张晓东｜南华大学｜学者主页

2026

基于RNA-seq技术对猪卵泡液外泌体SNP和InDel的筛选及功能分析

刘阳光，朱翠云，吴萍，叶海波，王倩倩，张晓东，殷宗俊

《农业生物技术学报》

2026

Structures and molecular mechanisms of RAD54B in modulating homologous recombination

Peng-Tao Liang, Stephanie Tye, Johanna Ertl da Costa, Neelam Maharshi, Bilge Argunhan, L. Kuhlen, Megan Battley, Elizabeth A. McCormack, W. Heyer, M. Löbrich, Xiao-Dong Zhang

bioRxiv

DOI

2025

Structures and mechanisms of AAA+ protein complexes in DNA processing.

Alexander Carver, Bowen Zhang, Xiao-Dong Zhang

Current Opinion in Structural Biology

DOI

2025

DNA Damage and Replication Stress-induced Checkpoints

L. Yates, Xiao-Dong Zhang, Peter M. Burgers

Annual Review of Biochemistry

DOI

2025

RAD51AP1 is a versatile RAD51 modulator

L. Kuhlen, Bilge Argunhan, Peng-Tao Liang, Janet Zhong, L. Masino, Xiao-Dong Zhang

bioRxiv

DOI

2024

Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin

Alexander Carver, Tai-Yuan Yu, L. Yates, Travis B. White, Raymond Wang, Katie Lister, M. Jasin, Xiao-Dong Zhang

bioRxiv

DOI

2024

Structural mechanisms of SLF1 interactions with Histone H4 and RAD18 at the stalled replication fork

Emma L Ryder, N. Nasir, Amy E O Durgan, M. Jenkyn-Bedford, Stephanie Tye, Xiao-Dong Zhang, Qiang Wu

Nucleic Acids Research

DOI

2023

Phosphoregulation of DNA repair via the Rad51 auxiliary factor Swi5–Sfr1

Peng-Tao Liang, Katie Lister, L. Yates, Bilge Argunhan, Xiaodong Zhang

Journal of Biological Chemistry

DOI

2023

Phosphoregulation of the checkpoint kinase Mec1ATR.

L. Yates, Xiaodong Zhang

DNA Repair

DOI

2023

Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein

O. Belan, Luke A Greenhough, L. Kuhlen, Roopesh Anand, Artur Kaczmarczyk, D. Gruszka, H. Yardimci, Xiaodong Zhang, David S. Rueda, S. West, S. Boulton

Molecules and Cells

DOI

2022

A DNA damage–induced phosphorylation circuit enhances Mec1ATR Ddc2ATRIP recruitment to Replication Protein A

L. Yates, Elias A. Tannous, R. Morgan, Peter M. Burgers, Xiaodong Zhang

bioRxiv

DOI

2022

Research progress in hepatitis B virus covalently closed circular DNA

Xiaodong Zhang, Yufei Wang, Guang Yang

Cancer Biology & Medicine

2022

Highlighted multi-modifications of enzymes: a novel succinylation mediated by histone acetyltransferase 1 in tumors

Xiaodong Zhang, Chunyu Hou, Guang Yang

Cancer Biology & Medicine

2022

CUL4B facilitates HBV replication by promoting HBx stabilization

Haixia Shan, Bo Wang, Xiaodong Zhang, Hui Song, Xi Li, Yongxin Zou, Baichun Jiang, Huili Hu, Hao Dou, Changshun Shao, Lifen Gao, Chunhong Ma, Xiaoyun Yang, Xiaohong Liang, Yaoqin Gong

Cancer Biology & Medicine

2021

The renaissance in biophysics and molecular biology enabled by the interface of DNA repair and replication with cancer

Xiaodong Zhang, T. Blundell, J. Tainer

Progress in Biophysics and Molecular Biology

DOI

2021

Faculty Opinions recommendation of Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.

Xiaodong Zhang

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI

2021

Faculty Opinions recommendation of Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.

Xiaodong Zhang

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI

2021

组蛋白乙酰基转移酶1在肝癌细胞中介导的蛋白质乙酰化修饰谱分析

袁红凤，贠昊林，赵丽娜，杨光，袁颖，耿俞，冯恋雲，王宇飞，张晓东

《中国生物化学与分子生物学报》

DOI

2021

USP14及其抑制剂调控肿瘤的发生与发展

杜雪花，张晓东

《中国生物化学与分子生物学报》

DOI

2021

增殖细胞核抗原通过其DNA结合结构域促进乙肝病毒rcDNA向cccDNA的转化（英文）

袁颖，冯巾晏，赵丽娜，杨光，赵曼，袁红凤，贠昊林，刘姿娴，李悦国，张晓东

《中国生物化学与分子生物学报》

DOI

2020

Roles of ATM and ATR in DNA double strand breaks and replication stress.

Rhys M. Williams, Xiaodong Zhang

Progress in Biophysics and Molecular Biology

DOI

2020

Faculty Opinions recommendation of METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.

Xiaodong Zhang

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI

2020

Faculty Opinions recommendation of DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex.

Xiaodong Zhang

DOI

2020

Mechanism of Auto-inhibition and Activation of Mec1ATR Checkpoint Kinase

Elias A. Tannous, L. Yates, Xiaodong Zhang, P. Burgers

Nature Structural & Molecular Biology

DOI

2020

Editorial overview: Macromolecular assemblies.

Xiaodong Zhang, T. Blundell

Current Opinion in Structural Biology

DOI

2020

Faculty Opinions recommendation of Dimers of DNA-PK create a stage for DNA double-strand break repair.

Xiaodong Zhang

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI

2020

Structures and regulations of ATM and ATR, master kinases in genome integrity.

Rhys M. Williams, L. Yates, Xiaodong Zhang

Current Opinion in Structural Biology

DOI

2020

Faculty Opinions recommendation of FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.

Xiaodong Zhang

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI

2020

Rad51 filament dynamics and its antagonistic modulators.

Alexa Carver, Xiaodong Zhang

Seminars in Cell and Developmental Biology

DOI

2019

Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations

L. Yates, Rhys M. Williams, S. Hailemariam, R. Ayala, P. Burgers, Xiaodong Zhang

Structure

DOI

2019

Faculty Opinions recommendation of DNA damage detection in nucleosomes involves DNA register shifting.

Xiaodong Zhang

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI

2019

Structure of nucleotide-bound Tel1/ATM

L. Yates, Rhys M. Williams, R. Ayala, Xiaodong Zhang

DOI

2019

Structural basis of homologous recombination

Yue-Ru Sun, T. McCorvie, L. Yates, Xiaodong Zhang

Cellular and Molecular Life Sciences

DOI

2019

Isomerization of BRCA1–BARD1 promotes replication fork protection

M. Daza-Martin, K. Starowicz, Mohammed Jamshad, Stephanie Tye, George E Ronson, Hannah L. Mackay, A. S. Chauhan, Alexandra K. Walker, Helen R. Stone, J. Beesley, Jennifer L. Coles, Alexander J. Garvin, G. Stewart, T. McCorvie, Xiaodong Zhang, R. Densham, Joanna R. Morris

Nature

DOI

2019

组蛋白乙酰转移酶HAT1信号通路促进HBV cccDNA微小染色体组装和表观遗传修饰

张晓东，杨光，Yang G

《临床肝胆病杂志》

2019

Hepatitis B virus X protein enhances hepatocarcinogenesis by depressing the targeting of NUSAP1 mRNA by miR-18b

Zhe Yang, Jiong Li, Guoxing Feng, Yuan Wang, Guang Yang, Yunxia Liu, Shuqin Zhang, Jinyan Feng, Xiaodong Zhang

Cancer Biology & Medicine

2018

Faculty of 1000 evaluation for Meta-analysis of DNA double-strand break response kinetics.

Xiaodong Zhang

DOI

2018

Structure and regulation of the human INO80-nucleosome complex

R. Ayala, O. Willhoft, R. Aramayo, M. Wilkinson, E. A. Mccormack, Lorraine Ocloo, D. Wigley, Xiaodong Zhang

Nature

DOI

2018

Faculty of 1000 evaluation for A class of environmental and endogenous toxins induces BRCA2 haploinsufficiency and genome instability.

Xiaodong Zhang

DOI

2018

A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

L. Yates, R. Aramayo, Nilisha Pokhrel, Colleen C. Caldwell, J. A. Kaplan, R. L. Perera, M. Spies, Edwin Antony, Xiaodong Zhang

Nature Communications

DOI

2018

Yeast RPA bound to ssDNA

L. Yates, R. Aramayo, Xiaodong Zhang

DOI

2017

Single-Particle Electron Microscopy Analysis of DNA Repair Complexes.

M. Sawicka, R. Aramayo, R. Ayala, R. Glyde, Xiaodong Zhang

Methods in Enzymology

DOI

2017

CryoEM structures of the human INO80 chromatin remodelling complex

R. Aramayo, O. Willhoft, R. Ayala, R. Bythell-Douglas, D. Wigley, Xiaodong Zhang

Nature Structural & Molecular Biology

DOI

2017

Crosstalk within a functional INO80 complex dimer regulates nucleosome sliding

O. Willhoft, E. A. Mccormack, R. Aramayo, R. Bythell-Douglas, Lorraine Ocloo, Xiaodong Zhang, D. Wigley

eLife

DOI

2017

Human Rvb1/Rvb2 heterohexamer in INO80 complex

R. Aramayo, R. Bythell-Douglas, R. Ayala, O. Willhoft, D. Wigley, Xiaodong Zhang

DOI

2017

HBx激活的MSL2蛋白通过泛素化降解APOBEC3B增强HBV cccDNA的稳定性促进肝癌的发生发展

Gao YE, 张晓东

《临床肝胆病杂志》

2017

Research progress of CRISPR/Cas9 technology

Xiaodong Zhang, Ju-Hua Zhou, Yan-Min Li

DOI

2017

Proteasome beta-4 subunit contributes to the development of melanoma and is regulated by miR-148b

Xiaodong Zhang, D. Lin, Yue-Qing Lin, Hongqing Chen, M. Zou, Shan Zhong, Xue-Mei Yi, Si-Qi Han

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine

DOI

2016

The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization

M. Sawicka, Paulina H. Wanrooij, V. Darbari, Elias A. Tannous, S. Hailemariam, D. Bose, A. Makarova, P. Burgers, Xiaodong Zhang

Journal of Biological Chemistry

DOI

2016

A second DNA binding site in human BRCA2 promotes homologous recombination

C. von Nicolai, Åsa Ehlén, Charlotte Martin, Xiaodong Zhang, A. Carreira

Nature Communications

DOI

2016

Microsoft Word - Sawicka_manuscript_R2_ms.docx

M. Sawicka, Paulina H. Wanrooij, V. Darbari, Elias A. Tannous, S. Hailemariam, D. Bose, A. Makarova, P. Burgers, Xiaodong Zhang

2015

乙肝病毒X蛋白通过CREB上调HBx结合蛋白促进肝癌细胞迁移

张伟英，张晓东，叶丽虹

《中国生物化学与分子生物学报》

2014

Structure and Mechanism of Action of the BRCA2 Breast Cancer Tumor Suppressor

Taha Shahid, Joanna Soroka, E. Kong, Laurent Malivert, M. Mcilwraith, Tillmann Pape, S. West, Xiaodong Zhang

Nature Structural &Molecular Biology

DOI

2012

Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex

M. Saravanan, J. Wuerges, D. Bose, E. A. Mccormack, N. Cook, Xiaodong Zhang, D. Wigley

Proceedings of the National Academy of Sciences of the United States of America

DOI

2012

ADP-BOUND C-TERMINAL DOMAIN OF ACTIN-RELATED PROTEIN ARP8 FROM S. CEREVISIAE

J. Wuerges, M. Saravanan, D. Bose, N. Cook, Xiaodong Zhang, D. Wigley

DOI

2011

乙肝病毒X蛋白突变体(HBxΔ127)通过ERK上调钙蛋白酶小亚基1促进肝癌细胞迁移

山长亮，张帅，张晓东，叶丽虹

《中国生物化学与分子生物学报》

2010

骨桥蛋白通过NF-κB上调钙蛋白酶小亚基1促进肝癌细胞迁移

张烜，叶丽虹，张晓东

《生物化学与生物物理进展》

2010

乙肝病毒X蛋白通过骨桥蛋白OPN促进肝癌细胞迁移

张烜，叶丽虹，张晓东

《中国生物化学与分子生物学报》

2008

COX-2在乙肝病毒X蛋白(HBx)促进肝癌细胞和肝细胞增殖中的作用

徐付卿，山长亮，叶丽虹，张晓东

《中国生物化学与分子生物学报》

2007

乙型肝炎病毒X蛋白结合蛋白(HBXIP)对细胞周期的影响

王凤泽，吴莲英，乔玲，张晓东，叶丽虹

《中国生物化学与分子生物学报》

2007

乙肝病毒X蛋白结合蛋白(HBXIP)增强肝癌细胞NF-κB转录活性的实验研究

王凤泽，沙丽，乔玲，吴莲英，张晓东，叶丽虹

《生物化学与生物物理进展》

2006

乙型肝炎病毒X蛋白与端粒酶的关系

张烜，张晓东，叶丽虹

《中国生物化学与分子生物学报》

2005

HBXIP基因对乙肝病毒X蛋白诱导细胞凋亡的影响

张晓东，马宏涛，叶丽虹，东楠，史志蔚，沙丽，王洪辉

《中国生物化学与分子生物学报》

2005

乙肝病毒X蛋白诱导肝癌细胞凋亡的信号转导途径

东楠，李楠，叶丽虹，张晓东

《中国生物化学与分子生物学报》

Faculty Opinions recommendation of Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.

Xiaodong Zhang

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature

DOI

精选作品

期刊论文

基于RNA-seq技术对猪卵泡液外泌体SNP和InDel的筛选及功能分析

Structures and molecular mechanisms of RAD54B in modulating homologous recombination

Structures and mechanisms of AAA+ protein complexes in DNA processing.

DNA Damage and Replication Stress-induced Checkpoints

RAD51AP1 is a versatile RAD51 modulator

Molecular basis of FIGNL1 in dissociating RAD51 from DNA and chromatin

Structural mechanisms of SLF1 interactions with Histone H4 and RAD18 at the stalled replication fork

Phosphoregulation of DNA repair via the Rad51 auxiliary factor Swi5–Sfr1

Phosphoregulation of the checkpoint kinase Mec1ATR.

Visualization of direct and diffusion-assisted RAD51 nucleation by full-length human BRCA2 protein

A DNA damage–induced phosphorylation circuit enhances Mec1ATR Ddc2ATRIP recruitment to Replication Protein A

Research progress in hepatitis B virus covalently closed circular DNA

Highlighted multi-modifications of enzymes: a novel succinylation mediated by histone acetyltransferase 1 in tumors

CUL4B facilitates HBV replication by promoting HBx stabilization

The renaissance in biophysics and molecular biology enabled by the interface of DNA repair and replication with cancer

Faculty Opinions recommendation of Bridging of DNA breaks activates PARP2-HPF1 to modify chromatin.

Faculty Opinions recommendation of Mechanisms of BRCA1-BARD1 nucleosome recognition and ubiquitylation.

组蛋白乙酰基转移酶1在肝癌细胞中介导的蛋白质乙酰化修饰谱分析

USP14及其抑制剂调控肿瘤的发生与发展

增殖细胞核抗原通过其DNA结合结构域促进乙肝病毒rcDNA向cccDNA的转化（英文）

Roles of ATM and ATR in DNA double strand breaks and replication stress.

Faculty Opinions recommendation of METTL3 and N6-Methyladenosine Promote Homologous Recombination-Mediated Repair of DSBs by Modulating DNA-RNA Hybrid Accumulation.

Faculty Opinions recommendation of DNA clamp function of the monoubiquitinated Fanconi anaemia ID complex.

Mechanism of Auto-inhibition and Activation of Mec1ATR Checkpoint Kinase

Editorial overview: Macromolecular assemblies.

Faculty Opinions recommendation of Dimers of DNA-PK create a stage for DNA double-strand break repair.

Structures and regulations of ATM and ATR, master kinases in genome integrity.

Faculty Opinions recommendation of FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.

Rad51 filament dynamics and its antagonistic modulators.

Cryo-EM Structure of Nucleotide-Bound Tel1ATM Unravels the Molecular Basis of Inhibition and Structural Rationale for Disease-Associated Mutations

Faculty Opinions recommendation of DNA damage detection in nucleosomes involves DNA register shifting.

Structure of nucleotide-bound Tel1/ATM

Structural basis of homologous recombination

Isomerization of BRCA1–BARD1 promotes replication fork protection

组蛋白乙酰转移酶HAT1信号通路促进HBV cccDNA微小染色体组装和表观遗传修饰

Hepatitis B virus X protein enhances hepatocarcinogenesis by depressing the targeting of NUSAP1 mRNA by miR-18b

Faculty of 1000 evaluation for Meta-analysis of DNA double-strand break response kinetics.

Structure and regulation of the human INO80-nucleosome complex

Faculty of 1000 evaluation for A class of environmental and endogenous toxins induces BRCA2 haploinsufficiency and genome instability.

A structural and dynamic model for the assembly of Replication Protein A on single-stranded DNA

Yeast RPA bound to ssDNA

Single-Particle Electron Microscopy Analysis of DNA Repair Complexes.

CryoEM structures of the human INO80 chromatin remodelling complex

Crosstalk within a functional INO80 complex dimer regulates nucleosome sliding

Human Rvb1/Rvb2 heterohexamer in INO80 complex

HBx激活的MSL2蛋白通过泛素化降解APOBEC3B增强HBV cccDNA的稳定性促进肝癌的发生发展

Research progress of CRISPR/Cas9 technology

Proteasome beta-4 subunit contributes to the development of melanoma and is regulated by miR-148b

The Dimeric Architecture of Checkpoint Kinases Mec1ATR and Tel1ATM Reveal a Common Structural Organization

A second DNA binding site in human BRCA2 promotes homologous recombination

Microsoft Word - Sawicka_manuscript_R2_ms.docx

乙肝病毒X蛋白通过CREB上调HBx结合蛋白促进肝癌细胞迁移

Structure and Mechanism of Action of the BRCA2 Breast Cancer Tumor Suppressor

Interactions between the nucleosome histone core and Arp8 in the INO80 chromatin remodeling complex

ADP-BOUND C-TERMINAL DOMAIN OF ACTIN-RELATED PROTEIN ARP8 FROM S. CEREVISIAE

乙肝病毒X蛋白突变体(HBxΔ127)通过ERK上调钙蛋白酶小亚基1促进肝癌细胞迁移

骨桥蛋白通过NF-κB上调钙蛋白酶小亚基1促进肝癌细胞迁移

乙肝病毒X蛋白通过骨桥蛋白OPN促进肝癌细胞迁移

COX-2在乙肝病毒X蛋白(HBx)促进肝癌细胞和肝细胞增殖中的作用

乙型肝炎病毒X蛋白结合蛋白(HBXIP)对细胞周期的影响

乙肝病毒X蛋白结合蛋白(HBXIP)增强肝癌细胞NF-κB转录活性的实验研究

乙型肝炎病毒X蛋白与端粒酶的关系

HBXIP基因对乙肝病毒X蛋白诱导细胞凋亡的影响

乙肝病毒X蛋白诱导肝癌细胞凋亡的信号转导途径

Faculty Opinions recommendation of Structure of the FA core ubiquitin ligase closing the ID clamp on DNA.

会议论文

癌蛋白乙型肝炎病毒X蛋白结合蛋白(HBXIP)促进卵巢癌细胞迁移的作用及其分子机制的研究

乙肝病毒X蛋白致癌的分子网络调节

HBXIP通过S100A4促进乳腺癌细胞增殖与迁移的研究

乙肝病毒X蛋白通过花生四烯酸代谢与p-ERK1/2正反馈促进和维持肝癌细胞的增殖

HBV X蛋白转化人肝细胞中与survivin协同作用的研究

研究方向