百晓学者学者目录

李剑

副教授、助理教授、博导，厦门大学

精选作品

期刊论文

2026

LC+LTCBDE术治疗胆囊结石合并胆总管结石的炎症指标变化和短期疗效

唐冠杰，郑彬，李剑

《实用医学杂志》

2025

基底细胞黏附分子作为癌症治疗靶点的研究进展

曹敏，叶慧，李文蕾，李剑，黄瑞晶

《药物生物技术》

2023

肿瘤相关靶点滋养层糖蛋白5T4的研究现状

郝瑞家，李桂霞，刘艳菊，郑学敏，黄瑞晶，李剑，吕明启，韩进，王根辈

《中国临床药理学杂志》

2023

靶向紧密连接蛋白6的药物在癌症治疗中的研究进展

李桂霞，毕宇鑫，郝瑞家，郑学敏，王根辈，李剑，王鹏银

《生物工程学报》

2023

Corrigendum: DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression

Kun Xu, Shenghui Sun, Mingjing Yan, Ju Cui, Yao Yang, Wenlin Li, Xiu-Qing Huang, L. Dou, Bei-Dong Chen, Wei-Qing Tang, Ming-Huang Lan, Jian Li, Tao Shen

Frontiers in Oncology

DOI

2023

Phosphoenolpyruvate induces endothelial dysfunction and cell senescence through stimulation of metabolic reprogramming

Tong An, Xiao-Yi Zhang, Xin Gao, Xi-Yue Zhang, Tao Shen, Hongxia Li, L. Dou, Xiu-Qing Huang, Yong Man, Guo-Ping Li, Wei-Qing Tang, Jian Li

Journal of Bioenergetics and Biomembranes

DOI

2023

Apigenin alleviates oxidative stress-induced myocardial injury by regulating SIRT1 signaling pathway.

Kun Xu, Yao Yang, M. Lan, Jian-Nan Wang, Bing Liu, Mingjing Yan, Huan Wang, Wenlin Li, Shenghui Sun, Kai-Yi Zhu, Xi-Yue Zhang, Ming-Yan Hei, Xiu-Qing Huang, L. Dou, Wei-Qing Tang, Qing He, Jian Li, Tao Shen

European Journal of Pharmacology

DOI

2023

Effects of HMGB1/RAGE/cathespin B inhibitors on alleviating hippocampal injury by regulating microglial pyroptosis and caspase activation in neonatal hypoxic–ischemic brain damage

Kai-Yi Zhu, Xing Zhu, Jie Yu, Lu Chen, Shi-Qi Liu, Mingjing Yan, Wei Yang, Yan-Yan Sun, Zhe Zhang, Jian Li, Tao Shen, Ming-Yan Hei

Journal of Neurochemistry

DOI

2023

Glycyrrhizin arginine salt protects against cisplation-induced acute liver injury by repressing BECN1-mediated ferroptosis

Jun Guo, Jiameng Yin, Pu Liu, Xin Zhang, Jie Wei, Mingjun Wang, Yanxia Xiao, Yongzhan Zhen, Yajun Lin, Jian Li

Frontiers in Pharmacology

DOI

2023

[Notch1 inhibits the mechanistic role of STING signaling to regulate hepatocyte lipophagy in nonalcoholic steatohepatitis].

T. Yang, J.-Y. Zhao, X. Wang, Z. Fang, L.-F. Jiang, Jian Li

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

DOI

2023

Impacts of Non-alcoholic Fatty Liver Disease on Acute Coronary Syndrome: Evidence and Controversies

Shun-Yi Shi, Fang Jia, Meng-Fei Wang, Ya-Feng Zhou, Jian Li

Current Atherosclerosis Reports

DOI

2022

miR-488-3p Protects Cardiomyocytes against Doxorubicin-Induced Cardiotoxicity by Inhibiting CyclinG1

Mingjing Yan, Yuan Cao, Que Wang, Kun Xu, L. Dou, Xiu-Qing Huang, Bei-Dong Chen, Wei-Qing Tang, M. Lan, Bing Liu, Kai-Yi Zhu, Yao Yang, Shenghui Sun, Xi-Yue Zhang, Yong Man, Ming-Yan Hei, Tao Shen, Jian Li

Oxidative Medicine and Cellular Longevity

DOI

2022

DDX17 protects hepatocytes against oleic acid/palmitic acid-induced lipid accumulation.

Xiao-Yi Zhang, Tong An, Xi-Yue Zhang, Tao Shen, Hongxia Li, L. Dou, Xiu-Qing Huang, Yong Man, Wei-Qing Tang, Jian Li

Biochemical and Biophysical Research Communications - BBRC

DOI

2022

Aging and aging-related diseases: from molecular mechanisms to interventions and treatments

Jun Guo, Xiu-Qing Huang, L. Dou, Mingjing Yan, Tao Shen, Wei-Qing Tang, Jian Li

Signal Transduction and Targeted Therapy

DOI

2022

Lysophosphatidylcholine disrupts cell adhesion and induces anoikis in hepatocytes

Hao Chen, Jia-Rui Ma, Jin Liu, L. Dou, Tao Shen, Huiyan Zuo, Fangzhi Xu, Li Zhao, Wei-Qing Tang, Yong Man, Yan-Yan Ma, Jian Li, Xiu-Qing Huang

FEBS Letters

DOI

2022

Delphinidin induces autophagic flux blockage and apoptosis by inhibiting both multidrug resistance gene 1 and DEAD-box helicase 17 expressions in liver cancer cells.

Shenghui Sun, Kun Xu, Mingjing Yan, Ju Cui, Kai-Yi Zhu, Yao Yang, Xiao-Yi Zhang, Wei-Qing Tang, Xiu-Qing Huang, L. Dou, Bei-Dong Chen, Ya-Jun Lin, Xi-Yue Zhang, Yong Man, Jian Li, Tao Shen

The Journal of pharmacy and pharmacology

DOI

2022

The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11β-HSD1

Mengliang Hu, Ting Han, Qi Pan, Dongsheng Ni, F. Gao, Li-Ying Wang, Hangjiang Ren, Xiao-Yi Zhang, Hao Jiao, Yuefeng Wang, D. Dai, Yong Man, Wei-Qing Tang, Yue Sun, Wei Li, Jian Li, Guo-Ping Li

International Journal on Biological Sciences

DOI

2022

DDX5 and DDX17—multifaceted proteins in the regulation of tumorigenesis and tumor progression

Kun Xu, Shenghui Sun, Mingjing Yan, Ju Cui, Yao Yang, Wenlin Li, Xiu-Qing Huang, L. Dou, Bei-Dong Chen, Wei-Qing Tang, M. Lan, Jian Li, Tao Shen

Frontiers in Oncology

DOI

2022

Application of proteomics and metabolomics to assess ammonia stress response and tolerance mechanisms of juvenile ornate rock lobster Panulirus ornatus.

Xianyun Ren, Shao-Ting Jia, Bao-Quan Gao, Qiansen Zhou, Yao Xu, Ping Liu, Jian Li

Science of the Total Environment

DOI

2022

Identification of Neuropeptides Using Long-Read RNA-Seq in the Swimming Crab Portunus trituberculatus, and Their Expression Profile Under Acute Ammonia Stress

Daixia Wang, Xiaochen Liu, Jingyan Zhang, Bao-Quan Gao, Ping Liu, Jian Li, Xianliang Meng

Frontiers in Physiology

DOI

2022

Antioxidant, Transcriptomic and Metabonomic Analysis of Hepatopancreatic Stress Resistance in Exopalaemon carinicauda Following Astaxanthin Feeding

Wenyang Li, Jia-Jia Wang, Ji-Tao Li, Ping Liu, Jian Li, Fazhen Zhao

Frontiers in Marine Science

DOI

2022

Proteomic Analysis Associated with the Immune Response in Hemocytes of Portunus trituberculatus Challenged with Vibrio parahaemolyticus

Bao-Quan Gao, Xianyun Ren, Jian-Jian Lv, Xianliang Meng, Ping Liu, Jian Li

Fishes

DOI

2021

单链尿激酶型纤溶酶原激活剂作用机制与临床应用的研究现状

荣华，王根辈，李剑，周水平，马晓慧

《中国临床药理学杂志》

DOI

2021

整合素αvβ3相关疾病与靶点药物的研发进展

姜智文，李文蕾，王轶博，李剑，徐寒梅

《药物生物技术》

DOI

2021

PD-L1和OX40靶点肿瘤免疫疗法研究进展

王丽文，李凤智，高文丽，曹小丹，李剑，胡加亮

《药物生物技术》

DOI

2021

PD-L1和VEGF双靶点联合阻断治疗的研究进展

赵梦泽，李凤智，王鹏银，李剑，徐寒梅

《中国生物工程杂志》

DOI

2021

Bone marrow macrophage‐derived exosomal miR‐143‐5p contributes to insulin resistance in hepatocytes by repressing MKP5

Lin-Fang Li, Huiyan Zuo, Xiu-Qing Huang, Tao Shen, Wei-Qing Tang, Xiao-Yi Zhang, Tong An, L. Dou, Jian Li

Cell Proliferation

DOI

2021

Protein Phosphatase 4 Promotes Hepatocyte Lipoapoptosis by Regulating RAC1/MLK3/JNK Pathway

Xiu-Qing Huang, Guang Yang, Li Zhao, Hui-Ping Yuan, Hao Chen, Tao Shen, Wei-Qing Tang, Yong Man, Jia-Rui Ma, Yan-Yan Ma, L. Dou, Jian Li

Oxidative Medicine and Cellular Longevity

DOI

2021

Cardiac Aging: From Basic Research to Therapeutics

Mingjing Yan, Shenghui Sun, Kun Xu, Xiu-Qing Huang, L. Dou, Jing Pang, Wei-Qing Tang, Tao Shen, Jian Li

Oxidative Medicine and Cellular Longevity

DOI

2021

Inhibition of TLR4 prevents hippocampal hypoxic-ischemic injury by regulating ferroptosis in neonatal rats.

Kai-Yi Zhu, Xing Zhu, Shenghui Sun, Wei Yang, Shi-Qi Liu, Zhen Tang, Rong Zhang, Jian Li, Tao Shen, Ming-Yan Hei

Experimental Neurology

DOI

2021

Polypeptide Globular Adiponectin Ameliorates Hypoxia/Reoxygenation-Induced Cardiomyocyte Injury by Inhibiting Both Apoptosis and Necroptosis

Kai-Yi Zhu, Jia Guo, Xiao-Xue Yu, Que Wang, Chao Yan, Quan Qiu, Wei-Qing Tang, Xiu-Qing Huang, Hong-Na Mu, L. Dou, Yun-Fei Bian, Q.-H. Han, Tao Shen, Jian Li, C. Xiao

Journal of Immunological Research

DOI

2021

Caffeic acid prevents non-alcoholic fatty liver disease induced by a high-fat diet through gut microbiota modulation in mice.

Hong-Na Mu, Qi Zhou, Rui-Yue Yang, Wei Tang, Hong-Xia Li, Si-Ming Wang, Jian Li, Wen-Xiang Chen, Jun Dong

Food Research International

DOI

2021

miR-23a/b-3p promotes hepatic lipid accumulation by regulating Srebp-1c and Fas.

Lin-Fang Li, Xiao-Yi Zhang, Hangjiang Ren, Xiu-Qing Huang, Tao Shen, Wei-Qing Tang, L. Dou, Jian Li

Journal of Molecular Endocrinology

DOI

2020

构建噬菌体展示抗体库过程中电穿孔法的条件优化

杨丽，石晓宇，李文蕾，李剑，徐寒梅

《中国生物工程杂志》

DOI

2020

外泌体通过发挥免疫调控作用影响血液肿瘤细胞生物学特性的研究进展

蒋小燕，杨雅芝，胡贤良，陈慧君，李剑

《中国实验血液学杂志》

DOI

2020

全合成噬菌体展示抗体库淘筛策略与多样性分析

王韵依，石晓宇，李文蕾，李剑，奚涛

《药物生物技术》

DOI

2020

Frequent RNF43 mutation contributes to moderate activation of Wnt signaling in colorectal signet-ring cell carcinoma

Yaqi Li, Jian Li, Renjie Wang, Long Zhang, Guoxiang Fu, Xueying Wang, Yebin Wang, Chuantao Fang, Dandan Zhang, Duo Du, Xiaoji Ma, Mengxue Pan, Qiang Guo, Xiaoya Xu, Xiang Hu, Yi Zhou, Shaobo Mo, Huijun Wang, Jianjun Gao, Shenglin Huang, Yun Liu, Sanjun Cai, Guoqiang Hua, Junjie Peng, Fa-Xing Yu

Protein & Cell

2020

USP47-mediated deubiquitination and stabilization of YAP contributes to the progression of colorectal cancer

Beiqing Pan, Yi Yang, Jian Li, Yu Wang, Chuantao Fang, Fa-Xing Yu, Yanhui Xu

Protein & Cell

2020

Enhanced peripheral blood miR-324-5p is associated with the risk of metabolic syndrome by suppressing ROCK1.

Jun Guo, chunxiao yang, Ya-Jun Lin, Gang Hu, Jie Wei, Xin Zhang, Xie-Hui Chen, Jian Li

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

DOI

2020

Ultraconserved element uc.333 increases insulin sensitivity by binding to miR-223

Yang Zhang, Jingyu Sun, He Yao, Ya-Jun Lin, Jie Wei, Gang Hu, Jun Guo, Jian Li

Aging

DOI

2020

Dexrazoxane Protects Cardiomyocyte from Doxorubicin-Induced Apoptosis by Modulating miR-17-5p

Xiao-Xue Yu, Yang Ruan, Tao Shen, Quan Qiu, Mingjing Yan, Shenghui Sun, L. Dou, Xiu-Qing Huang, Que Wang, Xi-Yue Zhang, Yong Man, Wei-Qing Tang, Ze-Ning Jin, Jian Li

BioMed Research International

DOI

2020

GPR120 facilitates cholesterol efflux in macrophages through activation of AMPK signaling pathway

Tong An, Xiao-Yi Zhang, Hong-Xia Li, L. Dou, Xiu-Qing Huang, Yong Man, Xi-Yue Zhang, Tao Shen, Guo-Ping Li, Jian Li, Wei-Qing Tang

The FEBS Journal

DOI

2019

慢性粒细胞白血病干细胞的微环境及对药物治疗反应的研究进展

贺玲，张小燕，杨雅芝，李剑

《中国医药导报》

2019

miR-154-5p Functions as an Important Regulator of Angiotensin II-Mediated Heart Remodeling

Que Wang, Xiao-Xue Yu, L. Dou, Xiu-Qing Huang, Kai-Yi Zhu, Jun Guo, Mingjing Yan, Si-Ming Wang, Yong Man, Wei-Qing Tang, Tao Shen, Jian Li

Oxidative Medicine and Cellular Longevity

DOI

2019

Dexrazoxane ameliorates doxorubicin-induced cardiotoxicity by inhibiting both apoptosis and necroptosis in cardiomyocytes.

Xiao-Xue Yu, Yang Ruan, Xiu-Qing Huang, L. Dou, M. Lan, Ju Cui, Bei-Dong Chen, H. Gong, Que Wang, Mingjing Yan, Shenghui Sun, Quan Qiu, Xi-Yue Zhang, Yong Man, Wei-Qing Tang, Jian Li, Tao Shen

Biochemical and Biophysical Research Communications - BBRC

DOI

2019

Diagnostic Value of Serum MiR-587 in Patients with Metabolic Syndrome.

Jun Guo, Ya-Jun Lin, Jie Wei, Xin Zhang, chunxiao yang, Jingyu Sun, Yang Zhang, Gang Hu, Jian Li

Clinical Laboratory

DOI

2019

Peripheral Blood miR-937 May Serve as a Biomarker for Metabolic Disorders by Targeting AMPKα.

chunxiao yang, Jun Guo, Ya-Jun Lin, Gang Hu, Wie Jie, Xin Zhang, Jingyu Sun, Jian Li

Clinical Laboratory

DOI

2018

间充质干细胞衰老相关信号通路

杨雅芝，张小燕，李剑

《中国实验血液学杂志》

2018

抗CD20抗体高产细胞株的筛选及质量评估

纪海姣，李文蕾，黄瑞晶，李剑，徐寒梅

《中国生物工程杂志》

2018

Ultraconserved element uc.372 drives hepatic lipid accumulation by suppressing miR-195/miR4668 maturation

Jun Guo, Weiwei Fang, Libo Sun, Yonggang Lu, L. Dou, Xiu-Qing Huang, Wei-Qing Tang, Liqing Yu, Jian Li

Nature Communications

DOI

2018

Metformin-Induced Changes of the Coding Transcriptome and Non-Coding RNAs in the Livers of Non-Alcoholic Fatty Liver Disease Mice

Jun Guo, Yuan Zhou, Y. Cheng, Weiwei Fang, Gang Hu, Jie Wei, Ya-Jun Lin, Yong Man, Lixin Guo, Mingxiao Sun, Qing-Hua Cui, Jian Li

Cellular Physiology and Biochemistry

DOI

2018

miR‑338‑3p mediates gluconeogenesis via targeting of PP4R1 in hepatocytes.

Shuyue Wang, Lin-Fang Li, Xie-Hui Chen, Xiu-Qing Huang, Jin Liu, Xuelin Sun, Yang Zhang, Tao Shen, Jun Guo, Yong Man, Wei-Qing Tang, L. Dou, Jian Li

Molecular Medicine Reports

DOI

2018

Liraglutide reduces hepatic glucolipotoxicity-induced liver cell apoptosis through NRF2 signaling in Zucker diabetic fatty rats

Jun Guo, Cai Li, chunxiao yang, Bing Li, Jie Wei, Ya-Jun Lin, Peng Ye, Gang Hu, Jian Li

Molecular Medicine Reports

DOI

2018

Peripheral Blood miR-139 May Serve as a Biomarker for Metabolic Disorders by Targeting FoxO1 and FoxP1.

Jun Guo, chunxiao yang, Wie Jie, Bing Li, Ya-Jun Lin, Peng Ye, Gang Hu, Jian Li

Clinical Laboratory

DOI

2018

miR-291b-3p mediated ROS-induced endothelial cell dysfunction by targeting HUR

Xiao-Fang Sui, Shuqian Yu, L. Dou, Xie-Hui Chen, Xue-Jie Li, Jun Yang, Yanan Su, Shuyue Wang, Feng-Ling Wang, Jian Li

International Journal of Molecular Medicine

DOI

2018

Long Noncoding RNA lncSHGL Recruits hnRNPA1 to Suppress Hepatic Gluconeogenesis and Lipogenesis

Junpei Wang, Weili Yang, Zhen-Zhen Chen, Ji Chen, Yu-Hong Meng, Biaoqi Feng, Libo Sun, L. Dou, Jian Li, Qing-Hua Cui, Ji-Chun Yang

Diabetes

DOI

2018

The Roles of Heat Shock Proteins 70 and 90 in Exopalaemon carinicauda After WSSV and Vibrio anguillarum Challenges

Ji-Tao Li, Jian Li, Ya-Fei Duan, Ping Chen, Ping Liu

Journal of Ocean University of China

DOI

2017

外泌小体在白血病细胞和骨髓间充质干细胞交叉对话中的作用

杨雅芝，张小燕，房丽君，万倩，李剑

《中国实验血液学杂志》

2017

长效蛋白多肽类药物技术研究进展

杜昭明，徐寒梅，王轶博，黄瑞晶，李剑

《药物生物技术》

2017

Mir-338-3p Mediates Tnf-A-Induced Hepatic Insulin Resistance by Targeting PP4r1 to Regulate PP4 Expression

L. Dou, Shuyue Wang, Libo Sun, Xiu-Qing Huang, Yang Zhang, Tao Shen, Jun Guo, Yong Man, Wei-Qing Tang, Jian Li

Cellular Physiology and Biochemistry

DOI

2017

Modified citrus pectin inhibits galectin-3 function to reduce atherosclerotic lesions in apoE-deficient mice

Yonggang Lu, Ming-Ming Zhang, Pei Zhao, M. Jia, Bing-Fen Liu, Q. Jia, Jun Guo, L. Dou, Jian Li

Molecular Medicine Reports

DOI

2017

NFE2 Induces miR-423-5p to Promote Gluconeogenesis and Hyperglycemia by Repressing the Hepatic FAM3A-ATP-Akt Pathway

Weili Yang, Junpei Wang, Zhen-Zhen Chen, Ji Chen, Yu-Hong Meng, Li-Ming Chen, Yong-Sheng Chang, B. Geng, Libo Sun, L. Dou, Jian Li, Y. Guan, Qing-Hua Cui, Ji-Chun Yang

Diabetes

DOI

2017

MiR-19a mediates gluconeogenesis by targeting PTEN in hepatocytes.

L. Dou, Shuyue Wang, Xiu-Qing Huang, Xuelin Sun, Yang Zhang, Tao Shen, Jun Guo, Yong Man, Wei-Qing Tang, Jian Li

Molecular Medicine Reports

DOI

2017

Hepatic MiR-291b-3p Mediated Glucose Metabolism by Directly Targeting p65 to Upregulate PTEN Expression

Jun Guo, L. Dou, Xiangyu Meng, Zhen-Zhen Chen, Weili Yang, Weiwei Fang, chunxiao yang, Xiu-Qing Huang, Wei-Qing Tang, Ji-Chun Yang, Jian Li

Scientific Reports

DOI

2016

骨髓间充质干细胞在慢性髓系白血病耐酪氨酸激酶抑制剂中的作用

张小燕，万倩，房丽君，李剑

《中国实验血液学杂志》

2016

CD200/CD200R在异基因造血干细胞移植后的表达水平及意义

黄月华，张薇，蔡昊，李天骄，李剑，韩冰，庄俊玲，朱铁楠，蔡华聪，周道斌

《中国实验血液学杂志》

2016

Liver MicroRNA-291b-3p Promotes Hepatic Lipogenesis through Negative Regulation of Adenosine 5′-Monophosphate (AMP)-activated Protein Kinase α1*

Xiangyu Meng, Jun Guo, Weiwei Fang, L. Dou, Meng Li, Xiu-Qing Huang, Shutong Zhou, Yong Man, Wei-Qing Tang, Liqing Yu, Jian Li

Journal of Biological Chemistry

DOI

2016

Protein phosphatase 4 plays dual roles during cell proliferation

Xiu-Qing Huang, Jin Liu, Tao Shen, Xiangyu Meng, L. Dou, Ya-Jun Lin, Jian Li

Cell Proliferation

DOI

2016

MicroRNA‐20a‐5p contributes to hepatic glycogen synthesis through targeting p63 to regulate p53 and PTEN expression

Weiwei Fang, Jun Guo, Yuan Cao, Shuyue Wang, Cheng Pang, Meng Li, L. Dou, Yong Man, Xiu-Qing Huang, Tao Shen, Jian Li

Journal of Cellular and Molecular Medicine

DOI

2016

GPR40 agonist ameliorates liver X receptor-induced lipid accumulation in liver by activating AMPK pathway

Meng Li, Xiangyu Meng, Jie Xu, Xiu-Qing Huang, Hong-Xia Li, Guo-Ping Li, Shu Wang, Yong Man, Wei-Qing Tang, Jian Li

Scientific Reports

DOI

2016

MicroRNA 152 regulates hepatic glycogenesis by targeting PTEN

Shuyue Wang, Lilin Wang, L. Dou, Jun Guo, Weiwei Fang, Meng Li, Xiangyu Meng, Yong Man, Tao Shen, Xiu-Qing Huang, Jian Li

The FEBS Journal

DOI

2016

Astragalus polysaccharide restores autophagic flux and improves cardiomyocyte function in doxorubicin-induced cardiotoxicity

Yuan Cao, Tao Shen, Xiu-Qing Huang, Ya-Jun Lin, Bei-Dong Chen, Jing Pang, Guo-Ping Li, Que Wang, Sylvia Zohrabian, Chao Duan, Yang Ruan, Yong Man, Shu Wang, Jian Li

OncoTarget

DOI

2016

Reduced miR-200b and miR-200c expression contributes to abnormal hepatic lipid accumulation by stimulating JUN expression and activating the transcription of srebp1

Jun Guo, Weiwei Fang, Libo Sun, Yonggang Lu, L. Dou, Xiu-Qing Huang, Mingxiao Sun, Cheng Pang, J. Qu, Guang-Hui Liu, Jian Li

OncoTarget

DOI

2015

重组人血小板源生长因子的发酵表达,纯化及其生物信息学分析

于聪，薛雯，范宝庆，曹小丹，黄瑞晶，孙明律，徐立华，李召杰，张军哲，张玲，李剑

《药物生物技术》

2015

rhFGF-21的高效表达及其纯化工艺的优化

于聪，李剑，周长林

《药物生物技术》

2015

靶向干扰慢性粒细胞白血病干细胞信号通路的研究进展

张小燕，张娟，史晋叔，万倩，房丽君，李剑

《基础医学与临床》

2015

间充质干细胞源性外泌体——未来生物疗法的理想载体

张娟，史晋叔，李剑

《中国实验血液学杂志》

2015

SIRT1 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the Oxidative Stress and p38MAPK Pathways

Yang Ruan, Chun-Ling Dong, Jigar Patel, Chao Duan, Xinyue Wang, Xi Wu, Yuan Cao, Lian-Mei Pu, D. Lu, Tao Shen, Jian Li

Cellular Physiology and Biochemistry

DOI

2015

MiR-301a Mediates the Effect of IL-6 on the AKT/GSK Pathway and Hepatic Glycogenesis by Regulating PTEN Expression

L. Dou, Shuyue Wang, Xiao-Fang Sui, Xiangyu Meng, Tao Shen, Xiu-Qing Huang, Jun Guo, Weiwei Fang, Yong Man, J. Xi, Jian Li

Cellular Physiology and Biochemistry

DOI

2015

Overexpression 11β-HSD1 develops into fatty liver without obesity in C57BL/6 mice

Shu Wang, Guo-Ping Li, Jie Xu, Feng Gao, Jian Li, Yong Man

2015

MiR-19a regulates PTEN expression to mediate glycogen synthesis in hepatocytes

L. Dou, Xiangyu Meng, Xiao-Fang Sui, Shuyue Wang, Tao Shen, Xiu-Qing Huang, Jun Guo, Weiwei Fang, Yong Man, J. Xi, Jian Li

Scientific Reports

DOI

2015

[Autophagy during cardiac stress: is the autophagy beneficial for detrimental].

Yuan Cao, Tao Shen, Jian Li

Sheng li ke xue jin zhan [Progress in physiology]

2015

Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-α-induced hepatic insulin resistance

Hongye Zhao, Xiu-Qing Huang, J. Jiao, Hangxiang Zhang, Jin Liu, Weiwei Qin, Xiangyu Meng, Tao Shen, Ya-Jun Lin, Jiaojiao Chu, Jian Li

Scientific Reports

DOI

2015

GW26-e0194 Apelin Ameliorates Myocardial Insulin Resistance and Improves Myocardial Injury in Diabetes

Hangxiang Zhang, Jiaojiao Chu, Tao Shen, Chongqing Yang, Xiu-Qing Huang, Shu Wang, Xiaoming Wang, Jian Li

DOI

2015

SAMHD1 Inhibits LINE-1 Retrotransposition by Promoting Stress Granule Formation

Si-Qi Hu, Jian Li, Feng-Wen Xu, S. Mei, Yann Le Duff, Lijuan Yin, Xiaojing Pang, S. Cen, Qi Jin, Chen Liang, Fei Guo

PLoS Genetics

DOI

2014

P53对胚胎干细胞分化的影响及作用机制

史晋叔，涂怀军，张娟，李剑

《基础医学与临床》

2014

来源于间充质干细胞的CAFs促进肿瘤生长

房丽君，李剑

《基础医学与临床》

2014

重组人血小板源生长因子的药学研究进展

范宝庆，薛雯，于聪，曹小丹，黄瑞晶，李静，徐立华，张学况，张玲，李剑

《中国医药生物技术》

2014

脾酪氨酸激酶抑制剂的研究进展

张玲玲，王义永，蒋华良，李剑

《中国药物化学杂志》

2014

抗TNF α全人抗体培养工艺的优化

刘小雅，李文蕾，黄瑞晶，李剑，王旻

《药物生物技术》

2014

Astragalus Polysaccharide Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the PI3k/Akt and p38MAPK Pathways

Yuan Cao, Yang Ruan, Tao Shen, Xiu-Qing Huang, Meng Li, Weiwei Yu, Yu-ping Zhu, Yong Man, Shu Wang, Jian Li

Oxidative Medicine and Cellular Longevity

DOI

2014

SIRT1 Functions as an Important Regulator of Estrogen-Mediated Cardiomyocyte Protection in Angiotensin II-Induced Heart Hypertrophy

Tao Shen, Ling Ding, Yang Ruan, Weiwei Qin, Ya-Jun Lin, Chao Xi, Yonggang Lu, L. Dou, Yu-ping Zhu, Yuan Cao, Yong Man, Yun-Fei Bian, Shu Wang, C. Xiao, Jian Li

Oxidative Medicine and Cellular Longevity

DOI

2014

Cardiac Shock Wave Therapy Attenuates H9c2 Myoblast Apoptosis by Activating the AKT Signal Pathway

Weiwei Yu, Tao Shen, Baoyi Liu, Shu Wang, Jian Li, D. Dai, Jian-Ping Cai, Qing He

Cellular Physiology and Biochemistry

DOI

2014

MiR-291b-3p Induces Apoptosis in Liver Cell Line NCTC1469 by Reducing the Level of RNA-binding Protein HuR

Jun Guo, Meng Li, Xiangyu Meng, Jing-Zhe Sui, L. Dou, Wei-Qing Tang, Xiu-Qing Huang, Yong Man, Shu Wang, Jian Li

Cellular Physiology and Biochemistry

DOI

2014

High glucose reduces hepatic glycogenesis by suppression of microRNA‑152.

Xiaoyun Zhao, Yonggang Lu, Fenghong Wang, L. Dou, Lilin Wang, Jun Guo, Jian Li

Molecular Medicine Reports

DOI

2014

Protein phosphatase 4 promotes hepatic lipogenesis through dephosphorylating acetyl‑CoA carboxylase 1 on serine 79.

Xiangyu Meng, Meng Li, Jun Guo, Wei-Qing Tang, Shu Wang, Yong Man, Xiu-Qing Huang, Jian Li

Molecular Medicine Reports

DOI

2013

骨髓血管微环境对造血干细胞“干性”的维持作用

刘莉，涂怀军，彭婷，喻松霞，贺玲，李剑

《基础医学与临床》

2013

人胚胎干细胞无血清无饲养层培养体系的建立

喻松霞，郭玲玲，贺文凤，贺玲，李洁，李剑

《基础医学与临床》

2013

T-Box20 Suppresses Oxidized Low-Density Lipoprotein-induced Human Vascular Endothelial Cell Injury by Upregulation of PPAR-γ

Tao Shen, Yu-ping Zhu, Jigar Patel, Yang Ruan, Bei-Dong Chen, Ge-Xin Zhao, Yuan Cao, Jing Pang, Han-Young Guo, Hong-Xia Li, Yong Man, Shu Wang, Jian Li

Cellular Physiology and Biochemistry

DOI

2013

miR-200s Contribute to Interleukin-6 (IL-6)-induced Insulin Resistance in Hepatocytes*

L. Dou, Ting Zhao, Lilin Wang, Xiu-Qing Huang, J. Jiao, Dan Gao, Hangxiang Zhang, Tao Shen, Yong Man, Shu Wang, Jian Li

Journal of Biological Chemistry

DOI

2013

Characterization of β-cell function and insulin resistance in overweight Chinese adolescents with normal glucose tolerance

Mingxiao Sun, Xiuqing Huang, Lei Jiang, Yi Yan, Bo-Wen Li, Wei-Juan Zhong, Jun-Fei Chen, Yi-Min Zhang, Zheng-Zhen Wang, Jian Li, Min-Hao Xie

Experimental and Therapeutic Medicine

DOI

2013

Astragalus polysaccharides suppress ICAM-1 and VCAM-1 expression in TNF-α-treated human vascular endothelial cells by blocking NF-κB activation

Yu-ping Zhu, Tao Shen, Ya-Jun Lin, Bei-Dong Chen, Yang Ruan, Yuan Cao, Y. Qiao, Yong Man, Shu Wang, Jian Li

Acta Pharmacologica Sinica

DOI

2013

miRNA-152和miRNA-200s在IL-6诱导的肝胰岛素抵抗中的作用

L. Dou, Jian Li

2013

Cloning and characterization of a novel apolipoprotein gene, apolipoprotein AV, in tree shrews

Guo-ping Li, Huairong Luo, Guotao Sun, Gui-Sheng Wu, Gang Wu, Yan Wang, Yong Man, Shu Wang, Jian Li, Bao-sheng Chen

Molecular Biology Reports

DOI

2012

C‐reactive protein promotes adhesion of monocytes to endothelial cells via NADPH oxidase‐mediated oxidative stress

Xiu-Qing Huang, Jing Zhang, Jin Liu, Liang Sun, Hongye Zhao, Yonggang Lu, Jian-Chang Wang, Jian Li

Journal of Cellular Biochemistry

DOI

2012

Panax Notogingseng Saponins Suppress RAGE/ MAPK Signaling and NF-kappaB Activation in Apolipoprotein-E-deficient Atherosclerosis-prone mice

L. Dou, Yonggang Lu, Tao Shen, Xiu-Qing Huang, Yong Man, Shu Wang, Jian Li

Cellular Physiology and Biochemistry

DOI

2012

NADPH oxidase 2 plays a critical role in dysfunction and apoptosis of pancreatic β-cells induced by very low-density lipoprotein

J. Jiao, L. Dou, Miao Li, Yonggang Lu, Han-Bang Guo, Yong Man, Shu Wang, Jian Li

Molecular and Cellular Biochemistry

DOI

2012

NADPH Oxidase 2-derived Reactive Oxygen Species are Involved in Dysfunction and Apoptosis of Pancreatic β-cells Induced by Low Density Lipoprotein

Miao Li, L. Dou, J. Jiao, Yonggang Lu, Han-Bang Guo, Yong Man, Shu Wang, Jian Li

Cellular Physiology and Biochemistry

DOI

2011

One-hour after-school exercise ameliorates central adiposity and lipids in overweight Chinese adolescents: a randomized controlled trial.

Mingxiao Sun, Xiuqing Huang, Yi Yan, Bo-Wen Li, Wei-Juan Zhong, Jun-Fei Chen, Yi-Min Zhang, Zheng-Zhen Wang, Lu Wang, Xiao-Cai Shi, Jian Li, Min-Hao Xie

2011

IL-6通过Sirt1/p53/caspase-3通路介导胰岛β细胞凋亡

Bo Liu, Ya-Jun Lin, Jian Li

2010

The Effects of Palmitate on Hepatic Insulin Resistance Are Mediated by NADPH Oxidase 3-derived Reactive Oxygen Species through JNK and p38MAPK Pathways*

Dan Gao, Shanwei Nong, Xiu-Qing Huang, Yonggang Lu, Hongye Zhao, Ya-Jun Lin, Yong Man, Shu Wang, Jie Yang, Jian Li

Journal of Biological Chemistry

DOI

2009

基质金属蛋白酶在间充质干细胞分化中的作用

陈新，章诺贝，李剑，石庆之

《中国组织工程研究》

2007

超速离心高效液相色谱测定血清脂蛋白亚类和脂蛋白（a）胆固醇

Jun Dong, Han-Bang Guo, Hong-Xia Li, Yong Man, Shu Wang, Jian Li, Wen-Xiang Chen

2006

脐血间充质干细胞的无血清培养

李剑，涂怀军，石庆芝，李洁，吴琼，戴革，戴育成

《中华血液学杂志》

2006

脐血间充质干细胞无血清培养的实验研究

涂怀军，李剑，石庆芝，李洁，吴琼，戴育成

《解放军医学杂志》

2003

Ndrg2基因表达对胃癌细胞增殖调控及其机理的研究

刘新平，邓艳春，韩炯，李剑，王吉村，李莹，药立波

《生物化学与生物物理进展》

2002

一种新的抑癌候选基因——NDR2在人类正常组织及相应肿瘤中的表达

李剑，刘新平，林树新，邓艳春，孟庆军，张文红，李树钧，聂晓燕，药立波

《生物化学与生物物理进展》

2002

从人T细胞淋巴瘤cDNA文库中筛选含PH结构域编码序列的新基因

李剑，刘新平，药立波，林树新，季少平，聂晓燕

《细胞与分子免疫学杂志》

会议论文

2024

CART细胞治疗在非肿瘤领域的临床研究进展

李剑

《中国药理学会药物临床试验专业委员会第六次学术年会暨第五届西湖临床研究与评价技术大会》

2024

CAR-T细胞疗法在非肿瘤疾病中的临床研究进展

郭宁红，陈慧君，李剑

《中国药理学会药物临床试验专业委员会第六次学术年会暨第五届西湖临床研究与评价技术大会会议指南》

DOI

2023

CART细胞治疗在实体瘤的临床研究进展及未来发展方向

李剑

《中国药理学会药物临床试验专业委员会第五次学术年会汇编》

DOI

2001

NDR2基因在人类正常组织及肿瘤中的表达

李剑，药立波，林树新，刘新平，邓艳春，聂晓燕

《中国生物化学与分子生物学会第八届会员代表大会暨全国学术会议论文摘要集》

预印本

2026

RareLens: Towards End-to-End Rare Disease Care via Aligning Divergent Large Language Model Reasoning

Xi Chen, Hongru Zhou, Shiyu Feng, Hanyu Zhou, Huahui Yi, Rongsheng Wang, Tiancheng He, Kun Wang, Pingping Liu, Qiankun Li, Sicheng Lin, Huiying Ou, Xiaohong Zheng, Tianying Zang, Zhuohang Wu, Leheng Jiang, Kexin Cao, Wenhan Zhang, ChengYi Li, Zhiyang Wang, Songlin Li, Benyou Wang, Ningbei Yin, Shaoting Zhang, Weili Fu, Jian Li, Kang Li

arXiv preprint

2026

Feature-Adaptive Fusion in Hybrid Quantum-Classical Neural Networks for Robust Biomedical Image Classification

Yan-Yan Hou, Jian Li, Chongqiang Ye, Hengji Li, Zhuo Wang, Qinghui Liu

arXiv preprint

2024

Evaluating and Enhancing Large Language Models Performance in Domain-specific Medicine: Osteoarthritis Management with DocOA

Xi Chen, MingKe You, Li Wang, WeiZhi Liu, Yu Fu, Jie Xu, Shaoting Zhang, Gang Chen, Kang Li, Jian Li

arXiv preprint

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