百晓学者学者目录

李大力

副教授、教授、研究员，华东师范大学

精选作品

期刊论文

2026

大规模表征RNA引导核酸酶的活性与特异性（英文）

郑基坛，王雪岩，吴明第，刘敬，冯虎，杨辉，李大力，王皓毅，胡家志，左二伟

Science Bulletin

2026

Optimization of RNP-CRISPR for high-efficiency gene editing in mouse intestinal organoids

Xiya Cao, Youyuan He, Haozhe Guo, Xiaoya Cao, Dan Zhang, Yuxuan Lai, Weihua Yang, Zixuan Ma, Xinghua Yu, Liren Wang, Dali Li, Zhiyang Zeng

Molecular and Cellular Biochemistry

DOI

2026

Engineered Un1Cas12f1 for multiplex genome editing with enhanced activity and targeting scope

Yanan Huo, Jiale Mei, Dan Zhang, Bing Yan, Dexin Zhang, Chao Dong, Shuming Yin, Meizhen Liu, X.-P. Wang, Dan Chen, Yuting Guan, Gaojie Song, Du Bing, Yongming Wang, Zongli Zheng, Hong Liu, Dali Li, Lei Yang, Liren Wang

Nature Communications

DOI

2026

Ultra-sensitive profiling of CRISPR-Cas off-target effects with Tracking-seq2

Ting-Ting Cong, Run-Da Xu, Xuan-Cheng Chen, Jun-Song Yuan, Zuo-Miao Lin, Wen-Qin Yang, An-Ji Ju, Liren Wang, Qing-Can Wang, Jiqin Zhang, Yin-Qing Li, Dali Li, Ming Zhu

Nature Communications

DOI

2026

High-diversity base mutagenesis via simultaneous adenine, cytosine and guanine editing

Meng-Jia Hong, Changming Luan, Meng Yuan, Hao Huang, Xinyuan Guo, Dihao Meng, Molin Huang, Ye Xu, Shang-Hui Zhao, Ke Chen, Jiao Chen, Dali Li, Liang Chen

Nature Communications

DOI

2026

Precise DNA base editing using AlphaFold3-based contact modelling

Haowei Meng, Zhi-Xin Lei, Yongchang Yan, Liren Wang, Si-Han Zhang, Xichen Rao, Chuyun Shao, Xiaoting Zhang, Ke Chen, Lei Yang, Rong-Rong Liu, Gao-Hui Yang, Ruo-Yu Shen, Rui-Chu Gu, Xin-Yan Wang, Yiya Wang, Suiru Lu, Zhicong Lv, Bo He, Han Wen, Dali Li, Cheng-Qi Yi

Nature

DOI

2026

Author Correction: Increasing the efficiency and targeting range of cytidine base editors through fusion of a single-stranded DNA-binding protein domain

Xiaohui Zhang, Liang Chen, Biyun Zhu, Liren Wang, Caiyu Chen, Meng-Jia Hong, Yifan Huang, Huiying Li, Honghui Han, Bailian Cai, Weishi Yu, Shuming Yin, Lei Yang, Zuozhen Yang, Meizhen Liu, Ying Zhang, Z. Mao, Yuxuan Wu, Ming-Yao Liu, Dali Li

Nature Cell Biology

DOI

2026

Rising Star Engineering the Genome for Curative Futures.

Dali Li

Journal of Molecular Biology

DOI

2025

基因编辑在肿瘤相关动物模型构建和CART治疗中的应用

李大力，朱一凡，国昊哲

《中国科学基金》

DOI

2025

Construction of pathogenic Sec16a mutation mouse model using CRISPR/Cas9

Yaqiang Hu, Zhiyang Zeng, Xinyu Ming, Shuming Yin, Y. Guan, Liangcai Gao, Dali Li

Animal Models and Experimental Medicine

DOI

2025

Long term remission and survival in patients with relapsed or refractory non-Hodgkin lymphoma after treatment of brl-201, a CRISPR-based non-viral PD-1 locus specifically integrated anti-CD19 CAR-T cells: 4-year follow-up of a first-in-human phase I study

Yong-Xian Hu, Qian Tan, Jiqin Zhang, Ming-Ming Zhang, Wen-Jun Wu, Guo-Qing Wei, Bing-He Tan, Jia-Zhen Cui, Yuxuan Wu, Dali Li, Bing Du, Mingyao Liu, He Huang

Blood

DOI

2025

Efficient mitochondrial A-to-G base editors for the generation of mitochondrial disease models.

Liang Chen, Meng-Jia Hong, Changming Luan, Meng Yuan, Yiming Wang, Xinyuan Guo, Yue Fang, Hao Huang, Xiao-Hua Dong, Hongyi Gao, Dan Zhang, Xi Chen, Dihao Meng, Molin Huang, Zongyi Yi, Ming-Yao Liu, Wensheng Wei, Liangcai Gao, Gao-Jie Song, Xiaoming Zhou, Dali Li

Nature Biotechnology

DOI

2025

A mitochondrial disease model is generated and corrected using engineered base editors in rat zygotes.

Liang Chen, Changming Luan, Meng-Jia Hong, Meng Yuan, Hao Huang, De-Bo Gao, Xinyuan Guo, Zhengxing Chen, Yongmei Li, Lei Yang, Zongyi Yi, Wensheng Wei, Ming-Yao Liu, Liangcai Gao, Honghui Han, Dali Li

Nature Biotechnology

DOI

2025

A rapid and efficient red-light-activated Cre recombinase system for genome engineering in mammalian cells and transgenic mice

Yang Zhou, Yu Wei, Jianli Yin, De-Qiang Kong, Wenjun Li, Xinyi Wang, Yi-Ning Yao, Qin Huang, Lei Li, Meng-Yao Liu, Longliang Qiao, Huiying Li, Jun-Wei Zhao, Tao P. Zhong, Dali Li, Liting Duan, Ning-Zi Guan, Haifeng Ye

bioRxiv

DOI

2025

Engineering a photoactivatable A-to-I RNA base editor for gene therapy in vivo

Huiying Li, Yuhao Qiu, Bo-Wen Song, Xinyi Quan, Dan Zhang, Xin-Ru Li, Jingyun Yang, Xiaohong Liu, Zhiyang Zeng, Ji Jing, Shuming Yin, Qi Dai, Liren Wang, Honghui Han, Haifeng Ye, Zhenliang Sun, Yiyun Cheng, Xue-Li Zhang, Bing Du, Ming-Yao Liu, Dali Li

Nature Biotechnology

DOI

2025

Generation and Phenotypic Analysis of the IL-10RAR104W/R104W Mouse Model

Xiao-Ya Cao, Zhiyang Zeng, Xi-Ya Cao, Youyuan He, Liren Wang, Dali Li, Xueli Zhang

Inflammatory Bowel Diseases

DOI

2025

A light-inducible RNA base editor for precise gene expression

Huiying Li, Dali Li

Nature Biotechnology

DOI

2024

Advancing CRISPR base editing technology through innovative strategies and ideas

Xiong-Wei Fan, Yang Lei, Liren Wang, Xiu-Shan Wu, Dali Li

Science China Life Sciences

DOI

2024

Corrigendum to "Long-term correction of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration" [Journal of Genetics and Genomics (2022) 49, 1114-1126].

Xi Chen, Xuran Niu, Yang Liu, Rui Zheng, Lei Yang, Jian Lu, Shuming Yin, Yu Wei, Jia‐Hong Pan, A. Sayed, Xueyun Ma, Meizhen Liu, Fengxiang Jing, Ming-Yao Liu, Jiazhi Hu, Liren Wang, Dali Li

Journal of genetics and genomics = Yi chuan xue bao

DOI

2024

Luteinizing Hormone Receptor Mutation (LHRN316S) Causes Abnormal Follicular Development Revealed by Follicle Single-Cell Analysis and CRISPR/Cas9

Chen Zhang, Yongqiang Nie, Bu-Fang Xu, Chunlan Mu, Geng. G. Tian, Xiaoyong Li, Wei-Wei Cheng, Ai-Jun Zhang, Dali Li, Ji Wu

Interdisciplinary Sciences Computational Life Sciences

DOI

2024

Dual-responsive nanocarriers for efficient cytosolic protein delivery and CRISPR-Cas9 gene therapy of inflammatory skin disorders

Echuan Tan, Tao Wan, Qi Pan, Jianan Duan, Song Zhang, Ruijue Wang, P. Gao, Jia Lv, Hui Wang, Dali Li, Yuan Ping, Yi-Yun Cheng

Science Advances

DOI

2024

Author Correction: Re-engineering the adenine deaminase TadA-8e for efficient and specific CRISPR-based cytosine base editing

Liang Chen, Biyun Zhu, Gaomeng Ru, Haowei Meng, Yongchang Yan, Meng-Jia Hong, Dan Zhang, Changming Luan, Shun Zhang, Hao Wu, Hongyi Gao, Sijia Bai, Changqing Li, Ruoyi Ding, Niannian Xue, Zhi-Xin Lei, Yuting Chen, Y. Guan, S. Siwko, Yiyun Cheng, Gao-Jie Song, Liren Wang, C. Yi, Ming-Yao Liu, Dali Li

Nature Biotechnology

DOI

2024

Targeted Gene Insertion: The Cutting Edge of CRISPR Drug Development with Hemophilia as a Highlight

Zhenjie Zhang, Siqi Zhang, H. Wong, Dali Li, Bo Feng

BioDrugs

DOI

2024

Allele-Specific Suppression of Variant MHC With High-Precision RNA Nuclease CRISPR-Cas13d Prevents Hypertrophic Cardiomyopathy

Ping Yang, Yingmei Lou, Zilong Geng, Zhizhao Guo, Shuo Wu, Yi-Ge Li, Kaiyuan Song, Ting Shi, Shasha Zhang, Junhao Xiong, Alex F. Chen, Dali Li, William T. Pu, Lin-Tai Da, Yan Zhang, Kun Sun, Bing Zhang

Circulation

DOI

2024

Amelioration of metabolic and behavioral defects through base editing in the PahR408W phenylketonuria mouse model.

Shuming Yin, Liangcai Gao, Xiao-Yu Sun, Mei Zhang, Hongyi Gao, Xiao-Qin Chen, Dan Zhang, Xinyu Ming, Lei Yang, Yaqiang Hu, Xi Chen, Meizhen Liu, Xia Zhan, Y. Guan, Liren Wang, Lian-Shu Han, Ping Zhu, Dali Li

Molecular Therapy

DOI

2024

Author Correction: Engineering a precise adenine base editor with minimal bystander editing

Liang Chen, Shun Zhang, Niannian Xue, Meng-Jia Hong, Xiaohui Zhang, Dan Zhang, Jing Yang, Sijia Bai, Yifan Huang, Haowei Meng, Hao Wu, Changming Luan, Biyun Zhu, Gaomeng Ru, Hongyi Gao, Liping Zhong, Meizhen Liu, Ming-Yao Liu, Yiyun Cheng, C. Yi, Liren Wang, Yong-Xiang Zhao, Gao-Jie Song, Dali Li

Nature Chemical Biology

DOI

2024

Genome editing technology and medical applications

Liren Wang, Bin Zhou, Dali Li

Science China Life Sciences

DOI

2024

Engineering IscB to develop highly efficient miniature editing tools in mammalian cells and embryos.

Niannian Xue, D. Hong, Dan Zhang, Qian Wang, Shun Zhang, Lei Yang, Xi Chen, Yongmei Li, Honghui Han, Chunyi Hu, Ming-Yao Liu, Gao-Jie Song, Y. Guan, Liren Wang, Yi-Fan Zhu, Dali Li

Molecules and Cells

DOI

2024

Engineered mitochondrial A-to-G editors with enhanced efficiency and targeting scope

Liang Chen, Meng-Jia Hong, Changming Luan, Meng Yuan, Yiming Wang, Xinyuan Guo, Yue Fang, Hao Huang, Xiao-Hua Dong, Hongyi Gao, Dan Zhang, Xi Chen, Dihao Meng, Molin Huang, Zongyi Yi, Ming-Yao Liu, Liangcai Gao, Gao-Jie Song, Xiaoming Zhou, Wensheng Wei, Dali Li

bioRxiv

DOI

2024

Engineering APOBEC3A deaminase for highly accurate and efficient base editing

Lei Yang, Yanan Huo, Man Wang, Dan Zhang, Tian-Ai Zhang, Hao Wu, Xichen Rao, Haowei Meng, Shuming Yin, Jiale Mei, De-Xin Zhang, Xi Chen, Jia Lv, Meizhen Liu, Yiyun Cheng, Y. Guan, Bo Feng, Gao-Jie Song, C. Yi, Ming-Yao Liu, Fan-Yi Zeng, Liren Wang, Dali Li

Nature Chemical Biology

DOI

2024

Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

Liang Chen, Meng-Jia Hong, Changming Luan, Hongyi Gao, Gaomeng Ru, Xinyuan Guo, Du-Juan Zhang, Shun Zhang, Chang-Wei Li, Jun Wu, Peyton B. Randolph, Alexander A. Sousa, Chao Qu, Yifan Zhu, Y. Guan, Liren Wang, Ming-Yao Liu, Bo Feng, Gao-Jie Song, David R. Liu, Dali Li

Nature Biotechnology

DOI

2023

利用CRISPR/Cas9技术构建基因编辑大鼠模型

刘梅珍，王立人，李咏梅，马雪云，韩红辉，李大力

《遗传》

2023

Improving adenine and dual base editors through introduction of TadA-8e and Rad51DBD

Niannian Xue, Xu Liu, Dan Zhang, Youming Wu, Yi Zhong, Jinxin Wang, W. Fan, Hai-Xia Jiang, Biyun Zhu, Xiyu Ge, Rachel V. L. Gonzalez, Liang Chen, Shun Zhang, Peilu She, Zhilin Zhong, Jian-Jian Sun, Xi Chen, Liren Wang, Zhimin Gu, P. Zhu, Ming-Yu Liu, Dali Li, Tao P. Zhong, Xiaohui Zhang

Nature Communications

DOI

2023

S271: AN UPDATED FOLLOW-UP OF BRL-101, CRISPR-CAS9-MEDIATED GENE EDITING OF THE BCL11A ENHANCER FOR TRANSFUSION-DEPENDENT BETA-THALASSE

Bin Fu, Xinhua Zhang, Li Wang, J. Liao, Shuanghong Chen, Biao Zheng, Wei Li, Fei Wang, Dali Li, Ming-Yu Liu, Yuxuan Wu

HemaSphere

DOI

2023

Waking up the silenced beauty: CRISPR/Cas9 mediated reactivation of fetal hemoglobin genes to treat severe beta-thalassemia in young patients

Liren Wang, S. Siwko, Dali Li

Life Medicine

DOI

2023

Efficacy and Safety of Brl-101, CRISPR-Cas9-Mediated Gene Editing of the BCL11A Enhancer in Transfusion-Dependent β-Thalassemia

Biao Zheng, Rong-Rong Liu, Xin-Hua Zhang, Bin Fu, Yajing Xu, Jun Shi, Xiaoqin Feng, Li Wang, Chris Wang, Rongmei Liang, Lingzhi Tan, Fei Wang, Dali Li, Yuxuan Wu, Mingyao Liu, Yong-Rong Lai

Blood

DOI

2023

Efficient A-to-C base editing with high specificity

Liang Chen, Dali Li, Nat. Biotechnol

Nature Biotechnology

DOI

2023

A/C Simultaneous Conversion Using the Dual Base Editor in Human Cells.

Xiaohui Zhang, Y. Guan, Dali Li

Methods in molecular biology

DOI

2023

Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos

Liang Chen, Meng-Jia Hong, Changming Luan, Hongyi Gao, Gaomeng Ru, Xinyuan Guo, Dujuan Zhang, Shun Zhang, Chang-Wei Li, Jun Wu, Peyton B. Randolph, Alexander Sousa, Chao Qu, Yifan Zhu, Y. Guan, Liren Wang, Ming-Yu Liu, Bo Feng, Gaojie Song, David R. Liu, Dali Li

Nature Biotechnology

DOI

2022

Long-term correction of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration

Xi Chen, Xuran Niu, Yang Liu, Rui Zheng, Lei Yang, Jian Lu, Shuming Yin, Yu Wei, Jiahao Pan, Ahmed Sayed, Xueyun Ma, Meizhen Liu, Fengxiang Jing, Mingyao Liu, Jiazhi Hu, Liren Wang, Dali Li

Journal of Genetics and Genomics

2022

Engineering of efficiency-enhanced Cas9 and base editors with improved gene therapy efficacies

Shuming Yin, Mei Zhang, Yang Liu, Xiaoyue Sun, Y. Guan, Xi Chen, Lei Yang, Yanan Huo, Jing Yang, Xiaohui Zhang, Honghui Han, Jiqin Zhang, Min-Min Xiao, Ming-Yu Liu, Jiazhi Hu, Liren Wang, Dali Li

Molecular Therapy

DOI

2022

ROS-responsive polypeptides for intracellular protein delivery and CRISPR/Cas9 gene editing

Echuan Tan, Tao Wan, Chunlei Yu, Qianqian Fan, Wenbang Liu, Hong Chang, Jia Lv, Hui Wang, Dali Li, Yuan Ping, Yiyun Cheng

Nano Today

DOI

2022

Gene editing and its applications in biomedicine

Guang-Lei Li, Xiangyang Li, Songkuan Zhuang, Liren Wang, Yifan Zhu, Yang-Can Chen, Wen Sun, Ze-Guang Wu, Zhuo Zhou, Jia Chen, Xingxu Huang, Jin Wang, Dali Li, Wei Li, Hao-Yi Wang, Wen-Sheng Wei

Science China Life Sciences

DOI

2021

利用基因编辑技术进行猪异种器官移植及人类疾病模型研究的进展

陆新章，张梅，娄颜坤，马育芳，李大力

《上海农业学报》

DOI

2020

双碱基编辑器高效介导腺嘌呤和胞嘧啶碱基转换

朱碧云，李大力

《生命的化学》

DOI

2019

基因治疗在临床应用中的研究进展

陈曦，陈亮，李大力

《生物工程学报》

DOI

2019

基因编辑技术及其在疾病治疗中的研究进展

牛煦然，尹树明，陈曦，邵婷婷，李大力

《遗传》

2019

基因编辑技术在细胞治疗中的研究进展

朱碧云，李林夕，王立人，李大力

《中国细胞生物学学报》

2017

基因编辑之“新宠”—单碱基基因组编辑系统

魏瑜，张晓辉，李大力

《遗传》

2017

CRISPR/Cas9系统:一种强大的在体基因治疗工具

张晓辉，王立人，刘明耀，李大力

《中国科学:生命科学》

2017

CRISPR/Cas9 system: a powerful technology for in vivo and ex vivo gene therapy

Xiaohui Zhang, Liren Wang, Mingyao Liu, Dali Li

Science China Life Sciences

2017

One-Step piggyBac Transposon-Based CRISPR/Cas9 Activation of Multiple Genes

Shenglan Li, Anqi Zhang, Haipeng Xue, Dali Li, Ying Liu

Molecular Therapy: Nucleic Acids

DOI

2017

The "new favorite" of gene editing technology-single base editors.

Yu Wei, Xiaohui Zhang, Dali Li

Yi chuan = Hereditas

DOI

2015

利用CRISPR/CAS9技术在生殖细胞中治愈小鼠遗传疾病(英文)

李大力

Science Bulletin

2015

利用CRISPR/Cas9技术构建定点突变小鼠品系

白敏，李崎，邵艳姣，黄元华，李大力，马燕琳

《遗传》

2013

GPR126条件性基因敲除载体的快速构建

叶湘漓，李大力

《中国生物工程杂志》

2013

A method of constructing point mutations

Dali Li, Ming-Yao Liu, Zhongwei Qiu

2012

BAI1基因敲除打靶载体的快速构建

雷立芳，李大力，周军媚，叶湘漓

《生命科学研究》

会议论文

2020

基因编辑在疾病治疗中的应用

李大力

《中国生物化学与分子生物学会2020全国学术在线会议摘要集》

DOI

预印本

2026

AAV-Mediated Dual-Gene Therapy Restores Metabolic Function in Mice with Propionic Acidemia

Hui Xu, Zewen Tao, T. Zhang, Xuli Zhang, Ying Zhou, Ziyan Cen, Jie Liu, Hao Zhang, Alimujiang Maimaitijiang, Dan Chen, Dali Li, Shuming Yin, Lei An, Xinwen Huang, Yue Zhang

bioRxiv (Cold Spring Harbor Laboratory)

DOI

2026

AAV-Mediated Dual-Gene Therapy Restores Metabolism and Mitochondrial Structure in Propionic Acidemia

Huixia Xu, Zewen Tao, Ting Zhang, Xuli Zhang, Ying Zhou, Ziyan Cen, Jie Liu, Hao Zhang, Jingjing Ruan, Xiaoxiao Yu, Kaiye Zhang, Alimujiang Maimaitijiang, Yong Shen, Dan Chen, Dali Li, Shuming Yin, Lei An, Xinwen Huang, Yue Zhang

SSRN Electronic Journal

DOI

研究方向

遗传疾病基因治疗基因编辑工具与治疗策略基因治疗动物模型构建

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