百晓学者学者目录

郑基深

副教授、副研究员、博士生导师、教授、研究员，中国科学技术大学

精选作品

期刊论文

2026

Quantitative Membrane Paramagnetic Relaxation Enhancement (mPRE) Measurements on Lipid-Anchored Proteins: Insight into Orientational Dynamics

Junyong Wu, Yongkui Yu, Longjie Wang, Leiyi Ji, Dan Liu, Mengqi Fang, Ji‐Shen Zheng, Dong Long

Journal of the American Chemical Society

DOI

2026

Traceless sortase ligation for chemical protein synthesis

Yongkang Zhou, Dong‐Liang Huang, Weichen Wang, Shi-Jun Zou, Guo-Xia Yu, Long-Jie Wang, Leilei Shi, Shan Tang, Ji‐Shen Zheng

Nature Synthesis

DOI

2026

Advances in Cyclic Peptides Targeting G Protein‐Coupled Receptors

Yingxin Zhou, Ni Li, Ji‐Shen Zheng

ChemBioChem

DOI

2025

Mechanically Triggered Protein Desulfurization

Dongyang Han, Yan Cui, Xiangyu Deng, Chuntong Li, Xinyue Zhu, Bingji Wang, Guo‐Chao Chu, Zhipeng A. Wang, Shan Tang, Ji‐Shen Zheng, Lu-Jun Liang, Lei Liu

Journal of the American Chemical Society

DOI

2025

Chemical Synthesis of the Mirror‐Image Fast‐PETase by the Enzyme‐Cleavable Solubilizing‐Tag Strategy

Shijun Zou, Guoxia Yu, Yongkang Zhou, Ji‐Shen Zheng

Chemistry - A European Journal

DOI

2025

Composite Mapping for Peptide‐Based Data Storage with Higher Coding Density and Fewer Synthesis Cycles

Anxun Zhang, Long-Jie Wang, Xiaowei Zhai, Yao Xiao, Yanchan Wu, Yongxi Zhao, Kai Liu, Ji‐Shen Zheng, Dong Chen

Advanced Science

DOI

2024

Mirror-image protein and peptide drug discovery through mirror-image phage display

Yun‐Kun Qi, Ji‐Shen Zheng, Lei Liu

Chem

DOI

2024

An Enzyme‐Cleavable Solubilizing‐Tag Facilitates the Chemical Synthesis of Mirror‐Image Proteins

Yupeng Zheng, Baochang Zhang, Weiwei Shi, Xiangyu Deng, Tongyue Wang, Dongyang Han, Yuxiang Ren, Ziyi Yang, Yongkang Zhou, Jian Kuang, Zhiwen Wang, Shan Tang, Ji‐Shen Zheng

Angewandte Chemie

DOI

2024

L‐Glycosidase‐Cleavable Natural Glycans Facilitate the Chemical Synthesis of Correctly Folded Disulfide‐Bonded D‐Proteins

Weiwei Shi, Tongyue Wang, Ziyi Yang, Yuxiang Ren, Dongyang Han, Yupeng Zheng, Xiangyu Deng, Shan Tang, Ji‐Shen Zheng

Angewandte Chemie International Edition

DOI

2024

Accurate de novo design of heterochiral protein–protein interactions

Ke Sun, Sicong Li, Bowen Zheng, Yanlei Zhu, Tongyue Wang, Mingfu Liang, Yue Yao, Kairan Zhang, Jizhong Zhang, Hongyong Li, Dongyang Han, Ji‐Shen Zheng, Brian Coventry, Longxing Cao, David A. Baker, Lei Liu, Peilong Lu

Cell Research

DOI

2024

Enhanced native chemical ligation by peptide conjugation in trifluoroacetic acid

Dong‐Liang Huang, Wu-Chen Guo, Wei-Wei Shi, Yun-Pu Gao, Yongkang Zhou, Long-Jie Wang, Chen Wang, Shan Tang, Lei Liu, Ji‐Shen Zheng

Science Advances

DOI

2024

Recent advances in chemical protein synthesis: method developments and biological applications

Suwei Dong, Ji‐Shen Zheng, Yiming Li, Huan Wang, Gong Chen, Yongxiang Chen, Ge‐Min Fang, Jun Guo, Chunmao He, Honggang Hu, Xuechen Li, Yanmei Li, Zigang Li, Man Pan, Shan Tang, Changlin Tian, Ping Wang, Bian Wu, Chuanliu Wu, Junfeng Zhao, Lei Liu

Science China Chemistry

DOI

2023

分裂内含肽：一种高效的无痕多肽片段连接工具

韩东阳，任宇祥，杨子毅，黄赫，郑基深

《高等学校化学学报》

2023

Backbone‐Installed Split Intein‐Assisted Ligation for the Chemical Synthesis of Mirror‐Image Proteins

Baochang Zhang, Yupeng Zheng, Guo‐Chao Chu, Xiangyu Deng, Tongyue Wang, Weiwei Shi, Yongkang Zhou, Shan Tang, Ji‐Shen Zheng, Lei Liu

Angewandte Chemie

DOI

2023

Chemical synthesis of a 28 kDa full-length PET degrading enzyme ICCG by the removable backbone modification strategy

Yun-Pu Gao, Peng-Fei Sun, Wu-Chen Guo, Yongkang Zhou, Ji‐Shen Zheng, Shan Tang

Bioorganic Chemistry

DOI

2023

Chemically Synthetic d -Sortase Enables Enzymatic Ligation of d -Peptides

Ruichao Ding, Weiwei Shi, Ji‐Shen Zheng

Organic Letters

DOI

2021

镜像蛋白信息编码与存储技术（英文）

郑基深，梁军，石威巍，李影，胡宏岗，田长麟，刘磊

Science Bulletin

2021

Chemical Synthesis of a Full-Length G-Protein-Coupled Receptor β 2 -Adrenergic Receptor with Defined Modification Patterns at the C-Terminus

Yulei Li, Jie Heng, Demeng Sun, Baochang Zhang, Xin Zhang, Yupeng Zheng, Weiwei Shi, Tongyue Wang, Jiuyi Li, Xiaoou Sun, Xiangyu Liu, Ji‐Shen Zheng, Brian K. Kobilka, Lei Liu

Journal of the American Chemical Society

DOI

2021

A mirror-image protein-based information barcoding and storage technology

Ji‐Shen Zheng, Jun Liang, Weiwei Shi, Ying Li, Honggang Hu, Changlin Tian, Lei Liu

《中国科学通报：英文版》

DOI

2020

The New Salicylaldehyde S , S -Propanedithioacetal Ester Enables N-to-C Sequential Native Chemical Ligation and Ser/Thr Ligation for Chemical Protein Synthesis

Dong‐Liang Huang, Ying Li, Jun Liang, Lu Yu, Min Xue, Xiuxiu Cao, Bin Xiao, Changlin Tian, Lei Liu, Ji‐Shen Zheng

Journal of the American Chemical Society

DOI

2020

Synthesis of Disulfide Surrogate Peptides Incorporating Large‐Span Surrogate Bridges Through a Native‐Chemical‐Ligation‐Assisted Diaminodiacid Strategy

Qian Qu, Shuai Gao, Fangming Wu, Mengge Zhang, Ying Li, Long‐Hua Zhang, Donald E. Bierer, Changlin Tian, Ji‐Shen Zheng, Lei Liu

Angewandte Chemie

DOI

2020

Chemical protein synthesis-assisted high-throughput screening strategies for d-peptides in drug discovery

Ying Li, Xiuxiu Cao, Changlin Tian, Ji‐Shen Zheng

Chinese Chemical Letters

DOI

2019

Chemical Synthesis of Native S‐Palmitoylated Membrane Proteins through Removable‐Backbone‐Modification‐Assisted Ser/Thr Ligation

Dong‐Liang Huang, Cédric Montigny, Yong Zheng, Véronica Beswick, Ying Li, Xiuxiu Cao, Thomas Barbot, Christine Jaxel, Jun Liang, Min Xue, Changlin Tian, Nadège Jamin, Ji‐Shen Zheng

Angewandte Chemie

DOI

2019

Ligation of Soluble but Unreactive Peptide Segments in the Chemical Synthesis of Haemophilus Influenzae DNA Ligase

Baochang Zhang, Qiang Deng, Chong Zuo, Bingjia Yan, Chao Zuo, Xiuxiu Cao, Ting F Zhu, Ji‐Shen Zheng, Lei Liu

Angewandte Chemie

DOI

2019

Recent advances in the chemical synthesis and semi-synthesis of poly-ubiquitin-based proteins and probes

Yun‐Kun Qi, Yanyan Si, Shanshan Du, Jun Liang, KeWei Wang, Ji‐Shen Zheng

Science China Chemistry

DOI

2019

Thiirane linkers directed histone H2A diubiquitination suggests plasticity in 53BP1 recognition

Jun Liang, Qingyue Gong, Ying Li, Yong Zheng, Ji‐Shen Zheng, Changlin Tian, Jiabin Li

Chemical Communications

DOI

2018

赖氨酸翻译后修饰蛋白质的化学(半)合成及其应用

王志鹏，李曼，李珲，刘志华，李影，郑基深

《有机化学》

2018

One-pot multi-segment condensation strategies for chemical protein synthesis

Chong Zuo, Baochang Zhang, Bingjia Yan, Ji‐Shen Zheng

Organic & Biomolecular Chemistry

DOI

2018

Reductive Amination/Alkylation Reactions: The Recent Developments, Progresses, and Applications in Protein Chemical Biology Studies

Zhipeng A. Wang, Yan-Yu Liang, Ji‐Shen Zheng

Current Organic Synthesis

DOI

2018

Channel activity of mirror-image M2 proton channel of influenza A virus is blocked by achiral or chiral inhibitors

Qing-Yan Guo, Longhua Zhang, Chao Zuo, Dong‐Liang Huang, Zhipeng A. Wang, Ji‐Shen Zheng, Changlin Tian

Protein & Cell

DOI

2018

Biochemical properties of K11,48-branched ubiquitin chains

Lujun Liang, Yanyan Si, Shan Tang, Dong‐Liang Huang, Zhipeng A. Wang, Changlin Tian, Ji‐Shen Zheng

Chinese Chemical Letters

DOI

2018

Erratum: Chemically synthesized histone H2A Lys13 di-ubiquitination promotes binding of 53BP1 to nucleosomes

Jiabin Li, Yun‐Kun Qi, Qiaoqiao He, Huasong Ai, Sanling Liu, Jiaxing Wang, Ji‐Shen Zheng, Lei Liu, Changlin Tian

Cell Research

DOI

2017

Practical Chemical Synthesis of Atypical Ubiquitin Chains by Using an Isopeptide‐Linked Ub Isomer

Shan Tang, Lujun Liang, Yanyan Si, Shuai Gao, Jiaxing Wang, Jun Liang, Ziqing Mei, Ji‐Shen Zheng, Lei Liu

Angewandte Chemie

DOI

2017

Chemical Synthesis of Diubiquitin‐Based Photoaffinity Probes for Selectively Profiling Ubiquitin‐Binding Proteins

Jun Liang, Lin Zhang, Xiang‐Long Tan, Yun‐Kun Qi, Shan Feng, Haiteng Deng, Yijing Yan, Ji‐Shen Zheng, Lei Liu, Changlin Tian

Angewandte Chemie

DOI

2017

Chemically synthesized histone H2A Lys13 di-ubiquitination promotes binding of 53BP1 to nucleosomes

Jiabin Li, Yun‐Kun Qi, Qiaoqiao He, Huasong Ai, Sanling Liu, Jiaxing Wang, Ji‐Shen Zheng, Lei Liu, Changlin Tian

Cell Research

DOI

2017

One-pot ligation strategy for atypical ubiquitin chains synthesis by using the trifluoroacetamidomethyl-protected isopeptide-linked Ub (Tfacm-isoUb) unit

Yanyan Si, Lujun Liang, Shan Tang, Yun‐Kun Qi, Yong Huang, Ji‐Shen Zheng

Tetrahedron Letters

DOI

2017

Chemical synthesis of membrane proteins by the removable backbone modification method

Shan Tang, Chao Zuo, Dong‐Liang Huang, Xiaoying Cai, Longhua Zhang, Changlin Tian, Ji‐Shen Zheng, Lei Liu

Nature Protocols

DOI

2017

Mirror-image polymerase chain reaction

Wenjun Jiang, Baochang Zhang, Chuyao Fan, Min Wang, Jiaxing Wang, Qiang Deng, Xianyu Liu, Chen Ji, Ji‐Shen Zheng, Lei Liu, Ting F Zhu

Cell Discovery

DOI

2017

Convergent Total Synthesis of Histone H2B Protein with Site-Specific Ubiquitination at Lys120

Jiabin Li, Ji‐Shen Zheng, Yun‐Kun Qi, Qiaoqiao He, Huasong Ai

Synlett

DOI

2017

Removable Backbone Modification Method for the Chemical Synthesis of Membrane Proteins

Jiabin Li, Shan Tang, Ji‐Shen Zheng, Changlin Tian, Lei Liu

Accounts of Chemical Research

DOI

2016

聚酰胺类多肽二级结构模拟物的结构设计与性质分析

王志鹏，田长麟，郑基深

《化学进展》

2016

Robust Chemical Synthesis of Membrane Proteins through a General Method of Removable Backbone Modification

Ji‐Shen Zheng, Yao He, Chao Zuo, Xiaoying Cai, Shan Tang, Zhipeng A. Wang, Longhua Zhang, Changlin Tian, Lei Liu

Journal of the American Chemical Society

DOI

2016

Chemical Synthesis of K34‐Ubiquitylated H2B for Nucleosome Reconstitution and Single‐Particle Cryo‐Electron Microscopy Structural Analysis

Jiabin Li, Qiaoqiao He, Yun-Tao Liu, Sanling Liu, Shan Tang, Chengmin Li, Demeng Sun, Xiaorun Li, Min Zhou, Ping Zhu, Guo‐Qiang Bi, Zhenghong Zhou, Ji‐Shen Zheng, Changlin Tian

ChemBioChem

DOI

2016

Efficient synthesis of longer Aβ peptides via removable backbone modification

Chao Zuo, Shan Tang, Yanyan Si, Zhipeng A. Wang, Changlin Tian, Ji‐Shen Zheng

Organic & Biomolecular Chemistry

DOI

2016

Protein/peptide secondary structural mimics: design, characterization, and modulation of protein–protein interactions

Zhipeng A. Wang, Xiaozhe Ding, Changlin Tian, Ji‐Shen Zheng

RSC Advances

DOI

2014

细胞穿透环肽

梁妍钰，唐姗，郑基深

《化学进展》

2014

Expedient Total Synthesis of Small to Medium-Sized Membrane Proteins via Fmoc Chemistry

Ji‐Shen Zheng, Mu Yu, Yun‐Kun Qi, Shan Tang, Fei Shen, Zhipeng Wang, Liang Xiao, Longhua Zhang, Changlin Tian, Lei Liu

Journal of the American Chemical Society

DOI

2012

多肽酰肼连接法合成环四肽

唐姗，郑基深，杨可，刘磊

《化学学报》

2012

面向蛋白质化学合成与修饰的新方法——C-端多肽硫酯改造及其应用

郑基深

《中国科学技术大学》

2012

Synthesis of Cyclic Peptides and Cyclic Proteins via Ligation of Peptide Hydrazides

Ji‐Shen Zheng, Shan Tang, Ye Guo, Haonan Chang, Lei Liu

ChemBioChem

DOI

2011

Chemical synthesis of a cyclotide via intramolecular cyclization of peptide O-esters

Ji‐Shen Zheng, Haonan Chang, Jing Shi, Lei Liu

Science China Chemistry

DOI

2007

蛋白质的化学全合成

李娟，郑基深，沈非，方葛敏，郭庆祥，刘磊

《化学进展》

会议论文

2019

膜蛋白化学合成与调控（英文）

Dong-Liang Huang, Cédric Montigny, Veronica Beswick, Nadège Jamin, 郑基深

《第十一届全国化学生物学学术会议论文摘要（第一卷）》

DOI

书籍章节

2022

Removable Backbone Modification (RBM) Strategy for the Chemical Synthesis of Hydrophobic Peptides/Proteins

Dong‐Liang Huang, Ying Li, Ji‐Shen Zheng

Methods in molecular biology

DOI

2022

Advances in peptide synthesis

Zhipeng A. Wang, Ji‐Shen Zheng

Elsevier eBooks

DOI

研究方向

蛋白质化学与合成生物学

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