王育才

2026

Two-step screening of lipid-polymer nanoparticles for efficient mRNA vaccine delivery and cancer immunotherapy

Nano Today

DOI

2026

Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors

Science

DOI

2026

Engineering Polymer–Lipid Integrated Nanoparticles with Quantitative Design Principles for Organ-Selective mRNA Delivery

Journal of the American Chemical Society

DOI

2026

Host biology as a determinant of in vivo delivery and its translational potential

Clinical and Translational Medicine

DOI

2026

Engineering a dual-antigen mRNA vaccine to restore immune control in chronic hepatitis B

Nature Communications

DOI

2026

Nanoparticles reach metastatic tumours via enhanced permeability of adjacent vessels

Nature Nanotechnology

DOI

2025

Intracellular Co-Delivery of Carbon Monoxide and Nitric Oxide Induces Mitochondrial Apoptosis for Cancer Therapy.

Angewandte Chemie

DOI

2025

Enhanced nanoparticle delivery across vascular basement membranes of tumours using nitric oxide

Nature Biomedical Engineering

DOI

2025

Generation of tolerogenic antigen-presenting cells in vivo via the delivery of mRNA encoding PDL1 within lipid nanoparticles

Nature Biomedical Engineering

DOI

2025

A single-chain mRNA vaccine co-expressing GPC and NP provides complete protection against lethal Dabie bandavirus challenge in mice

Molecular Therapy — Nucleic Acids

DOI

2025

cGAS mRNA–Based Immune Agonist Promotes Vaccine Responses and Antitumor Immunity

Cancer Immunology Research

DOI

2025

An mpox quadrivalent mRNA vaccine elicits sustained and protective immunity in mice against lethal vaccinia virus challenge

Emerging Microbes & Infections

DOI

2024

聚合物载体在mRNA递送领域的研究进展

《药学进展》

2024

Symmetrically Fluorinated D‐π‐A Structured Cyanine Dye for Highly Efficient NIR‐II Imaging‐Guided Cancer Phototheranostics

Small

DOI

2024

Helper Lipid-Enhanced mRNA Delivery for Treating Metabolic Dysfunction-Associated Fatty Liver Disease

Nano Letters

DOI

2024

Multicomponent Synthesis of Imidazole-Based Ionizable Lipids for Highly Efficient and Spleen-Selective Messenger RNA Delivery

Journal of the American Chemical Society

DOI

2024

Modular Satellite Nanoparticles for Remedying Primary and Secondary Injury in Cerebral Ischemia‐Reperfusion

Advanced Functional Materials

DOI

2024

基于纳米技术的mRNA递送系统的研究进展

Chinese Science Bulletin (Chinese Version)

DOI

2024

Boosting with Omicron-specific mRNA vaccine or historical SARS-CoV-2 vaccines elicits discriminating immune responses against Omicron variants

Acta Pharmaceutica Sinica B

DOI

2024

Helicity-directed recognition of bacterial phospholipid via radially amphiphilic antimicrobial peptides

Science Advances

DOI

2024

An mpox quadrivalent mRNA vaccine protects mice from lethal vaccinia virus challenge

Antiviral Research

DOI

2024

A potential bivalent mRNA vaccine candidate protects against both RSV and SARS-CoV-2 infections

Molecular Therapy

DOI

2024

Motility and tumor infiltration are key aspects of invariant natural killer T cell anti-tumor function

Nature Communications

DOI

2023

Solid-state atomic hydrogen as a broad-spectrum RONS scavenger for accelerated diabetic wound healing

National Science Review

DOI

2023

Aged-Signal-Eliciting Nanoparticles Stimulated Macrophage-Mediated Programmed Removal of Inflammatory Neutrophils.

ACS Nano

DOI

2023

Nanomedicines with high drug availability and drug sensitivity overcome hypoxia-associated drug resistance.

Biomaterials

DOI

2023

In Situ Albumin-Hitchhiking NIR-II Probes for Accurate Detection of Micrometastases.

Nano letters (Print)

DOI

2023

Overcoming oxygen heterogeneity of tumor microenvironments to boost cancer immunotherapy by oxygen-switchable ROS/RNS nanogenerators

Nano Today

DOI

2023

Pathogen Recognition-Driven Dendritic Cell-Specific Gene Silencing and Editing.

Nano letters (Print)

DOI

2023

Compartmentalized Nano-MOFs as Co-delivery Systems for Enhanced Antitumor Therapy.

ACS Applied Materials and Interfaces

DOI

2023

Engineering tumoral vascular leakiness with gold nanoparticles

Nature Communications

DOI

2023

Ultrahigh Enzyme Loading Metal–Organic Frameworks for Deep Tissue Pancreatic Cancer Photoimmunotherapy

Small

DOI

2023

Cationic Lipids‐Mediated Dual‐Targeting of Both Dendritic Cells and Tumor Cells for Potent Cancer Immunotherapy

Advanced Functional Materials

DOI

2023

Long‐term immune response to Omicron‐specific mRNA vaccination in mice, hamsters, and nonhuman primates

MedComm

DOI

2023

Antigen-caged-adjuvant nanovaccines elicit potent humoral and cellular immune responses

Nano Today

DOI

2023

Breaking through the basement membrane barrier to improve nanotherapeutic delivery to tumours

Nature Nanotechnology

DOI

2023

Construction of carbon dots having aggregation-induced emission and intramolecular charge transfer properties

Dyes and Pigments

DOI

2022

Nitric Oxide Induces Immunogenic Cell Death and Potentiates Cancer Immunotherapy.

ACS Nano

DOI

2022

Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis

Nature Biomedical Engineering

DOI

2022

Enhanced Intracellular Transcytosis of Nanoparticles by Degrading Extracellular Matrix for Deep Tissue Radiotherapy of Pancreatic Adenocarcinoma.

Nano letters (Print)

DOI

2022

Nano-integrated cascade antioxidases opsonized by albumin bypass the blood–brain barrier for treatment of ischemia-reperfusion injury

Biomaterials Science

DOI

2022

Omicron-specific mRNA vaccine elicits potent immune responses in mice, hamsters, and nonhuman primates

Cell Research

DOI

2021

Neutrophil Decoys with Anti‐Inflammatory and Anti‐Oxidative Properties Reduce Secondary Spinal Cord Injury and Improve Neurological Functional Recovery

Advanced Functional Materials

DOI

2021

Hydrogenated Oxide Material for Self‐Targeting and Automatic‐Degrading Photothermal Tumor Therapy in the NIR‐II Bio‐Window

Advanced Functional Materials

DOI

2021

Reversing Immunosuppression in Hypoxic and Immune‐Cold Tumors with Ultrathin Oxygen Self‐Supplementing Polymer Nanosheets under Near Infrared Light Irradiation

Advanced Functional Materials

DOI

2021

Nano-metal-organic-frameworks for treating H2O2-Secreting bacteria alleviate pulmonary injury and prevent systemic sepsis.

Biomaterials

DOI

2021

Phototherapy Facilitates Tumor Recruitment and Activation of Natural Killer T cells for Potent Cancer Immunotherapy.

Nano letters (Print)

DOI

2021

High drug loading and pH-responsive nanomedicines driven by dynamic boronate covalent chemistry for potent cancer immunotherapy

Nano Reseach

DOI

2021

Environmentally Adaptive Shape-Morphing Microrobots for Localized Cancer Cell Treatment

ACS Nano

DOI

2020

Self-Reporting and Splitting Nano-Pomegranates Potentiate Deep Tissue Cancer Radiotherapy via Elevated Diffusion and Transcytosis.

ACS Nano

DOI

2020

Furin‐Instructed Intracellular Gold Nanoparticle Aggregation for Tumor Photothermal Therapy

Advanced Functional Materials

DOI

2020

Protein Binding Affinity of Polymeric Nanoparticles as a Direct Indicator of Their Pharmacokinetics.

ACS Nano

DOI

2020

Bacterial outer membrane vesicles as a platform for biomedical applications: An update.

Journal of Controlled Release

DOI

2020

Pre- and post-irradiation mild hyperthermia enabled by NIR-II for sensitizing radiotherapy.

Biomaterials

DOI

2020

Voluntary‐Opsonization‐Enabled Precision Nanomedicines for Inflammation Treatment

Advances in Materials

DOI

2020

Nanovaccines integrating endogenous antigens and pathogenic adjuvants elicit potent antitumor immunity

Nano Today

DOI

2020

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Nature Communications

DOI

2020

Polyphosphoestered Nanomedicines with Tunable Surface Hydrophilicity for Cancer Drug Delivery

ACS Applied Materials & Interfaces

DOI

2020

Bioinspired Membrane-Disruptive Macromolecules as Drug-Free Therapeutics

ACS Applied Bio Materials

DOI

2019

Near-Infrared II Phototherapy Induces Deep Tissue Immunogenic Cell Death and Potentiates Cancer Immunotherapy.

ACS Nano

DOI

2019

Nano-Clustered Cascaded Enzymes for Targeted Tumor Starvation and Deoxygenation-Activated Chemotherapy without Systemic Toxicity.

ACS Nano

DOI

2019

Ultralong circulating choline phosphate liposomal nanomedicines for cascaded chemo-radiotherapy.

Biomaterials Science

DOI

2019

Pseudo-Neutrophil Cytokine Sponges Disrupt Myeloid Expansion and Tumor Trafficking to Improve Cancer Immunotherapy.

Nano letters (Print)

DOI

2019

Controlled Syntheses of Well-Defined Poly(thionophosphoester)s That Undergo Peroxide-Triggered Degradation

Macromolecules

DOI

2019

Facile syntheses of conjugated polymers for photothermal tumour therapy

Nature Communications

DOI

2019

Nanoenabled Modulation of Acidic Tumor Microenvironment Reverses Anergy of Infiltrating T Cells and Potentiates Anti-PD-1 Therapy.

Nano letters (Print)

DOI

2019

Tumor Reoxygenation and Blood Perfusion Enhanced Photodynamic Therapy using Ultrathin Graphdiyne Oxide Nanosheets.

Nano letters (Print)

DOI

2019

Enzyme-Activable Interferon-Poly(α-amino acid) Conjugates for Tumor Microenvironment Potentiation.

Biomacromolecules

DOI

2019

Microenvironment-activated nanoparticles for oxygen self-supplemented photodynamic cancer therapy

Biomaterials Science

DOI

2019

Au nanoparticles with enzyme-mimicking activity-ornamented ZIF-8 for highly efficient photodynamic therapy

Biomaterials Science

DOI

2019

ROS-sensitive biomimetic nanocarriers modulate tumor hypoxia for synergistic photodynamic chemotherapy

Biomaterials Science

DOI

2018

Hierarchical Multiplexing Nanodroplets for Imaging-Guided Cancer Radiotherapy via DNA Damage Enhancement and Concomitant DNA Repair Prevention.

ACS Nano

DOI

2018

Glucose & oxygen exhausting liposomes for combined cancer starvation and hypoxia-activated therapy.

Biomaterials

DOI

2018

Enzyme Degradable Hyperbranched Polyphosphoester Micellar Nanomedicines for NIR Imaging-Guided Chemo-Photothermal Therapy of Drug-Resistant Cancers.

Biomacromolecules

DOI

2018

PEG conjugated BODIPY-Br2 as macro-photosensitizer for efficient imaging-guided photodynamic therapy.

Journal of materials chemistry. B

DOI

2018

Ultrathin Polypyrrole Nanosheets via Space-Confined Synthesis for Efficient Photothermal Therapy in the Second Near-Infrared Window.

Nano letters (Print)

DOI

2018

Acidity-triggered TAT-presenting nanocarriers augment tumor retention and nuclear translocation of drugs

Nano Reseach

DOI

2018

Cancer Chemoradiotherapy Duo: Nano-Enabled Targeting of DNA Lesion Formation and DNA Damage Response.

ACS Applied Materials and Interfaces

DOI

2018

Optimized nanoparticle-mediated delivery of CRISPR-Cas9 system for B cell intervention

Nano Reseach

DOI

2018

The effect of surface charge on oral absorption of polymeric nanoparticles

Biomaterials Science

DOI

2018

Redox-sensitive dendrimersomes assembled from amphiphilic Janus dendrimers for siRNA delivery

Biomaterials Science

DOI

2018

Adaptive immune cells are necessary for the enhanced therapeutic effect of sorafenib-loaded nanoparticles

Biomaterials Science

DOI

2017

The influence of tumor-induced immune dysfunction on the immune cell distribution of gold nanoparticles in vivo.

Biomaterials Science

DOI

2017

NIR imaging-guided combined photodynamic therapy and chemotherapy by a pH-responsive amphiphilic polypeptide prodrug.

Biomaterials Science

DOI

2017

Sequentially Responsive Shell‐Stacked Nanoparticles for Deep Penetration into Solid Tumors

Advances in Materials

DOI

2017

Ruthenium nitrosyl functionalized graphene quantum dots as an efficient nanoplatform for NIR-light-controlled and mitochondria-targeted delivery of nitric oxide combined with photothermal therapy.

Chemical Communications

DOI

2017

Dipole Orientation Matters: Longer-Circulating Choline Phosphate than Phosphocholine Liposomes for Enhanced Tumor Targeting.

ACS Applied Materials and Interfaces

DOI

2017

Spatial Targeting of Tumor-Associated Macrophages and Tumor Cells with a pH-Sensitive Cluster Nanocarrier for Cancer Chemoimmunotherapy

Nano Letters

DOI

2017

Investigating the Effect of Chemical Structure of Semiconducting Polymer Nanoparticle on Photothermal Therapy and Photoacoustic Imaging

Theranostics

DOI

2017

A micellar cisplatin prodrug simultaneously eliminates both cancer cells and cancer stem cells in lung cancer

Biomaterials Science

DOI

2016

Surface charge critically affects tumor penetration and therapeutic efficacy of cancer nanomedicines

DOI

2016

NIR‐Activated Supersensitive Drug Release Using Nanoparticles with a Flow Core

DOI

2016

A Donor–Acceptor Conjugated Polymer with Alternating Isoindigo Derivative and Bithiophene Units for Near-Infrared Modulated Cancer Thermo-Chemotherapy

ACS Applied Materials & Interfaces

DOI

2016

Overcoming tumor resistance to cisplatin by cationic lipid-assisted prodrug nanoparticles

Biomaterials

DOI

2016

Fluorescent metallacycle-cored polymers via covalent linkage and their use as contrast agents for cell imaging

Proceedings of the National Academy of Sciences

DOI

2015

Promoting tumor penetration of nanoparticles for cancer stem cell therapy by TGF-β signaling pathway inhibition

Biomaterials

DOI

2015

Redox-Responsive Polyphosphoester-Based Micellar Nanomedicines for Overriding Chemoresistance in Breast Cancer Cells

ACS Applied Materials & Interfaces

DOI

2014

Radioactive 198Au-Doped Nanostructures with Different Shapes for In Vivo Analyses of Their Biodistribution, Tumor Uptake, and Intratumoral Distribution

ACS Nano

DOI

2014

Stimuli-Responsive Materials for Controlled Release of Theranostic Agents

Advanced Functional Materials

DOI

2014

Using SV119-Gold Nanocage Conjugates to Eradicate Cancer Stem Cells through a Combination of Photothermal and Chemo Therapies

Advanced Healthcare Materials

DOI

2014

Multiresponsive Polymer Assemblies Achieved by a Subtle Chain Terminal Modification

DOI

2013

Labeling Human Mesenchymal Stem Cells with Gold Nanocages for in vitro and in vivo Tracking by Two-Photon Microscopy and Photoacoustic Microscopy

Theranostics

DOI

2013

A Comparison Study of Gold Nanohexapods, Nanorods, and Nanocages for Photothermal Cancer Treatment

ACS Nano

DOI

2013

Robust synthesis of gold cubic nanoframes through a combination of galvanic replacement, gold deposition, and silver dealloying.

Small

DOI

2013

A thermoresponsive bubble-generating liposomal system for triggering localized extracellular drug delivery.

ACS Nano

DOI

2013

Radioluminescent Gold Nanocages with Controlled Radioactivity for Real-time In Vivo Imaging

Nano letters (Print)

DOI

2013

Evaluation of photothermal therapy of breast cancer with shape-controlled gold nanoparticles with 18F-FDG-PET/CT

2013

Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds

Biomaterials

DOI

2013

Enhanced drug delivery to hepatocellular carcinoma with a galactosylated core–shell polyphosphoester nanogel

Biomaterials Science

DOI

2012

Evaluating the Pharmacokinetics and in vivo Cancer Targeting Capability of Au Nanocages by Positron Emission Tomography Imaging

ACS Nano

DOI

2012

Protein-Protected Au Clusters as a New Class of Nanoscale Biosensors for Label-Free Fluorescence Detection of Proteases with High Sensitivity

Small

DOI

2012

Single-step assembly of cationic lipid-polymer hybrid nanoparticles for systemic delivery of siRNA.

ACS Nano

DOI

2012

Cover Picture: Synthesis and Characterization of Pd@MxCu1−x (M=Au, Pd, and Pt) Nanocages with Porous Walls and a Yolk–Shell Structure through Galvanic Replacement Reactions (Chem. Eur. J. 47/2012)

DOI

2012

In vivo evaluation of 64Cu radiolabeled gold nanocages for cancer PET imaging

2012

Synthesis and characterization of Pd@M(x)Cu(1-x) (M = Au, Pd, and Pt) nanocages with porous walls and a yolk-shell structure through galvanic replacement reactions.

Chemistry

DOI

2012

N-acetylgalactosamine functionalized mixed micellar nanoparticles for targeted delivery of siRNA to liver

Journal of Controlled Release

DOI

2012

Lipase-Sensitive Polymeric Triple-Layered Nanogel for “On-Demand” Drug Delivery

Journal of the American Chemical Society

DOI

2011

Quantifying the Coverage Density of Poly(ethylene glycol) Chains on the Surface of Gold Nanostructures

ACS Nano

DOI

2011

Nanomedicine: swarming towards the target.

Nature Materials

DOI

2011

A system comprising 'signalling' and 'receiving' modules — where the receiving module circulating in the bloodstream is directed to the tumour by a cascade triggered by the signalling module — improves the targeting effect of a nanomedicine.

2011

Syntheses and characterization of block copolymers of poly(aliphatic ester) with clickable polyphosphoester

DOI

2011

SV119-Gold Nanocage Conjugates: A New Platform for Targeting Cancer Cells via Sigma-2 Receptors

Nanoscale

DOI

2011

Nanofiber-mediated controlled release of siRNA complexes for long term gene-silencing applications

Biomaterials

DOI

2011

Doxorubicin-Tethered Responsive Gold Nanoparticles Facilitate Intracellular Drug Delivery for Overcoming Multidrug Resistance in Cancer Cells

ACS Nano

DOI

2011

Redox-Responsive Nanoparticles from the Single Disulfide Bond-Bridged Block Copolymer as Drug Carriers for Overcoming Multidrug Resistance in Cancer Cells

Bioconjugate Chemistry

DOI

2010

Poly(ε-caprolactone)-Block-poly(ethyl Ethylene Phosphate) Micelles for Brain-Targeting Drug Delivery: In Vitro and In Vivo Valuation

Pharmaceutical Research

DOI

2010

One-Pot Syntheses of Amphiphilic Centipede-like Brush Copolymers via Combination of Ring-Opening Polymerization and “Click” Chemistry

DOI

2010

Core–Shell–Corona Micelle Stabilized by Reversible Cross‐Linkage for Intracellular Drug Delivery

Macromolecular Rapid Communications

DOI

2010

Engineering nanoscopic hydrogels via photo-crosslinking salt-induced polymer assembly for targeted drug delivery

Chemical Communications

DOI

2009

Synthesis and Thermoresponsive Behaviors of Biodegradable Pluronic Analogs

DOI

2009

Biodegradable vesicular nanocarriers based on poly(ɛ-caprolactone)-block-poly(ethyl ethylene phosphate) for drug delivery

DOI

2009

Template-free synthesis of biodegradable nanogels with tunable sizes as potential carriers for drug delivery

DOI

2009

Tunable Thermosensitivity of Biodegradable Polymer Micelles of Poly(ε-caprolactone) and Polyphosphoester Block Copolymers

DOI

2009

Synthesis of PEG-Armed and Polyphosphoester Core-Cross-Linked Nanogel by One-Step Ring-Opening Polymerization

DOI

2009

Recent Progress in Polyphosphoesters: From Controlled Synthesis to Biomedical Applications

Macromolecular Bioscience

DOI

2009

Block Copolymer of Polyphosphoester and Poly( l -Lactic Acid) Modified Surface for Enhancing Osteoblast Adhesion, Proliferation, and Function

Biomacromolecules

DOI

2009

Gold Nanoparticles Stabilized by Thermosensitive Diblock Copolymers of Poly(ethylene glycol) and Polyphosphoester

Langmuir

DOI

2009

Shell-Detachable Micelles Based on Disulfide-Linked Block Copolymer As Potential Carrier for Intracellular Drug Delivery

Bioconjugate Chemistry

DOI

2008

Synthesis and characterization of star-shaped block copolymer of poly-(ɛ-caprolactone) and poly(ethyl ethylene phosphate) as drug carrier

DOI

2008

Synthesis and characterization of amphiphilic block copolymer of polyphosphoester and poly(L-lactic acid)

DOI

2008

Synthesis of Amphiphilic ABC 3-Miktoarm Star Terpolymer by Combination of Ring-Opening Polymerization and ``Click'' Chemistry

DOI

2008

Functionalized micelles from block copolymer of polyphosphoester and poly(ɛ-caprolactone) for receptor-mediated drug delivery

Journal of Controlled Release

DOI

2008

Thermoresponsive Block Copolymers of Poly(ethylene glycol) and Polyphosphoester: Thermo-Induced Self-Assembly, Biocompatibility, and Hydrolytic Degradation

Biomacromolecules

DOI

2007

Self-Assembled Micelles of Biodegradable Triblock Copolymers Based on Poly(ethyl ethylene phosphate) and Poly(ϵ-caprolactone) as Drug Carriers

Biomacromolecules

DOI

2006

Kinetics and Mechanism of 2-Ethoxy-2-oxo-1,3,2-dioxaphospholane Polymerization Initiated by Stannous Octoate

DOI

2006

Block Copolymerization of ε-Caprolactone and 2-Methoxyethyl Ethylene Phosphate Initiated by Aluminum Isopropoxide: Synthesis, Characterization, and Kinetics

DOI

2006

Synthesis and Micellization of Amphiphilic Brush−Coil Block Copolymer Based on Poly(ε-caprolactone) and PEGylated Polyphosphoester

Biomacromolecules

DOI