廖晨钟｜合肥工业大学｜学者主页

2026

Design and Synthesis of a Novel Covalent Dihydropteridinone Derivative as a Highly Potent and Orally Bioavailable PLK1 Inhibitor for the Treatment of Chronic Myeloid Leukemia

Jiaxu Zhou, Zhongtang Li, Xiaojiao Sun, Xiangyu Zhang, Yan He, Cheng Shi, Xiaowei Chi, Weiping Lyu, Weiping Lyu, Siyu Xiu, Tingting Yang, Yanming Chen, Zhongwei Wang, Qi Li, Ruqiu Zheng, Jiarui Du, Yu Lin, Jinghao Yan, Tengfei Li, Chenzhong Liao, Liangren Zhang, Zhenming Liu

Journal of Medicinal Chemistry

精选作品

期刊论文

Design and Synthesis of a Novel Covalent Dihydropteridinone Derivative as a Highly Potent and Orally Bioavailable PLK1 Inhibitor for the Treatment of Chronic Myeloid Leukemia

Structure-Guided Discovery of Novel Highly Potent and Selective MTA-Cooperative PRMT5 Inhibitors

Rational design, synthesis, and evaluations of HBV capsid assembly modulators featuring a core of 2-amino-5-(2-amino-2-oxoacetyl)-4-methylthiophene-3-carboxamide

Top 20 Best-Selling Small-Molecule Neurology Drugs in 2024: Market, Indications, Pharmacology, Discovery, and Synthesis

Layer-by-layer nanoencapsulation strategies for enhanced oral delivery and function of Lactobacillus plantarum B2

Design and Development of Small‐Molecule Drugs Targeting Enzymes Utilizing Two‐Metal‐Ion Catalytic Mechanisms

Perillyl alcohol ameliorates high-fat diet-induced obesity in mice by modulating gut microbiota and activating IRF4-mediated brown fat thermogenesis

Design, synthesis, and biological evaluation of highly potent and selective hMAO-B inhibitors featuring a tetrahydrobenzo[f][1,4]oxazepine core

mRNA-Based FRET-FLIM Imaging Platform for Quantifying Lipid Nanoparticle Endosomal Escape and Membrane Damage

Kinase Inhibitors for the Treatment of Brain Diseases

ACSS2 protects against alcohol-induced hepatocyte ferroptosis through regulation of hepcidin expression

High internal phase Pickering emulsion stabilized by bovine serum albumin amyloid-like fibril/gum arabic electrostatic complex as potential delivery vehicles for lycopene

Drugs targeting peroxisome proliferator-activated receptors

A novel zinc ferrite nanoparticle protects against MSU-induced gout arthritis via Nrf2/NF-κB/NLRP3 pathway

Structure-Based Discovery of a Highly Selective, Oral Polo-Like Kinase 1 Inhibitor with Potent Antileukemic Activity

Lycopene inhibits doxorubicin-induced heart failure by inhibiting ferroptosis through the Nrf2 signaling pathway

Fibroblast Growth Factor 21 Promotes Vascular Smooth Muscle Cell Contractile Polarization via p38 Mitogen-Activated Protein Kinase-Promoted Serum Response Factor Phosphorylation

Microenvironment-activatable nanoagent for real-time NIR-II monitoring and targeted therapy of arterial restenosis

Sesamol ameliorates cholestatic liver injury by modulating the liver-gut axis and EGFR-FXR signaling pathway

Discovery of potent, highly selective, and orally bioavailable factor XIa inhibitors for anticoagulant therapy

Targeting Histone Deacetylase 11 with a Highly Selective Inhibitor for the Treatment of MASLD

L -Ergothioneine ameliorates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease in C57BL/6J mice by activating DJ-1

Selective factor XI/XIa inhibitors: a beacon of hope in anticoagulation therapy

Progress with polo-like kinase (PLK) inhibitors: a patent review (2018–present)

Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation

CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway

Lycopene inhibits carrageenan-induced thrombi by regulating AKT/FoxO3a and TLR4/NF-κB pathways

Inhibition of Nogo-B reduces the progression of pancreatic cancer by regulation NF-κB/GLUT1 and SREBP1 pathways

Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB

Double-layer mucin microencapsulation enhances the stress tolerance and oral delivery of Lactobacillus plantarum B2

Hydroxypropyl-β-cyclodextrin inhibits the development of triple negative breast cancer by enhancing antitumor immunity

Fisetin treatment alleviates kidney injury in mice with diabetes-exacerbated atherosclerosis through inhibiting CD36/fibrosis pathway

Riboflavin Bioenriched Soymilk Alleviates Oxidative Stress Mediated Liver Injury, Intestinal Inflammation, and Gut Microbiota Modification in B2 Depletion-Repletion Mice.

Roxadustat alleviates nitroglycerin-induced migraine in mice by regulating HIF-1α/NF-κB/inflammation pathway

Perspectives in Medicinal Chemistry: Current Progress in the Development of Metalloprotein Inhibitors.

Perspectives in the Medicinal Chemistry.

Discovery and Pharmacophore Studies of Novel Pyrazole‐Based Anti‐Melanoma Agents

会议论文

Chlorogenic acid attenuates Alzheimer's disease by inhibiting tau hyperphosphorylation through activation of FGF21 pathway Running title:Chlorogenic acid attenuates Alzheimer's disease through FGF21 pathway

书籍章节

Chiglitazar/Carfloglitazar, a drug for the treatment of type 2 diabetes mellitus and more

Authentic HIV-1 integrase inhibitors for the treatment of HIV-1/AIDS