元海丹｜延边大学｜学者主页

2026

朝药治疗糖脂代谢性疾病研究进展

王梓漠，林圣喜，崔惠玲，李佳昱，狄雨凝，包菲菲，元海丹，朴光春

《中国民族医药杂志》

2026

Development and quality evaluation of azelastine hydrochloride oral dissolving film

Jingxin Sun, Xiao-Chen Yan, Yuxin Jiao, Haidan Yuan, Yong Jin, Ji-shan Quan

Journal of Industrial & Engineering Chemistry

DOI

2026

Preventive mechanisms of Potentilla longifolia against MASLD based on chemical profiling, network pharmacology, and metabolomics

Shengxi Lin, Liqiu Zhang, Zimo Wang, Jiayu Li, Huiling Cui, Feifei Bao, Yuning Di, Chengbin Xu, 戴天斌, Haidan Yuan, Guangchun Piao

npj Science of Food

DOI

2026

Hemerocallis lilioasphodelus root water extract ameliorates non-alcoholic fatty liver disease by regulating the gut-liver axis and activating AMPK-mediated lipid metabolism: an integrated study based on metabolomics and 16S rRNA sequencing

Liqiu Zhang, Shengxi Lin, Jiayu Li, Zimo Wang, Huiling Cui, Feifei Bao, Yuning Di, Chengbin Xu, 戴天斌, Haidan Yuan, Guangchun Piao

Journal of Ethnopharmacology

DOI

2025

MRI-Based Multifunctional Nanoliposomes for Enhanced HCC Therapy and Diagnosis.

Jingxin Sun, Zhehao Jin, Yong Jin, Haidan Yuan, Guang-Yu Jin, Ji-Shan Quan

Molecular Pharmaceutics

DOI

2024

Scopoletin ameliorates hyperlipidemia and hepatic steatosis via AMPK, Nrf2/HO-1 and NF-κB signaling pathways

Jianxiu Zhang, Yilin Yuan, Yilin Yuan, Xiaoyan Gao, Hui Li, Fengxia Yuan, Fengxia Yuan, Di Wu, Qinglong Cui, Guangchun Piao, Hai-Dan Yuan

Biochemical Pharmacology

DOI

2023

科罗索酸对高脂饲料诱导小鼠非酒精性脂肪肝的保护作用及其机制

王喆，王宇琪，张彩云，袁凤霞，徐天缘，朱穆朗玛，崔元赫，王湘琪，朴光春，元海丹

《延边大学医学学报》

2023

Anti-lipid accumulation effects and mechanism of the extract and isolated compounds from Potentilla longifolia

Zimo Wang, Yunlong Cui, Siyuan Xu, Xinyuan Liu, Qiyuan Bai, Jiayu Li, Huiling Cui, Yutong Wang, Shengxi Lin, Hai-Dan Yuan, Guangchun Piao

Fitoterapia

DOI

2022

Pharmacological Properties of Ginsenoside Re

Xiaoyan Gao, Guancheng Liu, Jian-Xiu Zhang, Linghe Wang, Chang Xu, Zi-An Yan, Ao Wang, Yi-Fei Su, Jung-Joon Lee, Guangchun Piao, Hai-Dan Yuan

Frontiers in Pharmacology

DOI

2021

锦鸡儿化学成分及其药理作用研究进展

柳慧哲，王龄鹤，闫姿安，许唱，朴光春，元海丹

《延边大学学报(自然科学版)》

DOI

2021

东莨菪内酯对高脂饲料诱导的肥胖小鼠脂质代谢的影响

金亮华，刘官成，王龄鹤，闫姿安，许唱，元海丹

《延边大学学报(自然科学版)》

DOI

2021

万年蒿活性部位中总香豆素和3种化合物的含量测定

赵懿瑶，林圣喜，孙琦，尚名洋，公金艳，王奥，苏艺菲，元海丹，朴光春

《延边大学医学学报》

DOI

2021

发酵人参对H4IIE大鼠肝癌细胞三酰甘油蓄积的抑制作用机制

金亮华，许唱，闫姿安，王龄鹤，元海丹

《延边大学医学学报》

DOI

2021

Corosolic acid ameliorates non‐alcoholic steatohepatitis induced by high‐fat diet and carbon tetrachloride by regulating TGF ‐β1/Smad2, NF‐κB, and AMPK signaling pathways

Guancheng Liu, Zhe Cui, Xiaoyan Gao, Huizhe Liu, Linghe Wang, Jinyan Gong, Ao Wang, Jianxiu Zhang, Qianqian Ma, Yuan Huang, Guangchun Piao, Hai-Dan Yuan

Phytotherapy Research

DOI

2020

栀子豉汤治疗抑郁症的研究进展

尹树铸，昌盛，元海丹

《吉林医药学院学报》

DOI

2020

Corosolic Acid Attenuates Hepatic Lipid Accumulation and Inflammatory Response via AMPK/SREBPs and NF-κB/MAPK Signaling Pathways

Jian-Xiu Zhang, Wei-Jun Feng, Guancheng Liu, Qianqian Ma, Hailan Li, Xiaoyan Gao, Hui-Zhe Liu, Guangchun Piao, Hai-Dan Yuan

The American Journal of Chinese Medicine

DOI

2020

Inhibitory Effects of Twenty-Nine Compounds From Potentilla longifolia on Lipid Accumulation and Their Mechanisms in 3T3-L1 Cells

Qianqian Ma, Li Ye, Wei Li, Shengxi Lin, Xiaoyan Zhao, Cheng Hua Jin, Guancheng Liu, Huan Liu, Yunpeng Sun, Hai-Dan Yuan, Guangchun Piao

Frontiers in Pharmacology

DOI

2020

Inhibitory effects of compounds from the roots of Potentilla longifolia on lipid accumulation

Shengxi Lin, Xiaoyan Zhao, Yunpeng Sun, Huan Liu, Mingyang Shang, Jinyan Gong, Qianqian Ma, Guangchun Piao, Hai-Dan Yuan

PLoS ONE

DOI

2019

科罗索酸药理作用研究进展

张建秀，柳慧哲，朴光春，元海丹

《国际药学研究杂志》

DOI

2018

朝药关苍术的化学成分及药理作用研究

李海兰，冯卫军，朴光春，元海丹

《中国药房》

2018

人参花乙醇提取物对大鼠酒精性脂肪肝的保护作用及其机制

安松兰，李海兰，冯卫军，元海丹

《延边大学医学学报》

2018

Synergistic Inhibitory Effects of Acacetin and 11 Other Flavonoids Isolated from Artemisia sacrorum on Lipid Accumulation in 3T3-L1 Cells

Qianqian Ma, Yunlong Cui, Siyuan Xu, Yiyao Zhao, Hai-Dan Yuan, Guangchun Piao

Journal of Agricultural and Food Chemistry

DOI

2017

大叶紫薇化学成分及药理作用研究进展

冯卫军，李海兰，朴光春，元海丹

《国际药学研究杂志》

2017

How Can Synergism of Traditional Medicines Benefit from Network Pharmacology?

Hai-Dan Yuan, Qianqian Ma, Heying Cui, Guancheng Liu, Xiaoyan Zhao, Wei Li, Guangchun Piao

Molecules

DOI

2017

Tetrahydropalmatine inhibits lipid accumulation through AMPK signaling pathway in 3T3-L1 adipocytes

Guangchun Piao, Guancheng Liu, Xuejun Jin, Dan Jin, Hai-Dan Yuan

Molecular Medicine Reports

DOI

2016

Flavonoids from Artemisia sacrorum Ledeb. and their cytotoxic activities against human cancer cell lines

Hai-Dan Yuan, Xuyang Lu, Qianqian Ma, Di Li, Guang‐Hua Xu, Guangchun Piao

Experimental and Therapeutic Medicine

DOI

2016

The Traditional Medicine and Modern Medicine from Natural Products

Hai-Dan Yuan, Qianqian Ma, Ye Li, Guangchun Piao

Molecules

DOI

2015

不同草苁蓉提取物中化学成分及药理作用的研究进展

马茜茜，元海丹，叶利，朴光春

《安徽农业科学》

2015

人参花提取物对酒精性脂肪肝的抑制作用

刘官成，元海丹，朴光春

《延边大学医学学报》

2015

Combination of deep sea water and Sesamum indicum leaf extract prevents high-fat diet-induced obesity through AMPK activation in visceral adipose tissue

Hai-Dan Yuan, Sung-Hyun Chung, Qianqian Ma, Li Ye, Guangchun Piao

Experimental and Therapeutic Medicine

DOI

2014

中药及其制剂抗肝损伤作用机制的研究进展

李娜，元海丹，李迪，赵琦，朴光春

《山东医药》

2013

芦丁对HepG2肝癌细胞AMPK蛋白信号通路的激活作用

元海丹，李海燕，王瑜玲，朴光春

《延边大学医学学报》

2013

D-四氢掌叶防己碱通过AMPK信号通路抑制HepG2肝癌细胞脂肪蓄积的作用及其机制

朴光春，王瑜，吕旭阳，元海丹

《延边大学医学学报》

2011

Cytotoxic fraction fromArtemisia sacrorumLedeb. against three human cancer cell lines and separation and identification of its compounds

Guangchun Piao, Yi‐Xian Li, Hai-Dan Yuan, Guang‐Zhu Jin

Natural Product Research

DOI

2011

An Active Part of Artemisia sacrorum Ledeb. Suppresses Gluconeogenesis through AMPK Mediated GSK3β and CREB Phosphorylation in Human HepG2 Cells

Hai-Dan Yuan, Guangchun Piao

Bioscience Biotechnology and Biochemistry

DOI

2010

Erratum to “Hepatoprotective effects of an active part from Artemisia sacrorum Ledeb. against acetaminophen-induced toxicity in mice” [J. Ethnopharmacol. 127 (2010) 528–533]

Hai-Dan Yuan, Guang‐Zhu Jin, Guangchun Piao

Journal of Ethnopharmacology

DOI

2010

An Active Part ofArtemisia sacrorumLedeb. Attenuates Hepatic Lipid Accumulation through Activating AMP-Activated Protein Kinase in Human HepG2 Cells

Hai-Dan Yuan, Hai Ying Yuan, Sung-Hyun Chung, Guang‐Zhu Jin, Guangchun Piao

Bioscience Biotechnology and Biochemistry

DOI

2010

Erratum: Protective Effects of the Active Part of Artemisia sacrorum Ledeb. against Acetaminophen-Induced Liver Injury in Mice[Biol. Pharm. Bull. 32(10): 1683-1688 (2009)]

Hai-Dan Yuan, Guang‐Zhu Jin, Guangchun Piao

Biological and Pharmaceutical Bulletin

DOI

2009

Hepatoprotective effects of an active part from Artemisia sacrorum Ledeb. against acetaminophen-induced toxicity in mice

Hai-Dan Yuan, Guang‐Zhu Jin, Guangchun Piao

Journal of Ethnopharmacology

DOI

2009

Protective Effects of the Active Part of Artemisia sacrorum Ledeb. against Acetaminophen-Induced Liver Injury in Mice

Hai-Dan Yuan, Guang‐Zhu Jin, Guangchun Piao

Biological and Pharmaceutical Bulletin

DOI

精选作品

期刊论文

朝药治疗糖脂代谢性疾病研究进展

Development and quality evaluation of azelastine hydrochloride oral dissolving film

Preventive mechanisms of Potentilla longifolia against MASLD based on chemical profiling, network pharmacology, and metabolomics

Hemerocallis lilioasphodelus root water extract ameliorates non-alcoholic fatty liver disease by regulating the gut-liver axis and activating AMPK-mediated lipid metabolism: an integrated study based on metabolomics and 16S rRNA sequencing

MRI-Based Multifunctional Nanoliposomes for Enhanced HCC Therapy and Diagnosis.

Scopoletin ameliorates hyperlipidemia and hepatic steatosis via AMPK, Nrf2/HO-1 and NF-κB signaling pathways

科罗索酸对高脂饲料诱导小鼠非酒精性脂肪肝的保护作用及其机制

Anti-lipid accumulation effects and mechanism of the extract and isolated compounds from Potentilla longifolia

Pharmacological Properties of Ginsenoside Re

锦鸡儿化学成分及其药理作用研究进展

东莨菪内酯对高脂饲料诱导的肥胖小鼠脂质代谢的影响

万年蒿活性部位中总香豆素和3种化合物的含量测定

发酵人参对H4IIE大鼠肝癌细胞三酰甘油蓄积的抑制作用机制

Corosolic acid ameliorates non‐alcoholic steatohepatitis induced by high‐fat diet and carbon tetrachloride by regulating TGF ‐β1/Smad2, NF‐κB, and AMPK signaling pathways

栀子豉汤治疗抑郁症的研究进展

Corosolic Acid Attenuates Hepatic Lipid Accumulation and Inflammatory Response via AMPK/SREBPs and NF-κB/MAPK Signaling Pathways

Inhibitory Effects of Twenty-Nine Compounds From Potentilla longifolia on Lipid Accumulation and Their Mechanisms in 3T3-L1 Cells

Inhibitory effects of compounds from the roots of Potentilla longifolia on lipid accumulation

科罗索酸药理作用研究进展

朝药关苍术的化学成分及药理作用研究

人参花乙醇提取物对大鼠酒精性脂肪肝的保护作用及其机制

Synergistic Inhibitory Effects of Acacetin and 11 Other Flavonoids Isolated from Artemisia sacrorum on Lipid Accumulation in 3T3-L1 Cells

大叶紫薇化学成分及药理作用研究进展

How Can Synergism of Traditional Medicines Benefit from Network Pharmacology?

Tetrahydropalmatine inhibits lipid accumulation through AMPK signaling pathway in 3T3-L1 adipocytes

Flavonoids from Artemisia sacrorum Ledeb. and their cytotoxic activities against human cancer cell lines

The Traditional Medicine and Modern Medicine from Natural Products

不同草苁蓉提取物中化学成分及药理作用的研究进展

人参花提取物对酒精性脂肪肝的抑制作用

Combination of deep sea water and Sesamum indicum leaf extract prevents high-fat diet-induced obesity through AMPK activation in visceral adipose tissue

中药及其制剂抗肝损伤作用机制的研究进展

芦丁对HepG2肝癌细胞AMPK蛋白信号通路的激活作用

D-四氢掌叶防己碱通过AMPK信号通路抑制HepG2肝癌细胞脂肪蓄积的作用及其机制

Cytotoxic fraction fromArtemisia sacrorumLedeb. against three human cancer cell lines and separation and identification of its compounds

An Active Part of Artemisia sacrorum Ledeb. Suppresses Gluconeogenesis through AMPK Mediated GSK3β and CREB Phosphorylation in Human HepG2 Cells

Erratum to “Hepatoprotective effects of an active part from Artemisia sacrorum Ledeb. against acetaminophen-induced toxicity in mice” [J. Ethnopharmacol. 127 (2010) 528–533]

An Active Part ofArtemisia sacrorumLedeb. Attenuates Hepatic Lipid Accumulation through Activating AMP-Activated Protein Kinase in Human HepG2 Cells

Erratum: Protective Effects of the Active Part of Artemisia sacrorum Ledeb. against Acetaminophen-Induced Liver Injury in Mice[Biol. Pharm. Bull. 32(10): 1683-1688 (2009)]

Hepatoprotective effects of an active part from Artemisia sacrorum Ledeb. against acetaminophen-induced toxicity in mice

Protective Effects of the Active Part of Artemisia sacrorum Ledeb. against Acetaminophen-Induced Liver Injury in Mice

会议论文

科罗索酸药理作用研究进展

Chemical constituents from the aerial parts of Potentilla viscosa

研究方向