhao, Tuo Shen, Michael Gordon Surette, Lixin Shen, Kangmin Duan

Molecular Microbiology

DOI

2012

PA2800 Plays an Important Role in Both Antibiotic Susceptibility and Virulence in Pseudomonas aeruginosa

Lixin Shen, Xiangli Gao, Jinhua Wei, Lin Chen, Xin Zhao, Бо Ли, Kangmin Duan

Current Microbiology

DOI

2011

Characterization of a novel gene related to antibiotic susceptibility in Pseudomonas aeruginosa

Lixin Shen, Yanling Ma, Haihua Liang

The Journal of Antibiotics

DOI

2011

Inactivation of MuxABC-OpmB transporter system in Pseudomonas aeruginosa leads to increased ampicillin and carbenicillin resistance and decreased virulence

Liang Yang, Lin Chen, Lixin Shen, Michael Gordon Surette, Kangmin Duan

The Journal of Microbiology

DOI

2010

铜绿假单胞菌中群体感应系统研究进展

梁海华，沈立新，马艳玲，段康民

《微生物学通报》

2010

Identification of Pseudomonas aeruginosa genes associated with antibiotic susceptibility

Lin Chen, Liang Yang, XingYan Zhao, Lixin Shen, Kangmin Duan

Science China Life Sciences

DOI

2009

铜绿假单胞菌群体感应抑制物筛选系统的构建及其应用

孙玮洁，王媛，沈立新，段康民

《生物工程学报》

2009

铜绿假单胞菌中Ⅲ型分泌系统受Rhl和PQS群体感应系统调节

孔伟娜，梁海华，沈立新，段康民

《微生物学报》

2009

Genomic Investigation of the Role of Antibiotics As Signal Molecules in Pseudomonas aeruginosa

Lixin Shen, Dan Zhang, Ying Shi, Haihua Liang, Kangmin Duan

International Conference on Bioinformatics and Biomedical Engineering

DOI

2009

Identification of a novel regulator of the quorum-sensing systems inPseudomonas aeruginosa

Haihua Liang, Lingling Li, Weina Kong, Lixin Shen, Kangmin Duan

FEMS Microbiology Letters

DOI

2008

铜绿假单胞菌中一个新的吩嗪合成调节基因

孔丽萍，梁海华，董兆麟，段康民，沈立新

《微生物学报》

2008

铜绿假单胞菌随机启动子库的构建及受铁调控基因的筛选和鉴定

王琰，魏金花，沈立新，段康民

《微生物学报》

2008

铜绿假单胞菌多重耐药基因的筛选及鉴定

赵兴艳，梁海华，沈立新，董兆麟，段康民

《微生物学报》

精选作品

期刊论文

Isoliquiritigenin targets las, rhl, and Pqs quorum sensing systems to mitigate the virulence and infection of Pseudomonas aeruginosa

Identification and characterization of alternative homologs of histidinol-phosphate phosphatase in Pseudomonas aeruginosa

A Unique Amino Acid, Se-Met, Regulates Autophagy and Inflammation in Pseudomonas aeruginosa Infection in Mice through the PAK1/Akt1/mTOR and NF-κB Signaling Pathway

咖啡酸对铜绿假单胞菌群体感应抑制探究

Veratryl Alcohol Attenuates the Virulence and Pathogenicity of Pseudomonas aeruginosa Mainly via Targeting las Quorum-Sensing System

A novel culture-enriched metagenomic sequencing strategy effectively guarantee the microbial safety of drinking water by uncovering the low abundance pathogens

STING strengthens host anti-hantaviral immunity through an interferon-independent pathway

Advance on Engineering of Bacteriophages by Synthetic Biology

中药抗细菌感染相关研究进展

Sennoside A inhibits quorum sensing system to attenuate its regulated virulence and pathogenicity via targeting LasR in Pseudomonas aeruginosa

LncRNA NEAT1 Potentiates SREBP2 Activity to Promote Inflammatory Macrophage Activation and Limit Hantaan Virus Propagation

Inhibition of Virulence Factors and Biofilm Formation by Wogonin Attenuates Pathogenicity of Pseudomonas aeruginosa PAO1 via Targeting pqs Quorum-Sensing System

Axl−/− neurons promote JEV infection by dampening the innate immunity

Deletion of the PA4427-PA4431 Operon of Pseudomonas aeruginosa PAO1 Increased Antibiotics Resistance and Reduced Virulence and Pathogenicity by Affecting Quorum Sensing and Iron Uptake

Subunit Vaccine ESAT-6:c-di-AMP Delivered by Intranasal Route Elicits Immune Responses and Protects Against Mycobacterium tuberculosis Infection

细菌铁离子摄取系统与宿主免疫

PA0335, a Gene Encoding Histidinol Phosphate Phosphatase, Mediates Histidine Auxotrophy in Pseudomonas aeruginosa

Recombinant BCG With Bacterial Signaling Molecule Cyclic di-AMP as Endogenous Adjuvant Induces Elevated Immune Responses After Mycobacterium tuberculosis Infection

The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses

Regulatory Effect of DNA Topoisomerase I on T3SS Activity, Antibiotic Susceptibility and Quorum- Sensing-Independent Pyocyanin Synthesis in Pseudomonas aeruginosa

The Two-Operon-Coded ABC Transporter Complex FpvWXYZCDEF is Required for Pseudomonas aeruginosa Growth and Virulence Under Iron-Limiting Conditions

Inhibition of Pseudomonas aeruginosa Biofilm Formation by Traditional Chinese Medicinal Herb Herba patriniae

细菌锌离子调控体系与感染

The role of the temperature-regulated acyltransferase (PA3242) on growth, antibiotic resistance and virulence in Pseudomonas aeruginosa

Identification of Genes that Regulate rsmA and Phenotypes Affected

病原菌耐药组的研究进展

细菌耐药性的起源与演变

铜绿假单胞菌耐药性与致病性共选择机制研究进展

Pleiotropic effects of temperature-regulated 2-OH-lauroytransferase (PA0011) on Pseudomonas aeruginosa antibiotic resistance, virulence and type III secretion system

铜绿假单胞菌对碳青霉烯类抗生素耐药相关基因的筛选

PA2580基因与铜绿假单胞菌环境压力耐受性相关

半枝莲对铜绿假单胞菌群体感应系统的抑制作用

沙门菌致病相关毒力因子概述

铜绿假单胞菌对碳青霉烯类抗生素耐药机制研究进展

Construction of a tightly-controlled expression system for use in Pseudomonas

Hybrid sensor kinase PA 1611 in P seudomonas aeruginosa regulates transitions between acute and chronic infection through direct interaction with RetS

PA2800 Plays an Important Role in Both Antibiotic Susceptibility and Virulence in Pseudomonas aeruginosa

Characterization of a novel gene related to antibiotic susceptibility in Pseudomonas aeruginosa

Inactivation of MuxABC-OpmB transporter system in Pseudomonas aeruginosa leads to increased ampicillin and carbenicillin resistance and decreased virulence

铜绿假单胞菌中群体感应系统研究进展

Identification of Pseudomonas aeruginosa genes associated with antibiotic susceptibility

铜绿假单胞菌群体感应抑制物筛选系统的构建及其应用

铜绿假单胞菌中Ⅲ型分泌系统受Rhl和PQS群体感应系统调节

Genomic Investigation of the Role of Antibiotics As Signal Molecules in Pseudomonas aeruginosa

Identification of a novel regulator of the quorum-sensing systems inPseudomonas aeruginosa

铜绿假单胞菌中一个新的吩嗪合成调节基因

铜绿假单胞菌随机启动子库的构建及受铁调控基因的筛选和鉴定

铜绿假单胞菌多重耐药基因的筛选及鉴定

预印本

4-Imidazolecarboxaldehyde attenuates virulence and pathogenicity of Pseudomonas aeruginosa by targeting las and rhl systems

Gp4.5, a Phage-Encoded Anti-Defense Protein, Promotes Lysis by Inhibiting the Host HigB Toxin and Remodeling Cellular Physiology

研究方向