苏维恒｜吉林大学｜学者主页

2026

Enhanced cellular immunity against varicella-zoster virus by β-sitosterol-substituted lipid nanoparticles in mRNA vaccines

Lijun Bian, Jiaxing Cui, Gaotian Li, Yi Cao, Dongdong Li, Dong Sun, Jingkai Gu, Liao Xing, Jingying Zhou, Yi Yang, Weiheng Su, Yan Chen, Yong Zhang

International Immunopharmacology

DOI

2025

Live attenuated influenza vaccine with low proportions of defective interfering particles elicits robust immunogenicity and cross-protection

Min Wu, Peihan Wang, Likun Wang, Cuidan Li, Rui Sheng, Hanwen Dong, Xiaoshu Fu, Entong Zhou, Chun Zhang, Tianyi Lu, Zhengyang Jin, Jiaqi Qin, Yuxuan Miao, Liya Yue, Dong Pan, Chao Li, C. Jason Liang, Irina Kiseleva, Руденко Лариса Георгиевна, Chunlai Jiang, Fei Chen, Weiheng Su

Nature Communications

DOI

2025

A novel adjuvant system BK-02 with CpG2006 and MF59 enhances the immunogenicity of a herpes zoster subunit vaccine

Zihan Wang, Yingnan Guo, Xin Tang, Ying Sun, Tingting Wu, Hanyu Peng, Cenrong Wang, Weiheng Su, Chunlai Jiang, Yang Zang, Yaru Quan, Kangwei Xu, Bo Sun

Frontiers in Immunology

DOI

2025

Silica-calcium phosphate nanoparticles delivering recombinant influenza hemagglutinin DNA can induce long-lasting T cell immune cross-protection in mice

Xiaoxi Liu, Qingyu Wang, Yuhua Shi, Li Zhan, Lipeng Xu, Jiaru Hui, Kunpeng Xie, Chenxi Li, Chunjiang Li, Weiheng Su, Xianbin Cheng, Yaming Shan

Frontiers in Immunology

DOI

2025

Induction of enhanced stem-directed neutralizing antibodies by HA2-16 ferritin nanoparticles with H3 influenza virus boost

Qingyu Wang, Jiaojiao Nie, Zejinxuan Liu, Yaotian Chang, Yangang Wei, Xin Yao, Lulu Sun, Xiaoxi Liu, Qicheng Liu, Xinyu Liang, Xinran Zhang, Yong Zhang, Weiheng Su, Qi Zhao, Yaming Shan, Yingwu Wang, Xianbin Cheng, Yuhua Shi

Nanoscale Advances

DOI

2024

A nucleoside-modified mRNA vaccine forming rabies virus-like particle elicits strong cellular and humoral immune responses against rabies virus infection in mice

Jie Liu, Jie Sun, Xue Ding, Wenhao Liu, Yipeng Wang, Zihan Wang, Hanyu Peng, Yong Zhang, Weiheng Su, Chunlai Jiang

Emerging Microbes & Infections

DOI

2024

TaqMan qPCR and IgM Detection in Samples of Patients with Tick-Borne Encephalitis Virus Infection in Northeast China

Menghan Yu, Xiaoshu Fu, Yanli Zhu, Miao Li, Min Wu, Entong Zhou, Hanwen Dong, Likun Wang, Ruoxi Wang, Fang Liu, Chunlai Jiang, Xiangwei Kong, Weiheng Su

International Journal of General Medicine

DOI

2023

干扰素受体1沉默的人二倍体MRC-5细胞系对水痘-带状疱疹病毒复制的影响

杨骁，姜承瀚，孙博，谷铁军，万明明，孙捷，丁雪，王岑嵘，周恩同，姜皓，苏维恒

《中国生物制品学杂志》

2023

Comparison of effects of multiple adjuvants and immunization routes on the immunogenicity and protection of HSV-2 gD subunit vaccine

Mingming Wan, Xiao Yang, Zhijun Chen, Weiheng Su, Linjun Cai, Ali Hou, Bo Sun, Yong Zhang, Wei Kong, Chunlai Jiang, Yan Zhou

Immunology Letters

DOI

2023

An Adenovirus-Based Recombinant Herpes Simplex Virus 2 (HSV-2) Therapeutic Vaccine Is Highly Protective against Acute and Recurrent HSV-2 Disease in a Guinea Pig Model

Mingming Wan, Xiao Yang, Jie Sun, Xue Ding, Zhijun Chen, Weiheng Su, Linjun Cai, Ali Hou, Bo Sun, Feng Gao, Chunlai Jiang, Yan Zhou

Viruses

DOI

2023

Establishment of a TaqMan-based real-time quantitative PCR method for detection of exogenous fowl adenovirus type Ⅰ, type Ⅲ and avian leukosis virus in human cold adapted live attenuated influenza vaccines

Min Wu, Bai-Hui Zhi, Rui Sheng, Entong Zhou, Qian Zhou, Jiemin Li, Xiaoshu Fu, WU Yan-chun, Yunchang Zhang, Pingjie Sun, Wei Ping Jia, Shi Liang, Dawei Liu, Hui John Zhao, Weiheng Su

Heliyon

DOI

2023

Enhancement of Neutralization Responses through Sequential Immunization of Stable Env Trimers Based on Consensus Sequences from Select Time Points by Mimicking Natural Infection

Mingming Wan, Xiao Yang, Jie Sun, Elena E. Giorgi, Xue Ding, Yan Zhou, Yong Zhang, Weiheng Su, Chunlai Jiang, Yaming Shan, Feng Gao

International Journal of Molecular Sciences

DOI

2022

Defective Interfering Particles of Influenza Virus and Their Characteristics, Impacts, and Use in Vaccines and Antiviral Strategies: A Systematic Review

Min Wu, Entong Zhou, Rui Sheng, Xiaoshu Fu, Jiemin Li, Chunlai Jiang, Weiheng Su

Viruses

DOI

2022

Immunogenicity of Varicella Zoster Virus DNA Vaccines Encoding Glycoprotein E and Immediate Early Protein 63 in Mice

Jie Liu, Junyang Lin, Linjun Cai, Jie Sun, Xue Ding, Cenrong Wang, Yanchun Wu, Xiaoling Gao, Weiheng Su, Chunlai Jiang

Viruses

DOI

2022

Antiviral effects of the petroleum ether extract of Tournefortia sibirica L. against enterovirus 71 infection in vitro and in vivo

Xinyu Huang, Jiemin Li, Yan Hong, Chenghan Jiang, Jiaxin Wu, Min Wu, Rui Sheng, Hongtao Liu, Jie Sun, Ying Xin, Weiheng Su

Frontiers in Pharmacology

DOI

2022

Antiviral Effects of ABMA and DABMA against Influenza Virus In Vitro and In Vivo via Regulating the Endolysosomal Pathway and Autophagy

Hongtao Liu, Chunlai Jiang, Yu Wu, Min Wu, Jiaxin Wu, Guanshu Zhao, Jie Sun, Xinyu Huang, Jiemin Li, Rui Sheng, Julien Barbier, Jean‐Christophe Cintrat, Daniel Gillet, Weiheng Su

International Journal of Molecular Sciences

DOI

2021

Interferon Inhibition Enhances the Pilot-Scale Production of Rabies Virus in Human Diploid MRC-5 Cells

Xiao Yang, Mingming Wan, Linjun Cai, Ali Hou, Bo Sun, Yan Zhou, Feng Gao, Weiheng Su, Chunlai Jiang

Viruses

DOI

2021

A defective viral genome strategy elicits broad protective immunity against respiratory viruses

Yinghong Xiao, Peter V. Lidsky, Yuta Shirogane, Ranen Aviner, Chien-Ting Wu, Weiyi Li, Weihao Zheng, Dale Talbot, Adam Catching, Gilad Doitsh, Weiheng Su, Colby E. Gekko, Arabinda Nayak, Joel D. Ernst, Leonid Brodsky, Elia Brodsky, Elsa Rousseau, Sara Capponi, Simone Bianco, Robert M. Nakamura, Peter K. Jackson, Judith Frydman, Raul Andino

Cell

DOI

2021

Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome

Yuta Shirogane, Elsa Rousseau, Jakub Voznica, Yinghong Xiao, Weiheng Su, Adam Catching, Zachary J. Whitfield, Igor M. Rouzine, Simone Bianco, Raul Andino

PLoS Pathogens

DOI

2020

Myristoylation of EV71 VP4 is Essential for Infectivity and Interaction with Membrane Structure

Jiaming Cao, Meng Qu, Hongtao Liu, Xuan Wan, Fang Li, Ali Hou, Yan Zhou, Bo Sun, Linjun Cai, Weiheng Su, Chunlai Jiang

Virologica Sinica

DOI

2019

Exosomes Released from Rabies Virus-Infected Cells May be Involved in the Infection Process

Jingyu Wang, Fan Wu, Chuntian Liu, Wenwen Dai, Yawei Teng, Weiheng Su, Wei Kong, Feng Gao, Linjun Cai, Ali Hou, Chunlai Jiang

Virologica Sinica

DOI

2019

Antiviral Efficacy of Flavonoids against Enterovirus 71 Infection in Vitro and in Newborn Mice

Wenwen Dai, Jinpeng Bi, Fang Li, Shuai Wang, Xinyu Huang, Xiangyu Meng, Bo Sun, Deli Wang, Wei Kong, Chunlai Jiang, Weiheng Su

Viruses

DOI

2019

Determination of the cleavage site of enterovirus 71 VP0 and the effect of this cleavage on viral infectivity and assembly

Jiaming Cao, Hongtao Liu, Meng Qu, Ali Hou, Yan Zhou, Bo Sun, Linjun Cai, Feng Gao, Weiheng Su, Chunlai Jiang

Microbial Pathogenesis

DOI

2018

Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo

Wenwen Dai, Yu Wu, Jinpeng Bi, Shuai Wang, Fang Li, Wei Kong, Julien Barbier, Jean‐Christophe Cintrat, Feng Gao, Daniel Gillet, Weiheng Su, Chunlai Jiang

Viruses

DOI

2018

Comparison of immunogenicity, efficacy and transcriptome changes of inactivated rabies virus vaccine with different adjuvants

Wei Shi, Yiming Kou, Jinghui Xiao, Lijuan Zhang, Feng Gao, Wei Kong, Weiheng Su, Chunlai Jiang, Yong Zhang

Vaccine

DOI

2017

Antiviral effects of Retro-2 cycl and Retro-2.1 against Enterovirus 71 in vitro and in vivo

Wenwen Dai, Yu Wu, Jinpeng Bi, Xiaotong Lu, Ali Hou, Yan Zhou, Bo Sun, Wei Kong, Julien Barbier, Jean‐Christophe Cintrat, Feng Gao, Daniel Gillet, Weiheng Su, Chunlai Jiang

Antiviral Research

DOI

2017

Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice

Wei Liu, Yan Zhou, Ziyan Wang, Zeqiang Zhang, Qizhi Wang, Weiheng Su, Yan Chen, Yan Zhang, Feng Gao, Chunlai Jiang, Wei Kong

Microbiology and Immunology

DOI

2017

Characterization of human enterovirus71 virus-like particles used for vaccine antigens

Dandan Zhao, Bo Sun, Shiyang Sun, Bin Fu, Chuntian Liu, Dawei Liu, Yanfei Chu, Youlei Ma, Lu Bai, Yongge Wu, Yan Zhou, Weiheng Su, Ali Hou, Linjun Cai, Fei Xu, Wei Kong, Chunlai Jiang

PLoS ONE

DOI

2017

Synonymous codon usage analysis of hand, foot and mouth disease viruses: A comparative study on coxsackievirus A6, A10, A16, and enterovirus 71 from 2008 to 2015

Weiheng Su, Xue Li, Meili Chen, Wenwen Dai, Shiyang Sun, Shuai Wang, Xin Sheng, Shixiang Sun, Gao Chen, Ali Hou, Yan Zhou, Bo Sun, Feng Gao, Jingfa Xiao, Zhewen Zhang, Chunlai Jiang

Infection Genetics and Evolution

DOI

2017

Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells

Jun Jin, Rujiao Li, Chunlai Jiang, Ruosi Zhang, Xiaomeng Ge, Fang Liang, Xin Sheng, Wenwen Dai, Meili Chen, Jiayan Wu, Jingfa Xiao, Weiheng Su

BMC Genomics

DOI

2015

Identification of a Common Epitope between Enterovirus 71 and Human MED25 Proteins Which May Explain Virus-Associated Neurological Disease

Peihu Fan, Xiaojun Li, Shiyang Sun, Weiheng Su, Dong An, Feng Gao, Wei Kong, Chunlai Jiang

Viruses

DOI

2015

A new EV71 VP3 epitope in norovirus P particle vector displays neutralizing activity and protection in vivo in mice

Liping Jiang, Rongjun Fan, Shiyang Sun, Peihu Fan, Weiheng Su, Yan Zhou, Feng Gao, Fei Xu, Wei Kong, Chunlai Jiang

Vaccine

DOI

2015

Enterovirus71 virus-like particles produced from insect cells and purified by multistep chromatography elicit strong humoral immune responses in mice

Dandan Zhao, B. Sun, H. Jiang, Shiqi Sun, Franklin T. Kong, Yuanyuan Ma, Liping Jiang, L. Bai, Xixian Chen, P. Yang, C. Liu, Yuyang Xu, Weiheng Su, Wei Kong, F. Xu, Chunlai Jiang

Journal of Applied Microbiology

DOI

2015

Eliciting neutralizing antibodies against the membrane proximal external region of HIV-1 Env by chimeric live attenuated influenza A virus vaccines

Yang Zang, Dongchuan Du, Na Li, Weiheng Su, Xintao Liu, Yan Zhang, Jianhui Nie, Youchun Wang, Wei Kong, Chunlai Jiang

Vaccine

DOI

2015

Enhanced Sensitivity for Detection of HIV-1 p24 Antigen by a Novel Nuclease-Linked Fluorescence Oligonucleotide Assay

Peihu Fan, Xiaojun Li, Weiheng Su, Wei Kong, Xianggui Kong, Zhenxin Wang, Youchun Wang, Chunlai Jiang, Feng Gao

PLoS ONE

DOI

2015

Production, characterization and immunogenicity of P particles derived from norovirus GII.4 genotype 2004 variant

Weiheng Su, Junshan Gao, Y. Zang, Hai-guang Wu, Ling Wang, Hongxing Hu, X. Yu, W. Kong, Chunlai Jiang

Acta Virologica

DOI

2014

蟾酥主要活性成分对EV71-EGFP病毒感染性克隆的抑制作用

陈嘉雯，徐琳，郜尧正，苏维恒，陈维金

《中国新药杂志》

2014

Identification of Luteolin as Enterovirus 71 and Coxsackievirus A16 Inhibitors through Reporter Viruses and Cell Viability-Based Screening

Lin Xu, Weiheng Su, Jun Jin, Jiawen Chen, Xiaojun Li, Xuyuan Zhang, Meiyan Sun, Shiyang Sun, Peihu Fan, Dong An, Huafei Zhang, Xiguang Zhang, Wei Kong, Tonghui Ma, Chunlai Jiang

Viruses

DOI

2014

Development of one-step real-time PCR assay for titrating trivalent live attenuated influenza vaccines

Yang Zang, Dongchuan Du, Peng Ge, Yongqing Xu, Xintao Liu, Yan Zhang, Weiheng Su, Irina Kiseleva, Руденко Лариса Георгиевна, Fei Xu, Wei Kong, Chunlai Jiang

Human Vaccines & Immunotherapeutics

DOI

2014

Identification of cinobufagin and resibufogenin as inhibitors of enterovirus 71 infection

Jiawen Chen, Lin Xu, Shiyang Sun, Huafei Zhang, Tonghui Ma, Weiheng Su, Chunlai Jiang

Chemical Research in Chinese Universities

DOI

2014

Evaluation of monovalent and bivalent vaccines against lethalEnterovirus71 andCoxsackievirusA16 infection in newborn mice

Shiyang Sun, Liping Jiang, Zhenglun Liang, Qunying Mao, Weiheng Su, Huafei Zhang, Xiaojun Li, Jun Jin, Lin Xu, Dandan Zhao, Peihu Fan, Dong An, Ping Yang, Jingcai Lu, Xiuping Lv, Bo Sun, Fei Xu, Wei Kong, Chunlai Jiang

Human Vaccines & Immunotherapeutics

DOI

2014

Analysis of Cross-Reactive Neutralizing Antibodies in Human HFMD Serum with an EV71 Pseudovirus-Based Assay

Huafei Zhang, Dong An, Wei Liu, Qunying Mao, Jun Jin, Lin Xu, Shiyang Sun, Liping Jiang, Xiaojun Li, Jie Shao, Hongxia Ma, Xueyong Huang, Shijie Guo, Haiying Chen, Tong Cheng, Lisheng Yang, Weiheng Su, Wei Kong, Zhenglun Liang, Chunlai Jiang

PLoS ONE

DOI

2014

The Variable Loop 3 in the Envelope Glycoprotein Is Critical for the Atypical Coreceptor Usage of an HIV-1 Strain

Yue Xiang, Wei Yong Liu, Yue Chen, Chuntao Zhang, Weiheng Su, Yan Zhang, Jiaxi Sun, Feng Gao, Chunlai Jiang

PLoS ONE

DOI

2013

Establishment of cell lines with increased susceptibility to EV71/CA16 by stable overexpression of SCARB2

Xiaojun Li, Peihu Fan, Jun Jin, Weiheng Su, Dong An, Lin Xu, Shiyang Sun, Yan Zhang, Xiangyu Meng, Feng Gao, Wei Kong, Chunlai Jiang

Virology Journal

DOI

精选作品

期刊论文

Enhanced cellular immunity against varicella-zoster virus by β-sitosterol-substituted lipid nanoparticles in mRNA vaccines

Live attenuated influenza vaccine with low proportions of defective interfering particles elicits robust immunogenicity and cross-protection

A novel adjuvant system BK-02 with CpG2006 and MF59 enhances the immunogenicity of a herpes zoster subunit vaccine

Silica-calcium phosphate nanoparticles delivering recombinant influenza hemagglutinin DNA can induce long-lasting T cell immune cross-protection in mice

Induction of enhanced stem-directed neutralizing antibodies by HA2-16 ferritin nanoparticles with H3 influenza virus boost

A nucleoside-modified mRNA vaccine forming rabies virus-like particle elicits strong cellular and humoral immune responses against rabies virus infection in mice

TaqMan qPCR and IgM Detection in Samples of Patients with Tick-Borne Encephalitis Virus Infection in Northeast China

干扰素受体1沉默的人二倍体MRC-5细胞系对水痘-带状疱疹病毒复制的影响

Comparison of effects of multiple adjuvants and immunization routes on the immunogenicity and protection of HSV-2 gD subunit vaccine

An Adenovirus-Based Recombinant Herpes Simplex Virus 2 (HSV-2) Therapeutic Vaccine Is Highly Protective against Acute and Recurrent HSV-2 Disease in a Guinea Pig Model

Establishment of a TaqMan-based real-time quantitative PCR method for detection of exogenous fowl adenovirus type Ⅰ, type Ⅲ and avian leukosis virus in human cold adapted live attenuated influenza vaccines

Enhancement of Neutralization Responses through Sequential Immunization of Stable Env Trimers Based on Consensus Sequences from Select Time Points by Mimicking Natural Infection

Defective Interfering Particles of Influenza Virus and Their Characteristics, Impacts, and Use in Vaccines and Antiviral Strategies: A Systematic Review

Immunogenicity of Varicella Zoster Virus DNA Vaccines Encoding Glycoprotein E and Immediate Early Protein 63 in Mice

Antiviral effects of the petroleum ether extract of Tournefortia sibirica L. against enterovirus 71 infection in vitro and in vivo

Antiviral Effects of ABMA and DABMA against Influenza Virus In Vitro and In Vivo via Regulating the Endolysosomal Pathway and Autophagy

Interferon Inhibition Enhances the Pilot-Scale Production of Rabies Virus in Human Diploid MRC-5 Cells

A defective viral genome strategy elicits broad protective immunity against respiratory viruses

Experimental and mathematical insights on the interactions between poliovirus and a defective interfering genome

Myristoylation of EV71 VP4 is Essential for Infectivity and Interaction with Membrane Structure

Exosomes Released from Rabies Virus-Infected Cells May be Involved in the Infection Process

Antiviral Efficacy of Flavonoids against Enterovirus 71 Infection in Vitro and in Newborn Mice

Determination of the cleavage site of enterovirus 71 VP0 and the effect of this cleavage on viral infectivity and assembly

Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo

Comparison of immunogenicity, efficacy and transcriptome changes of inactivated rabies virus vaccine with different adjuvants

Antiviral effects of Retro-2 cycl and Retro-2.1 against Enterovirus 71 in vitro and in vivo

Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice

Characterization of human enterovirus71 virus-like particles used for vaccine antigens

Synonymous codon usage analysis of hand, foot and mouth disease viruses: A comparative study on coxsackievirus A6, A10, A16, and enterovirus 71 from 2008 to 2015

Transcriptome analysis reveals dynamic changes in coxsackievirus A16 infected HEK 293T cells

Identification of a Common Epitope between Enterovirus 71 and Human MED25 Proteins Which May Explain Virus-Associated Neurological Disease

A new EV71 VP3 epitope in norovirus P particle vector displays neutralizing activity and protection in vivo in mice

Enterovirus71 virus-like particles produced from insect cells and purified by multistep chromatography elicit strong humoral immune responses in mice

Eliciting neutralizing antibodies against the membrane proximal external region of HIV-1 Env by chimeric live attenuated influenza A virus vaccines

Enhanced Sensitivity for Detection of HIV-1 p24 Antigen by a Novel Nuclease-Linked Fluorescence Oligonucleotide Assay

Production, characterization and immunogenicity of P particles derived from norovirus GII.4 genotype 2004 variant

蟾酥主要活性成分对EV71-EGFP病毒感染性克隆的抑制作用

Identification of Luteolin as Enterovirus 71 and Coxsackievirus A16 Inhibitors through Reporter Viruses and Cell Viability-Based Screening

Development of one-step real-time PCR assay for titrating trivalent live attenuated influenza vaccines

Identification of cinobufagin and resibufogenin as inhibitors of enterovirus 71 infection

Evaluation of monovalent and bivalent vaccines against lethalEnterovirus71 andCoxsackievirusA16 infection in newborn mice

Analysis of Cross-Reactive Neutralizing Antibodies in Human HFMD Serum with an EV71 Pseudovirus-Based Assay

The Variable Loop 3 in the Envelope Glycoprotein Is Critical for the Atypical Coreceptor Usage of an HIV-1 Strain

Establishment of cell lines with increased susceptibility to EV71/CA16 by stable overexpression of SCARB2

预印本

Evaluation of Rabies Virus Recombinant Trimerization Glycoprotein DNA Vaccine

研究方向