古天乐｜重庆医科大学｜学者主页

2025

利用CRISPR/Cas13d抑制肠道病毒71型感染

张晓晓，古天乐，吴朔，徐溪，王高文，遆新宇，张艳

《生命科学研究》

DOI

2025

“一境三脉”模式在病原生物学实验课程中的应用

涂增，邹晓毅，卢楠，柳静，古天乐，陆合

《基础医学教育》

DOI

2025

CRISPR/Cas13技术作为病毒核酸检测工具的研究进展

冯文杰，王芳，应旗康，古天乐，董宇航，张俊梅，李冬静，贺晓龙，吴兴安

《热带医学杂志》

2025

医学微生物学大型课堂教学中辅助教学方法的比较研究

黎志东，古天乐，应旗康

《微生物学杂志》

2025

“一境到底”在病原生物学教学中的应用

陆合，涂增，邹晓毅，武卫华，刘佳，柳静，古天乐

《基础医学教育》

DOI

2025

Novel Enterococcus faecium P2 as a probiotic for mitigating Clostridioides difficile infection.

Yihong Cui, Qianying Jia, Han Yan, Xinping Hua, Yu Tan, Wenwen Jian, Xue Gong, Kim Hayer, Siyi Xing, Yi Zhang, Jing Liu, Yuan Wu, Abbas Yadegar, Tianle Gu, Z. Tu

Microbial Pathogenesis

DOI

2025

Salt-inducible kinase 1 is a key gene in suppressing EVD68-induced asthma by modulating antiviral immunity

Juntong Liu, Yue Wang, Lingyun Zou, Xinyue Han, Mingqi Lv, Xi-Chuan Deng, Jingjing Liao, G. Zang, Lei Xu, Tianle Gu, Nan Lu, Guangyuan Zhang

Genes and Diseases

DOI

2025

A Novel HTNV Budding Inhibitor Interferes the Interaction Between Viral Glycoprotein and Host ESCRT Accessory Protein ALIX

Qi-Kang Ying, Xiaoxiao Zhang, Sheng-Zheng Wang, Tianle Gu, Junmei Zhang, Wenjie Feng, Dongjing Li, Yuhang Dong, Xin-Gan Wu, Fang Wang

Journal of Medical Virology

DOI

2025

Apatinib Inhibits HTNV by Stimulating TFEB-Driven Lysosome Biogenesis to Degrade Viral Protein.

Qi-Kang Ying, Xiaoxiao Zhang, Tianle Gu, Junmei Zhang, Yuhang Dong, Wenjie Feng, Dongjing Li, Xin-Gan Wu, Fang Wang

Antiviral Research

DOI

2024

利用CRISPR/Cas9技术建立STAT1敲除细胞系及其功能验证

张俊梅，王芳，应旗康，冯文杰，古天乐，吴兴安

《病毒学报》

2024

Investigating the Impact of HTNV Infection on the Gut Microbiota of Wild-Type and NLRX1 Knockout Mice

Wenjie Sun, Yaxin Ding, Zi-Yu Liu, Shi-Yuan Hou, Dan-Ni Sun, Ruixue Ma, Huarui Kang, Xiaohan Ma, Jiayu Wang, Hongrui Mu, Yunhua Lv, Tianle Gu, Qi-Kang Ying, Fang Wang, Xin-Gan Wu, Rong-Rong Liu

Advanced Gut & Microbiome Research

DOI

2024

Guanylate‐binding protein 1 inhibits Hantaan virus infection by restricting virus entry

Tianle Gu, Sirui Qu, Junmei Zhang, Qi-Kang Ying, Xiaoxiao Zhang, Yunhua Lv, Rong-Rong Liu, Yunan Feng, Fang Wang, Xin-Gan Wu

Journal of Medical Virology

DOI

2024

T-cell immunoglobulin and mucin 1 (TIM-1) mediates infection of Hantaan virus in Jurkat T cells

Ruixue Ma, Xu-Yang Zheng, Tianle Gu, Zi-Yu Liu, Shi-Yuan Hou, Dan-Ni Sun, Yaxin Ding, Fang Wang, Qi-Kang Ying, Xiaohan Ma, Huarui Kang, Rong-Rong Liu, Jian-Qi Lian, Xin-Gan Wu

Virus Research

DOI

2023

干扰素刺激基因鸟苷酸结合蛋白2(GBP2)质粒的构建及其抗汉滩病毒感染的作用

屈思瑞，王芳，张俊梅，应旗康，赵瑞华，古天乐，吴兴安

《细胞与分子免疫学杂志》

2023

汉坦病毒入胞机制研究进展

张俊梅，王芳，应旗康，古天乐，屈思瑞，冯文杰，高小朋，吴兴安

《热带医学杂志》

2023

Investigation of a subunit protein vaccine for HFRS based on a consensus sequence between envelope glycoproteins of HTNV and SEOV

Rongrong Liu, Yunhua Lv, Wenjie Sun, Min Li, Ningning Ge, Chengdong Zhu, Ya-Xin Ding, Zi-Yu Liu, Ruixue Ma, Yuxiao Huang, Shi-Yuan Hou, Qi-Kang Ying, Tianle Gu, Fang Wang, L. Nie, You-Chun Wang, Wei-Jing Huang, Jia-Yi Shu, Xin-Gan Wu

Virus Research

DOI

古天乐

精选作品

期刊论文

利用CRISPR/Cas13d抑制肠道病毒71型感染

“一境三脉”模式在病原生物学实验课程中的应用

CRISPR/Cas13技术作为病毒核酸检测工具的研究进展

医学微生物学大型课堂教学中辅助教学方法的比较研究

“一境到底”在病原生物学教学中的应用

Novel Enterococcus faecium P2 as a probiotic for mitigating Clostridioides difficile infection.

Salt-inducible kinase 1 is a key gene in suppressing EVD68-induced asthma by modulating antiviral immunity

A Novel HTNV Budding Inhibitor Interferes the Interaction Between Viral Glycoprotein and Host ESCRT Accessory Protein ALIX

Apatinib Inhibits HTNV by Stimulating TFEB-Driven Lysosome Biogenesis to Degrade Viral Protein.

利用CRISPR/Cas9技术建立STAT1敲除细胞系及其功能验证

Investigating the Impact of HTNV Infection on the Gut Microbiota of Wild-Type and NLRX1 Knockout Mice

Guanylate‐binding protein 1 inhibits Hantaan virus infection by restricting virus entry

T-cell immunoglobulin and mucin 1 (TIM-1) mediates infection of Hantaan virus in Jurkat T cells

干扰素刺激基因鸟苷酸结合蛋白2(GBP2)质粒的构建及其抗汉滩病毒感染的作用

汉坦病毒入胞机制研究进展

Investigation of a subunit protein vaccine for HFRS based on a consensus sequence between envelope glycoproteins of HTNV and SEOV

研究方向