百晓学者学者目录

李珊珊

副教授、教授、研究员，中国科学技术大学

精选作品

期刊论文

2026

Structure-driven RNA remodeling underlies broad substrate recognition by NSUN2

Q. P. Hu, Wen Yang, Yunyun Yu, Ran Yi, Yutong Zhang, Leyuan Duan, Feng Li, Kaiming Zhang, Qingguo Gong, Shanshan Li

Science China Life Sciences

DOI

2026

Dynamic monomer-dimer transition regulates DNA-guided RNA cleavage by MbpAgo

Xiaolong Zhao, Wen Yang, Linfeng An, Lu Chen, Jun Xiao, Kaiming Zhang, Shanshan Li

Nature Communications

DOI

2026

Self-splicing and cyclization mechanisms of the full-length Anabaena pre-tRNA

Xiaojing Zhang, Linfeng An, Wen Yang, Ran Yi, Ji Liu, Shanshan Li, Kaiming Zhang

Nature Chemical Biology

DOI

2026

Pre-splicing conformation and stepwise circularization of a group I intron in Azoarcus pre-tRNA

Yibao Hong, Jiashu Liu, Xiaojing Zhang, Ji Liu, Shanshan Li, Kaiming Zhang

Nature Communications

DOI

2026

Structural insights into type-I and type-II Lamassu antiphage systems

Ming Li, Xiaolong Zhao, Xingyu Zhao, Dong Li, Weijia Xiong, Zirui Gao, Ling Huang, Linfeng An, Yongxiang Gao, Shanshan Li, Yue Feng, Kaiming Zhang, Yi Zhang

Nature Chemical Biology

DOI

2026

Structural insights into the assembly and function of Retron Ec78 PtuAB

Leyuan Duan, Lu Chen, Qian Hu, Xiao Li, Shanshan Li, Kaiming Zhang, Qingguo Gong

Communications Biology

DOI

2025

Structural insights and engineering of the T4 td intron for improved RNA circularization

Linfeng An, Shanshan Li, Kaiming Zhang

Nature Catalysis

DOI

2025

Blind Prediction of Complex Water and Ion Ensembles Around RNA in CASP16

Rachael C. Kretsch, Elisa Posani, Eugene F. Baulin, Janusz Marek Bujnicki, Giovanni Bussi, Thomas E. Cheatham, Shi‐Jie Chen, Arne Elofsson, Masoud Amiri Farsani, Olivia N. Fisher, M. Michael Gromiha, Ayush Gupta, Michiaki Hamada, Kannan Harini, Gang Hu, David Y. C. Huang, Junichi Iwakiri, Anika Jain, Yuki Kagaya, Daisuke Kihara, Sebastian Kmiecik, Sowmya Ramaswamy Krishnan, Ikuo Kurisaki, Olivier Languin–Cattoën, Jun Li, Shanshan Li, Karim Malekzadeh, Tsukasa Nakamura, Wentao Ni, Chandran Nithin, Michael Z. Palo, Joon Hong Park, Smita P. Pilla, Simón Poblete, Fabrizio Pucci, Pranav Punuru, Anouka Saha, Kengo Sato, Ambuj Srivastava, Genki Terashi, Emilia Tugolukova, Jacob C. Verburgt, Qiqige Wuyun, Gül H. Zerze, Kaiming Zhang, Sicheng Zhang, Wei Hui Zheng, Yuanzhe Zhou, Wah Chiu, David Andrew Case, Rhiju Das

Proteins Structure Function and Bioinformatics

DOI

2025

Structural insights into higher-order natural RNA-only multimers

Shengchun Zhang, Ran Yi, Linfeng An, Ji Liu, Xuebiao Yao, Shanshan Li, Kaiming Zhang

Nature Structural & Molecular Biology

DOI

2025

The PAZ pocket and dimerization drive CpAgo’s guide-independent and DNA-guided dual catalysis

Yuchan Liu, Jiasu Zhang, Ji Liu, Shengchun Zhang, Linfeng An, Wenbing Xie, Kaiming Zhang, Shanshan Li

Nature Communications

DOI

2025

Complex water networks visualized by cryogenic electron microscopy of RNA

Rachael C. Kretsch, Shanshan Li, Grigore D Pintilie, Michael Z. Palo, David Andrew Case, Rhiju Das, Kaiming Zhang, Wah Chiu

Nature

DOI

2025

Structural insights into dynamics of the BMV TLS aminoacylation

Yang Wen, Ran Yi, Jing Yao, Yongxiang Gao, Shanshan Li, Qingguo Gong, Kaiming Zhang

Nature Communications

DOI

2025

Complex Water Networks Visualized through Cryogenic Electron Microscopy of RNA

Rachael C. Kretsch, Shanshan Li, Grigore D Pintilie, Michael Z. Palo, David Andrew Case, Rhiju Das, Kaming Zhang, Wah Chiu

Structural Dynamics

DOI

2024

An adenosine analog shows high antiviral potency against coronavirus and arenavirus mainly through an unusual base pairing mode

Xiaoying Jia, Xuping Jing, Ming Li, Minli Gao, Yao Hua Zhong, Entao Li, Yang Liu, Rui Li, Guoqiang Yao, Qiaojie Liu, Minmin Zhou, Yuxia Hou, Linfeng An, Yibao Hong, Shanshan Li, Jiancun Zhang, Wei Wang, Kaiming Zhang, Peng Gong, Sandra Chiu

Nature Communications

DOI

2024

Cryo-EM: A window into the dynamic world of RNA molecules

Xiaojing Zhang, Shanshan Li, Kaiming Zhang

Current Opinion in Structural Biology

DOI

2024

Tertiary folds of the SL5 RNA from the 5′ proximal region of SARS-CoV-2 and related coronaviruses

Rachael C. Kretsch, Lily Xu, Ivan N. Zheludev, Xueting Zhou, Rui Huang, Grace Nye, Shanshan Li, Kaiming Zhang, Wah Chiu, Rhiju Das

Proceedings of the National Academy of Sciences

DOI

2024

Bifurcated assembly pathway and dual function of a Lon-like protease revealed by cryo-EM Analysis

Ming Li, Hongwei Liu, Kan‐Yen Hsieh, Shengchun Zhang, Yongxiang Gao, Qingguo Gong, Kaiming Zhang, Chung‐I Chang, Shanshan Li

Fundamental Research

DOI

2024

Author Response: Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery

Jiyun Chen, Hong Chen, Shanshan Li, Xiaofeng Lin, Rong Hu, Kaiming Zhang, Liang Liu

DOI

2023

Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery

Jiyun Chen, Hong Chen, Shanshan Li, Xiaofeng Lin, Rong Hu, Kaiming Zhang, Liang Liu

eLife

DOI

2023

A 5+1 assemble-to-activate mechanism of the Lon proteolytic machine

Shanshan Li, Kan‐Yen Hsieh, Chiao-I Kuo, Tzu-Chi Lin, Szu-Hui Lee, Yi-Ru Chen, Chun-Hsiung Wang, Meng‐Ru Ho, See‐Yeun Ting, Kaiming Zhang, Chung‐I Chang

Nature Communications

DOI

2023

Snapshots of the second-step self-splicing of Tetrahymena ribozyme revealed by cryo-EM

Shanshan Li, Michael Z. Palo, Xiaojing Zhang, Grigore D Pintilie, Kaiming Zhang

Nature Communications

DOI

2023

3D RNA-scaffolded wireframe origami

Molly F. Parsons, Matthew F. Allan, Shanshan Li, Tyson R. Shepherd, Sakul Ratanalert, Kaiming Zhang, Krista M. Pullen, Wah Chiu, Silvi Rouskin, Mark Bathe

Nature Communications

DOI

2023

Snapshots of the first-step self-splicing ofTetrahymenaribozyme revealed by cryo-EM

Xiaojing Zhang, Shanshan Li, Grigore D Pintilie, Michael Z. Palo, Kaiming Zhang

Nucleic Acids Research

DOI

2023

Author Response: Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery

Jiyun Chen, Hong Chen, Shanshan Li, Xiaofeng Lin, Rong Hu, Kaiming Zhang, Liang Liu

DOI

2023

RNA structure determination: From 2D to 3D

Jie Deng, Xianyang Fang, Lin Huang, Shanshan Li, Lilei Xu, Keqiong Ye, Jinsong Zhang, Kaiming Zhang, Qiangfeng Cliff Zhang

Fundamental Research

DOI

2023

Reviewer #1 (Public Review): Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery

Chen Jiyun, Hong Chen, Shanshan Li, Lin Xiaofeng, Rong Hu, Kaiming Zhang, Liang Liu

DOI

2023

Reviewer #2 (Public Review): Structural and mechanistic insight into ribosomal ITS2 RNA processing by nuclease-kinase machinery

Chen Jiyun, Hong Chen, Shanshan Li, Lin Xiaofeng, Rong Hu, Kaiming Zhang, Liang Liu

DOI

2022

Cryo-EM structures of human m6A writer complexes

Shichen Su, Shanshan Li, Ting Deng, Minsong Gao, Yue Yin, Baixing Wu, Chao Peng, Jianzhao Liu, Jinbiao Ma, Kaiming Zhang

Cell Research

DOI

2022

Topological crossing in the misfolded Tetrahymena ribozyme resolved by cryo-EM

Shanshan Li, Michael Z. Palo, Grigore D Pintilie, Xiaojing Zhang, Zhaoming Su, Kalli Kappel, Wah Chiu, Kaiming Zhang, Rhiju Das

Proceedings of the National Academy of Sciences

DOI

2022

Planar 2D wireframe DNA origami

Xiao Wang, Shanshan Li, Hyungmin Jun, Torsten John, Kaiming Zhang, Hannah Fowler, Jonathan P. K. Doye, Wah Chiu, Mark Bathe

Science Advances

DOI

2021

Processive cleavage of substrate at individual proteolytic active sites of the Lon protease complex

Shanshan Li, Kan‐Yen Hsieh, Chiao-I Kuo, Shih-Chieh Su, Kai-Fa Huang, Kaiming Zhang, Chung‐I Chang

Science Advances

DOI

2021

Complete three-dimensional structures of the Lon protease translocating a protein substrate

Shanshan Li, Kan‐Yen Hsieh, Chiao-I Kuo, Szu-Hui Lee, Grigore D Pintilie, Kaiming Zhang, Chung‐I Chang

Science Advances

DOI

2021

Cryo-EM and antisense targeting of the 28-kDa frameshift stimulation element from the SARS-CoV-2 RNA genome

Kaiming Zhang, Ivan N. Zheludev, Rachel J. Hagey, Raphael Haslecker, Yixuan Jacob Hou, Rachael C. Kretsch, Grigore D Pintilie, Ramya Rangan, Wipapat Kladwang, Shanshan Li, Marie Teng-Pei Wu, Edward A. Pham, Claire Bernardin-Souibgui, Ralph Steven Baric, Timothy Patrick Sheahan, Victoria M. D’Souza, Jeffrey S. Glenn, Wah Chiu, Rhiju Das

Nature Structural & Molecular Biology

DOI

2021

Cryo-EM structures of full-length Tetrahymena ribozyme at 3.1 Å resolution

Zhaoming Su, Kaiming Zhang, Kalli Kappel, Shanshan Li, Michael Z. Palo, Grigore D Pintilie, Ramya Rangan, Bingnan Luo, Yuquan Wei, Rhiju Das, Wah Chiu

Nature

DOI

2021

Molecular basis for ATPase-powered substrate translocation by the Lon AAA+ protease

Shanshan Li, Kan‐Yen Hsieh, Shih-Chieh Su, Grigore D Pintilie, Kaiming Zhang, Chung‐I Chang

Journal of Biological Chemistry

DOI

2020

具有“眼见为实”魅力的结构生物学不断突破

张凯铭，李珊珊

《张江科技评论》

预印本

2026

Structural insights into the recognition and catalysis of tRNA by human NSUN2

Q. P. Hu, Wen Yang, Yunyun Yu, Ran Yi, Yutong Zhang, Leyuan Duan, Lei Wang, Fudong Li, Kaiming Zhang, Qingguo Gong, Shanshan Li

bioRxiv (Cold Spring Harbor Laboratory)

DOI

2025

Template-based RNA structure prediction advanced through a blind code competition

Youhan Lee, Shujun He, Toshiyuki Oda, G. John Rao, Yehyun Kim, Raehyun Kim, Hyunjin Kim, Cher Keng Heng, Danny Kowerko, Haowei Li, Hoa Nguyen, Arunodhayan Sampath Kumar, Raul Enrique Gomez, Meng Chen, Atsushi Yoshizawa, Shun Kuraishi, Kenji Ogawa, Shuxian Zou, Alejo Paullier, Bin Zhao, Huey-Long Chen, Tsu-An Hsu, Tatsuya Hirano, Wah Chiu, Jeanine Gezelle, Daniel B. Haack, Yibao Hong, Shekhar Jadhav, Deepak Koirala, Rachael C. Kretsch, Anna Lewicka, Shanshan Li, Marco Marcia, Joseph A. Piccirilli, Boris Rudolfs, Yoshita Srivastava, Anna-Lena Steckelberg, Zhaoming Su, Navtej Toor, Zi Yang, Zi Yang, Kaiming Zhang, Jian Zou, David A. Baker, Shi‐Jie Chen, Maggie Demkin, Andrew Favor, Alissa M. Hummer, Chaitanya K. Joshi, Andriy Kryshtafovych, Emine Küçükbenli, Zhichao Miao, John Moult, Christian Munley, Walter Reade, Théo Viel, Éric Westhof, Sicheng Zhang, Rhiju Das

bioRxiv (Cold Spring Harbor Laboratory)

DOI

书籍章节

2022

Near-Atomic Resolution Cryo-EM Image Reconstruction of RNA

Shanshan Li, Kaiming Zhang, Wah Chiu

Methods in molecular biology

DOI

研究方向

细菌核糖体质量控制，已

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