邱倩倩｜盐城师范学院｜学者主页

2026

海洋中药传承创新关键科学问题、研究策略与发展目标

侯小涛，邓家刚，郝二伟，杜正彩，侯万超，郭娟，付先军，陈娟林，韦凤尧，邱倩倩，韦雪丹，宋艳辉

《中草药》

2023

Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers.

Qianqian Qiu, Fanglian Chi, Daoguang Zhou, Zhancheng Xie, Yunxiao Liu, Hanyu Wu, Ziyu Yin, Wei Q. Shi, Hai Qian

Journal of Medicinal Chemistry

DOI

2023

Development of novel self‐assembled vaccines based on tumour‐specific antigenic peptide and TLR2 agonist for effective breast cancer immunotherapy via activating CD8+ T cells and enhancing their function

Wei Q. Shi, Zhenzhen Tong, Shuang Chen, Qianqian Qiu, Jia-Qi Zhou, Hai Qian

Immunology

DOI

2022

Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.

Wei Q. Shi, Ping Zhang, F. Zou, Jia-Qi Zhou, Ziyu Yin, Zilong Cai, Hesham Ghaleb, Yuxuan Jiang, Wenlong Huang, Yan Liu, Qianqian Qiu, Hai Qian

European journal of medicinal chemistry

DOI

2022

Structure-based discovery of receptor tyrosine kinase AXL degraders with excellent anti-tumor activity by selectively degrading AXL and inducing methuosis.

Wei Q. Shi, Ziying Feng, Fanglian Chi, Jia-Qi Zhou, Qianqian Qiu, Yuxuan Jiang, Shuang Chen, Yue Zhong, Huiting Jia, Wenlong Huang, Hai Qian

European journal of medicinal chemistry

DOI

2022

Corrigendum to <'Design, synthesis and biological evaluation of novel peptides with anti-cancer and drug resistance-reversing activities'><[European Journal of Medicinal Chemistry, 89 (2015) 540-548]>.

Xin Deng, Qianqian Qiu, Bao-Wei Yang, Xue-Kun Wang, Wenlong Huang, Hai Qian

European journal of medicinal chemistry

DOI

2022

Advances in Tumor Antigen‐Based Anticancer Immunotherapy: Recent Progress, Prevailing Challenges, and Future Perspective

Wei Q. Shi, Shuang Chen, Fanglian Chi, Qianqian Qiu, Yue Zhong, Xiaojia Bian, Haotong Zhang, Junting Xi, Hai Qian

Advances in Therapy

DOI

2021

Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- and BCRP-Mediated Multidrug Resistance.

Qianqian Qiu, F. Zou, Huilan Li, Wei Q. Shi, Daoguang Zhou, Ping Zhang, Teng Li, Ziyu Yin, Zilong Cai, Yuxuan Jiang, Wenlong Huang, Hai Qian

Journal of Medicinal Chemistry

DOI

2021

Design, synthesis, and biological activity evaluation of a series of novel sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.

Ziying Feng, Aiping Chen, Jing Shi, Daoguang Zhou, Wei Q. Shi, Qianqian Qiu, Xinhong Liu, Wenlong Huang, Jie-Ming Li, Hai Qian, Wenjie Zhang

Bioorganic chemistry (Print)

DOI

2021

Design, synthesis and immunological evaluation of self-assembled antigenic peptides from dual-antigen targets: a broad-spectrum candidate for an effective antibreast cancer therapy

Wei Q. Shi, Qianqian Qiu, Ziying Feng, Zhenzhen Tong, Weiwei Guo, F. Zou, Na Yue, Wenlong Huang, Hai Qian

Journal for ImmunoTherapy of Cancer

DOI

2021

Design, synthesis, and biological evaluation of novel 4,4‐difluoro‐1‐methyl‐N, 6‐diphenyl‐5, 6‐dihydro‐4H‐pyrimido [4, 5‐b] [1, 2, 4] triazolo [4, 3‐d] [1, 4] diazepin‐8‐amine derivatives as potential BRD4 inhibitors

Jiu-Hui Li, Wenjie Zhang, Qianqian Qiu, Daoguang Zhou, Ziying Feng, Zhenzhen Tong, Jiaxin Wei, Wenlong Huang, Jie-Ming Li, Hai Qian, Wei Q. Shi

Chemical Biology and Drug Design

DOI

2021

Design, synthesis, and biological evaluation of novel FXR agonists based on auraptene.

Qianqian Qiu, Yanjuan Wang, Guolong Gu, Fan Yu, Shichao Zhang, Yining Zhao, B. Ling

Bioorganic chemistry (Print)

DOI

2020

药学专业无机化学课程的教学改革

邱倩倩，叶静

《广东化工》

2020

Discovery of potent inhibitors against P-glycoprotein-mediated multidrug resistance aided by late-stage functionalization of 2-(4-(pyridin-2-yl)phenoxy)pyridine analogue.

Yao Ma, Dawei Yin, Jingjia Ye, Xi-Duan Wei, Yameng Pei, Xue-yong Li, Guangxu Si, Xuan-Yu Chen, Zhe-Sheng Chen, Yi Dong, F. Zou, Wei Q. Shi, Qianqian Qiu, Hai Qian, Gang Liu

Journal of Medicinal Chemistry

DOI

2020

Synthetic tumor-specific antigenic peptides with a strong affinity to HLA-A2 elicit anti-breast cancer immune response through activating CD8+ T cells.

Wei Q. Shi, Qianqian Qiu, Zhenzhen Tong, Wei-Wei Guo, F. Zou, Ziying Feng, Yao Wang, Wenlong Huang, Hai Qian

European journal of medicinal chemistry

DOI

2020

Design, synthesis and biological evaluation of novel 6-phenyl-1,3a,4,10b-tetrahydro-2H-benzo[c]thiazolo[4,5-e]azepin-2-one derivatives as potential BRD4 inhibitors.

Qifei Li, Jieming Li, Yan Cai, Yuxing Zou, Bin Chen, F. Zou, Jiaxian Mo, Ting Han, Wei-Wei Guo, Wenlong Huang, Qianqian Qiu, Hai Qian

Bioorganic & Medicinal Chemistry

DOI

2020

Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents.

Zhiwen Ye, Chunxiao Liu, F. Zou, Yan Cai, Bin Chen, Yuxing Zou, Jiaxian Mo, Ting Han, Wenlong Huang, Qianqian Qiu, Hai Qian

Bioorganic & Medicinal Chemistry

DOI

2020

Design, synthesis and structure-activity relationship studies of novel partial FXR agonists for the treatment of fatty liver.

Qianqian Qiu, Wen-Ling Wang, Xiaojuan Zhao, Yan-Li Chen, Shiyuan Zhao, Jilan Zhu, Xiaojuan Xu, Rongqing Geng

Bioorganic chemistry (Print)

DOI

2020

Novel HLA-A2 restricted antigenic peptide derivatives with high affinity for the treatment of breast cancer expressing NY-ESO-1.

Wei Q. Shi, Zhenzhen Tong, Qianqian Qiu, Na Yue, Wei-Wei Guo, F. Zou, Daoguang Zhou, Jiu-Hui Li, Wenlong Huang, Hai Qian

Bioorganic chemistry (Print)

DOI

2019

Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells.

Mutta Kairuki, Qianqian Qiu, Miao-Bo Pan, Qifei Li, Jia-Qi Zhou, Hesham Ghaleb, Wenlong Huang, Hai Qian, Cheng Jiang

Bioorganic & Medicinal Chemistry

DOI

2019

Design, Synthesis and Biological Evaluation of Novel Tumor-Specific Antigenic Peptide Derivatives as Potential Vaccine Candidates with a Strong Affinity to HLA-A2

Wei Q. Shi, Qianqian Qiu, Zhenzhen Tong, Wei-Wei Guo, F. Zou, Ziying Feng, Qifei Li, Na Yue, Wenlong Huang, Hai Qian

Social Science Research Network

DOI

2019

Design, synthesis and biological evaluation of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide derivatives as novel P-glycoprotein inhibitors reversing multidrug resistance.

Qianqian Qiu, Jia-Qi Zhou, Wei Q. Shi, Mutta Kairuki, Wenglong Huang, Hai Qian

Bioorganic chemistry (Print)

DOI

2019

Discovery to solve multidrug resistance: Design, synthesis, and biological evaluation of novel agents

Qianqian Qiu, Wei Q. Shi, Shiyuan Zhao, Yan Zhu, Zhengquan Ding, Shao-Yang Zhou, Mutta Kairuki, Wenlong Huang, Hai Qian

Archiv der Pharmazie

DOI

2019

Discovery of aromatic amides with triazole-core as potent reversal agents against P-glycoprotein-mediated multidrug resistance.

Qianqian Qiu, Jilan Zhu, Qiutong Chen, Zi-Hua Jiang, Ji-Ting Xu, Xueting Jiang, Wenlong Huang, Zhongquan Liu, Jing Ye, Xiaojuan Xu

Bioorganic chemistry (Print)

DOI

2019

Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold.

Zheng Li, Q. Ren, Xuekun Wang, Zongtao Zhou, Li-Jun Hu, Liming Deng, Li Guan, Qianqian Qiu

Bioorganic chemistry (Print)

DOI

2018

Design, synthesis and evaluation of a novel series of inhibitors reversing P‐glycoprotein‐mediated multidrug resistance

Hesham Ghaleb, Huilan Li, Mutta Kairuki, Qianqian Qiu, Xinzhou Bi, Chunxiao Liu, Chen Liao, Jieming Li, Kamal Hezam, Wenlong Huang, Hai Qian

Chemical Biology and Drug Design

DOI

2018

pH-Sensitive micelles with mitochondria-targeted and aggregation-induced emission characterization: synthesis, cytotoxicity and biological applications.

Jieming Li, Yan Liu, Huilan Li, Wei Q. Shi, Xinzhou Bi, Qianqian Qiu, Bo Zhang, Wenlong Huang, Hai Qian

Biomaterials Science

DOI

2017

Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Zheng Li, Chunxiao Liu, Xue Xu, Qianqian Qiu, Xin Su, Yuxuan Dai, Jianyong Yang, Huilan Li, Wei Q. Shi, Chen Liao, Miao-Bo Pan, Wenlong Huang, Hai Qian

European journal of medicinal chemistry

DOI

2017

Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance.

Qianqian Qiu, Wei Q. Shi, Zheng Li, Bo Zhang, Miao-Bo Pan, Jian Cui, Yuxuan Dai, Wenlong Huang, Hai Qian

Journal of Medicinal Chemistry

DOI

2017

Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance.

Qianqian Qiu, Baomin Liu, Jian Cui, Zheng Li, Xin Deng, Hao Qiang, Jieming Li, Chen Liao, Bo Zhang, Wei Q. Shi, Miao-Bo Pan, Wenlong Huang, Hai Qian

Journal of Medicinal Chemistry

DOI

2017

A novel mitochondria‐targeting fluorescent probe for hydrogen sulfide in living cells

Wei Q. Shi, Miao-Bo Pan, Hao Qiang, Qianqian Qiu, Wenlong Huang, Haiyan Lin, Hai Qian, Liang Ge

Chemical Biology and Drug Design

DOI

2016

Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2.

Hao Qiang, Weijie Gu, Dan-Dan Huang, Wei Q. Shi, Qianqian Qiu, Yuxuan Dai, Wenlong Huang, Hai Qian

Bioorganic & Medicinal Chemistry

DOI

2016

Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors.

Yu-Xiang Wu, Miao-Bo Pan, Yuxuan Dai, Baomin Liu, Jian Cui, Wei Q. Shi, Qianqian Qiu, Wenlong Huang, Hai Qian

Bioorganic & Medicinal Chemistry

DOI

2016

Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development

Zheng Li, Qianqian Qiu, X. Geng, Jianyong Yang, Wenlong Huang, Hai Qian

Expert Opinion on Investigational Drugs

DOI

2016

Quinazoline-N-phenethyl tetrahydroisoquinoline compound and preparation method and application thereof

Wenlong Huang, Hai Qian, Jian Cui, Baomin Liu, Qianqian Qiu, Yu-Xiang Wu, Miao-Bo Pan

2016

Phenylbutazone, a New Long‐Acting Agent that can Improve the Peptide Pharmacokinetic Based on Serum Albumin as a Drug Carrier

Jie Zhou, Xue Li, Xiaoyun Zhu, Jian Sun, Qianqian Qiu, Wenlong Huang, Hai Qian

Chemical Biology and Drug Design

DOI

2016

Design, Synthesis, and Biological Evaluation of Novel Cholesteryl Peptides with Anticancer and Multidrug Resistance‐Reversing Activities

Xin Deng, Qianqian Qiu, Xue-Kun Wang, Wenlong Huang, Hai Qian

Chemical Biology and Drug Design

DOI

2016

Design, synthesis and biological evaluation of novel triazole-core reversal agents against P-glycoprotein-mediated multidrug resistance

Bo Zhang, Tianxiao Zhao, Jie Zhou, Qianqian Qiu, Yuxuan Dai, Miao-Bo Pan, Wenlong Huang, Hai Qian

DOI

2016

Synthesis of Analogues of BCTC Incorporating a Pyrrolidinyl Linker and Biological Evaluation as Transient Receptor Potential Vanilloid 1 Antagonists

Lin Yan, Jing-Jie Wang, Miao-Bo Pan, Qianqian Qiu, Wenlong Huang, Hai Qian

Chemical Biology and Drug Design

DOI

2015

Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Zheng Li, Qianqian Qiu, Xue Xu, Xue-Kun Wang, Lei Jiao, Xin Su, Miao-Bo Pan, Wenlong Huang, Hai Qian

European journal of medicinal chemistry

DOI

2015

Design, synthesis and biological evaluation of novel peptides with anti-cancer and drug resistance-reversing activities.

Xin Deng, Qianqian Qiu, Bao-Wei Yang, Xue-Kun Wang, Wenlong Huang, Hai Qian

European journal of medicinal chemistry

DOI

2015

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.

Xue-Kun Wang, Tianxiao Zhao, Bao-Wei Yang, Zheng Li, Jian Cui, Yuxuan Dai, Qianqian Qiu, Hao Qiang, Wenlong Huang, Hai Qian

Bioorganic & Medicinal Chemistry

DOI

2015

Design, synthesis and structure-activity relationship studies of novel phenoxyacetamide-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Zheng Li, Xue-Kun Wang, Xue Xu, Jianyong Yang, Qianqian Qiu, Hao Qiang, Wenlong Huang, Hai Qian

Bioorganic & Medicinal Chemistry

DOI

2015

Synthesis of Carbamide Derivatives Bearing Tetrahydroisoquinoline Moieties and Biological Evaluation as Analgesia Drugs in Mice

Qianqian Qiu, Jing-Jie Wang, Xin Deng, Hai Qian, Haiyan Lin, Wenlong Huang

Archiv der Pharmazie

DOI

2015

A High‐Sensitivity Coumarin‐Based Fluorescent Probe for Monitoring Hydrogen Sulfide in Living Cells

Qianqian Qiu, Xin Deng, Lei Jiao, Tianxiao Zhao, Fan-Fei Meng, Wenlong Huang, Hai Qian

Chemical Biology and Drug Design

DOI

2015

Design, Synthesis and in vivo Evaluation of Novel C‐Aryl Glucosides as Potent Sodium‐Dependent Glucose Cotransporters Inhibitors for the Treatment of Diabetes

Zheng Li, Xue-Kun Wang, Xue Xu, Qianqian Qiu, Lei Jiao, Wenlong Huang, Hai Qian

Chemical Biology and Drug Design

DOI

2015

Evaluation of Anti‐inflammatory and Analgesic Effects of Synthesized Derivatives of Ibuprofen

Jing-Jie Wang, Dong-Yan Dai, Qianqian Qiu, Xin Deng, Haiyan Lin, Hai Qian, Wenlong Huang

Chemical Biology and Drug Design

DOI

2015

Synthesis and in vitro anti-cancer evaluation of luteinizing hormone-releasing hormone-conjugated peptide

Xin Deng, Qianqian Qiu, Ke Ma, Wenlong Huang, Hai Qian

Amino Acids

DOI

2015

Reversal of P-glycoprotein-medicated multidrug resistance by LBM-A5 in vitro and a study of its pharmacokinetics in vivo.

Tianxiao Zhao, Yun-sheng Song, Baomin Liu, Qianqian Qiu, Lei Jiao, Yunman Li, Wenlong Huang, Hai Qian

Canadian Journal of Physiology and Pharmacology

DOI

2015

Aliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability.

Xin Deng, Qianqian Qiu, Ke Ma, Xue-Kun Wang, Wenlong Huang, Hai Qian

Organic and biomolecular chemistry

DOI

2015

6,7‐Dimethoxy‐2‐{2‐[4‐(1H‐1,2,3‐triazol‐1‐yl)phenyl]ethyl}‐1,2,3,4‐tetrahydroisoquinolines as Superior Reversal Agents for P‐Glycoprotein‐Mediated Multidrug Resistance

Baomin Liu, Qianqian Qiu, Tianxiao Zhao, Lei Jiao, Yunman Li, Wenlong Huang, Hai Qian

ChemMedChem

DOI

2014

Design, synthesis and evaluation of novel triazole core based P-glycoprotein-mediated multidrug resistance reversal agents.

Lei Jiao, Qianqian Qiu, Baomin Liu, Tianxiao Zhao, Wenlong Huang, Hai Qian

Bioorganic & Medicinal Chemistry

DOI

2014

C- a novel class of inhibitors arylglucosides sglt2

Wen-Long Huang, Hai Qian, Zheng Li, Xue-Kun Wang, Lei Jiao, Qianqian Qiu

2014

Discovery of Novel P‐Glycoprotein‐Mediated Multidrug Resistance Inhibitors Bearing Triazole Core via Click Chemistry

Baomin Liu, Qianqian Qiu, Tianxiao Zhao, Lei Jiao, Jianyu Hou, Yunman Li, Hai Qian, Wenlong Huang

Chemical Biology and Drug Design

DOI

精选作品

期刊论文

海洋中药传承创新关键科学问题、研究策略与发展目标

Exploration of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Bispecific Inhibitors Based on the Moiety of Fedratinib for Treatment of Both Hematologic Malignancies and Solid Cancers.

Development of novel self‐assembled vaccines based on tumour‐specific antigenic peptide and TLR2 agonist for effective breast cancer immunotherapy via activating CD8+ T cells and enhancing their function

Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.

Structure-based discovery of receptor tyrosine kinase AXL degraders with excellent anti-tumor activity by selectively degrading AXL and inducing methuosis.

Corrigendum to <'Design, synthesis and biological evaluation of novel peptides with anti-cancer and drug resistance-reversing activities'><[European Journal of Medicinal Chemistry, 89 (2015) 540-548]>.

Advances in Tumor Antigen‐Based Anticancer Immunotherapy: Recent Progress, Prevailing Challenges, and Future Perspective

Structure-Based Discovery of Pyrimidine Aminobenzene Derivatives as Potent Oral Reversal Agents against P-gp- and BCRP-Mediated Multidrug Resistance.

Design, synthesis, and biological activity evaluation of a series of novel sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia.

Design, synthesis and immunological evaluation of self-assembled antigenic peptides from dual-antigen targets: a broad-spectrum candidate for an effective antibreast cancer therapy

Design, synthesis, and biological evaluation of novel 4,4‐difluoro‐1‐methyl‐N, 6‐diphenyl‐5, 6‐dihydro‐4H‐pyrimido [4, 5‐b] [1, 2, 4] triazolo [4, 3‐d] [1, 4] diazepin‐8‐amine derivatives as potential BRD4 inhibitors

Design, synthesis, and biological evaluation of novel FXR agonists based on auraptene.

药学专业无机化学课程的教学改革

Discovery of potent inhibitors against P-glycoprotein-mediated multidrug resistance aided by late-stage functionalization of 2-(4-(pyridin-2-yl)phenoxy)pyridine analogue.

Synthetic tumor-specific antigenic peptides with a strong affinity to HLA-A2 elicit anti-breast cancer immune response through activating CD8+ T cells.

Design, synthesis and biological evaluation of novel 6-phenyl-1,3a,4,10b-tetrahydro-2H-benzo[c]thiazolo[4,5-e]azepin-2-one derivatives as potential BRD4 inhibitors.

Discovery of novel potent GPR40 agonists containing imidazo[1,2-a]pyridine core as antidiabetic agents.

Design, synthesis and structure-activity relationship studies of novel partial FXR agonists for the treatment of fatty liver.

Novel HLA-A2 restricted antigenic peptide derivatives with high affinity for the treatment of breast cancer expressing NY-ESO-1.

Designed P-glycoprotein inhibitors with triazol-tetrahydroisoquinoline-core increase doxorubicin-induced mortality in multidrug resistant K562/A02 cells.

Design, Synthesis and Biological Evaluation of Novel Tumor-Specific Antigenic Peptide Derivatives as Potential Vaccine Candidates with a Strong Affinity to HLA-A2

Design, synthesis and biological evaluation of N-(4-(2-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-4-oxo-3,4-dihydrophthalazine-1-carboxamide derivatives as novel P-glycoprotein inhibitors reversing multidrug resistance.

Discovery to solve multidrug resistance: Design, synthesis, and biological evaluation of novel agents

Discovery of aromatic amides with triazole-core as potent reversal agents against P-glycoprotein-mediated multidrug resistance.

Discovery of HWL-088: A highly potent FFA1/GPR40 agonist bearing a phenoxyacetic acid scaffold.

Design, synthesis and evaluation of a novel series of inhibitors reversing P‐glycoprotein‐mediated multidrug resistance

pH-Sensitive micelles with mitochondria-targeted and aggregation-induced emission characterization: synthesis, cytotoxicity and biological applications.

Discovery of phenylsulfonyl acetic acid derivatives with improved efficacy and safety as potent free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Exploration of 2-((Pyridin-4-ylmethyl)amino)nicotinamide Derivatives as Potent Reversal Agents against P-Glycoprotein-Mediated Multidrug Resistance.

Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance.

A novel mitochondria‐targeting fluorescent probe for hydrogen sulfide in living cells

Design, synthesis and biological evaluation of 4-aminopyrimidine-5-cabaldehyde oximes as dual inhibitors of c-Met and VEGFR-2.

Design, synthesis and biological evaluation of LBM-A5 derivatives as potent P-glycoprotein-mediated multidrug resistance inhibitors.

Free fatty acid receptor agonists for the treatment of type 2 diabetes: drugs in preclinical to phase II clinical development

Quinazoline-N-phenethyl tetrahydroisoquinoline compound and preparation method and application thereof

Phenylbutazone, a New Long‐Acting Agent that can Improve the Peptide Pharmacokinetic Based on Serum Albumin as a Drug Carrier

Design, Synthesis, and Biological Evaluation of Novel Cholesteryl Peptides with Anticancer and Multidrug Resistance‐Reversing Activities

Design, synthesis and biological evaluation of novel triazole-core reversal agents against P-glycoprotein-mediated multidrug resistance

Synthesis of Analogues of BCTC Incorporating a Pyrrolidinyl Linker and Biological Evaluation as Transient Receptor Potential Vanilloid 1 Antagonists

Design, synthesis and Structure-activity relationship studies of new thiazole-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Design, synthesis and biological evaluation of novel peptides with anti-cancer and drug resistance-reversing activities.

Synthesis and biological evaluation of phenoxyacetic acid derivatives as novel free fatty acid receptor 1 agonists.

Design, synthesis and structure-activity relationship studies of novel phenoxyacetamide-based free fatty acid receptor 1 agonists for the treatment of type 2 diabetes.

Synthesis of Carbamide Derivatives Bearing Tetrahydroisoquinoline Moieties and Biological Evaluation as Analgesia Drugs in Mice

A High‐Sensitivity Coumarin‐Based Fluorescent Probe for Monitoring Hydrogen Sulfide in Living Cells

Design, Synthesis and in vivo Evaluation of Novel C‐Aryl Glucosides as Potent Sodium‐Dependent Glucose Cotransporters Inhibitors for the Treatment of Diabetes

Evaluation of Anti‐inflammatory and Analgesic Effects of Synthesized Derivatives of Ibuprofen

Synthesis and in vitro anti-cancer evaluation of luteinizing hormone-releasing hormone-conjugated peptide

Reversal of P-glycoprotein-medicated multidrug resistance by LBM-A5 in vitro and a study of its pharmacokinetics in vivo.

Aliphatic acid-conjugated antimicrobial peptides--potential agents with anti-tumor, multidrug resistance-reversing activity and enhanced stability.

6,7‐Dimethoxy‐2‐{2‐[4‐(1H‐1,2,3‐triazol‐1‐yl)phenyl]ethyl}‐1,2,3,4‐tetrahydroisoquinolines as Superior Reversal Agents for P‐Glycoprotein‐Mediated Multidrug Resistance

Design, synthesis and evaluation of novel triazole core based P-glycoprotein-mediated multidrug resistance reversal agents.

C- a novel class of inhibitors arylglucosides sglt2

Discovery of Novel P‐Glycoprotein‐Mediated Multidrug Resistance Inhibitors Bearing Triazole Core via Click Chemistry

研究方向