刘晗青｜江苏大学｜学者主页

2026

BRD4在细胞衰老中的多重调控机制及其在癌症治疗中的应用进展

李之焕，尚东胜，刘晗青，屠志刚

《江苏大学学报(医学版)》

DOI

2026

The therapy-induced senescence-associated secretory phenotype and epithelial-mesenchymal transition axis in ovarian cancer: molecular mechanisms and therapeutic opportunities

Ruiqi Wang, Dongsheng Shang, Zhigang Tu, Hanqing Liu

Expert Opinion on Therapeutic Targets

DOI

2025

Targeting CD30L in B-cell non-Hodgkin lymphoma: novel peptide conjugates and their therapeutic potential

Chaowen Shi, Tianzheng Lan, Yufeng Gao, Zhiquan Liang, Yafei Zhang, Yanbei Tu, Hanqing Liu, Zhigang Tu

Molecular Cancer

DOI

2025

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen

Exploration

DOI

2024

Expression, molecular mechanisms and therapeutic potentials of ATF1 in cancers

Ziwen Lu, Hangyu Dong, Zhigang Tu, Hanqing Liu

Life Sciences

DOI

2024

Menin signaling and therapeutic targeting in breast cancer

Peng Liu, Peng Liu, Chaowen Shi, Lipeng Qiu, Dongsheng Shang, Zhigang Tu, Zhigang Tu, Hanqing Liu

Current Problems in Cancer

DOI

2024

PTEN inhibition enhances sensitivity of ovarian cancer cells to the poly (ADP-ribose) polymerase inhibitor by suppressing the MRE11-RAD50-NBN complex

Lipeng Qiu, Ruyan Li, Yue Wang, Ziwen Lu, Zhigang Tu, Hanqing Liu

British Journal of Cancer

DOI

2023

Transient HSP90 inhibition enhances the sensitivity of mantle cell lymphoma to poly (ADP-ribose) polymerase (PARP) inhibitors

Chao-Wen Shi, Dewan Ren, Yufeng Gao, Ya-Mei Dang, Z. Tu, Hanqing Liu

Genes and Diseases

DOI

2023

CETSA and thermal proteome profiling strategies for target identification and drug discovery of natural products

Yanbei Tu, Lihua Tan, Hongxun Tao, Yanfang Li, Hanqing Liu

Phytomedicine

DOI

2022

BRCA1、BRCA2、RAD51和FANCD2在上皮性卵巢癌中的表达及其与临床病理特征的关系

刘兰兰，王志新，袁思锐，石春燕，卢子文，胡兴，刘晗青，屠志刚

《江苏大学学报(医学版)》

2022

RAD54B mutations enhance the sensitivity of ovarian cancer cells to poly(ADP-ribose) polymerase (PARP) inhibitors

Peng Liu, Chun-Ju Lin, Lanlan Liu, Ziwen Lu, Z. Tu, Hanqing Liu

Journal of Biological Chemistry

DOI

2022

Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial–mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer

Ziwen Lu, Sirui Yuan, L. Ruan, Z. Tu, Hanqing Liu

Cell Death and Disease

DOI

2022

Editorial: Molecular Targets and Therapeutic Strategies in Gynecological Cancers

Ziwen Lu, Hanqing Liu

Frontiers in Oncology

DOI

2022

Therapeutic targeting of DNA damage repair pathways guided by homologous recombination deficiency scoring in ovarian cancers

Chun-Shien Lin, Peng Liu, Chaowen Shi, Li-Peng Qiu, D. Shang, Ziwen Lu, Z. Tu, Hanqing Liu

Fundamental & Clinical Pharmacology

DOI

2022

The landscape of UBE2S in hepatocellular carcinoma: Prognostic significance, immuno-oncology feature and drug response

Lipeng Qiu, Yue Wang, Zhihuan Li, Z. Tu, Hanqing Liu

Genes and Diseases

DOI

2022

HSP90 Inhibitor Ganetespib Enhances the Sensitivity of Mantle Cell Lymphoma to Bruton’s Tyrosine Kinase Inhibitor Ibrutinib

Ziwen Lu, Zhi-Xin Wang, Z. Tu, Hanqing Liu

Frontiers in Pharmacology

DOI

2021

HSP90 inhibition downregulates DNA replication and repair genes via E2F1 repression

Hanqing Liu, Ziwen Lu, Xiaofeng Shi, Lanlan Liu, Pei-Shan Zhang, E. Golemis, Z. Tu

Journal of Biological Chemistry

DOI

2020

Geranylgeranylation promotes proliferation, migration and invasion of gastric cancer cells through the YAP signaling pathway.

Jing Wei, Ke Peng, Jun Zhu, Lincui Wang, Tiantian Han, Ai-Qin Sun, Gen-Bao Shao, Hanqing Liu, Wan-Nian Yang, Qiong Lin

American journal of translational research

2020

Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro‐inflammatory cytokines

D. Shang, Danlin Sun, Chunyan Shi, Jun Xu, M. Shen, Xing Hu, Hanqing Liu, Z. Tu

Aging Cell

DOI

2020

ASK1 inhibits proliferation and migration of lung cancer cells via inactivating TAZ.

Tiantian Han, Jinyi Gao, Lincui Wang, Y. Qu, Ai-Qin Sun, Ke Peng, Jun Zhu, Hanqing Liu, Wan-Nian Yang, Gen-Bao Shao, Qiong Lin

American Journal of Cancer Research

2020

Deep learning based multi-drug synergy prediction model for individually optimized anti-cancer therapy

Chunlai Feng, Hengwei Chen, Mengqiu Sun, Shengnan She, Hanqing Liu, Mengjie Rui

Zenodo (CERN European Organization for Nuclear Research)

DOI

2020

ASK1 inhibits proliferation and migration of lung cancer cells via inactivating TAZ.

Tiantian Han, Jinyi Gao, Lincui Wang, Yaping Qu, Aiqin Sun, Ke Peng, Jun Zhu, Hanqing Liu, Wannian Yang, Genbao Shao, Qiong Lin

PubMed

2020

Geranylgeranylation promotes proliferation, migration and invasion of gastric cancer cells through the YAP signaling pathway.

Jing Wei, Ke Peng, Jun Zhu, Lincui Wang, Tiantian Han, Aiqin Sun, Genbao Shao, Hanqing Liu, Wannian Yang, Qiong Lin

PubMed

2019

Unexpected activities in regulating ciliation contribute to off-target effects of targeted drugs

Anna A. Kiseleva, Vladislav A. Korobeynikov, A. Nikonova, Pei-Shan Zhang, P. Makhov, A. Deneka, M. Einarson, I. Serebriiskii, Hanqing Liu, J. R. Peterson, E. Golemis

Clinical Cancer Research

DOI

2019

Targeting Membrane Receptors of Ovarian Cancer Cells for Therapy.

Zhiquan Liang, Ziwen Lu, Ya-Fei Zhang, D. Shang, Ruyan Li, Lanlan Liu, Zhi-Cong Zhao, Pei-Shan Zhang, Qiong Lin, Chunlai Feng, Yi-Bang Zhang, Peng Liu, Z. Tu, Hanqing Liu

Current Cancer Drug Targets

DOI

2019

NOD-like receptor signaling in inflammation-associated cancers: From functions to targeted therapies.

Peng Liu, Ziwen Lu, Lanlan Liu, Ruyan Li, Zhiquan Liang, M. Shen, Han Xu, Dewan Ren, Mengchen Ji, Sirui Yuan, D. Shang, Yi-Bang Zhang, Hanqing Liu, Z. Tu

Phytomedicine

DOI

2019

Roles of MYC-targeting long non-coding RNA MINCR in cell cycle regulation and apoptosis in non-small cell lung Cancer

Sheng-min Chen, Tianyi Gu, Ziwen Lu, Li-Peng Qiu, Guoliang Xiao, Xiao-Zhong Zhu, Feng Li, Hui Yu, Gang Li, Hanqing Liu

Respiratory Research

DOI

2019

Cellular Senescence-Inducing Small Molecules for Cancer Treatment.

Peng Liu, Ziwen Lu, Yan-Fang Wu, D. Shang, Zhi-Cong Zhao, Yanting Shen, Ya-Fei Zhang, F. Zhu, Hanqing Liu, Z. Tu

Current Cancer Drug Targets

DOI

2019

Circular RNAs in hepatocellular carcinoma: Biomarkers, functions and mechanisms.

Li-Peng Qiu, Han Xu, Mengchen Ji, D. Shang, Ziwen Lu, Yi-Hang Wu, Z. Tu, Hanqing Liu

Life Science

DOI

2019

Microscopy-Based Automated Live Cell Screening for Small Molecules That Affect Ciliation

Pei-Shan Zhang, Anna A. Kiseleva, Vladislav A. Korobeynikov, Hanqing Liu, M. Einarson, E. Golemis

Frontiers in Genetics

DOI

2019

Discovery of HB-EGF binding peptides and their functional characterization in ovarian cancer cell lines

Yanting Shen, L. Ruan, C. Lian, Ruyan Li, Z. Tu, Hanqing Liu

Cell Death Discovery

DOI

2019

4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer.

Zhi-Cong Zhao, D. Shang, Li-Peng Qiu, Chang Guo, Yan-Yan Li, Hanqing Liu, Guo-Yue Yuan, Z. Tu

Life Science

DOI

2019

Poly (ADP-ribose) polymerase inhibitors combined with other small-molecular compounds for the treatment of ovarian cancer.

Lanlan Liu, Peng Liu, Zhiquan Liang, Ruyan Li, M. Shen, Han Xu, Dewan Ren, Mengchen Ji, Yuhua Yang, Ziwen Lu, D. Shang, Yi-Bang Zhang, Hanqing Liu, Z. Tu

Anti-Cancer Drugs

DOI

2019

The Hippo signaling effector WWTR1 is a metastatic biomarker of gastric cardia adenocarcinoma

Jing Wei, Lincui Wang, Jun Zhu, Ai-Qin Sun, Guanzhen Yu, Miao Chen, Pan Huang, Hanqing Liu, Gen-Bao Shao, Wan-Nian Yang, Qiong Lin

Cancer Cell International

DOI

2018

Targeting the ErbB Family in Head and Neck Cancer

Anna A. Kiseleva, T. Beck, I. Serebriiskii, Hanqing Liu, B. Burtness, E. Golemis

DOI

2018

Ciliary signaling in cancer

Hanqing Liu, Anna A. Kiseleva, E. Golemis

Nature Reviews. Cancer

DOI

2018

Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation

D. Shang, Yan-Fang Wu, Ya Ding, Ziwen Lu, Yanting Shen, F. Zhu, Hanqing Liu, Chunyin Zhu, Z. Tu

Clinical and Experimental Pharmacology and Physiology

DOI

2017

Roles of partitioning‐defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells

L. Ruan, Yanting Shen, Ziwen Lu, D. Shang, Zhi-Cong Zhao, Yong-Jin Lu, Yan-Fang Wu, Ya-Fei Zhang, Z. Tu, Hanqing Liu

Clinical and Experimental Pharmacology and Physiology

DOI

2017

TARGETING HEAT SHOCK PROTEIN 90 AND ITS DOWNSTREAM SIGNALING HUBS FOR THE TREATMENT OF MANTLE CELL LYMPHOMA

Hanqing Liu, Peng Zhang, Dongsheng Shang, X. Shi, Ziwen Lu, L. Liu, M. Shen, Zhigang Tu

Hematological Oncology

DOI

2016

Abstract A64: Targeting HSP90 with ganetespib for targeted therapy of gastric cancer

Hanqing Liu, Pei-Shan Zhang, Zhiquan Liang, L. Ruan, C. Lian, Jian Lu, Y. Hua, Hai-Feng Shi, Ke-Ping Chen, Z. Tu

DOI

2016

Heparin-Binding Epidermal Growth Factor-Like Growth Factor as a Potent Target for Breast Cancer Therapy

C. Lian, L. Ruan, D. Shang, Yan-Fang Wu, Yong-Jin Lu, P. Lu, Yuhua Yang, Yafang Wei, Xiaojing Dong, Dewan Ren, Ke-Ping Chen, Hanqing Liu, Z. Tu

Cancer Biotherapy and Radiopharmaceuticals

DOI

2016

Abstract B14: Targeting heat shock protein 90 with ganetespib for the treatment of lymphoma

Hanqing Liu, Zhiquan Liang, Pei-Shan Zhang, Jing-Jing Zhao, L. Ruan, Yong-Jin Lu, D. Shang, Yingchaun Sun, Z. Tu

DOI

2016

Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin

A. Gaponova, A. Deneka, T. Beck, Hanqing Liu, G. Andrianov, A. Nikonova, E. Nicolas, M. Einarson, E. Golemis, I. Serebriiskii

OncoTarget

DOI

2015

Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization

U. D. Ramirez, A. Nikonova, Hanqing Liu, A. Pecherskaya, Sarah H. Lawrence, I. Serebriiskii, Yan Zhou, M. Robinson, M. Einarson, E. Golemis, E. Jaffe

BMC Cancer

DOI

2015

Abstract 682: Targeting heat shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer

Hanqing Liu, Jian Lu, Y. Hua, Pei-Shan Zhang, Zhiquan Liang, L. Ruan, C. Lian, Hai-Feng Shi, Ke-Ping Chen, Z. Tu

DOI

2015

The non-additive contribution of hydroxyl substituents to Akt kinase–apigenin affinity

Jian Lu, Zhuyi Zhang, Zhong Ni, Hai-Jun Shen, Z. Tu, Hanqing Liu, Rong-Zhu Lu, Hai-Feng Shi

DOI

2015

Abstract 2614: Targeting heat shock protein 90 with Ganetespib for the treatment of lymphoma

Z. Tu, Hanqing Liu, Jing-Jing Zhao, Pei-Shan Zhang, Zhiquan Liang, L. Ruan, Yong-Jin Lu, D. Shang, Yingchaun Sun, Li-Li Xu, Ke-Ping Chen, Quji Danzeng

DOI

2015

Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment

Hanqing Liu, Z. Tu, Fan Feng, Hai-Feng Shi, Ke-Ping Chen, Xi-Ming Xu

Acta Pharmaceutica

DOI

2015

2D-DIGE and MALDI TOF/TOF MS analysis reveal that small GTPase signaling pathways may play an important role in cadmium-induced colon cell malignant transformation.

Jian Lu, Zhong-Ping Zhou, Jianzhou Zheng, Zhuyi Zhang, Rong-Zhu Lu, Hanqing Liu, Hai-Feng Shi, Z. Tu

Toxicology and Applied Pharmacology

DOI

2015

Targeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer

Hanqing Liu, Junjie Lu, Y Hua, Peipei Zhang, Z Liang, Ling‐Ling Ruan, C Lian, Hongyun Shi, K Chen, Zhigang Tu

Cell Death and Disease

DOI

2014

EGFR Inhibitors as Therapeutic Agents in Head and Neck Cancer

Hanqing Liu, J. Cracchiolo, T. Beck, I. Serebriiskii, E. Golemis

DOI

2014

QM/MM-PB/SA scoring of the interaction strength between Akt kinase and apigenin analogues

Jian Lu, Zhuyi Zhang, Zhong Ni, Hai-Jun Shen, Z. Tu, Hanqing Liu, Rong-Zhu Lu

Comput. Biol. Chem.

DOI

2014

Integrating In Silico Resources to Map a Signaling Network

Hanqing Liu, T. Beck, E. Golemis, I. Serebriiskii

Methods in molecular biology

DOI

2013

Network analysis identifies an HSP90-central hub susceptible in ovarian cancer

Hanqing Liu, F. Xiao, I. Serebriiskii, S. O’Brien, Marisa A. Maglaty, I. Astsaturov, S. Litwin, Lainie P. Martin, D. Proia, E. Golemis, D. Connolly

Clinical Cancer Research

DOI

2012

Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGFR inhibitors via increased EGFR degradation

A. Sukhanova, A. Gorin, I. Serebriiskii, L. Gabitova, Hui Zheng, Diana Restifo, B. Egleston, D. Cunningham, T. Bagnyukova, Hanqing Liu, A. Nikonova, G. Adams, Yan Zhou, Dong-Hua Yang, R. Mehra, B. Burtness, Kathy Q. Cai, Andres J Klein-Szanto, L. Kratz, R. Kelley, L. Weiner, G. Herman, E. Golemis, I. Astsaturov

Cancer Discovery

DOI

2012

Abstract 276: Targeting signaling networks via RNAi to improve therapy for ovarian cancer

Hanqing Liu, I. Serebriiskii, M. Einarson, A. Pecherskaya, Yan Zhou, H. Pathak, A. Godwin, E. Golemis

DOI

精选作品

期刊论文

BRD4在细胞衰老中的多重调控机制及其在癌症治疗中的应用进展

The therapy-induced senescence-associated secretory phenotype and epithelial-mesenchymal transition axis in ovarian cancer: molecular mechanisms and therapeutic opportunities

Targeting CD30L in B-cell non-Hodgkin lymphoma: novel peptide conjugates and their therapeutic potential

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Expression, molecular mechanisms and therapeutic potentials of ATF1 in cancers

Menin signaling and therapeutic targeting in breast cancer

PTEN inhibition enhances sensitivity of ovarian cancer cells to the poly (ADP-ribose) polymerase inhibitor by suppressing the MRE11-RAD50-NBN complex

Transient HSP90 inhibition enhances the sensitivity of mantle cell lymphoma to poly (ADP-ribose) polymerase (PARP) inhibitors

CETSA and thermal proteome profiling strategies for target identification and drug discovery of natural products

BRCA1、BRCA2、RAD51和FANCD2在上皮性卵巢癌中的表达及其与临床病理特征的关系

RAD54B mutations enhance the sensitivity of ovarian cancer cells to poly(ADP-ribose) polymerase (PARP) inhibitors

Partitioning defective 6 homolog alpha (PARD6A) promotes epithelial–mesenchymal transition via integrin β1-ILK-SNAIL1 pathway in ovarian cancer

Editorial: Molecular Targets and Therapeutic Strategies in Gynecological Cancers

Therapeutic targeting of DNA damage repair pathways guided by homologous recombination deficiency scoring in ovarian cancers

The landscape of UBE2S in hepatocellular carcinoma: Prognostic significance, immuno-oncology feature and drug response

HSP90 Inhibitor Ganetespib Enhances the Sensitivity of Mantle Cell Lymphoma to Bruton’s Tyrosine Kinase Inhibitor Ibrutinib

HSP90 inhibition downregulates DNA replication and repair genes via E2F1 repression

Geranylgeranylation promotes proliferation, migration and invasion of gastric cancer cells through the YAP signaling pathway.

Activation of epidermal growth factor receptor signaling mediates cellular senescence induced by certain pro‐inflammatory cytokines

ASK1 inhibits proliferation and migration of lung cancer cells via inactivating TAZ.

Deep learning based multi-drug synergy prediction model for individually optimized anti-cancer therapy

ASK1 inhibits proliferation and migration of lung cancer cells via inactivating TAZ.

Geranylgeranylation promotes proliferation, migration and invasion of gastric cancer cells through the YAP signaling pathway.

Unexpected activities in regulating ciliation contribute to off-target effects of targeted drugs

Targeting Membrane Receptors of Ovarian Cancer Cells for Therapy.

NOD-like receptor signaling in inflammation-associated cancers: From functions to targeted therapies.

Roles of MYC-targeting long non-coding RNA MINCR in cell cycle regulation and apoptosis in non-small cell lung Cancer

Cellular Senescence-Inducing Small Molecules for Cancer Treatment.

Circular RNAs in hepatocellular carcinoma: Biomarkers, functions and mechanisms.

Microscopy-Based Automated Live Cell Screening for Small Molecules That Affect Ciliation

Discovery of HB-EGF binding peptides and their functional characterization in ovarian cancer cell lines

4,5-Diphenyl-2-methyl picolinate induces cellular senescence by accumulating DNA damage and activating associated signaling pathways in gastric cancer.

Poly (ADP-ribose) polymerase inhibitors combined with other small-molecular compounds for the treatment of ovarian cancer.

The Hippo signaling effector WWTR1 is a metastatic biomarker of gastric cardia adenocarcinoma

Targeting the ErbB Family in Head and Neck Cancer

Ciliary signaling in cancer

Identification of a pyridine derivative inducing senescence in ovarian cancer cell lines via P21 activation

Roles of partitioning‐defective protein 6 (Par6) and its complexes in the proliferation, migration and invasion of cancer cells

TARGETING HEAT SHOCK PROTEIN 90 AND ITS DOWNSTREAM SIGNALING HUBS FOR THE TREATMENT OF MANTLE CELL LYMPHOMA

Abstract A64: Targeting HSP90 with ganetespib for targeted therapy of gastric cancer

Heparin-Binding Epidermal Growth Factor-Like Growth Factor as a Potent Target for Breast Cancer Therapy

Abstract B14: Targeting heat shock protein 90 with ganetespib for the treatment of lymphoma

Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin

Compounds identified by virtual docking to a tetrameric EGFR extracellular domain can modulate Grb2 internalization

Abstract 682: Targeting heat shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer

The non-additive contribution of hydroxyl substituents to Akt kinase–apigenin affinity

Abstract 2614: Targeting heat shock protein 90 with Ganetespib for the treatment of lymphoma

Virosome, a hybrid vehicle for efficient and safe drug delivery and its emerging application in cancer treatment

2D-DIGE and MALDI TOF/TOF MS analysis reveal that small GTPase signaling pathways may play an important role in cadmium-induced colon cell malignant transformation.

Targeting heat-shock protein 90 with ganetespib for molecularly targeted therapy of gastric cancer

EGFR Inhibitors as Therapeutic Agents in Head and Neck Cancer

QM/MM-PB/SA scoring of the interaction strength between Akt kinase and apigenin analogues

Integrating In Silico Resources to Map a Signaling Network

Network analysis identifies an HSP90-central hub susceptible in ovarian cancer

Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGFR inhibitors via increased EGFR degradation

Abstract 276: Targeting signaling networks via RNAi to improve therapy for ovarian cancer

研究方向