冉冬芝｜重庆医科大学｜学者主页

2026

METTL3-m6A-MALAT1 axis exacerbates the autophagy impairment and lipid accumulation in NAFLD by regulating miR-690

Guowei Zhu, Junqing Yang, Dongzhi Ran, Ying Luo, Yanyi Wang, wenjia guo, Xiaodan Tan, Xiaobing Zhao, Yuanhong Gan, Huafeng Yin, Hong Wang

Biochemical Pharmacology

DOI

2025

Concomitant use of low molecular weight heparin mitigates bortezomib-induced peripheral Neuropathy: Analysis of the FDA adverse event reporting system

Yibei Zhao, Sha Zhang, Jing Huang, Yaji Yang, Dongzhi Ran, Long Meng

European Journal of Pharmacology

DOI

2025

Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats

Laurent F. Martin, Harrison J. Stratton, Lyuba Salih, Nicolas LA. Dumaire, Kimberly Gomez, L. Do, Santiago I. Loya-Lopez, Cheng Tang, Aida Calderon-Rivera, Dongzhi Ran, Venkatrao Nunna, S. Bellampalli, L. François-Moutal, Shizhen Luo, F. Porreca, Mohab Ibrahim, V. Rogemond, Jérôme Honnorat, R. Khanna, Aubin Moutal

Nature Communications

DOI

2024

Nrf1 Reduces COX-2 Expression and Maintains Cellular Homeostasis After Cerebral Ischemia/Reperfusion By Targeting IL-6/TNF-α Protein Production

Jing Yang, Junqing Yang, Ying Luo, Dongzhi Ran, Rongsong Xia, Qixue Zheng, Peishuang Yao, Hong Wang

Journal of Neuroimmune Pharmacology

DOI

2024

Mechanism, and treatment of anti-CV2/CRMP5 autoimmune pain

Laurent Martin, Harrison J. Stratton, Kimberly Gomez, L. Do, Santiago I. Loya-Lopez, Cheng Tang, Aida Calderon-Rivera, Dongzhi Ran, Venkatrao Nunna, S. Bellampalli, L. François-Moutal, N. Dumaire, Lyuba Salih, Shizhen Luo, F. Porreca, Mohab Ibrahim, V. Rogemond, J. Honnorat, Rajesh Khanna, Aubin Moutal

bioRxiv

DOI

2023

ccd3-1改善大鼠神经病理性疼痛的作用研究

刘霞，鲁懿，冉冬芝，涂钰均，王琼，杨俊卿

《中国临床药理学杂志》

2023

A peptidomimetic modulator of the Ca V 2.2 N-type calcium channel for chronic pain

Kimberly Gómez, Ulises Santiago, Tyler S. Nelson, Heather N. Allen, Aida Calderón‐Rivera, Sara Hestehave, Erick Josué Rodríguez-Palma, Yuan Zhou, Paz Duran, Santiago Loya‐López, Elaine Zhu, Upasana Kumar, Rory Shields, Eda Köşeli, Bryan D. Mckiver, Denise Giuvelis, Wanhong Zuo, Kufreobong E. Inyang, Angie Dorame, Aude Chefdeville, Dongzhi Ran, Samantha Perez‐Miller, Yi Lü, Xia Liu, Handoko Handoko, Paramjit S. Arora, Marcel Pátek, Aubin Moutal, May Khanna, Huijuan Hu, Geoffroy O. Laumet, Tamara E. King, Jing Wang, Mohamad Imad Damaj, Olga Anna Korczeniewska, Carlos Jaime Camacho, Rajesh Khanna

Proceedings of the National Academy of Sciences

DOI

2023

Neuropilin-1 Is Essential For VEGFA-Mediated Increase Of Sensory Neuron Activity And Development Of Pain-Like Behaviors

Paz Duran, Kimberly Gomez, Raquel Tonello, Lisa Boinon, Aida Calderon-Rivera, Santiago I. Loya-Lopez, Dongzhi Ran, Nigel W. Bunnett, R. Khanna

Journal of Pain

DOI

2023

A Selective Peptidomimetic Modulator Of Cav2.2 (N-Type) Voltage-Gated Calcium Channels For Chronic Pain

Kimberly Gomez, Ulises Santiago, Aida Calderon-Rivera, Paz Duran, Santiago I. Loya-Lopez, Dongzhi Ran, S. Perez-Miller, H. Handoko, P. Arora, M. Patek, Tamara King, Huijuan Hu, C. Camacho, R. Khanna

Journal of Pain

DOI

2023

Identification and targeting of a unique NaV1.7 domain driving chronic pain

Kimberly Gomez, Harrison J. Stratton, Paz Duran, Santiago Loya, Cheng Tang, Aida Calderon-Rivera, L. François-Moutal, M. Khanna, Cynthia L Madura, Shizhen Luo, Bryan D. Mckiver, Edward Choi, Dongzhi Ran, Lisa Boinon, S. Perez-Miller, M. Damaj, Aubin Moutal, R. Khanna

Proceedings of the National Academy of Sciences of the United States of America

DOI

2022

RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG

Longjie Zhang, Lan Luo, Lifen Xue, Dongzhi Ran, Fang Yan Yang, Qiang Tang, Wengao Jiang

Experimental Neurology

DOI

2022

Distinct Role of Mono-2-ethylhexyl Phthalate in Neuronal Transmission in Rat CA3 Hippocampal Neurons: Involvement of Ion Channels

Yi Lü, Hong Wang, Junqing Yang, Wengao Jiang, Xin Hong, Ying Luo, Santiago Loya‐López, Huaiyu Gu, Dongzhi Ran

Molecules

DOI

2022

Targeting the VEGF-A/Neuropilin 1 axis for relief of neuropathic pain

Harrison J. Stratton, Lisa Boinon, Kimberly Gomez, Laurent F Martin, Paz Duran, Dongzhi Ran, Yuan Zhou, Shizhen Luo, S. Perez-Miller, M. Patek, Mohab M. Ibrahim, Amol M. Patwardhan, Aubin Moutal, R. Khanna

Pain

DOI

2022

The natural product argentatin C attenuates postoperative pain via inhibition of voltage‐gated sodium and T‐type voltage‐gated calcium channels

Paz Duran, Santiago I. Loya-Lopez, Dongzhi Ran, Cheng Tang, Aida Calderon-Rivera, Kimberly Gomez, Harrison J. Stratton, Sun Huang, Ya-ming Xu, E. M. Kithsiri Wijeratne, S. Perez-Miller, Zhiming Shan, Song Cai, Anna T. Gabrielsen, Angie Dorame, Kyleigh A. Masterson, Omar Alsbiei, Cynthia L. Madura, Guoqing Luo, Aubin Moutal, J. Streicher, G. Zamponi, A. A. Leslie Gunatilaka, R. Khanna

British Journal of Pharmacology

DOI

2022

Cell specific regulation of NaV1.7 activity and trafficking in rat nodose ganglia neurons

Santiago I. Loya-Lopez, Paz Duran, Dongzhi Ran, Aida Calderon-Rivera, Kimberly Gomez, Aubin Moutal, R. Khanna

Neurobiology of Pain

DOI

2022

Neuronal allodynic mechanisms of Slc7a5 (LAT1) in the spared nerve injury rodent model of neuropathic pain

A. Goins, Kimberly Gomez, Dongzhi Ran, M. Afaghpour-Becklund, R. Khanna, Sascha R. A. Alles

Pflügers Archiv: European Journal of Physiology

DOI

2022

Stereospecific Effects of Benzimidazolonepiperidine Compounds on T-Type Ca2+ Channels and Pain.

Kimberly Gomez, Cheng Tang, Bin Tan, S. Perez-Miller, Dongzhi Ran, Santiago Loya, Aida Calderon-Rivera, Harrison J. Stratton, Paz Duran, Kyleigh A. Masterson, Anna T. Gabrielsen, Omar Alsbiei, Angie Dorame, M. Serafini, Aubin Moutal, Jun Wang, R. Khanna

ACS Chemical Neuroscience

DOI

2021

Effects of Mono-2-ethylhexyl Phthalate on the Neural Transmission of PNs in Drosophila Antennal Lobe

Xia Liu, Junqing Yang, Zongjie Gan, Hong Wang, Zhuqin Hu, Jia Liu, Dongzhi Ran

Neurotoxicity Research

DOI

2021

ZNRF2 attenuates focal cerebral ischemia/reperfusion injury in rats by inhibiting mTORC1-mediated autophagy

Chao Gu, Junqing Yang, Ying Luo, Dongzhi Ran, Xiaodan Tan, Pu Xiang, Huizhi Fei, Yi Lü, Wenjia Guo, Yujun Tu, Xia Liu, Hong Wang

Experimental Neurology

DOI

2021

Effect of TO901317 on GF to promote the differentiation of human bone marrow mesenchymal stem cells into dopamine neurons on Parkinson’s disease

Miaomiao Li, Junqing Yang, Oumei Cheng, Zhe Peng, Yin Luo, Dongzhi Ran, Yang Yang, Pu Xiang, Haifeng Huang, Xiaodan Tan, Hong Wang

Therapeutic Advances in Chronic Disease

DOI

2021

Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15

Kimberly Gomez, Dongzhi Ran, Cynthia L Madura, Aubin Moutal, R. Khanna

Molecular Brain

DOI

2021

Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel

Dongzhi Ran, Kimberly Gomez, Aubin Moutal, M. Patek, S. Perez-Miller, R. Khanna

Channels

DOI

2020

RAGE Signaling pathway in hippocampus dentate gyrus involved in GLT-1 decrease induced by chronic unpredictable stress in rats

Fang Yang, Hong Wang, Huali Chen, Dongzhi Ran, Qiang Tang, Ping Weng, Yuzhuo Sun, Wengao Jiang

Brain Research Bulletin

DOI

2020

A modulator of the low-voltage activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies

Song Cai, P. Tuohy, Chunlong Ma, Naoya Kitamura, Kimberly Gomez, Yuan Zhou, Dongzhi Ran, S. Bellampalli, Jie Yu, Shizhen Luo, Angie Dorame, N. Y. Pham, G. Molnar, J. Streicher, M. Patek, S. Perez-Miller, Aubin Moutal, Jun Wang, R. Khanna

Pain

DOI

2020

SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

Aubin Moutal, Laurent F Martin, Lisa Boinon, Kimberly Gomez, Dongzhi Ran, Yuan Zhou, Harrison J. Stratton, Song Cai, Shizhen Luo, Kerry Beth Gonzalez, S. Perez-Miller, Amol M. Patwardhan, Mohab M. Ibrahim, R. Khanna

Pain

DOI

2020

Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific NaV1.7 regulation in the pathogenesis of chronic neuropathic pain

Aubin Moutal, Song Cai, Jie Yu, Harrison J. Stratton, Aude Chefdeville, Kimberly Gomez, Dongzhi Ran, Cynthia L Madura, Lisa Boinon, Maira Soto, Yuan Zhou, Zhiming Shan, Lindsey A. Chew, K. Rodgers, R. Khanna

bioRxiv

DOI

2020

Studies on CRMP2 SUMOylation-deficient transgenic mice reveal novel insights into the trafficking of NaV1.7 channels

Kimberly Gomez, Dongzhi Ran, Cynthia L Madura, Aubin Moutal, R. Khanna

bioRxiv

DOI

2019

Neural mechanisms underlying the deficit of learning and memory by exposure to Di(2-ethylhexyl) phthalate in rats

Dongzhi Ran, Ying Luo, Zongjie Gan, Jia Liu, Junqing Yang

Ecotoxicology and Environmental Safety

DOI

2019

Changes in the levels of 12/15-lipoxygenase, apoptosis-related proteins and inflammatory factors in the cortex of diabetic rats and the neuroprotection of baicalein

Yuke Li, Qi Chen, Dongzhi Ran, Hong Wang, Weimin Du, Ying Luo, Wengao Jiang, Yang Yang, Junqing Yang

Free Radical Biology and Medicine

DOI

2018

Adapentpronitrile, a New Dipeptidyl Peptidase-IV Inhibitor, Ameliorates Diabetic Neuronal Injury Through Inhibiting Mitochondria-Related Oxidative Stress and Apoptosis

Yang Lü, Wenli Han, Ying Luo, Xiangnan Hu, Ying Dong Xu, Huan Li, Congli Hu, Dan Yang Huang, Jie Ma, Yang Yang, Qi Chen, Yuke Li, Jiahua Zhang, Hui Xia, Zhihao Chen, Hong Wang, Dongzhi Ran, Junqing Yang

Frontiers in Cellular Neuroscience

DOI

2018

Melatonin attenuates hLRRK2‑induced long‑term memory deficit in a Drosophila model of Parkinson's disease

Dongzhi Ran, Baogang Xie, Zongjie Gan, Xicui Sun, Huaiyu Gu, Junqing Yang

Biomedical Reports

DOI

2017

cAMP/PKA-CREB-BDNF signaling pathway in hippocampus mediates cyclooxygenase 2-induced learning/memory deficits of rats subjected to chronic unpredictable mild stress

Ying Luo, Shengnan Kuang, Huan Li, Dongzhi Ran, Junqing Yang

Oncotarget

DOI

冉冬芝

精选作品

期刊论文

METTL3-m6A-MALAT1 axis exacerbates the autophagy impairment and lipid accumulation in NAFLD by regulating miR-690

Concomitant use of low molecular weight heparin mitigates bortezomib-induced peripheral Neuropathy: Analysis of the FDA adverse event reporting system

Anti-CV2/CRMP5 autoantibodies as drivers of sensory neuron excitability and pain in rats

Nrf1 Reduces COX-2 Expression and Maintains Cellular Homeostasis After Cerebral Ischemia/Reperfusion By Targeting IL-6/TNF-α Protein Production

Mechanism, and treatment of anti-CV2/CRMP5 autoimmune pain

ccd3-1改善大鼠神经病理性疼痛的作用研究

A peptidomimetic modulator of the Ca V 2.2 N-type calcium channel for chronic pain

Neuropilin-1 Is Essential For VEGFA-Mediated Increase Of Sensory Neuron Activity And Development Of Pain-Like Behaviors

A Selective Peptidomimetic Modulator Of Cav2.2 (N-Type) Voltage-Gated Calcium Channels For Chronic Pain

Identification and targeting of a unique NaV1.7 domain driving chronic pain

RAGE signaling pathway is involved in CUS-induced depression-like behaviors by regulating the expression of NR2A and NR2B in rat hippocampus DG

Distinct Role of Mono-2-ethylhexyl Phthalate in Neuronal Transmission in Rat CA3 Hippocampal Neurons: Involvement of Ion Channels

Targeting the VEGF-A/Neuropilin 1 axis for relief of neuropathic pain

The natural product argentatin C attenuates postoperative pain via inhibition of voltage‐gated sodium and T‐type voltage‐gated calcium channels

Cell specific regulation of NaV1.7 activity and trafficking in rat nodose ganglia neurons

Neuronal allodynic mechanisms of Slc7a5 (LAT1) in the spared nerve injury rodent model of neuropathic pain

Stereospecific Effects of Benzimidazolonepiperidine Compounds on T-Type Ca2+ Channels and Pain.

Effects of Mono-2-ethylhexyl Phthalate on the Neural Transmission of PNs in Drosophila Antennal Lobe

ZNRF2 attenuates focal cerebral ischemia/reperfusion injury in rats by inhibiting mTORC1-mediated autophagy

Effect of TO901317 on GF to promote the differentiation of human bone marrow mesenchymal stem cells into dopamine neurons on Parkinson’s disease

Non-SUMOylated CRMP2 decreases NaV1.7 currents via the endocytic proteins Numb, Nedd4-2 and Eps15

Comparison of quinazoline and benzoylpyrazoline chemotypes targeting the CaVα-β interaction as antagonists of the N-type CaV2.2 channel

RAGE Signaling pathway in hippocampus dentate gyrus involved in GLT-1 decrease induced by chronic unpredictable stress in rats

A modulator of the low-voltage activated T-type calcium channel that reverses HIV glycoprotein 120-, paclitaxel-, and spinal nerve ligation-induced peripheral neuropathies

SARS-CoV-2 Spike protein co-opts VEGF-A/Neuropilin-1 receptor signaling to induce analgesia

Studies on CRMP2 SUMOylation-deficient transgenic mice identify sex-specific NaV1.7 regulation in the pathogenesis of chronic neuropathic pain

Studies on CRMP2 SUMOylation-deficient transgenic mice reveal novel insights into the trafficking of NaV1.7 channels

Neural mechanisms underlying the deficit of learning and memory by exposure to Di(2-ethylhexyl) phthalate in rats

Changes in the levels of 12/15-lipoxygenase, apoptosis-related proteins and inflammatory factors in the cortex of diabetic rats and the neuroprotection of baicalein

Adapentpronitrile, a New Dipeptidyl Peptidase-IV Inhibitor, Ameliorates Diabetic Neuronal Injury Through Inhibiting Mitochondria-Related Oxidative Stress and Apoptosis

Melatonin attenuates hLRRK2‑induced long‑term memory deficit in a Drosophila model of Parkinson's disease

cAMP/PKA-CREB-BDNF signaling pathway in hippocampus mediates cyclooxygenase 2-induced learning/memory deficits of rats subjected to chronic unpredictable mild stress

预印本

Therapeutic effect of TO901317 on 6-OHDA-induced Parkinson rats in vitro and in vivo

研究方向