韩思飞｜中国药科大学｜学者主页

2026

代谢性疾病治疗新策略——靶向脂质代谢通路的药物递送

黄丹，邰光杰，徐明，胡罗娟，韩思飞

《药学进展》

2026

An oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport enabling bioavailability in animals and humans.

J. Simpson, T. Quach, Sifei Han, Luojuan Hu, Natalie L. Trevaskis, Nathania J. Leong, Garima Sharma, Dan Zheng, Steven M. Paul, Christopher J. H. Porter, D. Bonner, Michael C. Chen

Science Translational Medicine

DOI

2026

Cervical Lymph Duct-Cannulated Rat Model for Assessing Lymphatic Transport from the Head and Brain.

Zi-Han Zhu, Hefeng Song, Wei Liu, Ming-Liang Tian, Thu A. Hoang, S. B. Reddiar, Natalie L. Trevaskis, Sifei Han, Luojuan Hu

Journal of Visualized Experiments

DOI

2026

Enhancing Oral Bioavailability of Poorly Water-Soluble Natural Products via Lipid–Drug Conjugates

Xiao-Li Zou, Bin Zhang, Lianghe Mei, Sifei Han, Kai-Xian Chen

Pharmaceutics

DOI

2026

In situ formation of chylomicron-incorporated lipid nanoparticle via muramyl dipeptide conjugation potentiates lymphatic transport of chemoimmunotherapeutic for leukemia therapy

Pengbo Zhao, Yu Ding, Yinyin Yuan, Huanyu Qin, Jinyu Dai, Di Wu, Zhenduo Duan, Lihui Xin, Luojuan Hu, Sifei Han, X. Xin, Lifang Yin

Chemical Engineering Journal

DOI

2025

提升难溶性药物口服吸收的脂质递送策略

李小花，胡罗娟，韩思飞

《中南药学》

2025

Optimizing Triglyceride Prodrugs of a Model Immunomodulator: Conjugation through the Phenol of Mycophenolic Acid (MPA) Markedly Promotes Lymphatic Drug Transport.

Luojuan Hu, T. Quach, D. Zheng, Nathania J. Leong, Garima Sharma, S. Lim, D. Bonner, Natalie L. Trevaskis, Jamie Simpson, Sifei Han, Christopher J. H. Porter

Molecular Pharmaceutics

DOI

2025

Oral Doxorubicin Lipid Nanoparticles Enhance Triple‐Negative Breast Cancer Therapy via Immune Activation and Reduced Cardiotoxicity

Jia Meng, Xuling Jiang, Yinyin Yuan, Sifei Han, Feng Qian

Advances in Therapy

DOI

2025

Subcutaneously administered anti-PD-(L)1 antibodies are predominantly absorbed via the lymphatic system, resulting in high drug exposure to draining lymph nodes.

Xiaoxuan Fei, Junyi Pei, Simin Yan, Weihong Ge, Li Li, Jian-Jun Zou, Huimin Zhang, Lie Sun, Sifei Han, Luojuan Hu

Journal of Pharmacy and Science

DOI

2025

Abstract 4342: The lymphatic system plays a major role in the absorption of subcutaneously administered trastuzumab in a lymph-duct cannulated rat model

Junyi Pei, Xiaoxuan Fei, Luojuan Hu, Huimin Zhang, Sifei Han

Cancer Research

DOI

2025

Predicting lymphatic transport potential using graph transformer based on limited historical data from in vivo studies.

Yunfeng Li, Ruiyan Liu, Zonghao Ji, Lina Gao, Xiao-Lu Wang, Jia-Zhi Zhang, Luojuan Hu, Youyang Qu, Jun Bai, Di Wu, Sifei Han

Journal of Controlled Release

DOI

2024

基于淋巴系统的药物及其递送系统研究进展

胡罗娟，顾景凯，尤启冬，韩思飞

《药学学报》

DOI

2024

Lymphatic uptake of a highly lipophilic protease inhibitor prodrug from a lipid-based formulation is limited by instability in the intestine.

Yining Xie, Zijun Lu, Ian K. Styles, S. B. Reddiar, A. Phillips, J. Windsor, Christopher J. H. Porter, Sifei Han, Natalie L. Trevaskis

Journal of Pharmacy and Science

DOI

2024

Intestinal Lymphatic Biology, Drug Delivery, and Therapeutics: Current Status and Future Directions

S. B. Reddiar, Yining Xie, Mohammad Abdallah, Sifei Han, Luojuan Hu, O. Feeney, Gracia Gracia, Abel Anshabo, Zijun Lu, Muhammad Asim Farooq, Ian K. Styles, A. Phillips, J. Windsor, Christopher J. H. Porter, En-Yuan Cao, Natalie L. Trevaskis

Pharmacological Reviews

DOI

2023

Increasing Linker Chain Length and Intestinal Stability Enhances Lymphatic Transport and Lymph Node Exposure of Triglyceride Mimetic Prodrugs of a Model Immunomodulator Mycophenolic Acid.

Sifei Han, T. Quach, Luojuan Hu, S. Lim, Dan Zheng, Nathania J. Leong, G. Sharma, D. Bonner, J. Simpson, Natalie L. Trevaskis, C. Porter

Molecular Pharmaceutics

DOI

2022

Corrigendum: Triglyceride-mimetic prodrugs of buprenorphine enhance oral bioavailability via promotion of lymphatic transport

T. Quach, Luojuan Hu, Sifei Han, S. Lim, D. Senyschyn, Preeti Yadav, Natalie L. Trevaskis, J. Simpson, C. Porter

Frontiers in Pharmacology

DOI

2022

Editorial: Lymphatic delivery and targeting of drugs, vaccines, and imaging agents

Sifei Han, Natalie L. Trevaskis, P. Gershkovich, L. Kagan

Frontiers in Pharmacology

DOI

2022

Triglyceride-Mimetic Prodrugs of Buprenorphine Enhance Oral Bioavailability via Promotion of Lymphatic Transport

T. Quach, Luojuan Hu, Sifei Han, S. Lim, D. Senyschyn, Preeti Yadav, Natalie L. Trevaskis, J. Simpson, C. Porter

Frontiers in Pharmacology

DOI

2021

Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles

Sifei Han, Lianghe Mei, T. Quach, C. Porter, Natalie L. Trevaskis

Pharmaceutical Research

DOI

2021

Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice.

Ruby Kochappan, En-Yuan Cao, Sifei Han, Luojuan Hu, T. Quach, D. Senyschyn, Vilena Ivanova Ferreira, Given Lee, Nathania J. Leong, G. Sharma, S. Lim, C. Nowell, Ziqi Chen, U. V. von Andrian, D. Bonner, J. Mintern, J. Simpson, Natalie L. Trevaskis, C. Porter

Journal of Controlled Release

DOI

2021

Intestinal delivery in a long-chain fatty acid formulation enables lymphatic transport and systemic exposure of orlistat.

Given Lee, Sifei Han, Zijun Lu, Jiwon Hong, A. Phillips, J. Windsor, C. Porter, Natalie L. Trevaskis

International journal of pharmaceutics

DOI

2020

The impact of conjugation position and linker chemistry on the lymphatic transport of a series of glyceride and phospholipid mimetic prodrugs.

Sifei Han, T. Quach, Luojuan Hu, S. Lim, Gracia Gracia, Natalie L. Trevaskis, J. Simpson, C. Porter

Journal of Pharmacy and Science

DOI

2020

Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans

Natalie L. Trevaskis, Given Lee, Alistair Escott, K. L. Phang, Jiwon Hong, En-Yuan Cao, K. Katneni, S. Charman, Sifei Han, W. Charman, A. Phillips, J. Windsor, C. Porter

Frontiers in Physiology

DOI

2019

Lymphatic uptake of liposomes after intraperitoneal administration primarily occurs via the diaphragmatic lymphatics and is dependent on liposome surface properties.

Given Lee, Sifei Han, I. Inocencio, En-Yuan Cao, Jiwon Hong, A. Phillips, J. Windsor, C. Porter, Natalie L. Trevaskis

Molecular Pharmaceutics

DOI

2018

Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations.

H. Williams, Leigh Ford, Sifei Han, K. J. Tangso, S. Lim, David M. Shackleford, David T. Vodak, H. Benameur, C. Pouton, P. Scammells, C. Porter

Molecular Pharmaceutics

DOI

2018

Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations.

H. Williams, Leigh Ford, S. Lim, Sifei Han, J. Baumann, Hannah Sullivan, David T. Vodak, A. Igonin, H. Benameur, C. Pouton, P. Scammells, C. Porter

Journal of Pharmacy and Science

DOI

2017

Triglyceride-mimetic approaches for targeted drug delivery to the lymphatic system: a mechanistic study

Sifei Han

DOI

2017

Computational Models of the Gastrointestinal Environment. 2. Phase Behavior and Drug Solubilization Capacity of a Type I Lipid-Based Drug Formulation after Digestion.

Woldeamanuel A. Birru, Dallas B. Warren, Sifei Han, H. Benameur, C. Porter, C. Pouton, David K. Chalmers

Molecular Pharmaceutics

DOI

2016

Glyceride-Mimetic Prodrugs Incorporating Self-Immolative Spacers Promote Lymphatic Transport, Avoid First-Pass Metabolism, and Enhance Oral Bioavailability.

Luojuan Hu, T. Quach, Sifei Han, S. Lim, Preeti Yadav, D. Senyschyn, Natalie L. Trevaskis, J. Simpson, C. Porter

Angewandte Chemie

DOI

2016

Lymphatic Transport and Lymphocyte Targeting of a Triglyceride Mimetic Prodrug Is Enhanced in a Large Animal Model: Studies in Greyhound Dogs.

Sifei Han, Luojuan Hu, Gracia, T. Quach, J. Simpson, G. Edwards, Natalie L. Trevaskis, C. Porter

Molecular Pharmaceutics

DOI

2016

Constitutive Triglyceride Turnover into the Mesenteric Lymph Is Unable to Support Efficient Lymphatic Transport of a Biomimetic Triglyceride Prodrug.

Sifei Han, Luojuan Hu, T. Quach, J. Simpson, Natalie L. Trevaskis, C. Porter

Journal of Pharmacy and Science

DOI

2016

自己犠牲スペーサーを取り込んだグリセリド類似プロドラッグはリンパ輸送を促進し,初回通過代謝を避け,経口生物学的利用性を増加する

Luojuan Hu, T. Quach, Sifei Han, F. L. Shea, Y. Preeti, Senyschyn Danielle, L. Natalie, S. Jamie, J. H. Porter Christopher

2015

Profiling the Role of Deacylation-Reacylation in the Lymphatic Transport of a Triglyceride-Mimetic Prodrug

Sifei Han, Luojuan Hu, T. Quach, J. Simpson, Natalie L. Trevaskis, C. Porter

Pharmaceutical Research

DOI

2015

The mesenteric lymph duct cannulated rat model: application to the assessment of intestinal lymphatic drug transport.

Natalie L. Trevaskis, Luojuan Hu, S. Caliph, Sifei Han, C. Porter

Journal of Visualized Experiments

DOI

2014

Targeted delivery of a model immunomodulator to the lymphatic system: comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies.

Sifei Han, T. Quach, Luojuan Hu, A. Wahab, W. Charman, V. Stella, Natalie L. Trevaskis, J. Simpson, C. Porter

Journal of Controlled Release

DOI

2013

The impact of lymphatic transport on the systemic disposition of lipophilic drugs.

S. Caliph, En-Yuan Cao, J. Bulitta, Luojuan Hu, Sifei Han, C. Porter, Natalie L. Trevaskis

Journal of Pharmacy and Science

DOI

精选作品

期刊论文

代谢性疾病治疗新策略——靶向脂质代谢通路的药物递送

An oral allopregnanolone prodrug bypasses liver metabolism via lymphatic transport enabling bioavailability in animals and humans.

Cervical Lymph Duct-Cannulated Rat Model for Assessing Lymphatic Transport from the Head and Brain.

Enhancing Oral Bioavailability of Poorly Water-Soluble Natural Products via Lipid–Drug Conjugates

In situ formation of chylomicron-incorporated lipid nanoparticle via muramyl dipeptide conjugation potentiates lymphatic transport of chemoimmunotherapeutic for leukemia therapy

提升难溶性药物口服吸收的脂质递送策略

Optimizing Triglyceride Prodrugs of a Model Immunomodulator: Conjugation through the Phenol of Mycophenolic Acid (MPA) Markedly Promotes Lymphatic Drug Transport.

Oral Doxorubicin Lipid Nanoparticles Enhance Triple‐Negative Breast Cancer Therapy via Immune Activation and Reduced Cardiotoxicity

Subcutaneously administered anti-PD-(L)1 antibodies are predominantly absorbed via the lymphatic system, resulting in high drug exposure to draining lymph nodes.

Abstract 4342: The lymphatic system plays a major role in the absorption of subcutaneously administered trastuzumab in a lymph-duct cannulated rat model

Predicting lymphatic transport potential using graph transformer based on limited historical data from in vivo studies.

基于淋巴系统的药物及其递送系统研究进展

Lymphatic uptake of a highly lipophilic protease inhibitor prodrug from a lipid-based formulation is limited by instability in the intestine.

Intestinal Lymphatic Biology, Drug Delivery, and Therapeutics: Current Status and Future Directions

Increasing Linker Chain Length and Intestinal Stability Enhances Lymphatic Transport and Lymph Node Exposure of Triglyceride Mimetic Prodrugs of a Model Immunomodulator Mycophenolic Acid.

Corrigendum: Triglyceride-mimetic prodrugs of buprenorphine enhance oral bioavailability via promotion of lymphatic transport

Editorial: Lymphatic delivery and targeting of drugs, vaccines, and imaging agents

Triglyceride-Mimetic Prodrugs of Buprenorphine Enhance Oral Bioavailability via Promotion of Lymphatic Transport

Lipophilic Conjugates of Drugs: A Tool to Improve Drug Pharmacokinetic and Therapeutic Profiles

Targeted delivery of mycophenolic acid to the mesenteric lymph node using a triglyceride mimetic prodrug approach enhances gut-specific immunomodulation in mice.

Intestinal delivery in a long-chain fatty acid formulation enables lymphatic transport and systemic exposure of orlistat.

The impact of conjugation position and linker chemistry on the lymphatic transport of a series of glyceride and phospholipid mimetic prodrugs.

Intestinal Lymph Flow, and Lipid and Drug Transport Scale Allometrically From Pre-clinical Species to Humans

Lymphatic uptake of liposomes after intraperitoneal administration primarily occurs via the diaphragmatic lymphatics and is dependent on liposome surface properties.

Enhancing the Oral Absorption of Kinase Inhibitors Using Lipophilic Salts and Lipid-Based Formulations.

Transformation of Biopharmaceutical Classification System Class I and III Drugs Into Ionic Liquids and Lipophilic Salts for Enhanced Developability Using Lipid Formulations.

Triglyceride-mimetic approaches for targeted drug delivery to the lymphatic system: a mechanistic study

Computational Models of the Gastrointestinal Environment. 2. Phase Behavior and Drug Solubilization Capacity of a Type I Lipid-Based Drug Formulation after Digestion.

Glyceride-Mimetic Prodrugs Incorporating Self-Immolative Spacers Promote Lymphatic Transport, Avoid First-Pass Metabolism, and Enhance Oral Bioavailability.

Lymphatic Transport and Lymphocyte Targeting of a Triglyceride Mimetic Prodrug Is Enhanced in a Large Animal Model: Studies in Greyhound Dogs.

Constitutive Triglyceride Turnover into the Mesenteric Lymph Is Unable to Support Efficient Lymphatic Transport of a Biomimetic Triglyceride Prodrug.

自己犠牲スペーサーを取り込んだグリセリド類似プロドラッグはリンパ輸送を促進し,初回通過代謝を避け,経口生物学的利用性を増加する

Profiling the Role of Deacylation-Reacylation in the Lymphatic Transport of a Triglyceride-Mimetic Prodrug

The mesenteric lymph duct cannulated rat model: application to the assessment of intestinal lymphatic drug transport.

Targeted delivery of a model immunomodulator to the lymphatic system: comparison of alkyl ester versus triglyceride mimetic lipid prodrug strategies.

The impact of lymphatic transport on the systemic disposition of lipophilic drugs.

会议论文

利用脂蛋白代谢通路提高药物经肠淋巴系统转运(英文)