何宁宁｜青岛大学｜学者主页

精选作品

期刊论文

2026

Tissue-resident Limosilactobacillus reuteri modulates intratumoral arachidonic acid metabolism to enhance CD8+ T cell-mediated anti-PD1 response

Ying Deng, Rongzhang Chen, Xinran Gao, Haoyu Wu, Ningning He, Nan Hu, Wenting Zhang, Lu-Jun Chen, Xiao Zheng, Jingting Jiang

Journal of Translational Medicine

DOI

2026

Metabolic Dysregulation and Metabolite-Targeted Interventions in Autism Spectrum Disorder: Mechanisms and Translational Perspectives

Yu Fang, Zechen Dou, Yanan Liu, Yishan Zong, Shengxiang Wang, Shangyong Li, Ningning He, Ning Li

Metabolites

DOI

2026

Bacteroides cellulosilyticus -derived 2-hydroxyphenylacetic acid rectifies hepatic lipid homeostasis in MASLD by targeting the PPARγ-CD36 axis

Kaiwei Chen, Zizhen Yang, Jixing Peng, Chunyan Liu, Ying Yu, Xinchi Cai, Bei Liu, Shuao Li, Shuao Li, Tiantian Chen, Samil Jung, Yu Tian, Qianyue Xu, Xing Rao, Zhinan Wu, Haoyu Wang, Yan Di, Linna Wang, Jianxun Wang, Myeong‐Sok Lee, Yuanqiang Zou, Ningning He, Shangyong Li, Shangyong Li

Gut Microbes

DOI

2026

Integrated Multi-Omics Analysis of Antarctic Krill Oil in Alleviating DSS-Induced Colitis and Modulating Gut Microbiota in Mice

Shuyin Yang, Xinnan Zhao, Tiantian Chen, Yichen Lin, Yan Di, Zhijun Tan, Ningning He, Shangyong Li, Jixing Peng

Marine Drugs

DOI

2026

Gut Commensal Phocaeicola vulgatus AF107-22 Alleviates Obesity-Induced Metabolic Syndrome via Promoting Gut Microbiota-Derived Spermidine Synthesis

Zizhen Yang, Fengjuan Zhang, Hui Li, Bei Liu, P. Liu, Zhinan Wu, Yichen Li, Jiahao Miao, Xiaofang Li, Hewei Liang, Yiyi Zhong, Liang Xiao, Yuanqiang Zou, Ningning He, Shangyong Li

Journal of Agricultural and Food Chemistry

DOI

2026

ELABELA targets the METTL3/PI3K/AKT axis to enhance trophoblast invasion in early-onset preeclampsia

Lijing Wang, Xiaokun Wang, Xue Wang, Mingsheng Wu, Minghui Ou, Ningning He

BMC Pregnancy and Childbirth

DOI

2026

Ultrasound-Activated Nanoplatform Counteracts Triple-Negative Breast Cancer via Remodeling Intratumoral Microbiota–Metabolism and Inducing Ferroptosis

Shuao Li, Yuxiu Gao, Danni Jiang, Xiaoyu Wu, Yanan Feng, Fang Chen, Ningning He, Shangyong Li, Luxia Jing, Cheng Zhao

Biomaterials Research

DOI

2026

Pectic oligosaccharides reshape the gut microbiota-mediated intestinal vitamin B 7 metabolic network to alleviate metabolic dysfunction-associated steatotic liver disease

Zizhen Yang, Yujia Fu, Shuhan Liu, Jiayi Liu, W. H. Zhang, Chenxi Feng, Xinai Man, Shangyong Li, Ningning He, Fengjuan Zhang

Food & Function

DOI

2026

Stachyose supplementation attenuates ischemic stroke injury via gut-brain axis mediated adenine metabolism and neuroactive ligand-receptor signaling

Zichen Zhang, Haoyan Zhang, Xueying Liu, Shengxiang Wang, Yichen Liu, Peng Liu, Shangyong Li, Jieting Zhang, Ningning He, Shihai Liu

Current Research in Food Science

DOI

2026

Amelioration of colitis through restored gut ecology using Christensenella intestinihominis AF73-05CM02 as a probiotic in mice

Zhinan Wu, Xiaofan Sun, Xiaofang Li, Haoyu Wang, Hewei Liang, M Wang, Zizhen Yang, Kunyi Zhao, Ningning He, Liang Xiao, L L Ren, Yang Sun, Shangyong Li, Yuanqiang Zou

Communications Biology

DOI

2026

Lactobacillus gasseri TF08-1 Alleviates DSS-Induced Acute Colitis by Protecting Intestinal Epithelial Barrier

Qianyue Xu, Mengmeng Wang, Haoyu Wang, Zhinan Wu, Xiaofang Li, Jingxi Sun, Zizhen Yang, Ningning He, Yang Sun, Haifeng Zhang, Yiyi Zhong, Liang Xiao, Shangyong Li, Yuanqiang Zou

Probiotics and Antimicrobial Proteins

DOI

2026

Lacto-N-triose II alleviates metabolic dysfunction-associated Steatotic liver disease via microbiota-dependent citrulline biosynthesis

Kaiwei Chen, Huiqing Yu, Bei Liu, Zizhen Yang, Wei Zhang, Yu Tian, Zhinan Wu, Haoyu Wang, Liang Xiao, Yiyi Zhong, Haifeng Zhang, XU Fang, Yuanqiang Zou, Shangyong Li, Ningning He

Food Research International

DOI

2025

Lacto-N-Triose II Alleviates DSS-Induced Colitis via Gut Microbiota and Metabolites Associated with the PI3K-Akt Pathway

Qingyuan Hao, Weihao Dong, Mengjie Mu, Jiahao Miao, Xinchi Cai, Ying Yu, Ningning He, Shengwei Xu, Shangyong Li

Journal of Agricultural and Food Chemistry

DOI

2025

Multiomics Analysis Reveals the Therapeutic Effect of GRAS Yeast-Derived 2’-Fucosyllactose in DSS-Induced Colitis

Mengjie Mu, Hui Li, Zhiyuan Xing, Geun-soo Kim, Qingyuan Hao, Ningning He, Shangyong Li, Fengjuan Zhang

Journal of Agricultural and Food Chemistry

DOI

2025

Stachyose attenuates DSS-induced colitis and is associated with elevated colonic medium-chain fatty acids: an integrated multi-omics analysis

Geun-soo Kim, Kaiwei Chen, Zhiyuan Xing, Xiaoyu Wu, Haoyan Zhang, Yu Fang, Zishuai Zhang, Ningning He, Shangyong Li, Fengjuan Zhang

npj Science of Food

DOI

2025

Lactobacillus gasseri TF08-1 ameliorates high-fat diet induced nonalcoholic fatty liver disease and regulates gut microbiota in mice

Qianyue Xu, Ningning He, Yu Tian, Zhinan Wu, Haoyu Wang, Bei Liu, Zizhen Yang, Haifeng Zhang, Qiang Luo, Yiyi Zhong, Liang Xiao, Shangyong Li, Yuanqiang Zou

Journal of Applied Microbiology

DOI

2025

Ameliorating Effect of Bifidobacterium breve CM02‐09T on High‐Fat Diet‐Induced Nonalcoholic Fatty Liver Disease in Mice

Yu Tian, Qianyue Xu, Zhinan Wu, Haoyu Wang, Xiangtao Hu, Ningning He, Hui Li, Bei Liu, Yiyi Zhong, Haifeng Zhang, Mengmeng Wang, Liang Xiao, Shangyong Li, Yuanqiang Zou

The FASEB Journal

DOI

2025

ELABELA targets the MEK/ERK axis to enhance trophoblast invasion in early-onset preeclampsia

Lijing Wang, Xue Wang, Ningning He, Lin Yang, Yang Zou, Zhanping Weng, Li Guo

Scientific Reports

DOI

2025

Multiomics Analysis of Bacteroides cellulosilyticus Anticolitis via Gut Microbiota Metabolite-Mediated PI3K-Akt Signaling Pathway

Mengjie Mu, Qianqian Xu, Qingyuan Hao, Xiaofang Li, Zhijun Wu, Qingfeng Zhang, Shuhan Liu, Xinai Man, Liang Xiao, Yuanqiang Zou, Shangyong Li, Ningning He

Journal of Agricultural and Food Chemistry

DOI

2025

Therapeutic effect of Faecalibacterium longum CM04-06 on DSS-induced ulcerative colitis in mice

Xiaofang Li, Ningning He, Haoyu Wang, Zhinan Wu, Mengmeng Wang, Hewei Liang, Liang Xiao, Zizhen Yang, Cunyin Li, Ping Xu, Tong Dai, Shangyong Li, Yuanqiang Zou

Journal of Applied Microbiology

DOI

2025

3-Fucosyllactose Prevents Nonalcoholic Fatty Liver Disease by Modulating the Gut Microbiota-Derived Pantothenate in Mice

Bei Liu, Ningning He, Hui Li, Zizhen Yang, Yichen Lin, Xiaoyu O. Wu, Haoyan Zhang, Ziheng Zhang, Zishuai Zhang, Yu Tian, Zhinan Wu, Yuanqiang Zou, Jixing Peng, Shangyong Li

Journal of Agricultural and Food Chemistry

DOI

2025

Application of prebiotic stachyose on metabolic diseases and other human diseases through regulation of gut microbiota

Ziheng Zhang, Jiajing Wu, Zishuai Zhang, Shuhan Liu, Zizhen Yang, Jingyi Wang, Yanan Liu, Shangyong Li, Ningning He, Ning Li

Journal of Functional Foods

DOI

2025

Optimizing Triple-Negative Breast Cancer Therapy via Ultrasound-Enhanced Piezocatalysis for Targeted Chemodrug Release

Qingwen Xue, Ningning He, Yuxiu Gao, Xuehui Zhang, Shuao Li, Fang Chen, Chunping Ning, Xiaoyu Wu, Jingtong Yao, Ziheng Zhang, Shangyong Li, Cheng Zhao

International Journal of Nanomedicine

DOI

2025

Gut microbiota-derived short chain fatty acids act as mediators of the gut-liver-brain axis

Cheng Li, Jingtong Yao, Chang‐Hao Yang, Shengnan Yu, Zizhen Yang, Lijing Wang, Shangyong Li, Ningning He

Metabolic Brain Disease

DOI

2025

Faecalibacterium longum alleviates high-fat diet-induced obesity and protects the intestinal epithelial barrier in mice

Haoyu Wang, Shengnan Yu, Kunyi Zhao, Tongyuan Hu, Zhinan Wu, Hewei Liang, Xiaoqian Lin, Luwen Cui, Jingtong Yao, Xiaomin Liu, Xin Tong, Ningning He, Liang Xiao, Karsten Kristiansen, Shangyong Li, Yuanqiang Zou

Gut Microbes Reports

DOI

2025

Gut Commensal Antibiotic-Resistant Parabacteroides goldsteinii Ameliorates Mouse Colitis through Valine–Isobutyrate Metabolism

Ningning He, Mengjie Mu, Xiaofang Li, Qingyuan Hao, Kaiwei Chen, Xinnan Zhao, Yang Sun, Haoyu Wang, Zhijun Wu, Hewei Liang, Mengmeng Wang, Liang Xiao, Tao Yu, Zhipeng Wang, Jixing Peng, Yuanqiang Zou, Shangyong Li

Research

DOI

2024

基础与临床融通的基础医学综合性实验教学改革与实践

何宁宁，张蓓，李尚勇

《高校医学教学研究(电子版)》

2024

Microwave ablation combined with PD‐L1 blockade synergistically promotes Cxcl9‐mediated antitumor immunity

Ningning He, Hao Huang, Shao-Xian Wu, Wei-Peng Ji, Yi-Cheng Tai, Ruichen Gao, Yingting Liu, Yun-Gang Liu, Lu-Jun Chen, Dawei Zhu, Xiao Zheng, Jing-Ting Jiang

Cancer Science

DOI

2024

Tregs ST2 deficiency enhances the abscopal anti-tumor response induced by microwave ablation.

Shao-Xian Wu, Jing Jiao, Nuo Wang, Ningning He, You Wu, Hong-Wei Jiang, Zhang Fang, Rongzhang Chen, Yingting Liu, Yun-Gang Liu, Lu-Jun Chen, Xiao Zheng, Jing-Ting Jiang

International Immunopharmacology

DOI

2024

Characteristics of Ultrasound-Driven Barium Titanate Nanoparticles and the Mechanism of Action on Solid Tumors

Shuao Li, Ningning He, Xiaoyu Wu, Fang Chen, Qingwen Xue, Shangyong Li, Cheng Zhao

International Journal of Nanomedicine

DOI

2024

Application of high intensity focused ultrasound combined with nanomaterials in anti-tumor therapy

Xuehui Zhang, Ningning He, Liang Zhang, Tong Dai, Zihan Sun, Yuqing Shi, Shangyong Li, Ning Yu

Drug Delivery

DOI

2024

The therapeutic effect and possible mechanisms of alginate oligosaccharide on metabolic syndrome by regulating gut microbiota

Jingyi Wang, Zixuan Zhang, Tong Dai, Ziheng Zhang, Qingfeng Zhang, Jingtong Yao, Lijing Wang, Ningning He, Shangyong Li

Food & Function

DOI

2023

临床医学专业生物信息学课程教学改革实践与思考

何宁宁，商士朋，李尚勇

《高校医学教学研究(电子版)》

2023

基于基因数据库分析GRB2在肾癌中的表达及其与患者预后的关系

解宸一，杨亚楠，王硕，赵万东，吕志远，宋静宜，何宁宁

《精准医学杂志》

2023

Contribution of immune cells in synergistic anti-tumor effect of ablation and immunotherapy

Ningning He, Jing-Ting Jiang

Translational Oncology

DOI

2023

The association and application of sonodynamic therapy and autophagy in diseases

Fang Chen, Qingwen Xue, Ningning He, Xuehui Zhang, Shangyong Li, Cheng Zhao

Life Sciences

DOI

2021

基于数据挖掘分析人组织激肽释放酶家族在结直肠癌中的表达和预后研究

郭佩，何宁宁，夏玉军

《癌症进展》

2019

Synergistic anticancer effect of Grb2 and ITGA1 on cancer cells highly expressing Grb2 through suppressing ERK phosphorylation.

Qingxia Ma, Jingyi Song, Hailong Ma, Kaixuan Gao, Yuecheng Yang, Ningning He

PubMed

2018

Let‑7i‑5p inhibits the proliferation and metastasis of colon cancer cells by targeting kallikrein‑related peptidase�6

Jingyi Song, Lijing Wang, Qingxia Ma, Yuecheng Yang, Zhengtao Yang, Bin Wang, Ningning He

Oncology Reports

DOI

预印本

2026

Identification of implications of m6A regulators and autophagy-associated genes for prognosis in ovarian cancer

Yanru Chen, Xiaoni Yu, Weixin Chu, Shipeng Shang, Ningning He, Li Guo

medRxiv

DOI

2026

Complete Genomes of Cultivated Gut Bacteria Reveal Mobile Genetic Element-Driven Functional Diversity with Therapeutic Implications

Hao Wang, Yuzheng Gu, Wenxin He, Jinlong Yang, Hewei Liang, Mengmeng Wang, Zhinan Wu, Yangfeng Wen, Jinhong Wang, Xing Rao, Yaqi Fan, Jiayi Ma, Xinyu Yang, Xin Tong, Liye Yang, Yusheng Xu, Juan Zhao, Tao Zeng, Yuning Zhang, Yiyi Zhong, Haifeng Zhang, Chuan Liu, Xuechun Shen, Karsten Kristiansen, Juan Yang, Fushu Liu, Zejun Yang, Wangsheng Li, Peng Gao, Jun Xu, Shangyong Li, Ningning He, Bo Wang, Xin Jin, Chuanyu Liu, Xun Xu, Yuliang Dong, Hongwei Zhou, Feng Zhao, Liang Xiao, Yuanqiang Zou

bioRxiv (Cold Spring Harbor Laboratory)

DOI

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