童九翠｜皖南医学院｜学者主页

2026

豆腐果苷调控PRKCB启动子区DNA甲基化改善C6细胞凋亡的机制

葛鹏，张晓彤，马明悦，蒋臻熠，杜鑫，芦娟，张袁祥，童九翠

《皖南医学院学报》

2026

METTL3-dependent m⁶A maturation of miR-140-3p contributes to hippocampal neuronal apoptosis through the OTX2/Wnt/β-catenin axis under chronic stress

Yuanxiang Zhang, Xin Du, Mengxue Fu, Haitao Hu, Juan Lu, Tongshuai Pan, L. Yuan, Yi-Gao Wu, Jiucui Tong

Molecular Biology Reports

DOI

2026

FGF13 exerts neuroprotective effects via activation of the PI3K/AKT signaling pathway and serves as a potential biomarker for depression.

Haitao Hu, Juan Lu, Xin Du, Peng Ge, Mengxue Fu, Tongshuai Pan, L. Yuan, Yuanxiang Zhang, Yi-Gao Wu, Jiucui Tong

Biochemical and Biophysical Research Communications - BBRC

DOI

2025

豆腐果苷通过NCALD/sGC/cGMP/PKG轴缓解慢性不可预见性温和应激大鼠的抑郁样行为

杜鑫，张晓彤，芦娟，葛鹏，胡海涛，付梦雪，张袁祥，王国栋，童九翠

《南方医科大学学报》

2025

[Helicid alleviates depression-like behavior in rats with chronic unpredictable mild stress through the NCALD/sGC/cGMP/PKG axis].

Xin Du, Xiao-Tong Zhang, Juan Lu, Peng Ge, Hai-Sheng Hu, Mengxue Fu, Yuanxiang Zhang, Guodong Wang, Jiucui Tong

Nan fang yi ke da xue xue bao = Journal of Southern Medical University

DOI

2025

VPS25 alleviates depression-like behavior in rats by inhibiting apoptosis in the hippocampus.

L. Yuan, Xiaofang Huang, Qi Wang, Beibei Hou, Sifan Xu, Zhiming Zhou, Yi-Gao Wu, Jiucui Tong

Brain Research Bulletin

DOI

2024

Helicid Alleviates Neuronal Apoptosis of Rats with Depression-Like Behaviors by Downregulating lncRNA-NONRATT030918.2

Yuan Zhang, Zhenyi Jiang, Mei Wang, Xiaotong Zhang, Peng Ge, Wei Wang, Yuanxiang Zhang, Jiucui Tong

Molecular Neurobiology

DOI

2023

Corrigendum to "Antidepressant-like effects of helicid on a chronic unpredictable mild stress-induced depression rat model: Inhibiting the IKK/IκBα/NF-κB pathway through NCALD to reduce inflammation" [Int. Immunopharmacol. 93 (2021) 107165].

Yuanxiang Zhang, Xiaotong Zhang, Hong-jin Li, Tao Zhou, An-cheng Zhou, Zheng-Ling Zhong, Yanhao Liu, Li-Li Yuan, Hao-yu Zhu, Di Luan, Jiucui Tong

International Immunopharmacology

DOI

2022

基于网络药理学研究豆腐果苷抗抑郁作用机制

蒋臻熠，张远，李泽朋，张晓彤，张袁祥，童九翠

《安徽医科大学学报》

2022

Helicid Improves Lipopolysaccharide-Induced Apoptosis of C6 Cells by Regulating SH2D5 DNA Methylation via the CytC/Caspase9/Caspase3 Signaling Pathway

Yuan Zhang, Mei Wang, Xiaotong Zhang, Zhenyi Jiang, Yuanxiang Zhang, Xiangjun Fu, Yanna Li, Danping Cao, Jun Han, Jiucui Tong

Contrast Media & Molecular Imaging

DOI

2021

豆腐果苷对慢性不可预知温和应激大鼠神经钙调素δ表达的影响

江思艳，张袁祥，李须逸，齐卫卫，童九翠

《中国现代应用药学》

2021

Antidepressant-like effects of helicid on a chronic unpredictable mild stress-induced depression rat model: Inhibiting the IKK/IκBα/NF-κB pathway through NCALD to reduce inflammation.

Yuanxiang Zhang, Xiaotong Zhang, Hong-jin Li, Taofeng Zhou, An-cheng Zhou, Zheng-Ling Zhong, Yanhao Liu, Li-Li Yuan, Hao-Yu Zhu, Di Luan, Jiucui Tong

International Immunopharmacology

DOI

2021

Helicid Reverses the Effect of Overexpressing NCALD, Which Blocks the sGC/cGMP/PKG Signaling Pathway in the CUMS-Induced Rat Model

Xiaotong Zhang, Yuan Zhang, Yuanxiang Zhang, Zhen Jiang, Hui Yang, Lan Jiang, Bin Yang, Jiucui Tong

Journal of Healthcare Engineering

DOI

2020

豆腐果苷对间歇低氧大鼠记忆损伤的保护作用

张袁祥，周安成，张晓彤，李红金，刘言浩，董健，童九翠

《皖南医学院学报》

2020

Helicid Reverses Lipopolysaccharide‐Induced Inflammation and Promotes GDNF Levels in C6 Glioma Cells through Modulation of Prepronociceptin

Yuanxiang Zhang, Di Luan, Yanhao Liu, Hong-jin Li, Jian Dong, Xiaotong Zhang, Li-Li Yuan, Zheng-Ling Zhong, Lan Jiang, Xuyi Li, Mingquan Ye, Jiucui Tong

Chemistry and Biodiversity

DOI

2019

豆腐果苷抗抑郁作用的分子机制研究

童九翠

《安徽师范大学》

2019

Helicid Ameliorates Learning and Cognitive Ability and Activities cAMP/PKA/CREB Signaling in Chronic Unpredictable Mild Stress Rats.

Xu-Yi Li, Wei Qi, Yuanxiang Zhang, Si-Yan Jiang, Bin Yang, L. Xiong, Jiucui Tong

Biological and Pharmaceutical Bulletin

DOI

2019

Antidepressant effect of helicid in chronic unpredictable mild stress model in rats.

Jiucui Tong, Zhi-Ming Zhou, Wei Qi, Si-Yan Jiang, Bin Yang, Zheng-Ling Zhong, Yuan-Wei Jia, Xuyi Li, L. Xiong, L. Nie

International Immunopharmacology

DOI

2018

抑郁症患者BDNF Val66Met基因多态性与抗抑郁药疗效的Meta分析

李须逸，齐卫卫，郑鹏飞，江蕙，钱叶礼，宗艺璇，郭亚鹏，江思艳，童九翠

《牡丹江医科大学学报》

2016

BDNF信号通路在天然抗抑郁药中的研究进展

齐卫卫，钟正灵，郭亚鹏，李须逸，童九翠

《中国临床药理学与治疗学》

2016

Research progress of BDNF signaling pathway in natural antidepressants

Wei-Wei Qi, Zheng-Ling Zhong, Ya-Peng Guo, Xu-Yi Li, Jiucui Tong

2016

BDNFシグナル経路の天然抗うつ薬における研究の進展【JST・京大機械翻訳】

Wei-Wei Qi, Zheng-Ling Zhong, Ya-Peng Guo, Xu-Yi Li, Jiucui Tong

2012

豆腐果苷对慢性应激小鼠海马神经元再生的影响

童九翠，吕坤，杨斌，陈艾东，贾元威，钟民，江思艳

《中国药学杂志》

2012

Effects of Helicid on Hippocampal Neurogenesis in Chronically Stressed Mice

Jiucui Tong, Kun Lv, Bin Yang, Ai-Dong Chen, Yuan-Wei Jia, Min Zhong, Si-Yan Jiang

2011

豆腐果苷在大鼠体内代谢的初步研究

贾元威，谢海棠，王广基，孙建国，王玮，许美娟，黄青，童九翠

《中国药理学通报》

2010

豆腐果苷对慢性应激小鼠行为学的影响

童九翠，谢海棠，杨斌，陈艾东，李海刚，潘行山，贾元威，钟民，江思艳

《中国临床药理学与治疗学》

2009

豆腐果苷衍生物W0620对行为绝望小鼠抗抑郁作用的研究

童九翠，谢海棠，孙瑞元，江思艳，杨斌，芮家亮

《中国药理学通报》

2008

豆腐果苷衍生物W0620实验性抗抑郁作用量效关系研究

童九翠，孙瑞元，江思艳，杨斌，芮家亮，李娟，谢海棠

《中国临床药理学与治疗学》

2007

豆腐果苷WN7-6类衍生物抗抑郁活性筛选探索研究

童九翠，谢海棠，江思艳，杨斌，芮家亮

《中国临床药理学与治疗学》

2007

Bean-curd pectin analogue and its use in medicine for preventing depression

Rui-Yuan Sun, Hua-Hui Song, Li-Sheng Zhang, Wen-Lie Peng, Xiao-Chang Dai, Ri-Hui Cao, Yun-Feng Li, Hong-Ju Yang, Yun-Yan Jiang, Zi-Hou Wang, Yan-Hua Wang, Jiucui Tong, Zhi-Pu Luo, Li-Kun Hu, Hai-Tang Xie, Nan Zhao, H. Wen, Ling Que

童九翠

精选作品

期刊论文

豆腐果苷调控PRKCB启动子区DNA甲基化改善C6细胞凋亡的机制

METTL3-dependent m⁶A maturation of miR-140-3p contributes to hippocampal neuronal apoptosis through the OTX2/Wnt/β-catenin axis under chronic stress

FGF13 exerts neuroprotective effects via activation of the PI3K/AKT signaling pathway and serves as a potential biomarker for depression.

豆腐果苷通过NCALD/sGC/cGMP/PKG轴缓解慢性不可预见性温和应激大鼠的抑郁样行为

[Helicid alleviates depression-like behavior in rats with chronic unpredictable mild stress through the NCALD/sGC/cGMP/PKG axis].

VPS25 alleviates depression-like behavior in rats by inhibiting apoptosis in the hippocampus.

Helicid Alleviates Neuronal Apoptosis of Rats with Depression-Like Behaviors by Downregulating lncRNA-NONRATT030918.2

Corrigendum to "Antidepressant-like effects of helicid on a chronic unpredictable mild stress-induced depression rat model: Inhibiting the IKK/IκBα/NF-κB pathway through NCALD to reduce inflammation" [Int. Immunopharmacol. 93 (2021) 107165].

基于网络药理学研究豆腐果苷抗抑郁作用机制

Helicid Improves Lipopolysaccharide-Induced Apoptosis of C6 Cells by Regulating SH2D5 DNA Methylation via the CytC/Caspase9/Caspase3 Signaling Pathway

豆腐果苷对慢性不可预知温和应激大鼠神经钙调素δ表达的影响

Antidepressant-like effects of helicid on a chronic unpredictable mild stress-induced depression rat model: Inhibiting the IKK/IκBα/NF-κB pathway through NCALD to reduce inflammation.

Helicid Reverses the Effect of Overexpressing NCALD, Which Blocks the sGC/cGMP/PKG Signaling Pathway in the CUMS-Induced Rat Model

豆腐果苷对间歇低氧大鼠记忆损伤的保护作用

Helicid Reverses Lipopolysaccharide‐Induced Inflammation and Promotes GDNF Levels in C6 Glioma Cells through Modulation of Prepronociceptin

豆腐果苷抗抑郁作用的分子机制研究

Helicid Ameliorates Learning and Cognitive Ability and Activities cAMP/PKA/CREB Signaling in Chronic Unpredictable Mild Stress Rats.

Antidepressant effect of helicid in chronic unpredictable mild stress model in rats.

抑郁症患者BDNF Val66Met基因多态性与抗抑郁药疗效的Meta分析

BDNF信号通路在天然抗抑郁药中的研究进展

Research progress of BDNF signaling pathway in natural antidepressants

BDNFシグナル経路の天然抗うつ薬における研究の進展【JST・京大機械翻訳】

豆腐果苷对慢性应激小鼠海马神经元再生的影响

Effects of Helicid on Hippocampal Neurogenesis in Chronically Stressed Mice

豆腐果苷在大鼠体内代谢的初步研究

豆腐果苷对慢性应激小鼠行为学的影响

豆腐果苷衍生物W0620对行为绝望小鼠抗抑郁作用的研究

豆腐果苷衍生物W0620实验性抗抑郁作用量效关系研究

豆腐果苷WN7-6类衍生物抗抑郁活性筛选探索研究

Bean-curd pectin analogue and its use in medicine for preventing depression

研究方向