百晓学者学者目录

岳晓平

硕士生导师、讲师，江西师范大学

精选作品

期刊论文

2026

Machine-Learning-Guided Discovery and Engineering a Carbonyl Reductase for Efficient Stereoselective Synthesis of Chiral Aryl α-Fluoro β-Hydroxy Esters via Dynamic Kinetic Resolution

Xiaoping Yue, Qipeng Yan, Yi-Tong Li, Jia-Le Wang, Xinyu Sun, Yu-Ping Li, Qilin Gao, Jian-Bo Wang, Fen-Er Chen

ACS Sustainable Chemistry & Engineering

DOI

2025

Mutagenesis of a Single Site Inverts the Stereopreference of Imine Reductase

Yi-Tong Li, Yun-Yun Yang, Meng-Ting Zhang, Xiaoping Yue, Rey-Ting Guo, Ze-Du Huang, Fen-Er Chen

ACS Catalysis

DOI

2024

Rational redesign of the loop dynamics of carbonyl reductase LfSDR1 to improve the stereoselectivity for asymmetric synthesis of bulky chiral alcohols.

Xiaoping Yue, Yi-Tong Li, M. Wei, Yu Duan, Lin Yang, Fen-Er Chen

International Journal of Biological Macromolecules

DOI

2023

羰基还原酶立体选择性合成芳基α-氯-β-羟基酯的应用研究

岳晓平

《四川大学》

2023

Asymmetric synthesis of syn-aryl-(2S,3R)-2-chloro-3-hydroxy esters via an engineered ketoreductase-catalyzed dynamic reductive kinetic resolution

Xiaoping Yue, Yi-Tong Li, Di Sang, Yuan Tao, Ze-Du Huang, Fen-Er Chen

Chinese Chemical Letters

DOI

2023

Asymmetric Synthesis of Sterically Hindered 1-Substituted Tetrahydro-β-carbolines Enabled by Imine Reductase: Enzyme Discovery, Protein Engineering, and Reaction Development.

Yi-Tong Li, Xiaoping Yue, Zhi-Ning Li, Ze-Du Huang, Fen-Er Chen

Organic Letters

DOI

2023

Sustainable asymmetric synthesis of diltiazem precursor enabled by recombinant Escherichia coli whole cells co‐expressing an engineered ketoreductase and glucose dehydrogenase

Xiaoping Yue, Yi-Tong Li, Lin Yang, Di Sang, Ze-Du Huang, Fen-Er Chen

Biotechnology Journal

DOI

2022

Biocatalytic dynamic reductive kinetic resolution of aryl α-chloro β-keto esters: divergent, stereocontrolled synthesis of diltiazem, clentiazem, and siratiazem.

Xiaoping Yue, Yi-Tong Li, Minjie Liu, Di Sang, Ze-Du Huang, Fen-Er Chen

Chemical Communications

DOI

2020

Development of a Practical, Biocatalytic Synthesis of tert-Butyl (R)-3-Hydroxyl-5-hexenoate: A Key Intermediate to the Statin Side Chain

Cheng Hu, Minjie Liu, Xiaoping Yue, Ze-Du Huang, Fen-Er Chen

DOI

研究方向

生物催化以及生物催化技术在连续流化学中的应用研究

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