顾景凯｜吉林大学｜学者主页

2026

Multi-kinetic analysis reveals drug release and structural dissociation behaviors of paclitaxel-loaded polymeric micelles

Runtong Zhang, Mingyang Zhao, Yi Lu, Huiping Lu, Jingkai Gu, Jun He, Wei Wu

Acta Pharmaceutica Sinica B

2026

Self-Assembly Orchestrates Bidirectional Pharmacokinetics Between a Hydrophobic Drug and its Amphiphilic-Polymer Carrier

Deqi Cai, Tao Sun, Yuyao Zhang, Dinglingge Cao, Xiangjun Meng, Yanshuang Zhang, Zhi Zhang, Wenqian Li, Chenchen Jiao, Wen Guo, Dong Sun, Lin Yu, Jiandong Ding, Jingkai Gu

CCS Chemistry

DOI

2026

Deciphering the In Vivo Metabolism of Polyethylene Glycol by a Polymeromics Approach

Xinyi Wang, Jiayi Yao, Mingyang Zhao, Hao Wang, Jingkai Gu, Xiangjun Meng

Analytical Chemistry

DOI

2026

Deciphering the In Vivo Fate of PEGylated rhGH via a Molecular Ruler-Based MS Strategy

Kexin Liu, Yuqing Zou, Qian Gu, Shiwen Song, Jingkai Gu

Analytical Chemistry

DOI

2026

The impact of the DiI fluorescent probe on the in vivo fate of paclitaxel-loaded methoxy polyethylene glycol-block-poly (d,l-lactide) micelles

Jiayi Yao, Jiaqi Wang, Peipei Bu, Kexin Liu, Mingyang Zhao, Jingkai Gu, Xiangjun Meng

Drug Metabolism and Disposition

DOI

2025

Deciphering the biological fate of mRNA-LNP-based biologics: A perspective from tissue to intracellular distribution

Xin Xu, Lili Cui, Yong Zhang, Jingkai Gu

Acta Pharmaceutica Sinica B

DOI

2025

Unraveling metabolic complexity of multi-payload PEG-irinotecan prodrug: A deconvolution-based LC-Q-TOF MS approach for preclinical pharmacokinetic characterization

Shi-Wen Song, Mingyang Zhao, Xiang-Rong Song, Huaidong Yu, Xin Xu, Dong Sun, Jingkai Gu

Chinese Chemical Letters

DOI

2025

Deciphering the in vivo fate and biomacromolecular interactions of DSPE-PEG2000.

D. Cai, Chong Su, Mingyang Zhao, Huan Yang, Zhe Zhang, Yingze Liu, Jingkai Gu

Journal of Controlled Release

DOI

2025

Clopidogrel-indobufen conjugates as dual antiplatelet prodrugs with enhanced bioactivation and synchronized pharmacokinetic-pharmacodynamic profiles in rats.

Zhe Zhang, D. Qin, Jia-Xin Song, Huan Yang, Jingkai Gu, Yingjie Guo, Dong Sun

Drug Metabolism And Disposition

DOI

2025

Label-Free Analysis Reveals In Vivo Premature Drug Release Governed by Diffusion from Polymeric Micelles

Jiayi Yao, Jiefang Sun, Xinyi Wang, Haoran Wang, Yuqi Liu, Mingyang Zhao, Xiangjun Meng, Jingkai Gu

Nano Letters

DOI

2025

Full-profile bioanalysis of polydisperse macromolecular hydroxyethyl starch 130/0.4 in rat plasma via LC-IS-CID coupled with MRM

Xin Xu, Huan Yang, Jiachong Chi, Xiangjun Meng, Jingkai Gu

Chinese Chemical Letters

DOI

2025

Pharmacokinetics, tissue distribution and metabolism of hydroxyethyl starch 130/0.4 in rats

Xin Xu, Huan Yang, Jiachong Chi, Huimin Sun, Xiangjun Meng, Jingkai Gu

International Journal of Biological Macromolecules

DOI

2024

基于淋巴系统的药物及其递送系统研究进展

胡罗娟，顾景凯，尤启冬，韩思飞

《药学学报》

DOI

2024

纳米药物递送系统体内命运分析新方法与新技术研究进展

王心怡，付淑军，孟祥骏，吴伟，顾景凯

《药学进展》

2024

Real-time platelet P2Y12 receptor occupancy as a promising pharmacodynamics biomarker for bridging the gap between PK/PD of clopidogrel therapy

Haipeng Li, Yueming Gu, Yumeng Zhao, Aiyun Xu, Dong Sun, Jingkai Gu

Acta Pharmaceutica Sinica B

DOI

2024

Pharmacokinetic/Pharmacodynamic Assessment of the Structural Refinement of Clopidogrel Focusing on the Balance between Bioactivation and Deactivation

Dong Sun, Yingze Liu, Lin Zhu, Zhi-Ping Xu, Yu-Yao Zhang, Haipeng Li, Huan Yang, Xia Cao, Jingkai Gu

Drug Metabolism And Disposition

DOI

2024

Quantitatively analyzing the dissociation and release of disulfide-containing organic nanoparticles.

Wenhai Lin, Lei Yin, Xin Wang, Chaonan Li, Wei Zhang, Qing Pei, Huixuan Qi, Ting-Ting Sun, Zhi-Gang Xie, Jingkai Gu

Journal of materials chemistry. B

DOI

2024

Advanced bioanalytical techniques for pharmacokinetic studies of nanocarrier drug delivery systems

Xiangjun Meng, Jiayi Yao, Jingkai Gu

Journal of Pharmaceutical Analysis

DOI

2024

Overcoming the challenge of potent endogenous interferences in limaprost quantification: An innovative methodology combining differential mobility spectrometry with LC-MS/MS for ultra-high sensitivity, selectivity and significantly enhanced throughput

Xiangjun Meng, Chong Su, Zhi Long Zhang, Yaoshuang Li, Yuyao Zhang, Jingtao Li, Leling Gan, Jingkai Gu

Talanta

DOI

2023

纳米药物药代动力学研究——专栏致辞

顾景凯，相小强

《药学学报》

2023

Special Section on New and Emerging Areas and Technologies in Drug Metabolism and Disposition, Part I — Minireview Bioanalytical Assays for Pharmacokinetic and Biodistribution Study of Antibody-Drug Conjugates

Lei Yin, Aiyun Xu, Yumeng Zhao, Jingkai Gu

2023

Simultaneous separation and analysis of multiple doxorubicin hydrochloride liposomes forms in serum by circular nonuniform electric field gel electrophoresis

Peijie Xie, Xinlei Yang, Zakia Fatima, Ruilin Yang, Huaze Sun, Yuhang Xing, Xin Xu, Jingkai Gu, Lu Liu, Donghao Li

Analytica Chimica Acta

DOI

2023

Differential Mobility Spectrometry-Tandem Mass Spectrometry with Multiple Ion Monitoring Coupled with in Source-Collision Induced Dissociation: A New Strategy for the Quantitative Analysis of Pharmaceutical Polymer Excipients in Rat Plasma

Yuyao Zhang, Zhi Zhang, Yingze Liu, Deqi Cai, Jingkai Gu, Dong Sheng Sun

Molecules

DOI

2023

Bioanalytical Assays for Pharmacokinetic and Biodistribution Study of Antibody-Drug Conjugates

Lei Yin, Aiyun Xu, Yumeng Zhao, Jingkai Gu

Drug Metabolism and Disposition

DOI

2023

Identification, structure elucidation and origin of a common pyridinium-thiocyanate intermediate in electrospray mass spectrometry among the benziamidazole-class proton pump inhibitors

Dong Bai Sun, Chunyu Wang, Yanxia Fan, Jingkai Gu

Journal of Pharmaceutical Analysis

DOI

2023

Full-profile pharmacokinetics, anticancer activity and toxicity of an extended release trivalent PEGylated irinotecan prodrug

Shiwen Song, Dong Sheng Sun, Hong Wang, Jinliang Wang, Huijing Yan, Xuan Zhao, J. Paul Fawcett, Xin Ping Xu, Deqi Cai, Jingkai Gu

Acta Pharmaceutica Sinica B

DOI

2022

Identification and high-throughput quantification of baicalein and its metabolites in plasma and urine

Hao Wang, Yantong Sun, Wei Feng Guo, Jing Wang, Jingyi Gao, Wenwen Peng, Jingkai Gu

Journal of Ethnopharmacology

DOI

2022

Pharmacokinetic Study of Conjugated Equine Estrogens in Healthy Chinese Postmenopausal Women Using a Parallel Two-Column LC–MS/MS Method

Meiyun Shi, Lei Yin, Yantong Sun, Can Wang, Lanlan Cai, Tinglan Zhang, Xiaotong Zhou, J. Paul Fawcett, Xiaoli Gao, Jingkai Gu

Clinical Pharmacokinetics

DOI

2022

Antibiotics-Induced Disruption of Gut Microbiota Increases Systemic Exposure of Clopidogrel Active Metabolite in Type 2 Diabetic Rats

Chen Xue, Yingrui Liu, Hongwei Yao, Wenfang Song, Yu Song, Jingkai Gu, Yingjie Guo

Drug Metabolism and Disposition

DOI

2022

Evaluation of efficacy and safety after replacement of methyl hydrogen with deuterium at methyl formate of Clopidogrel

Zhiping Xu, Yujia Miao, Tianlong Wu, Liang Chen, Mingyue Gao, Yantong Sun, Yingze Liu, Jinjin Niu, Deqi Cai, Xiaohua Li, Chen Chen, Shengyang Liu, Jingkai Gu, Xia Cao

European Journal of Pharmaceutical Sciences

DOI

2022

Biological fate and interaction with cytochromes P450 of the nanocarrier material, d-α-tocopheryl polyethylene glycol 1000 succinate

Tianming Ren, Runzhi Li, Liqiang Zhao, J. Paul Fawcett, Dong Sheng Sun, Jingkai Gu

Acta Pharmaceutica Sinica B

DOI

2022

The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems

Lei Yin, Yiling Pang, Lin Shan, Jingkai Gu

Drug Metabolism and Disposition

DOI

2021

纳米药物非临床药代动力学的研究策略及关注要点

付淑军，黄芳华，顾景凯，吴伟，孙涛，王庆利

《中国临床药理学与治疗学》

2021

High-throughput and trace analysis of diazepam in plasma using DART-MS/MS and its pharmacokinetic application

Yingze Liu, Chong Su, Yuyao Zhang, Di Zhang, Yaoshuang Li, Jingkai Gu, Ensi Wang, Dong Sheng Sun

Analytical Biochemistry

DOI

2021

High‐throughput bioanalysis of sitagliptin in plasma using direct analysis in real time mass spectrometry and its application in the pharmacokinetic study thereof

Yingze Liu, Xiangjun Meng, Yuyao Zhang, Linge Zhang, Yuqin Shan, Jingkai Gu, Dong Sheng Sun

Journal of Separation Science

DOI

2021

Disposition and fate of polyoxyethylene glycerol ricinoleate as determined by LC-Q-TOF MS coupled with MSALL, SWATH and HR MS/MS techniques

Ruifeng Bai, Dong Sheng Sun, Yuqin Shan, Zhiqiong Guo, Dafeng Chu, J. Paul Fawcett, Jingkai Gu

Chinese Chemical Letters

DOI

2021

The biological fate of the polymer nanocarrier material monomethoxy poly(ethylene glycol)-block-poly(d,l-lactic acid) in rat

Xiangjun Meng, Zhi Zhang, Jin Tong, Hui Sun, J. Paul Fawcett, Jingkai Gu

Acta Pharmaceutica Sinica B

DOI

2021

A Novel, Differential Mobility Spectrometry Tandem Mass Spectrometric Method for the in Vivo Quantitation of Ursolic Acid

Yuyao Zhang, Zhi Zhang, J. Paul Fawcett, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2020

Type 2 diabetes mellitus decreases systemic exposure of clopidogrel active metabolite through upregulation of P-glycoprotein in rats

Hongwei Yao, Jingkai Gu, Yuqin Shan, Yani Wang, Xue Chen, Dong Sheng Sun, Yingjie Guo

Biochemical Pharmacology

DOI

2020

Current status of in vivo bioanalysis of nano drug delivery systems

Tingting Wang, Di Zhang, Dong Sheng Sun, Jingkai Gu

Journal of Pharmaceutical Analysis

DOI

2020

Comprehensive Bioanalysis of Ultrahigh Molecular Weight, Highly Disperse Poly(ethylene oxide) in Rat via Microsolid Phase Extraction and RPLC-Q-Q-TOF Coupled with the MSALL Technique

Zhi Zhang, Hui Jiang, Yuyao Zhang, Di Zhang, J. Paul Fawcett, Jingkai Gu

Analytical Chemistry

DOI

2020

Simultaneous determination of ferulic acid, paeoniflorin, and albiflorin in rat plasma by ultra‐high performance liquid chromatography with tandem mass spectrometry: Application to a pharmacokinetic study of Danggui‐Shaoyao‐San

Heyun Zhu, Jiao Guan, Hui Zhang, Sheng Chang, Liming Wang, Jianyi Shi, Bo Feng, Jingkai Gu

Journal of Separation Science

DOI

2020

Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals

Zhi Long Zhang, Yuyao Zhang, Shiwen Song, Lei Yin, Dong Sheng Sun, Jingkai Gu

Journal of Separation Science

DOI

2020

Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein

Tingting Wang, Yingjie Guo, Yang He, Tianming Ren, Lei Yin, J. Paul Fawcett, Jingkai Gu, Sun Huimin

Acta Pharmaceutica Sinica B

DOI

2020

A Pharmacodynamic Study of CN-218, a Novel Antiplatelet and Antithrombotic Agent Primarily Targeting the P2Y12 Receptor

Xiaohua Li, Peng Liu, Zhiping Xu, Dong Sun, Jingkai Gu, Yujia Miao, Jujin Zhang, Xia Cao

Cardiovascular Drugs and Therapy

DOI

2019

脂质体药代动力学分析方法研究进展

张志，张瑀峣，顾景凯

《中国医药工业杂志》

DOI

2019

Synthesis, bioconversion, pharmacokinetic and pharmacodynamic evaluation of N-isopropyl-oxy-carbonyloxymethyl prodrugs of CZh-226, a potent and selective PAK4 inhibitor

Jing Guo, Tingting Wang, Tianxiao Wu, Kehan Zhang, Wenbo Yin, Mingyue Zhu, Yu Pang, Chenzhou Hao, Zhonggui He, Maosheng Cheng, Yang Liu, Jiang Zheng, Jingkai Gu, Dongmei Zhao

European Journal of Medicinal Chemistry

DOI

2019

Simultaneous determination of eight bioactive constituents of Zhi‐Zi‐Hou‐Po decoction in rat plasma by ultra high performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study

Heyun Zhu, Jiao Guan, Jianyi Shi, Pan Xu, Sheng Chang, Tianyi Zhang, Bo Feng, Jingkai Gu

Journal of Separation Science

DOI

2019

Uptake and release profiles of PEGylated liposomal doxorubicin nanoparticles: A comprehensive picture based on separate determination of encapsulated and total drug concentrations in tissues of tumor-bearing mice

Hao Wang, Zheng Mi, Jingyi Gao, Jing Wang, Qi Zhang, J. Paul Fawcett, Yang He, Jingkai Gu

Talanta

DOI

2019

Comparative pharmacokinetic study of PEGylated gemcitabine and gemcitabine in rats by LC-MS/MS coupled with pre-column derivatization and MSALL technique

Lei Yin, Tianming Ren, Shiying Zhao, Meiyun Shi, Jingkai Gu

Talanta

DOI

2019

Liquid chromatography tandem mass spectrometry with triple stage fragmentation for highly selective analysis and pharmacokinetics of alarelin in rat plasma

Zhi Zhang, Runzhi Li, Shihao Liu, Lei Yin, Tongtong Xu, J. Paul Fawcett, Jingkai Gu

Journal of Separation Science

DOI

2019

Ultrahigh-throughput absolute quantitative analysis of linezolid in human plasma by direct analysis in real time mass spectrometry without chromatographic separation and its application to a pharmacokinetic study

Lei Yin, Yixuan Feng, Jin Tong, Zhiqiong Guo, Yuyao Zhang, Qi Zhang, Yantong Sun, J. Paul Fawcett, Jingkai Gu

Analytical and Bioanalytical Chemistry

DOI

2019

Enhanced Platelet Response to Clopidogrel in Zucker Diabetic Fatty Rats due to Impaired Clopidogrel Inactivation by Carboxylesterase 1 and Increased Exposure to Active Metabolite

Hongwei Yao, Ruifeng Bai, Tianming Ren, Yani Wang, Jingkai Gu, Yingjie Guo

Drug Metabolism and Disposition

DOI

2019

Development and application of a high-throughput liquid chromatography–tandem mass spectrometric method for the simultaneous determination of thymosin α1 and its recombinant human form in plasma and urine

Tingting Wang, Lei Yin, Hao Wang, J. Paul Fawcett, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2019

Absorption, distribution, metabolism and excretion of the biomaterials used in Nanocarrier drug delivery systems

Chong Su, Yingze Liu, Runzhi Li, Wei Wu, J. Paul Fawcett, Jingkai Gu

Advanced Drug Delivery Reviews

DOI

2018

Micro-solid phase extraction and LC–MS3 for the determination of triptorelin in rat plasma and application to a pharmacokinetic study

Tianming Ren, Zhi Zhang, J. Paul Fawcett, Dong Sheng Sun, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2018

Study on antiplatelet effect of a new thiophenopyridine platelets P2Y12 receptor antagonist DV-127

Zhiping Xu, Jingkai Gu, Mingyue Gao, Na Du, Peng Liu, Xueyu Xu, Jiayu Wang, Xia Cao

Thrombosis Research

DOI

2018

A Unique Collision-Induced Dissociation Reaction of Cholamine Derivatives of Certain Prostaglandins

Dong Sheng Sun, Chong Su, Yingze Liu, Xiangjun Meng, J. Paul Fawcett, Yingjie Guo, Jingkai Gu

Journal of the American Society for Mass Spectrometry

DOI

2018

Poly (l-glutamic acid)-g-methoxy poly (ethylene glycol)-gemcitabine conjugate improves the anticancer efficacy of gemcitabine

Chenguang Yang, Wantong Song, Dawei Zhang, Haiyang Yu, Lei Yin, Na Shen, Mingxiao Deng, Zhaohui Tang, Jingkai Gu, Xuesi Chen

International Journal of Pharmaceutics

DOI

2018

Analytical methods for investigating in vivo fate of nanoliposomes: A review

Chong Su, Yingze Liu, Yang He, Jingkai Gu

Journal of Pharmaceutical Analysis

DOI

2018

Bioanalysis of free and liposomal Amphotericin B in rat plasma using solid phase extraction and protein precipitation followed by LC-MS/MS

Chong Su, Hong Fei Yang, Hui Sun, J. Paul Fawcett, Dong Sheng Sun, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2018

Establishment of a Charge Reversal Derivatization Strategy to Improve the Ionization Efficiency of Limaprost and Investigation of the Fragmentation Patterns of Limaprost Derivatives Via Exclusive Neutral Loss and Survival Yield Method

Dong Sheng Sun, Xiangjun Meng, Tianming Ren, J. Paul Fawcett, Hualu Wang, Jingkai Gu

Journal of the American Society for Mass Spectrometry

DOI

2018

The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines

Wenhai Lin, Lei Yin, Tingting Sun, Tingting Wang, Zhigang Xie, Jingkai Gu, Xiabin Jing

Biomacromolecules

DOI

2018

Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry

Chunsu Liang, Hui Sun, Xiangjun Meng, Lei Yin, J. Paul Fawcett, Huai-Dong Yu, Ting Liu, Jingkai Gu

Acta Pharmaceutica Sinica B

DOI

2018

Differential mobility spectrometry followed by tandem mass spectrometry with multiple ion monitoring for bioanalysis of eptifibatide in rat plasma

Tianming Ren, Runzhi Li, Xiangjun Meng, J. Paul Fawcett, Dong Sheng Sun, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2018

Simultaneous quantitative analysis of retagliptin and its main active metabolite in human multiple matrices by liquid chromatography tandem mass spectrometry

Xiangjun Meng, Lanlan Cai, Tianming Ren, Dong Sheng Sun, Jingkai Gu

Analytical Methods

DOI

2018

[Pharmacokinetics of Phosphate Retagliptin Tabletin in Patients with Renal Dysfunction].

Chao Hu, Jing Juan Zheng, Jia Miao, Fang Liu, Tingting Hu, Jingkai Gu, Shiqing Shu, Ying Wang, Xiaohong Zhu, Maozhi Liang

PubMed

2017

基于质谱技术的贝伐珠单抗及其糖基化修饰的表征、定量与药代动力学分析

丛宇婷，胡良海，叶明亮，顾景凯，邹汉法

《分析化学》

2017

A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study

Chong Su, Hui Sun, Hong Fei Yang, Lei Yin, Jiwen Zhang, J. Paul Fawcett, Jingkai Gu

Analytical and Bioanalytical Chemistry

DOI

2017

Differential mobility spectrometry tandem mass spectrometry with multiple ion monitoring for the bioanalysis of liraglutide

Xiangjun Meng, Haitong Xu, Zhi Zhang, J. Paul Fawcett, Junru Li, Yan Yang, Jingkai Gu

Analytical and Bioanalytical Chemistry

DOI

2017

Simultaneous quantitative analysis of polyethylene glycol (PEG), PEGylated paclitaxel and paclitaxel in rats by MS/MSALL technique with hybrid quadrupole time-of-flight mass spectrometry

Heping Sun, Qi Zhang, Zhi Zhang, Jin Tong, Dafeng Chu, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2017

Development and Application of an MSALL-Based Approach for the Quantitative Analysis of Linear Polyethylene Glycols in Rat Plasma by Liquid Chromatography Triple-Quadrupole/Time-of-Flight Mass Spectrometry

Xiaotong Zhou, Xiangjun Meng, Longmei Cheng, Chong Su, Yantong Sun, Lingxia Sun, Zhaohui Tang, J. Paul Fawcett, Yan Yang, Jingkai Gu

Analytical Chemistry

DOI

2017

Analysis of therapeutic monoclonal antibody glycoforms by mass spectrometry for pharmacokinetics study

Yuting Cong, Lianghai Hu, Zhang Zhang, Yin Han Gao, Mingming Dong, Hongqiang Qin, Mingliang Ye, Jingkai Gu, Hanfa Zou

Talanta

DOI

2017

MS All strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra

Lei Yin, Chong Su, Tianming Ren, Xiangjun Meng, Meiyun Shi, J. Paul Fawcett, Mengliang Zhang, Wei Hu, Jingkai Gu

The Analyst

DOI

2016

Determination of rabeprazole enantiomers in dog plasma by supercritical fluid chromatography tandem mass spectrometry and its application to a pharmacokinetic study

Chong Su, Hong Fei Yang, Xiangjun Meng, J. Paul Fawcett, Jianming Cao, Yan Yang, Jingkai Gu

Journal of Separation Science

DOI

2016

Effect of Polymorphisms inCYP3A4, PPARA, NR1I2, NFKB1, ABCG2andSLCO1B1on the Pharmacokinetics of Lovastatin in Healthy Chinese Volunteers

Gui-Lian Zhao, Mei Liu, Xiujun Wu, Guofei Li, Feng Qiu, Jingkai Gu, Limei Zhao

Pharmacogenomics

DOI

2016

A Parallel-Column LC–MS/MS Method for High-Throughput Analysis of Eight Antiepileptic Drugs in Clinical Therapeutic Drug Monitoring

Lei Yin, Meiyun Shi, Tingting Wang, Miaomin Zhang, Xiaojun Zhao, Ying Zhang, Jingkai Gu

Chromatographia

DOI

2016

Synthesis and Pharmacokinetic Study of Three Gemfibrozil Salts: An Exploration of the Structure–Property Relationship

Qiuhong Yang, Tianming Ren, Yang Song, Xiaoqin Li, Yingnan Chi, Yan Yang, Jingkai Gu, Changwen Hu

Crystal Growth & Design

DOI

2016

Influences of CYP2D6*10 polymorphisms on the pharmacokinetics of iloperidone and its metabolites in Chinese patients with schizophrenia: a population pharmacokinetic analysis

Qi Pei, Lu Huang, Jie Huang, Jingkai Gu, Yun Kuang, Xiao‐cong Zuo, Junjie Ding, Hongyi Tan, Chengxian Guo, Shikun Liu, Guoping Yang

Acta Pharmacologica Sinica

DOI

2016

Rapid and sensitive liquid chromatography with tandem mass spectrometry method for the simultaneous quantification of yonkenafil and its major metabolites in rat plasma

Heping Sun, Jiang Wang, Yantong Sun, Wenwen Peng, Lingxia Sun, Yan Yang, Jingkai Gu

Journal of Separation Science

DOI

2016

A novel prodrug strategy to improve the oral absorption of O-desmethylvenlafaxine

Mingyuan Liu, Yantong Sun, Sen Zhao, Youxin Li, Riyang Piao, Yan Yang, Jingkai Gu

Experimental and Therapeutic Medicine

DOI

2016

Significant Improvement of Metabolic Characteristics and Bioactivities of Clopidogrel and Analogs by Selective Deuteration

Xueyu Xu, Xue Zhao, Zhichao Yang, Hao Wang, Xiangjun Meng, Chong Su, Mingyuan Liu, J. Paul Fawcett, Yan Yang, Jingkai Gu

Molecules

DOI

2016

Simultaneous quantitation of the diastereoisomers of scholarisine and 19‐epischolarisine, vallesamine, and picrinine in rat plasma by supercritical fluid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study

Zhichao Yang, Lingxia Sun, Chunsu Liang, Yongwei Xu, Jianming Cao, Yan Yang, Jingkai Gu

Journal of Separation Science

DOI

2016

Sodium Salts and Solvate of Rebamipide: Synthesis, Structure, and Pharmacokinetic Study

Yingnan Chi, Chuanrong Liu, Tianming Ren, Xiaoying Wang, Qiuhong Yang, Zhichao Yang, Yan Yang, Yang Song, Jingkai Gu, Changwen Hu

Crystal Growth & Design

DOI

2016

Simultaneous analysis of gemfibrozil, morphine, and its two active metabolites in different mouse brain structures using solid‐phase extraction with ultra‐high performance liquid chromatography and tandem mass spectrometry with a deuterated internal standard

Zizhao Yang, Lu Wang, Mingcheng Xu, Jingkai Gu, Lushan Yu, Su Zeng

Journal of Separation Science

DOI

2016

Development and validation of an enantioselective SFC-MS/MS method for simultaneous separation and quantification of oxcarbazepine and its chiral metabolites in beagle dog plasma

Zhichao Yang, Xueyu Xu, Lingxia Sun, Xue Zhao, Hao Wang, J. Paul Fawcett, Yan Yang, Jingkai Gu

Journal of Chromatography B

DOI

2016

A Bioequivalence Test by the Direct Comparison of Concentration-versus-Time Curves Using Local Polynomial Smoothers

Suyan Tian, Howard H. Chang, Dana E. Orange, Jingkai Gu, Mayte Suárez‐Fariñas

Computational and Mathematical Methods in Medicine

DOI

2016

Development of a GC-MS method for the determination and pharmacokinetics of trans-π-oxocamphor after intravenous administration of Vitacamphorae injection in rat

Chunsu Liang, Zhichao Yang, Xiangjun Meng, Lei Yin, J. Paul Fawcett, Can Wang, Yan Yang, Jian Wang, Jingkai Gu

Analytical Methods

DOI

2015

酶切型稳定同位素标记肽段为内标用于药物代谢酶的绝对定量分析

刘喜东，丛宇婷，胡良海，张养军，顾景凯，钱小红

《分析化学》

2015

基于蛋白质组学的药物代谢酶与转运体定量分析研究进展

杨波，王静，丛宇婷，胡良海，顾景凯

《药学学报》

2015

Simultaneous determination of carboprost methylate and its active metabolite carboprost in dog plasma by liquid chromatography–tandem mass spectrometry with positive/negative ion-switching electrospray ionization and its application to a pharmacokinetic study

Lei Yin, Xiangjun Meng, Xiaotong Zhou, Tinglan Zhang, Heping Sun, Zhichao Yang, Bo Yang, Ning Xiao, J. Paul Fawcett, Yan Yang, Jingkai Gu

Journal of Chromatography B

DOI

2015

Simultaneous determination of ten antiepileptic drugs in human plasma by liquid chromatography and tandem mass spectrometry with positive/negative ion‐switching electrospray ionization and its application in therapeutic drug monitoring

Lei Yin, Tingting Wang, Meiyun Shi, Ying Zhang, Xiaojun Zhao, Yan Yang, Jingkai Gu

Journal of Separation Science

DOI

2015

An LC-MS/MS method to determine PABA and DIP

Lei Yin, Junfeng Yang, Xiangjun Meng, Bo Yang, Chong Su, Zhichao Yang, Mi Zheng, Limei Zhao, Jingkai Gu, Guijie Xin

Analytical Methods

DOI

2015

Application of A High-Throughput, Parallel HPLC System for Quantitative Chiral Analysis of Pantoprazole

Hao Wang, Yantong Sun, Yan Yang, Wei Feng Guo, Zheng Mi, Weiping Zhang, J. Paul Fawcett, Jingkai Gu

Bioanalysis

DOI

2015

Liquid chromatography–tandem mass spectrometry method for simultaneous determination of valproic acid and its ene-metabolites in epilepsy patient plasma

Huan Lu, Chong Su, Lei Yin, Liqiang Gu, Jingkai Gu, Xiaohui Chen

Journal of Pharmaceutical Analysis

DOI

2015

Quantitative MS analysis of therapeutic mAbs and their glycosylation for pharmacokinetics study

Yuting Cong, Zhang Zhang, Shen Zhang, Lianghai Hu, Jingkai Gu

PROTEOMICS - CLINICAL APPLICATIONS

DOI

2015

Simultaneous quantitation of two diastereoisomers of lobaplatin in rat plasma by supercritical fluid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study

Xiangjun Meng, Bo Yang, Jingyi Gao, Wenwen Peng, Hao Wang, Meiyun Shi, Russell J. Mortishire‐Smith, Yan Yang, Jingkai Gu

Journal of Separation Science

DOI

2015

Simultaneous Quantification of Simvastatin and Simvastatin Acid in Human Plasma with a Highly Sensitive LC-ESI-MS/MS Method: Application to a Pharmacokinetic Study in Healthy Chinese Volunteers with a Fixed Dose of Simvastatin and Extended-Release Niacin Combination Tablet

Qiuying Li, Yan Gong Yang, Guobing Shi, Jie Zhang, Guo‐Qing Li, Yin Sui, Yunbiao Tang, Jingkai Gu

Current Pharmaceutical Analysis

DOI

2015

Three Candesartan Salts with Enhanced Oral Bioavailability

Yingnan Chi, Wenting Xu, Yan Yang, Zhichao Yang, Hongjin Lv, Yang Song, Zhengguo Lin, Jikun Li, Jingkai Gu, Craig L. Hill, Changwen Hu

Crystal Growth & Design

DOI

2015

Determination of lansoprazole enantiomers in dog plasma by column‐switching liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study

Hao Wang, Yantong Sun, Xiangjun Meng, Bo Yang, Jian Wang, Yan Yang, Jingkai Gu

Journal of Separation Science

DOI

2015

Pharmacokinetics, Pharmacodynamics, and Tolerability of Single and Multiple Doses of Trandolapril, an Effective Angiotensin-Converting Enzyme Inhibitor, in Healthy Chinese Subjects

Xiaojiao Li, Chang Liu, Min Wu, Hong Zhang, Yanfu Sun, Longmei Cheng, Hong Chen, Chengjiao Liu, Lizhi Yang, Qi Zhang, Yuchen Cao, Jingkai Gu, Yanhua Ding

European Journal of Drug Metabolism and Pharmacokinetics

DOI

2015

Pharmacokinetic Properties of Single- and Multiple-Dose Pitavastatin Calcium Tablets in Healthy Chinese Volunteers

Zhu Luo, Yunhui Zhang, Jingkai Gu, Ping Feng, Ying Wang

Current Therapeutic Research

DOI

2015

Determination of thymopentin in beagle dog blood by liquid chromatography with tandem mass spectrometry and its application to a preclinical pharmacokinetic study

Meiyun Shi, Yan Yang, Xiaotong Zhou, Lanlan Cai, Chunxue Fang, Can Wang, Heping Sun, Yantong Sun, Yin Han Gao, Jingkai Gu, J. Paul Fawcett

Journal of Separation Science

DOI

2015

Single- and Multiple-Dose Pharmacokinetics and Tolerability of Limaprost in Healthy Chinese Subjects

Hong Chen, Qi Zhang, Xiaojiao Li, Hong Zhang, Yanfu Sun, Lei Yin, Chengjiao Liu, Yuchen Cao, Jingkai Gu, Yanhua Ding

Clinical Drug Investigation

DOI

2015

Quantification of Niacin and Its Metabolite Nicotinuric Acid in Human Plasma by LC-MS/MS: Application to a Clinical Trial of a Fixed Dose Combination Tablet of Niacin Extended-Release/Simvastatin (500 mg/10 mg) in Healthy Chinese Volunteers

Pingping Zhang, Yantong Sun, Guobing Shi, Yin Sui, Qiuying Li, Yunbiao Tang, Jingkai Gu

International Journal of Analytical Chemistry

DOI

2014

5种雌激素类化合物的电喷雾四级杆飞行时间质谱裂解规律研究

张婷岚，史美云，邸欣，顾景凯

《药学学报》

DOI

2014

基于蛋白质组学的细胞色素P450和葡萄糖醛酸转移酶亚型绝对定量分析

刘喜东，朱俊，丛宇婷，胡良海，叶明亮，顾景凯，邹汉法

《分析化学》

2014

Pharmacokinetics of escin Ia in rats after intravenous administration

Xiujun Wu, Xiangyong Cui, Liantian Tian, Feng Gao, Xin Guan, Jingkai Gu

Journal of Ethnopharmacology

DOI

2014

Dissolution and pharmacokinetic properties of two paliperidone cocrystals with 4-hydroxybenzoic and 4-aminobenzoic acid

Tingting Zhang, Yan Yang, Xiaojun Zhao, Jiangtao Jia, Hongmin Su, Hongming He, Jingkai Gu, Guangshan Zhu

CrystEngComm

DOI

2014

Determination of a deuterohemin–peptide conjugate in rat plasma by liquid chromatography–tandem mass spectrometry and application to a preclinical pharmacokinetic study

Hao Wang, Yantong Sun, Wei Feng Guo, Chunxue Fang, J. Paul Fawcett, Wei Li, Yin Han Gao, Yan Yang, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2014

Quantitative analysis of cytochrome P450 isoforms in human liver microsomes by the combination of proteomics and chemical probe‐based assay

Xidong Liu, Lianghai Hu, Guang‐Bo Ge, Bo Yang, Jing Ning, Shixin Sun, Ling Yang, Klaus Pors, Jingkai Gu

PROTEOMICS

DOI

2014

Corrigendum to “Rapid and sensitive LC–MS/MS assay for the quantitation of 20(S)-protopanaxadiol in human plasma” [J. Chromatogr. B 877 (5–6) (2009) 581–585]

Dan Zhang, Yingwu Wang, Jiangbin Han, Weisong Yu, Lili Deng, J. Paul Fawcett, Zeyuan Liu, Jingkai Gu

Journal of Chromatography B

DOI

2014

A rapid and sensitive UFLC-MS/MS method for the simultaneous determination of gentiopicroside and swertiamarin in rat plasma and its application in pharmacokinetics

Bo Feng, Heyun Zhu, Jiao Guan, Longshan Zhao, Jingkai Gu, Lei Yin, J. Paul Fawcett, Wenshu Liu

Journal of Pharmacy and Pharmacology

DOI

2014

Amorphous solid dispersion of berberine with absorption enhancer demonstrates a remarkable hypoglycemic effect via improving its bioavailability

Zhaojie Meng, Ming Zhang, Wei Shengnan, Bi Xiaojia, Grant Michael Hatch, Jingkai Gu, Chen Li

International Journal of Pharmaceutics

DOI

2014

Pharmacokinetic study of calenduloside E and its active metabolite oleanolic acid in beagle dog using liquid chromatography–tandem mass spectrometry

Meiyun Shi, Yan Yang, Yantong Sun, Longmei Cheng, Sen Zhao, Huibo Xu, J. Paul Fawcett, Xiaobo Sun, Jingkai Gu

Journal of Chromatography B

DOI

2014

Absolute Quantification of Cytochrome P450 and Uridine-Diphosphate Glucuronosyl Transferase Isoforms by Proteomics-based Approach

Xi-Dong LIU, Jun Zhu, Yuting Cong, Lianghai Hu, Mingliang Ye, Jingkai Gu, Hanfa Zou

Chinese Journal of Analytical Chemistry

DOI

2014

Trantinterol, a Novel β2-Adrenoceptor Agonist, Noncompetitively Inhibits P-Glycoprotein Functionin Vitroandin Vivo

Tingting Wang, Yantong Sun, Wenxiao Ma, Zhichao Yang, Junfeng Yang, Jingrui Liu, Hong-Bo Fan, Yan Yang, Jingkai Gu, J. Paul Fawcett, Yingjie Guo

Molecular Pharmaceutics

DOI

2014

LC-MS/MS method for the quantitation of cefotetan in human plasma and its application to pharmacokinetic study

Meiyun Shi, Lei Yin, Lanlan Cai, Can Wang, Xidong Liu, Sen Zhao, Yantong Sun, Paul Fawcett, Limei Zhao, Yan Yang, Jingkai Gu

Chemical Research in Chinese Universities

DOI

2014

Simultaneous determination of temozolomide acid and its hexyl ester in plasma by LC-MS/MS: application to the first pharmacokinetic study of temozolomide hexyl ester in rats

Yunhui Zhang, Yantong Sun, Qun He, Jiangbin Han, Meiyun Shi, Chunxue Fang, J. Paul Fawcett, Yan Yang, Jingkai Gu

Analytical Methods

DOI

2013

从国家自然科学基金资助项目看我国药物分析学科的发展

马利萍，顾景凯，曾苏

《药物分析杂志》

2013

电喷雾四极杆飞行时间质谱研究紫杉醇类药物的裂解规律

马文晓，王浩，王婷婷，杨艳，顾景凯

《药学学报》

DOI

2013

Comparative pharmacokinetics and the bioavailability of escin Ib and isoescin Ib following the administration of escin, pure escin Ib and isoescin Ib in rats

Xiujun Wu, Mengliang Zhang, Xiangyong Cui, J. Paul Fawcett, Jingkai Gu

Journal of Ethnopharmacology

DOI

2013

Phenolic Esters of O-Desmethylvenlafaxine with Improved Oral Bioavailability and Brain Uptake

Yang Zhang, Yan Yang, Sen Zhao, Zhichao Yang, Hong Yang, J. Paul Fawcett, Youxin Li, Jingkai Gu, Tiemin Sun

Molecules

DOI

2013

Using Dissolution and Pharmacokinetics Studies of Crystal Form to Optimize the Original Iloperidone

Tingting Zhang, Yan Yang, Haitao Wang, Fuxing Sun, Xiaojun Zhao, Jiangtao Jia, Jingrui Liu, Wei Feng Guo, Xiaoqiang Cui, Jingkai Gu, Guangshan Zhu

Crystal Growth & Design

DOI

2013

pH Dictates the Release of Hydrophobic Drug Cocktail from Mesoporous Nanoarchitecture

Faheem Muhammad, Aifei Wang, Mingyi Guo, Jianyun Zhao, Wenxiu Qi, Guo Yingjie, Jingkai Gu, Guangshan Zhu

ACS Applied Materials & Interfaces

DOI

2013

Determination of Prostaglandin E1 in dog plasma using liquid chromatography–tandem mass spectrometry and its application to a pharmacokinetic study

Yunhui Zhang, Yantong Sun, Guoqing Li, Lei Yin, Tingting Wang, Yan Yang, Jingkai Gu

Journal of Chromatography B

DOI

2013

Evaluation of calcipotriol transdermal permeation through pig, rat and mouse skin using liquid chromatography–tandem mass spectrometry

Xiaojiao Li, Jing Wang, Guoqing Li, Changqing Lin, Xueju Zhang, Yantong Sun, Yan Xiong Yang, Jingkai Gu

Biomedical Chromatography

DOI

2013

A liquid chromatography–tandem mass spectrometric method for the simultaneous quantitation of five components of Ixeris sonchifoliain (Bge.) Hance in rat plasma and its application to a pharmacokinetic study

Lei Yin, Meiyun Shi, Yantong Sun, Xiaocheng Sun, Huan Meng, J. Paul Fawcett, Yan Yang, Jingkai Gu

Journal of Chromatography B

DOI

2013

Ternary system of dihydroartemisinin with hydroxypropyl-β-cyclodextrin and lecithin: Simultaneous enhancement of drug solubility and stability in aqueous solutions

Dan Wang, Hai-Yan Li, Jingkai Gu, Tao Guo, Shuo Yang, Zhen Guo, Xueju Zhang, Weifeng Zhu, Jiwen Zhang

Journal of Pharmaceutical and Biomedical Analysis

DOI

2013

Simultaneous analysis of codeine and its active metabolites in human plasma using liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study after oral administration of codeine

Xiujun Wu, Weiping Zhang, Yin Bai, Tao Guo, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2013

A highly selective probe for human cytochrome P450 3A4: isoform selectivity, kinetic characterization and its applications

Guang‐Bo Ge, Jing Ning, Lianghai Hu, Ziru Dai, Jie Hou, Yun‐Feng Cao, Zhenwen Yu, Chun‐Zhi Ai, Jingkai Gu, Xiaochi Ma, Ling Yang

Chemical Communications

DOI

2012

Determination of thalidomide concentration in human plasma by liquid chromatography-tandem mass spectrometry

Nan Bai, Xiangyong Cui, Jin Wang, CHUN-GUANG SUN, Hekun Mei, Beibei Liang, Yun Cai, XIU-JIE SONG, Jingkai Gu, Rui Wang

Experimental and Therapeutic Medicine

DOI

2012

Quantitation of bivalirudin, a novel anticoagulant peptide, in human plasma by LC–MS/MS: Method development, validation and application to pharmacokinetics

Xiao‐Jiao Li, Yantong Sun, Lei Yin, Zhang Xue-ju, Yan Yang, J. Paul Fawcett, Yimin Cui, Jingkai Gu

Journal of Pharmaceutical Analysis

DOI

2012

Ultra-sensitive assay for paclitaxel in intracellular compartments of A549 cells using liquid chromatography–tandem mass spectrometry

Tingting Wang, Wenxiao Ma, Yantong Sun, Yan Yang, Weiping Zhang, J. Paul Fawcett, Hongwei Du, Jingkai Gu

Journal of Chromatography B

DOI

2012

Pharmacokinetics and bioavailability of cimicifugosides after oral administration of Cimicifuga foetida L. extract to rats

Yunyun Gai, Wanhui Liu, Chunjie Sha, Yinglin Wang, Sun Yan-tong, Xiao‐Jiao Li, J. Paul Fawcett, Jingkai Gu

Journal of Ethnopharmacology

DOI

2012

Protein target discovery of drug and its reactive intermediate metabolite by using proteomic strategy

Lianghai Hu, J. Paul Fawcett, Jingkai Gu

Acta Pharmaceutica Sinica B

DOI

2012

A Single-Center, Randomized, Open-Label, Dose-Escalation Study to Evaluate the Pharmacokinetics of Tacrine Analogue Octahydrogenacridine Succinate Tablets in Healthy Chinese Subjects

Xia Zhao, Yan Liang, Junyu Xu, Dongmei Zhang, Depu Wang, Jingkai Gu, Yimin Cui

Biological and Pharmaceutical Bulletin

DOI

2011

Determination of landiolol, an ultra-short-acting β1-receptor antagonist, in human plasma by liquid chromatography–tandem mass spectrometry

Qun He, Meiyun Shi, Xidong Liu, Yantong Sun, Lianghai Hu, Yan Yang, J. Paul Fawcett, Jingkai Gu, Limei Zhao

Journal of Chromatography B

DOI

2011

Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rat

Xiujun Wu, Mengliang Zhang, Xiangyong Cui, Feng Gao, Qun He, Xiao‐Jiao Li, Jiwen Zhang, J. Paul Fawcett, Jingkai Gu

Journal of Ethnopharmacology

DOI

2011

Characterization and mapping of the multi-component release kinetics of a Traditional Chinese Medicine dosage form using a modified LC/MS/MS method and chemomic release kinetic theory

Haiyan Li, Xiangyong Cui, Feng Gao, Peter York, Qun Shao, Xianzhen Yin, Tao Guo, Zhen Guo, Jingkai Gu, Jiwen Zhang

Acta Pharmaceutica Sinica B

DOI

2011

Simultaneous Determination of Escin Ia and Its Isomer Isoescin Ia by LC–MS–MS: Application to a Pharmacokinetic Study of Escin Ia in Rats

Mengliang Zhang, Xiujun Wu, Xiangyong Cui, Feng Gao, Chao Zhang, Yan Yang, Jingkai Gu

Chromatographia

DOI

2011

Determination of repaglinide in human plasma by high-performance liquid chromatography–tandem mass spectrometry

Jie Zhang, Feng Gao, Xin Guan, Yantong Sun, Jingkai Gu, J. Paul Fawcett

Acta Pharmaceutica Sinica B

DOI

2011

Development and Validation of an Improved Method for the Quantitation of Sertraline in Human Plasma using LC-MS-MS and Its Application to Bioequivalence Studies

Mengliang Zhang, Feng Gao, X. Cui, Yu Zhang, Yonghai Sun, Jingkai Gu, Yonghai Sun

Journal of Chromatographic Science

DOI

2011

Pharmacokinetics, Pharmacodynamics, Tolerability and Safety of Single Doses of Bivalirudin in Healthy Chinese Subjects

Dongmei Zhang, Zining Wang, Xia Zhao, Wei Lu, Jingkai Gu, Yimin Cui

Biological and Pharmaceutical Bulletin

DOI

2011

Effect of Dining on the Pharmacokinetics of Losartan

Fang Yi, Jingkai Gu

Zhongguo yaofang

2010

LC–MS–MS Determination of Troxerutin in Plasma and Its Application to a Pharmacokinetic Study

Xiangyong Cui, Mengliang Zhang, Xin Guan, Lei Yin, Yantong Sun, J. Paul Fawcett, Jingkai Gu

Chromatographia

DOI

2010

Pharmacokinetics of felbinac after intravenous administration of felbinac trometamol in rats

Chao Zhang, Xiangyong Cui, Yan Yang, Feng Gao, Yantong Sun, Jingkai Gu, J. Paul Fawcett, Wei Yang, Wei Wang

Xenobiotica

DOI

2010

A liquid chromatography–tandem mass spectrometry method for the simultaneous quantification of escin Ia and escin Ib in human plasma: application to a pharmacokinetic study after intravenous administration

Lidong Liu, Xiujun Wu, Dan Wu, Yingwu Wang, Pengfei Li, Yantong Sun, Yan Yang, Jingkai Gu, Yimin Cui

Biomedical Chromatography

DOI

2010

Research of Traditional Chinese Medicine in Terms of Herbalomics

Haiyan Li, Guo Zhen, Peter York, Qun Shao, Jingkai Gu, Zhang Jiwen

World Science and Technology

DOI

2010

Validated LC–MS/MS method for the determination of sarpogrelate in human plasma: Application to a pharmacokinetic and bioequivalence study in Chinese volunteers

Chao Zhang, Lu Wang, Yan Jun Yang, Yantong Sun, Jie Zhang, Guoqing Li, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2010

Simultaneous analysis of isomers of escin saponins in human plasma by liquid chromatography–tandem mass spectrometry: Application to a pharmacokinetic study after oral administration

Xiujun Wu, Lidong Liu, Mengliang Zhang, Dan Wu, Yingwu Wang, Yantong Sun, J. Paul Fawcett, Jingkai Gu, Jiwen Zhang

Journal of Chromatography B

DOI

2010

Effect of Trantinterol on Cytochrome P450 Enzymes

Jingkai Gu

Journal of Jilin University(Science Edition)

2009

Simultaneous quantitation of hydrochlorothiazide and metoprolol in human plasma by liquid chromatography–tandem mass spectrometry

Feng Gao, Mengliang Zhang, Xiangyong Cui, Zhonghua Wang, Yantong Sun, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2009

Simultaneous quantitation of paracetamol, caffeine, pseudoephedrine, chlorpheniramine and cloperastine in human plasma by liquid chromatography–tandem mass spectrometry

Hao Li, Chao Zhang, Jiang Wang, Yao Jiang, J. Paul Fawcett, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2009

Determination of silodosin in human plasma by liquid chromatography–tandem mass spectrometry

Xia Zhao, Yuwang Liu, Jun‐Yu Xu, Dan Zhang, Ying Fang Zhou, Jingkai Gu, Yimin Cui

Journal of Chromatography B

DOI

2009

Quantitation of the tacrine analogue octahydroaminoacridine in human plasma by liquid chromatography–tandem mass spectrometry

Jiangbin Han, Shuang Jiang, Xiangyong Cui, Yantong Sun, Guoqing Li, Jiwen Zhang, J. Paul Fawcett, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2009

Validated LC–MS/MS assay for the determination of felbinac: Application to a preclinical pharmacokinetics study of felbinac trometamol injection in rat

Chao Zhang, Lu Wang, Wei Yang, Xisha Wang, J. Paul Fawcett, Yantong Sun, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2009

Pharmacokinetics of 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol and its active metabolite after oral and intravenous administration in rat

X. Zhang, Jinghua Xu, D. Zhang, Jingkai Gu, Yuqing Zhao

Xenobiotica

DOI

2009

Rapid and sensitive assay for trantinterol, a novel β2-adrenoceptor agonist, in human plasma using liquid chromatography–tandem mass spectrometry

Yantong Sun, Mingyuan Liu, Jiwen Zhang, Yao Jiang, Weisong Yu, J. Paul Fawcett, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2009

Rapid and sensitive LC–MS/MS assay for the quantitation of 20(S)-protopanaxadiol in human plasma

Dan Zhang, Yingwu Wang, Jiangbin Han, Weisong Yu, Lili Deng, J. Paul Fawcett, Zeyuan Liu, Jingkai Gu

Journal of Chromatography B

DOI

2008

Quantitation of bergenin in human plasma by liquid chromatography/tandem mass spectrometry

Weisong Yu, Yingwu Wang, Yunhui Zhang, Dan Zhang, Jing Lan, Zeyuan Liu, Jingkai Gu, J. Paul Fawcett

Journal of Chromatography B

DOI

2008

Simultaneous Nonchiral Determination of Artemisinin and Arteannuin B in Artemisia annua Using Circular Dichroism Detection

Jing Chen, Jingkai Gu, Rui Zhao, Ronghua Dai, Jinhui Wang

Chromatographia

DOI

2008

Application of Chemomic Release Kinetics to Evaluation of the Release Characteristics of Yinqiaojiedu Tablets

Libing Chen, Zhonghua Wang, Dan-Dan FU, Ling Die, Weihong Ge, Jingkai Gu, Peter York, Qun Shao, Jiwen Zhang

Chinese Journal of Natural Medicines

DOI

2008

Determination of Acetonitrile Volume Fraction in Mobile Phase by HPLC

Yi Wu, Zhiwu Wang, Jingkai Gu, Yingwu Wang

Chemical Research in Chinese Universities

DOI

2008

Determination of Ranolazine in Human Plasma by Liquid Chromatographic--Tandem Mass Spectrometric Assay

Limei Zhao, Hao Li, Yiqun Jiang, R. Piao, P. Li, Jingkai Gu

Journal of Chromatographic Science

DOI

2008

Liquid chromatographic–tandem mass spectrometric method for the simultaneous quantitation of telmisartan and hydrochlorothiazide in human plasma

Tingting Yan, Hao Li, Lili Deng, Yingjie Guo, Weisong Yu, J. Paul Fawcett, Dan Zhang, Yimin Cui, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2008

A rapid and sensitive LC–MS/MS assay to quantify yonkenafil in rat plasma with application to preclinical pharmacokinetics studies

Jiang Wang, Yao Jiang, Yingwu Wang, Yunbiao Tang, Guosheng Teng, J. Paul Fawcett, Jian Kong, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2008

Determination of ecabet in human plasma by high-performance liquid chromatography–tandem mass spectrometry

Dan Zhang, Xiaolin Du, Mingyuan Liu, Hao Li, Yao Jiang, Limei Zhao, Jingkai Gu

Journal of Chromatography B

DOI

2008

Novel Theory and Methods for Chemomic Multi-component Release/Dissolution Kinetics of Traditional Chinese Medicine

Jiwen Zhang, Libing Chen, Jingkai Gu, Weihong Ge, Yang Ming

Chinese Journal of Natural Medicines

DOI

2007

Simultaneous quantitation of dexamethasone palmitate and dexamethasone in human plasma by liquid chromatography/tandem mass spectrometry

Yan Yang, Hao Li, Kan Gao, Mingyuan Liu, Yantong Sun, Tingting Yan, J. Paul Fawcett, Yimin Cui, Jingkai Gu

Journal of Chromatography B

DOI

2007

Determination of long‐acting release octreotide, an octapeptide analogue of somatostation, in human plasma by liquid chromatography/tandem mass spectrometry

Yao Jiang, Jiang Wang, Yingwu Wang, Xiaolin Du, Yunhui Zhang, J. Paul Fawcett, Jingkai Gu

Rapid Communications in Mass Spectrometry

DOI

2007

Quantitation of iptakalim in human plasma by high-performance liquid chromatography–tandem mass spectrometry

Guosheng Teng, Yingwu Wang, Yunbiao Tang, Rui Wang, Yi Fang, J. Paul Fawcett, Jingkai Gu

Journal of Chromatography B

DOI

2007

Rapid and Sensitive LC-MS/MS Method for Quantification of Fexofenadine in Human Plasma —– Application to a Bioequivalence Study in Chinese Volunteers

Guosheng Teng, Lesheng Teng, Yi Wu, Yongzhong Tang, L Liu, Jingkai Gu

Chemical Research in Chinese Universities

DOI

2007

Determination of 25-OH-PPD in rat plasma by high-performance liquid chromatography–mass spectrometry and its application in rat pharmacokinetic studies

Xiangrong Zhang, Dan Zhang, Jinghua Xu, Jingkai Gu, Yuqing Zhao

Journal of Chromatography B

DOI

2007

Liquid Chromatography-Electrospray Quadrupole Linear Ion Trap Mass Spectrometric Method for Quantitation of Domperidone in Chinese Healthy Volunteers

Yi Wu, Y CHU, Yao‐Sheng Zhang, Dejun Wu, Jingkai Gu

Chemical Research in Chinese Universities

DOI

2007

Highly sensitive assay for tiotropium, a quaternary ammonium, in human plasma by high‐performance liquid chromatography/tandem mass spectrometry

Jiang Wang, Yao Jiang, Yingwu Wang, Hao Li, J. Paul Fawcett, Jingkai Gu

Rapid Communications in Mass Spectrometry

DOI

2007

A liquid chromatography/tandem mass spectrometry method for the simultaneous quantification of valsartan and hydrochlorothiazide in human plasma

Hao Li, Yingwu Wang, Yao Jiang, Yunbiao Tang, Jiang Wang, Limei Zhao, Jingkai Gu

Journal of Chromatography B

DOI

2007

Liquid chromatographic–electrospray tandem mass spectrometric determination of bisoprolol in human plasma

Mingyuan Liu, Dan Zhang, Yantong Sun, Yingwu Wang, Zeyuan Liu, Jingkai Gu

Biomedical Chromatography

DOI

2007

Liquid chromatography tandem mass spectrometry assay to determine the pharmacokinetics of aildenafil in human plasma

Jiang Wang, Yao Jiang, Yingwu Wang, Xia Zhao, Yimin Cui, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2007

Quantitation of Armillarisin A in human plasma by liquid chromatography–electrospray tandem mass spectrometry

Yan Wang, Yingwu Wang, Pengfei Li, Yunbiao Tang, J. Paul Fawcett, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2006

Rapid and sensitive liquid chromatography–tandem mass spectrometry method for the quantitation of colchicine in human plasma

Yao Jiang, Jiang Wang, Yingwu Wang, Hao Li, J. Paul Fawcett, Jingkai Gu

Journal of Chromatography B

DOI

2006

Determination of clarithromycin in human plasma by liquid chromatography–electrospray ionization tandem mass spectrometry

Yao Jiang, Jiang Wang, Hao Li, Yingwu Wang, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2006

Determination of miglitol in human plasma by liquid chromatography/tandem mass spectrometry

Xin Li, Yingwu Wang, Jiang Wang, J. Paul Fawcett, Limei Zhao, Jingkai Gu

Rapid Communications in Mass Spectrometry

DOI

2006

Liquid chromatographic/tandem mass spectrometric method for the quantitation of tranilast in human plasma

Jing Lan, Jian Wang, Dan Wu, Yingwu Wang, J. Paul Fawcett, Jingkai Gu

Rapid Communications in Mass Spectrometry

DOI

2006

Pharmacokinetics of Huperzine A in Dogs Following Single Intravenous and Oral Administrations

Dafeng Chu, Wanhui Liu, Youxin Li, Pengfei Li, Jingkai Gu, Ke Liu

Planta Medica

DOI

2005

Autosampler Programming for Improved Sample Throughput in Liquid Chromatography/Mass Spectrometry

Yingwu Wang, Dafang Zhong, J. Paul Fawcett, Jingkai Gu

Clinical Chemistry

DOI

2005

Determination of omeprazole in human plasma by liquid chromatography–electrospray quadrupole linear ion trap mass spectrometry

Jian Wang, Yingwu Wang, J. Paul Fawcett, Yan Wang, Jingkai Gu

Journal of Pharmaceutical and Biomedical Analysis

DOI

2005

Characterization of the pharmacokinetics of dioscin in rat

Kong M. Li, Y TANG, J. Paul Fawcett, Jingkai Gu, Dafang Zhong

Steroids

DOI

2005

Rapid and sensitive liquid chromatography–tandem mass spectrometry method for the quantitation of levodropropizine in human plasma

Yunbiao Tang, Limei Zhao, Yingwu Wang, J. Paul Fawcett, Jingkai Gu

Journal of Chromatography B

DOI

2005

Determination of dioscin in rat plasma by liquid chromatography–tandem mass spectrometry

Ke Li, Yingwu Wang, Jingkai Gu, Xiaoyan Chen, Dafang Zhong

Journal of Chromatography B

DOI

2005

Determination of Metformin in Human Plasma by Liquid Chromatography-tandem Mass Spectrometric Assay

Jingkai Gu

2004

电喷雾四级杆飞行时间质谱法在分析青霉素类药物负离子裂解规律中的应用

郑岩，王英武，周慧，顾景凯

《分析化学》

2004

电喷雾电离-四极杆飞行时间质谱法研究三种β2-受体激动剂的质谱裂解特征

王英武，顾景凯，王玲，陈刚

《质谱学报》

2004

Liquid chromatographic–tandem mass spectrometric method for the quantitation of huperzine A in dog plasma

Yingwu Wang, Dafeng Chu, Jingkai Gu, J. Paul Fawcett, Yi Wu, Wanhui Liu

Journal of Chromatography B

DOI

2003

三唑仑苯二氮燐类药物的电喷雾质谱裂解特征

李馨，王英武，顾景凯，钟大放，王玲，陈刚

《分析化学》

2003

电喷雾-串联四极杆-飞行时间质谱法分析寡肽的一级结构

王英武，王玲，顾景凯，陈刚，钟大放，周慧

《分析化学》

2003

Determination of ketotifen and its conjugated metabolite in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study

Xiaoyan Chen, Dafang Zhong, Dan Liu, Yingwu Wang, Ying Han, Jingkai Gu

Rapid Communications in Mass Spectrometry

DOI

2003

Sensitive liquid chromatographic assay for the simultaneous determination of 5-fluorouracil and its prodrug, tegafur, in beagle dog plasma

Dafeng Chu, Jingkai Gu, Wanhui Liu, J. Paul Fawcett, Qingguang Dong

Journal of Chromatography B

DOI

2002

Isolation and identification of the glucuronide of 4-(3H-1,2-dihydro-1-pyrrolizinone-2-methylamino)benzoic acid from rabbit urine

Qingguang Dong, Jingkai Gu, Dafang Zhong, J. Paul Fawcett, Dafeng Chu

Journal of Chromatography B

DOI

2002

[Identification of estazolam, alprazolam and triazolam in human urine by LC/MSn].

Jingkai Gu, Rong Xia, Dafang Zhong, Lu Sun

PubMed

1999

用电喷雾离子阱质谱法分析生物样品中艾司唑仑及其主要代谢物

顾景凯，钟大放，姜浩，陈笑艳

《药物分析杂志》

精选作品

期刊论文

Multi-kinetic analysis reveals drug release and structural dissociation behaviors of paclitaxel-loaded polymeric micelles

Self-Assembly Orchestrates Bidirectional Pharmacokinetics Between a Hydrophobic Drug and its Amphiphilic-Polymer Carrier

Deciphering the In Vivo Metabolism of Polyethylene Glycol by a Polymeromics Approach

Deciphering the In Vivo Fate of PEGylated rhGH via a Molecular Ruler-Based MS Strategy

The impact of the DiI fluorescent probe on the in vivo fate of paclitaxel-loaded methoxy polyethylene glycol-block-poly (d,l-lactide) micelles

Deciphering the biological fate of mRNA-LNP-based biologics: A perspective from tissue to intracellular distribution

Unraveling metabolic complexity of multi-payload PEG-irinotecan prodrug: A deconvolution-based LC-Q-TOF MS approach for preclinical pharmacokinetic characterization

Deciphering the in vivo fate and biomacromolecular interactions of DSPE-PEG2000.

Clopidogrel-indobufen conjugates as dual antiplatelet prodrugs with enhanced bioactivation and synchronized pharmacokinetic-pharmacodynamic profiles in rats.

Label-Free Analysis Reveals In Vivo Premature Drug Release Governed by Diffusion from Polymeric Micelles

Full-profile bioanalysis of polydisperse macromolecular hydroxyethyl starch 130/0.4 in rat plasma via LC-IS-CID coupled with MRM

Pharmacokinetics, tissue distribution and metabolism of hydroxyethyl starch 130/0.4 in rats

基于淋巴系统的药物及其递送系统研究进展

纳米药物递送系统体内命运分析新方法与新技术研究进展

Real-time platelet P2Y12 receptor occupancy as a promising pharmacodynamics biomarker for bridging the gap between PK/PD of clopidogrel therapy

Pharmacokinetic/Pharmacodynamic Assessment of the Structural Refinement of Clopidogrel Focusing on the Balance between Bioactivation and Deactivation

Quantitatively analyzing the dissociation and release of disulfide-containing organic nanoparticles.

Advanced bioanalytical techniques for pharmacokinetic studies of nanocarrier drug delivery systems

Overcoming the challenge of potent endogenous interferences in limaprost quantification: An innovative methodology combining differential mobility spectrometry with LC-MS/MS for ultra-high sensitivity, selectivity and significantly enhanced throughput

纳米药物药代动力学研究——专栏致辞

Special Section on New and Emerging Areas and Technologies in Drug Metabolism and Disposition, Part I — Minireview Bioanalytical Assays for Pharmacokinetic and Biodistribution Study of Antibody-Drug Conjugates

Simultaneous separation and analysis of multiple doxorubicin hydrochloride liposomes forms in serum by circular nonuniform electric field gel electrophoresis

Differential Mobility Spectrometry-Tandem Mass Spectrometry with Multiple Ion Monitoring Coupled with in Source-Collision Induced Dissociation: A New Strategy for the Quantitative Analysis of Pharmaceutical Polymer Excipients in Rat Plasma

Bioanalytical Assays for Pharmacokinetic and Biodistribution Study of Antibody-Drug Conjugates

Identification, structure elucidation and origin of a common pyridinium-thiocyanate intermediate in electrospray mass spectrometry among the benziamidazole-class proton pump inhibitors

Full-profile pharmacokinetics, anticancer activity and toxicity of an extended release trivalent PEGylated irinotecan prodrug

Identification and high-throughput quantification of baicalein and its metabolites in plasma and urine

Pharmacokinetic Study of Conjugated Equine Estrogens in Healthy Chinese Postmenopausal Women Using a Parallel Two-Column LC–MS/MS Method

Antibiotics-Induced Disruption of Gut Microbiota Increases Systemic Exposure of Clopidogrel Active Metabolite in Type 2 Diabetic Rats

Evaluation of efficacy and safety after replacement of methyl hydrogen with deuterium at methyl formate of Clopidogrel

Biological fate and interaction with cytochromes P450 of the nanocarrier material, d-α-tocopheryl polyethylene glycol 1000 succinate

The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems

纳米药物非临床药代动力学的研究策略及关注要点

High-throughput and trace analysis of diazepam in plasma using DART-MS/MS and its pharmacokinetic application

High‐throughput bioanalysis of sitagliptin in plasma using direct analysis in real time mass spectrometry and its application in the pharmacokinetic study thereof

Disposition and fate of polyoxyethylene glycerol ricinoleate as determined by LC-Q-TOF MS coupled with MSALL, SWATH and HR MS/MS techniques

The biological fate of the polymer nanocarrier material monomethoxy poly(ethylene glycol)-block-poly(d,l-lactic acid) in rat

A Novel, Differential Mobility Spectrometry Tandem Mass Spectrometric Method for the in Vivo Quantitation of Ursolic Acid

Type 2 diabetes mellitus decreases systemic exposure of clopidogrel active metabolite through upregulation of P-glycoprotein in rats

Current status of in vivo bioanalysis of nano drug delivery systems

Comprehensive Bioanalysis of Ultrahigh Molecular Weight, Highly Disperse Poly(ethylene oxide) in Rat via Microsolid Phase Extraction and RPLC-Q-Q-TOF Coupled with the MSALL Technique

Simultaneous determination of ferulic acid, paeoniflorin, and albiflorin in rat plasma by ultra‐high performance liquid chromatography with tandem mass spectrometry: Application to a pharmacokinetic study of Danggui‐Shaoyao‐San

Recent advances in the bioanalytical methods of polyethylene glycols and PEGylated pharmaceuticals

Impact of molecular weight on the mechanism of cellular uptake of polyethylene glycols (PEGs) with particular reference to P-glycoprotein

A Pharmacodynamic Study of CN-218, a Novel Antiplatelet and Antithrombotic Agent Primarily Targeting the P2Y12 Receptor

脂质体药代动力学分析方法研究进展

Synthesis, bioconversion, pharmacokinetic and pharmacodynamic evaluation of N-isopropyl-oxy-carbonyloxymethyl prodrugs of CZh-226, a potent and selective PAK4 inhibitor

Simultaneous determination of eight bioactive constituents of Zhi‐Zi‐Hou‐Po decoction in rat plasma by ultra high performance liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study

Uptake and release profiles of PEGylated liposomal doxorubicin nanoparticles: A comprehensive picture based on separate determination of encapsulated and total drug concentrations in tissues of tumor-bearing mice

Comparative pharmacokinetic study of PEGylated gemcitabine and gemcitabine in rats by LC-MS/MS coupled with pre-column derivatization and MSALL technique

Liquid chromatography tandem mass spectrometry with triple stage fragmentation for highly selective analysis and pharmacokinetics of alarelin in rat plasma

Ultrahigh-throughput absolute quantitative analysis of linezolid in human plasma by direct analysis in real time mass spectrometry without chromatographic separation and its application to a pharmacokinetic study

Enhanced Platelet Response to Clopidogrel in Zucker Diabetic Fatty Rats due to Impaired Clopidogrel Inactivation by Carboxylesterase 1 and Increased Exposure to Active Metabolite

Development and application of a high-throughput liquid chromatography–tandem mass spectrometric method for the simultaneous determination of thymosin α1 and its recombinant human form in plasma and urine

Absorption, distribution, metabolism and excretion of the biomaterials used in Nanocarrier drug delivery systems

Micro-solid phase extraction and LC–MS3 for the determination of triptorelin in rat plasma and application to a pharmacokinetic study

Study on antiplatelet effect of a new thiophenopyridine platelets P2Y12 receptor antagonist DV-127

A Unique Collision-Induced Dissociation Reaction of Cholamine Derivatives of Certain Prostaglandins

Poly (l-glutamic acid)-g-methoxy poly (ethylene glycol)-gemcitabine conjugate improves the anticancer efficacy of gemcitabine

Analytical methods for investigating in vivo fate of nanoliposomes: A review

Bioanalysis of free and liposomal Amphotericin B in rat plasma using solid phase extraction and protein precipitation followed by LC-MS/MS

Establishment of a Charge Reversal Derivatization Strategy to Improve the Ionization Efficiency of Limaprost and Investigation of the Fragmentation Patterns of Limaprost Derivatives Via Exclusive Neutral Loss and Survival Yield Method

The Effect of Molecular Structure on Cytotoxicity and Antitumor Activity of PEGylated Nanomedicines

Separation and simultaneous quantitation of PGF2α and its epimer 8-iso-PGF2α using modifier-assisted differential mobility spectrometry tandem mass spectrometry

Differential mobility spectrometry followed by tandem mass spectrometry with multiple ion monitoring for bioanalysis of eptifibatide in rat plasma

Simultaneous quantitative analysis of retagliptin and its main active metabolite in human multiple matrices by liquid chromatography tandem mass spectrometry

[Pharmacokinetics of Phosphate Retagliptin Tabletin in Patients with Renal Dysfunction].

基于质谱技术的贝伐珠单抗及其糖基化修饰的表征、定量与药代动力学分析

A validated UPLC-MS/MS method coupled with protein precipitation and ion exchange solid phase extraction for the quantitation of porcine relaxin B29 in dog plasma and its application to a pharmacokinetic study

Differential mobility spectrometry tandem mass spectrometry with multiple ion monitoring for the bioanalysis of liraglutide

Simultaneous quantitative analysis of polyethylene glycol (PEG), PEGylated paclitaxel and paclitaxel in rats by MS/MSALL technique with hybrid quadrupole time-of-flight mass spectrometry

Development and Application of an MSALL-Based Approach for the Quantitative Analysis of Linear Polyethylene Glycols in Rat Plasma by Liquid Chromatography Triple-Quadrupole/Time-of-Flight Mass Spectrometry

Analysis of therapeutic monoclonal antibody glycoforms by mass spectrometry for pharmacokinetics study

MS All strategy for comprehensive quantitative analysis of PEGylated-doxorubicin, PEG and doxorubicin by LC-high resolution q-q-TOF mass spectrometry coupled with all window acquisition of all fragment ion spectra

Determination of rabeprazole enantiomers in dog plasma by supercritical fluid chromatography tandem mass spectrometry and its application to a pharmacokinetic study

Effect of Polymorphisms inCYP3A4, PPARA, NR1I2, NFKB1, ABCG2andSLCO1B1on the Pharmacokinetics of Lovastatin in Healthy Chinese Volunteers

A Parallel-Column LC–MS/MS Method for High-Throughput Analysis of Eight Antiepileptic Drugs in Clinical Therapeutic Drug Monitoring

Synthesis and Pharmacokinetic Study of Three Gemfibrozil Salts: An Exploration of the Structure–Property Relationship