梁凯威｜武汉大学｜学者主页

2026

A dual-module ECAS complex couples transcription elongation and RNA processing

Ying Xiang, Honghong Wang, Zhinang Yin, Ruijing Xiao, Zemin Song, Rui Lu, Rong Dai, Jiaqin Ye, Conghui Li, Yali Cui, Mengxuan Wang, Junhui Lv, Qiuzi Li, Fuqi Wang, Zhuoshi Li, Kaiwen Zhang, Yiming Zhang, Di Wu, Pingping Fang, Kaiwei Liang

Molecular Cell

DOI

2025

KAT6A chimeras form a self-reinforcing epigenetic module with NURF and MLL/COMPASS to sustain AML

Junhui Lv, Zhinang Yin, Conghui Li, Honglin Wen, Jian Ni, Peiyuan Yang, Zemin Song, Ying Xiang, Honghong Wang, Rui Lu, Li Huang, Ying Zhou, Hai‐Bing Zhou, Ruijing Xiao, Pingping Fang, Kaiwei Liang

Genome biology

DOI

2025

Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation

Zemin Song, Yali Cui, Lilan Xin, Ruijing Xiao, Jingjing Feng, Conghui Li, Zhinang Yin, Honghong Wang, Qiuzi Li, Mengxuan Wang, Baoyi Lin, Yiming Zhang, Ying Zhou, Li‐Min Huang, Yanli He, Xiaoqing Li, Xiaoyan Liu, Shangqin Liu, Fuling Zhou, Zheng Liu, Hai‐Bing Zhou, Pingping Fang, Kaiwei Liang

Cell stem cell

DOI

2025

Author Correction: R-loop-dependent promoter-proximal termination ensures genome stability

Congling Xu, Chengyu Li, Jiwei Chen, Yan Xiong, Zhibin Qiao, Pengyu Fan, Conghui Li, Shuangyu Ma, Jin Liu, Aixia Song, Bolin Tao, Tao Xu, Wei Xu, Yayun Chi, Jingyan Xue, Pu Wang, Dan Ye, Hongzhou Gu, Peng Zhang, Qiong Wang, Ruijing Xiao, Jingdong Cheng, Hai Zheng, Xiaoli Yu, Zhen Zhang, Jiong Wu, Kaiwei Liang, Yan-Jun Liu, Huasong Lu, Fei Chen

Nature

DOI

2024

Global coupling of R-loop dynamics with RNA polymerase II modulates gene expression and early development of Drosophila

Xian-Hong Zhang, Shao-Bo Liang, Zhuoyun Yi, Zhaohui Qiao, Bo Xu, Huichao Geng, Hong-Hong Wang, Xinhuan Yin, Mingliang Tang, W. Ge, Yong-Zhen Xu, Kaiwei Liang, Yu-Jie Fan, Liang Chen

Nucleic Acids Research

DOI

2024

The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release.

Zhen-Ning Wang, Ai-Xia Song, Bo-Lin Tao, Maojian Miao, Yi Luo, Jingwen Wang, Zhi-Nang Yin, Rui-Jing Xiao, Xin-Wen Zhou, Xue-Ying Shang, Shibin Hu, Kaiwei Liang, Charles G. Danko, F. X. Chen

Molecules and Cells

DOI

2024

KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity

Yulong Qiang, Jiachen Fan, Chuanshuai Xie, Leilei Yan, Xiaofei Song, Nan Zhang, Yan Lin, Jie Xiong, Wei Zhang, Yu Liu, Lei Wei, Yu Li, Shizhen Chen, Kaiwei Liang, Feng Li

Cancer Research

DOI

2023

PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex

Jiaxing Jin, Hui Bai, Han Yan, Ting Deng, Tianyu Li, Ruijing Xiao, Lina Fan, Xue Bai, Hanhan Ning, Zhe Liu, Kai Zhang, Xudong Wu, Kaiwei Liang, Ping Ma, Xin Gao, Deqing Hu

Nature Communications

DOI

2023

R-loop-dependent promoter-proximal termination ensures genome stability

Nature

DOI

2023

G-quadruplex in hepatitis B virus pregenomic RNA promotes its translation

Jingjing Wang, Haiyan Huang, Kaitao Zhao, Yan Teng, Li Zhao, Zaichao Xu, Yingcheng Zheng, Lu Zhang, Conghui Li, Yurong Duan, Kaiwei Liang, Xiang Zhou, Xiaoming Cheng, Yuchen Xia

Journal of Biological Chemistry

DOI

2023

SARS-CoV-2 nsp13 Restricts Episomal DNA Transcription without Affecting Chromosomal DNA

Aixin Li, Bei Zhang, Kaitao Zhao, Zhinang Yin, Yan Teng, Lu Zhang, Zaichao Xu, Kaiwei Liang, Xiaoming Cheng, Yuchen Xia

Journal of Virology

DOI

2023

CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation

Min Qiu, Zhinang Yin, Honghong Wang, Lingyu Lei, Conghui Li, Yali Cui, Rong Dai, Peiyuan Yang, Ying Xiang, Qiuzi Li, Junhui Lv, Zhuang Hu, Min Chen, Hai‐Bing Zhou, Pingping Fang, Ruijing Xiao, Kaiwei Liang

Science Advances

DOI

2023

The super elongation complex drives transcriptional addiction in MYCN -amplified neuroblastoma

Donghai Wang, Zhinang Yin, Honghong Wang, Liyuan Wang, Tianyu Li, Ruijing Xiao, Ting Xie, Ruyi Han, Rui Dong, Hudan Liu, Kaiwei Liang, Guoliang Qing

Science Advances

DOI

2023

CDK13 phosphorylates the translation machinery and promotes tumorigenic protein synthesis

Chao Wu, Ting Xie, Ying Guo, Donghai Wang, Min Qiu, Ruyi Han, Guoliang Qing, Kaiwei Liang, Hudan Liu

Oncogene

DOI

2022

Genome-Wide Native R-Loop Profiling by R-Loop Cleavage Under Targets and Tagmentation (R-Loop CUT&Tag).

Hong-Hong Wang, Conghui Li, Kaiwei Liang

Methods in molecular biology

DOI

2022

G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes

Conghui Li, Zhinang Yin, Ruijing Xiao, Beili Huang, Yali Cui, Honghong Wang, Ying Xiang, Lingrui Wang, Lingyu Lei, Jiaqin Ye, Tianyu Li, Youquan Zhong, Fangteng Guo, Yuchen Xia, Pingping Fang, Kaiwei Liang

Genome biology

DOI

2022

PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression

Xianchun Lan, Song Ding, Tianzhe Zhang, Ying Yi, Conghui Li, Wenwen Jin, Jian Chen, Kaiwei Liang, Hengbin Wang, Wei Jiang

Nature Communications

DOI

2021

Genomic profiling of native R loops with a DNA-RNA hybrid recognition sensor

Kang Wang, Hong-Hong Wang, Conghui Li, Zhi-Nang Yin, Ruijing Xiao, Qiuzi Li, Ying Xiang, Wen Wang, Jian Huang, Liang Chen, Pingping Fang, Kaiwei Liang

Science Advances

DOI

2021

Ligand-induced native G-quadruplex stabilization impairs transcription initiation

Conghui Li, Hong-Hong Wang, Zhi-Nang Yin, Pingping Fang, Ruijing Xiao, Ying Xiang, Wen Wang, Qiuzi Li, Beili Huang, Jian Huang, Kaiwei Liang

Genome Research

DOI

2021

YTHDF1 promotes mRNA degradation via YTHDF1‐AGO2 interaction and phase separation

Jiong Li, Ke Chen, Xin Dong, Yating Xu, Qi Sun, Hong-Hong Wang, Zhen Chen, Cong Liu, Rong Liu, Zhe Yang, Xiangfei Mei, Rongyu Zhang, Liuping Chang, Zongwen Tian, Jianjun Chen, Kaiwei Liang, Chunjiang He, Mengcheng Luo

Cell Proliferation

DOI

2021

CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism

Wenli Huang, Tuersunayi Abudureheman, Jing Xia, Lei Chu, Hang Zhou, Wei‐Wei Zheng, Neng Zhou, Rongyi Shi, Minghao Li, Jianmin Zhu, Kai Qing, Chao Ji, Kaiwei Liang, Sa Guo, Gang Yin, Cai‐Wen Duan

Frontiers in Cell and Developmental Biology

DOI

2020

DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation

Kaixiang Cao, Michal Ugarenko, Patrick A. Ozark, Juan Wang, Stacy A. Marshall, E. Rendleman, Kaiwei Liang, Lu Wang, L. Zou, Edwin R. Smith, Feng Yue, A. Shilatifard

Proceedings of the National Academy of Sciences of the United States of America

DOI

2020

Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase

Hai Zheng, Yilun Qi, Shibin Hu, Xuan Duc Cao, Congling Xu, Zhinang Yin, Xizi Chen, Yan Li, Weida Liu, Jie Li, Jiawei Wang, Gang Wei, Kaiwei Liang, Fei Chen, Yanhui Xu

Science

DOI

2019

Transcriptional addiction in mixed lineage leukemia: new avenues for target therapies

Ruijing Xiao, Hong-Hong Wang, Kaiwei Liang

Blood Science

DOI

2018

Targeting Processive Transcription Elongation Via SEC Disruption for Myc Induced Cancer Therapy

Kaiwei Liang, Edwin R. Smith, Yuki Aoi, Kristen L. Stoltz, H. Katagi, Ashley R Woodfin, E. Rendleman, Stacy A. Marshall, D. C. Murray, Lu Wang, Patrick A. Ozark, R. Mishra, R. Hashizume, G. Schiltz, A. Shilatifard

Cell

DOI

2018

Human TFIIH Kinase CDK 7 Regulates Transcription-Associated Chromatin Modifications Graphical Abstract Highlights

Benjamin Erickson, B. L. Allen, N. Fong, Jeremy R. Jacobsen, Kaiwei Liang, R. Dowell, David L. Bentley

2018

A CHAF1B-dependent molecular switch in hematopoiesis and leukemia pathogenesis

Andrew G. Volk, Kaiwei Liang, P. Suraneni, Xinyu Li, Jian-Yun Zhao, Marinka Bulic, Stacy A. Marshall, K. Pulakanti, Sébastien Malinge, J. Taub, Y. Ge, S. Rao, E. Bartom, A. Shilatifard, J. Crispino

Cancer Cell

DOI

2018

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia

J. Crispino, Andrew G. Volk, Kaiwei Liang, Y. Ge, E. Bartom, Sébastien Malinge, A. Shilatifard

Experimental Hematology

DOI

2017

Human TFIIH kinase CDK7 regulates transcription-associated chromatin modifications

C. Ebmeier, Benjamin Erickson, B. L. Allen, M. Allen, Hyunmin Kim, N. Fong, Jeremy R. Jacobsen, Kaiwei Liang, A. Shilatifard, R. Dowell, W. Old, D. Bentley, D. Taatjes

Cell Reports

DOI

2017

Therapeutic targeting of MLL degradation pathways in MLL-rearranged leukemia

Kaiwei Liang, Andrew G. Volk, Jeffrey S. Haug, Stacy A. Marshall, Ashley R Woodfin, E. Bartom, J. Gilmore, L. Florens, M. Washburn, Kelly D. Sullivan, J. Espinosa, J. Cannova, Ji-Wang Zhang, Edwin R. Smith, J. Crispino, A. Shilatifard

Cell

DOI

2017

A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism

Lu Wang, Clayton K. Collings, Zi-Bo Zhao, Kira A. Cozzolino, Quanhong Ma, Kaiwei Liang, Stacy A. Marshall, Christie C. Sze, R. Hashizume, Jeffrey N. Savas, A. Shilatifard

Genes & Development

DOI

2015

Mitotic Transcriptional Activation: Clearance of Actively Engaged Pol II Via Transcriptional Elongation Control in Mitosis

Kaiwei Liang, Ashley R Woodfin, Brian D. Slaughter, J. Unruh, A. Box, Ryan A. Rickels, Xin Gao, J. Haug, S. Jaspersen, A. Shilatifard

Molecules and Cells

DOI

2015

Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing

Kaiwei Liang, Xin Gao, J. Gilmore, L. Florens, M. Washburn, Edwin R. Smith, A. Shilatifard

Molecular and Cellular Biology

DOI

2014

CCL23在成人急性髓系白血病中的表达研究

贺艳丽，王平，胡艳洁，杜雯，梁凯威，卢聪，李小青，黄士昂，郑金娥

《南昌大学学报(医学版)》

2012

Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4.

Hans-Martin Herz, Mo-Han Man, Alexander S. Garruss, Kaiwei Liang, Yoh-hei Takahashi, Kristen Mickey, O. Voets, C. Verrijzer, A. Shilatifard

Genes & Development

DOI

梁凯威

精选作品

期刊论文

A dual-module ECAS complex couples transcription elongation and RNA processing

KAT6A chimeras form a self-reinforcing epigenetic module with NURF and MLL/COMPASS to sustain AML

Mechano-oncogenic cytoskeletal remodeling drives leukemic transformation with mitochondrial vesicle-mediated STING activation

Author Correction: R-loop-dependent promoter-proximal termination ensures genome stability

Global coupling of R-loop dynamics with RNA polymerase II modulates gene expression and early development of Drosophila

The phosphatase PP1 sustains global transcription by promoting RNA polymerase II pause release.

KDM5C-Mediated Recruitment of BRD4 to Chromatin Regulates Enhancer Activation and BET Inhibitor Sensitivity

PRMT2 promotes HIV-1 latency by preventing nucleolar exit and phase separation of Tat into the Super Elongation Complex

R-loop-dependent promoter-proximal termination ensures genome stability

G-quadruplex in hepatitis B virus pregenomic RNA promotes its translation

SARS-CoV-2 nsp13 Restricts Episomal DNA Transcription without Affecting Chromosomal DNA

CDK12 and Integrator-PP2A complex modulates LEO1 phosphorylation for processive transcription elongation

The super elongation complex drives transcriptional addiction in MYCN -amplified neuroblastoma

CDK13 phosphorylates the translation machinery and promotes tumorigenic protein synthesis

Genome-Wide Native R-Loop Profiling by R-Loop Cleavage Under Targets and Tagmentation (R-Loop CUT&Tag).

G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes

PCGF6 controls neuroectoderm specification of human pluripotent stem cells by activating SOX2 expression

Genomic profiling of native R loops with a DNA-RNA hybrid recognition sensor

Ligand-induced native G-quadruplex stabilization impairs transcription initiation

YTHDF1 promotes mRNA degradation via YTHDF1‐AGO2 interaction and phase separation

CDK9 Inhibitor Induces the Apoptosis of B-Cell Acute Lymphocytic Leukemia by Inhibiting c-Myc-Mediated Glycolytic Metabolism

DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation

Identification of Integrator-PP2A complex (INTAC), an RNA polymerase II phosphatase

Transcriptional addiction in mixed lineage leukemia: new avenues for target therapies

Targeting Processive Transcription Elongation Via SEC Disruption for Myc Induced Cancer Therapy

Human TFIIH Kinase CDK 7 Regulates Transcription-Associated Chromatin Modifications Graphical Abstract Highlights

A CHAF1B-dependent molecular switch in hematopoiesis and leukemia pathogenesis

A CHAF1B-Dependent Molecular Switch in Hematopoiesis and Leukemia

Human TFIIH kinase CDK7 regulates transcription-associated chromatin modifications

Therapeutic targeting of MLL degradation pathways in MLL-rearranged leukemia

A cytoplasmic COMPASS is necessary for cell survival and triple-negative breast cancer pathogenesis by regulating metabolism

Mitotic Transcriptional Activation: Clearance of Actively Engaged Pol II Via Transcriptional Elongation Control in Mitosis

Characterization of Human Cyclin-Dependent Kinase 12 (CDK12) and CDK13 Complexes in C-Terminal Domain Phosphorylation, Gene Transcription, and RNA Processing

CCL23在成人急性髓系白血病中的表达研究

Enhancer-associated H3K4 monomethylation by Trithorax-related, the Drosophila homolog of mammalian Mll3/Mll4.

研究方向