万雨顺｜重庆医科大学｜学者主页

2026

Intranasal delivery of a vasoactive intestinal peptide-based circRNA vaccine induces systemic and mucosal immunity against RSV in mice

Junqi Xiang, Jie Xu, Jing Zhu, Bo Yang, Mingling Wan, Jiangyu Cai, Shuying Chen, Yuncheng Wang, 杨善蓉, Yaokai Wang, Li Lin, Qiqi Zhang, Na Zang, Enmei Liu, Yushun Wan

Molecular Therapy

DOI

2026

A self-assembled nanoparticle vaccine displaying chimeric and trimeric RBD-HRC elicits broad-spectrum neutralizing antibodies against multiple coronaviruses

Didi Wan, Lei Li, He Feng, Mengyu Wang, Shuo Jia, Pengyu Zhang, Jiaxu Wang, Junxia Yang, Y.Y. Zhang, Boya Ji, Yushun Wan, Zhengkun Xie, Jian Shang

Microbiology Spectrum

DOI

2025

UBXN7 facilitates SARS-CoV-2 replication via inhibiting the K48-linked ubiquitination of viral N protein

Tian Xia, Min Hua Luo, Yuncheng Wang, Yaping Qin, Xiaoning Li, Shuying Chen, Junqi Xiang, Shanrong Yang, Yaokai Wang, Jing Zhu, Bo Yang, Lin Li, Jiajun Yan, Yunxiao Dou, Jian Shang, Na Zang, Yong Lin, Xiaohong Yao, Yushun Wan

PLoS Pathogens

DOI

2025

Structural and functional constraints on spike activation and host protease utilization limit cell entry of SARS-CoV-2-related bat coronaviruses

Qingqing Li, Xiao Cai, Xiaoning Li, Yi-Bing Zhang, Ru Li, Zirui Kang, Didi Wan, Jiaxu Wang, Lili Li, Junxia Yang, Jianxiang Shi, Shuiling Jin, Xiangdong Sun, Ying Peng, Na Zang, Zhengkun Xie, Yushun Wan, Jian Shang

Journal of Virology

DOI

2025

DNAJ Homolog Subfamily C Member 11 Stabilizes SARS-CoV-2 NSP3 to Promote Double-Membrane Vesicle Formation

Shuying Chen, Shanrong Yang, Xiaoning Li, Junqi Xiang, Jiangyu Cai, Yaokai Wang, Qingqing Li, Na Zang, Jiaxu Wang, Jian Shang, Yushun Wan

Viruses

DOI

2024

Diphyllin elicits a doubled-pronged attack on the entry of SARS-CoV-2 by inhibiting cathepsin L and furin

Binli Mao, Vu Thuy Khanh Le‐Trilling, Haoran Tang, Jie Hu, M Schmitz, K Barbet, Dan Xu, Zhen Wei, Beinu Guo, Denise Mennerich, Chun Yao, Jin‐Xin Liu, Zhenghan Li, Yushun Wan, Xiaoyong Zhang, Kai Wang, Ni Tang, Zebo Yu, Mirko Trilling, Yong Lin

Virus Research

DOI

2024

A T cell–based SARS-CoV-2 spike protein vaccine provides protection without antibodies

Juan Shi, Jian Zheng, Xiujuan Zhang, Wanbo Tai, Ryan Compas, Jack Deno, Natalie Jachym, A. Verma, Gang Wang, Xiaoqing Guan, Abby E. Odle, Yu-Shun Wan, Fang Li, S. Perlman, Liang Qiao, Lanying Du

JCI Insight

DOI

2023

Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

Q. Geng, Yu-Shun Wan, Fu-Chun Hsueh, J. Shang, G. Ye, Fan Bu, Morgan Herbst, Rowan Wilkens, Bin Liu, Fang Li

eLife

DOI

2021

Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection

Q. Geng, Wanbo Tai, V. K. Baxter, Juan Shi, Yu-Shun Wan, Xiujuan Zhang, S. Montgomery, S. Taft-Benz, Elizabeth J. Anderson, Audrey C Knight, Kenneth H. Dinnon, S. Leist, R. Baric, J. Shang, Sung-Wook Hong, A. Drelich, C. Tseng, M. Jenkins, M. Heise, L. Du, Fang Li

PLoS Pathogens

DOI

2021

The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates

G. Ye, Joseph P. Gallant, Jian Zheng, C. Massey, K. Shi, Wanbo Tai, Abby E. Odle, M. Vickers, J. Shang, Yu-Shun Wan, L. Du, H. Aihara, S. Perlman, Aaron M. LeBeau, Fang Li

eLife

DOI

2021

Author response: The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates

G. Ye, Joseph P. Gallant, Jian Zheng, C. Massey, K. Shi, Wanbo Tai, Abby E. Odle, M. Vickers, J. Shang, Yu-Shun Wan, L. Du, H. Aihara, S. Perlman, Aaron M. LeBeau, Fang Li

DOI

2020

Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry

J. Shang, Yu-Shun Wan, Chang Liu, B. Yount, K. Gully, Yang Yang, Ashley A. Auerbach, G. Peng, R. Baric, Fang Li

PLoS Pathogens

DOI

2020

Structural basis of receptor recognition by SARS-CoV-2

J. Shang, G. Ye, K. Shi, Yu-Shun Wan, C. Luo, H. Aihara, Q. Geng, Ashley A. Auerbach, Fang Li

Nature

DOI

2020

Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus

Yu-Shun Wan, J. Shang, R. Graham, R. Baric, Fang Li

Journal of Virology

DOI

2020

武漢からの新規コロナウイルスによる受容体認識:SARSコロナウイルスの10年間の構造研究に基づく解析【JST・京大機械翻訳】

Yu-Shun Wan, J. Shang, G. Rachel, S. Ralph, Fang Li

2020

The Development of a Novel Nanobody Therapeutic for SARS-CoV-2

G. Ye, Joseph P. Gallant, C. Massey, K. Shi, Wanbo Tai, Jian Zheng, Abby E. Odle, M. Vickers, J. Shang, Yu-Shun Wan, A. Drelich, K. R. Kempaiah, Vivian Tat, S. Perlman, L. Du, C. Tseng, H. Aihara, Aaron M. LeBeau, Fang Li

bioRxiv

DOI

2020

Cell entry mechanisms of SARS-CoV-2

J. Shang, Yu-Shun Wan, C. Luo, G. Ye, Q. Geng, Ashley A. Auerbach, Fang Li

Proceedings of the National Academy of Sciences of the United States of America

DOI

2020

Structural basis for receptor recognition by the novel coronavirus from Wuhan

J. Shang, G. Ye, K. Shi, Yu-Shun Wan, C. Luo, H. Aihara, Q. Geng, Ashley A. Auerbach, Fang Li

DOI

2019

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry

Yu-Shun Wan, J. Shang, Shi-Hui Sun, Wanbo Tai, Jing Chen, Q. Geng, Lei He, Yuehong Chen, Jian-Ming Wu, Zheng-Li Shi, Yu-Sen Zhou, L. Du, Fang Li

Journal of Virology

DOI

2018

Lysosomal Proteases Are a Determinant of Coronavirus Tropism

Yuan Zheng, J. Shang, Yang Yang, Chang Liu, Yu-Shun Wan, Q. Geng, Michelle Wang, R. Baric, Fang Li

Journal of Virology

DOI

万雨顺

精选作品

期刊论文

Intranasal delivery of a vasoactive intestinal peptide-based circRNA vaccine induces systemic and mucosal immunity against RSV in mice

A self-assembled nanoparticle vaccine displaying chimeric and trimeric RBD-HRC elicits broad-spectrum neutralizing antibodies against multiple coronaviruses

UBXN7 facilitates SARS-CoV-2 replication via inhibiting the K48-linked ubiquitination of viral N protein

Structural and functional constraints on spike activation and host protease utilization limit cell entry of SARS-CoV-2-related bat coronaviruses

DNAJ Homolog Subfamily C Member 11 Stabilizes SARS-CoV-2 NSP3 to Promote Double-Membrane Vesicle Formation

Diphyllin elicits a doubled-pronged attack on the entry of SARS-CoV-2 by inhibiting cathepsin L and furin

A T cell–based SARS-CoV-2 spike protein vaccine provides protection without antibodies

Lys417 acts as a molecular switch that regulates the conformation of SARS-CoV-2 spike protein

Novel virus-like nanoparticle vaccine effectively protects animal model from SARS-CoV-2 infection

The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates

Author response: The development of Nanosota-1 as anti-SARS-CoV-2 nanobody drug candidates

Structure of mouse coronavirus spike protein complexed with receptor reveals mechanism for viral entry

Structural basis of receptor recognition by SARS-CoV-2

Receptor Recognition by the Novel Coronavirus from Wuhan: an Analysis Based on Decade-Long Structural Studies of SARS Coronavirus

武漢からの新規コロナウイルスによる受容体認識:SARSコロナウイルスの10年間の構造研究に基づく解析【JST・京大機械翻訳】

The Development of a Novel Nanobody Therapeutic for SARS-CoV-2

Cell entry mechanisms of SARS-CoV-2

Structural basis for receptor recognition by the novel coronavirus from Wuhan

Molecular Mechanism for Antibody-Dependent Enhancement of Coronavirus Entry

Lysosomal Proteases Are a Determinant of Coronavirus Tropism

研究方向