百晓学者学者目录

寇晓娣

博士生导师、教授、研究员、硕士生导师，天津中医药大学

精选作品

期刊论文

2026

Cu2+-selective porphyrin probes with multifunctional anti-AD activities and the structural-activity insights from X-ray single crystal analysis.

Jie Zhi, Hui-Xin Feng, Qingyan Xue, Zi Pang, Rui Shen, Ai-Hon Yang, Xiao-Di Kou

European journal of medicinal chemistry

DOI

2026

Construction and anti-Alzheimer’s disease potential of gallic acid-mediated berberine-metal self-assemblies

Lijun Zhang, Xiang Zhou, Jianhua Wu, Huiyan Wang, Aolin Zhang, Rui Shen, Ai-Hon Yang, Xiao-Di Kou

Journal of Molecular Structure

DOI

2026

Zinc-porphyrin complex as multifunctional anti-AD agent: Synthesis, X-ray single crystal analysis and activity study.

Xiang Zhou, Lijun Zhang, Jie Zhi, Lihua Zhao, Rui Shen, Ai-Hon Yang, Xiao-Di Kou

Journal of Inorganic Biochemistry

DOI

2025

Carrier-free nanoparticles—new strategy of improving druggability of natural products

Yaqi Yao, Zhen-Na Xu, Haoran Ding, Shen-Shen Yang, Bo-Han Chen, Mengjiao Zhou, Yehan Zhu, Ai-Hon Yang, Xing-Xu Yan, Chen-Rui Liang, Xiao-Di Kou, Bo Chen, Wei Huang, Yu-Bo Li

Journal of Nanobiotechnology

DOI

2025

From natural isoflavone to multitarget ligand: biochanin A derivatives with multifunctional activities against Alzheimer's Disease

Xinjie Jiang, Yiyi Sun, Xiaoyue Yi, Tong Liu, Yunhua Wang, Rui Shen, Ai-Hon Yang, Xiao-Di Kou

Journal of Molecular Structure

DOI

2025

Novel Biochanin A Carbamate Derivatives as Multifunctional Anti‐Alzheimer's Disease Metal Chelators: Design, Synthesis, and Activity Evaluation

Yiyi Sun, Xinjie Jiang, Xiaoyue Yi, Cai-Yun Wang, Xiang-Yu Zhang, Rui Shen, Ai-Hon Yang, Xiao-Di Kou

Chemistry and Biodiversity

DOI

2025

Design, synthesis, biological evaluation, and X‐ray single crystal structure of novel computer‐aided‐drug‐designbased α‐mangostin derivatives: Multifunctional ligands against Alzheimer's disease

Quanzhen Chen, Xiangyu Li, Wenting Xiao, Yiyi Sun, Rui Shen, Xiao-Di Kou, Ai-Hon Yang

Archiv der Pharmazie

DOI

2025

Study on the structure–activity relationships of natural γ-pyranone products and their derivatives with anti-AD activities focusing on metal chelation

Jun-Yi Mao, Cai-Yun Wang, Xiangyu Li, Ruihao Du, Xiang-Yu Zhang, Rui Shen, Ai-Hon Yang, Xiao-Di Kou

Molecular diversity

DOI

2024

Diosmetin derivatives as multifunctional anti‐AD ligands: Design, synthesis, and biological evaluation

Ai-Hon Yang, Xiaoyue Yi, Hongwei Zhang, Rui Shen, Xiao-Di Kou

Chemical Biology and Drug Design

DOI

2024

The new multidrug crystal of berberine and naringenin based on the couplet medicine of TCM: crystal structure, physicochemical property, and synergistic anti-AD effect

Wenting Xiao, Xinyan Zou, Lijun Zhang, Rui Shen, Ai-Hon Yang, Xiao-Di Kou

Journal of Molecular Structure

DOI

2024

Study of multifunctional anti-AD ligands: design, synthesis, X-ray crystal structure and biological evaluation of diosmetin derivatives

Ai-Hon Yang, Xiaoyue Yi, Hongwei Zhang, Quanzhen Chen, Rui Shen, Xiao-Di Kou

Molecular diversity

DOI

2023

A Review on the Natural Components Applied as Lead Compounds for Potential Multi-target Anti-AD Theranostic Agents.

Xiao-Di Kou, Xuliu Shi, Zi Pang, Ai-Hon Yang, Rui Shen, Li-Hua Zhao

Current Medicinal Chemistry

DOI

2023

Emodin derivatives as promising multi-aspect intervention agents for amyloid aggregation: molecular docking/dynamics simulation, bioactivities evaluation, and cytoprotection

Rui Shen, Wenshuang Zhao, Xiangyu Li, Juanjuan Liu, Ai-Hon Yang, Xiao-Di Kou

Molecular diversity

DOI

2023

A coumarin-based multifunctional chemosensor for Cu2+/Al3+ as an AD theranostic agent: Synthesis, X-ray single crystal analysis and activity study.

Xiao-Di Kou, Chengting Hu, Zi Pang, Xinyu Zhang, Huiyan Wang, Rui Shen, Ai-Hon Yang

Analytica Chimica Acta

DOI

2022

Study on the novel usnic acid derivatives: design, synthesis, X-Ray crystal structure of Cu(II) complex and anti-AD activities

Ai-Hon Yang, Wenjing Liu, Xiangyu Li, Wanru Wu, Xiao-Di Kou, Rui Shen

Journal of Molecular Structure

DOI

2022

Corrigendum to "Multifunctional fluorescence sensor as a potential theranostic agent against Alzheimer's disease" [Spectrochim. Acta Part A: Molec. Biomolec. Spectrosc. 267 (2022) 120587].

Xiao-Di Kou, Xingying Li, Chengting Hu, Juanjuan Liu, Yuhong Chen, Yang Zhang, Ai-Hon Yang, Rui Shen

Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy

DOI

2022

Novel coumarin derivatives as multifunctional anti-AD agents: Design, synthesis, X-ray crystal structure and biological evaluation

Ai-Hon Yang, Hongwei Zhang, Chengting Hu, Xi Wang, Rui Shen, Xiao-Di Kou, Huiyan Wang

Journal of Molecular Structure

DOI

2022

A multifunctional anti-AD approach: Design, synthesis, X-ray crystal structure, biological evaluation and molecular docking of chrysin derivatives.

Ai-Hon Yang, Chang Liu, Hongwei Zhang, J Wu, Rui Shen, Xiao-Di Kou

European journal of medicinal chemistry

DOI

2022

A multifunctional metal regulator as the potential theranostic agent: Design, synthesis, anti-AD activities and metallic ion sensing properties.

Xiao-Di Kou, Chengting Hu, Xuliu Shi, Xingying Li, Ai-Hon Yang, Rui Shen

Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy

DOI

2022

Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal framework as a synergistic anti-AD agent.

Rui Shen, Yuhong Chen, Xiangyu Li, Xi Wang, Ai-Hon Yang, Xiao-Di Kou

International journal of pharmaceutics

DOI

2022

Study on Multi-target Synergistic Treatment of Alzheimer's Disease Based on Metal Chelators.

Ai-Hon Yang, J Wu, Yuhong Chen, Rui Shen, Xiao-Di Kou

Current Drug Targets

DOI

2022

Synthesis, single crystal characterization and anti-AD activities of a novel complex of Cu(II) with in situ formed protonated chrysin derivative ligand

Chang Liu, Jianhua Wu, Chengting Hu, Ai‐Hong Yang, Rui Shen, Xiaodi Kou

Journal of Inorganic Biochemistry

DOI

2021

Multifunctional fluorescence sensor as a potential theranostic agent against Alzheimer's disease.

Xiao-Di Kou, Xing-Ying Li, Chengting Hu, Juanjuan Liu, Yuhong Chen, Yang Zhang, Ai-Hon Yang, Rui Shen

Spectrochimica Acta Part A - Molecular and Biomolecular Spectroscopy

DOI

2021

Novel chrysin derivatives as hidden multifunctional agents for anti-Alzheimer's disease: design, synthesis and in vitro evaluation.

Chang Liu, Xiao-Di Kou, Xi Wang, Jian-Hua Wu, Ai-Hon Yang, Rui Shen

European Journal of Pharmaceutical Sciences

DOI

2021

Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease.

Jia-Rui Wu, Xiao-Di Kou, Hui Ju, Hong-Wei Zhang, Ai-Hon Yang, Rui Shen

Bioorganic & Medicinal Chemistry Letters

DOI

2021

A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease.

Ai-Hon Yang, Chang Liu, Jia-Rui Wu, Xiao-Di Kou, Rui Shen

European Journal of Pharmacology

DOI

2021

Emodin derivatives with multi-factor anti-AD activities: AChE inhibitor, anti-oxidant and metal chelator

Xiao-Di Kou, Juanjuan Liu, Yu-Hong Chen, Ai-Hon Yang, Rui Shen

DOI

2020

Design, Synthesis and Biological Evaluation of Xanthone Derivatives for Possible Treatment of Alzheimer's Disease Based on Multi‐Target Strategy

Ai-Hon Yang, Qiao Yu, Hui Ju, Lu-Lu Song, Xiao-Di Kou, Rui Shen

Chemistry and Biodiversity

DOI

2019

Design, synthesis and anti-Alzheimer's disease activity study of xanthone derivatives based on multi-target strategy.

Xiao-Di Kou, Lu-Lu Song, Yunhua Wang, Qiao Yu, Hui Ju, Ai-Hon Yang, Rui Shen

Bioorganic & Medicinal Chemistry Letters

DOI

会议论文

2022

香豆素衍生物的设计合成及抗AD活性研究

汪明萌，缪雨菲，毛骏祎，杨爱红，申蕊，寇晓娣

《2022国际阿尔茨海默病及相关病学术大会论文集》

DOI

2022

以异优散酮为先导物的多靶点抗AD配体设计、合成及生物活性研究

王茂青，李祥宇，赵文爽，申蕊，杨爱红，寇晓娣

《2022国际阿尔茨海默病及相关病学术大会论文集》

DOI

预印本

2026

Deciphering the Compatibility Mechanism of Traditional Chinese Medicine Formulae via Network Proximity Analysis and Multi-Dimensional Weighted Modeling: A Case Study of Kaixinsan for Inhibiting AD Neuronal Apoptosis

Jiale Ren, Yifang Luo, Qi Wu, Xueqian Guo, Weiwei Xue, Husileng Hai, Guiying Wen, Xiaodi Kou, Zhen Yang, Bo Kang, Yanjun Zhang

SSRN Electronic Journal

DOI

研究方向

中药活性成分合成与结构修饰神经退行性疾病多靶点治疗诊断

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