周庆同｜复旦大学｜学者主页

2025

Amoebicidal action of isoliquiritigenin and glabridin from Glycyrrhiza species: Mechanisms and effects against Acanthamoeba castellanii

Lijun Chen, Dai Dong, Wenwen Jing, Qingtong Zhou, Meng Feng, Xunjia Cheng

Phytomedicine

DOI

2025

Molecular mechanism underlying non-discriminatory recognition of relaxin-3 by RXFP3 and RXFP4

Yan Chen, Qingtong Zhou, Shiyu Yan, J.J. Yan, Dehua Yang, Jian Chen, Ming‐Wei Wang

Communications Biology

DOI

2025

Relief of loperamide-induced constipation by peptidic and small molecule RXFP4 agonists in mice

Shiyu Yan, Yan Chen, Jiang Wang, Qiuying Wang, Qingtong Zhou, Hong Shu Liu, Ming‐Wei Wang, Dehua Yang

Biochemical Pharmacology

DOI

2025

Oral FPR2/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease

Wensheng Yang, Qing Liu, Li Yang, Guan-yi Li, Lin Shi, Jiakui Li, Linyu Li, Yuan Li, Xilin Ge, Xiaozhen Wang, Wei Wu, Jun Yan, Guang-fei Wang, Qingtong Zhou, Qiang Liu, Ming-Wei Wang, Zhiping Li

Acta Pharmacologica Sinica

DOI

2025

Computation-Enabled Structure-Based Discovery of Potent Binders for Small-Molecule Aptamers

Qingtong Zhou, Zheng Zhang, Ling Gao, Guanyi Li, Yue Zhang, Weili Yang, Yaxue Zhao, Dehua Yang, Ming‐Wei Wang, Zhaofeng Luo, Xiaole Xia

Journal of Chemical Theory and Computation

DOI

2025

Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways

Lijun Chen, Wei Han, Wenwen Jing, Meng Feng, Qingtong Zhou, Xunjia Cheng

International Journal for Parasitology Drugs and Drug Resistance

DOI

2025

gmx_RRCS: A Precision Tool for Detecting Subtle Conformational Dynamics in Molecular Simulations

Wei Han, Zhenghan Chen, Ming-Wei Wang, Qingtong Zhou

Journal of Molecular Biology

DOI

2025

Structural basis for the constitutive activity of the melanocortin receptor family

Wenbo Feng, Qingtong Zhou, Chang Zheng, Dehua Yang, Ming‐Wei Wang

Structure

DOI

2024

A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM

Yan-Yan Chen, Yang Li, Qingtong Zhou, Z. Cong, Shi Lin, Jiahui Yan, Xianyue Chen, De-Hua Yang, Tianlei Ying, Ming-Wei Wang

Cell Discovery

DOI

2024

Absence of PNET formation and normal longevity in a mouse model of Mahvash disease

Ying-Na Xu, Qiao-Feng Liu, Chuan-Wei Chen, Qiuying Wang, Tianyuan Du, Run Yu, Qingtong Zhou, Dehua Yang, Ming-Wei Wang

Heliyon

DOI

2024

Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide

Wen-Zhuo Li, Qingtong Zhou, Z. Cong, Qing-Ning Yuan, Wen-Xin Li, Feng-Hui Zhao, H. E. Xu, Li-Hua Zhao, Dehua Yang, Ming-Wei Wang

Cell Discovery

DOI

2024

Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9–36) in conjunction with LSN3318839

Jie Li, Guan-Yi Li, Yiting Mai, Xiao Liu, Dehua Yang, Qingtong Zhou, Ming-Wei Wang

bioRxiv

DOI

2024

Correction to "Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor".

Hong-Yue Liu, Pengfei Yan, Hongbo Han, Zhaoyu Zhang, Qingtong Zhou, Jian Zhang, Jie Zheng, Fei Xu, W. Shui

Journal of the American Chemical Society

DOI

2024

Distinct roles of the extracellular surface residues of glucagon-like peptide-1 receptor in β-arrestin 1/2 signaling.

Sai-Fei Lei, Qian Meng, Yan-Yun Liu, Qiao-Feng Liu, A. Dai, Xiao-qing Cai, Ming-Wei Wang, Qingtong Zhou, Hu Zhou, De-Hua Yang

European Journal of Pharmacology

DOI

2024

Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor.

Hong-Yue Liu, Pengfei Yan, Zhaoyu Zhang, Hongbo Han, Qingtong Zhou, Jie Zheng, Jian Zhang, Fei Xu, W. Shui

Journal of the American Chemical Society

DOI

2024

Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with Gs proteins

Z. Cong, Feng-Hui Zhao, Yang Li, G. Luo, Yiting Mai, Xianyue Chen, Yan-Yan Chen, Shi Lin, Xiao-qing Cai, Qingtong Zhou, De-Hua Yang, Ming-Wei Wang

Cell Discovery

DOI

2024

Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology.

Qingtong Zhou, Guan-Yi Li, K. Hang, Jie Li, Dehua Yang, Ming-Wei Wang

Annual Review of Pharmacology and Toxicology

DOI

2024

Disulfide-Directed Multicyclic Peptides with N-Terminally Extendable α-Helices for Recognition and Activation of G Protein-Coupled Receptors

Shihui Fan, Jie Li, Jie Zhuang, Qingtong Zhou, Yiting Mai, Bingni Lin, Ming‐Wei Wang, Chuanliu Wu

Journal of the American Chemical Society

DOI

2024

Visualizing the dual interaction of calcineurin with PI4KA and FAM126A

Qingtong Zhou, Xiao Rong Liu, Ming‐Wei Wang

Structure

DOI

2024

Structural insights into human zinc transporter ZnT1 mediated Zn2+ efflux

Yonghui Long, Zhini Zhu, Zixuan Zhou, Chuanhui Yang, Yulin Chao, Yuwei Wang, Qingtong Zhou, Ming‐Wei Wang, Qianhui Qu

EMBO Reports

DOI

2024

Novel anti-Acanthamoeba effects elicited by a repurposed poly (ADP-ribose) polymerase inhibitor AZ9482

Lijun Chen, Wei Han, Wenwen Jing, Meng Feng, Qingtong Zhou, Xunjia Cheng

Frontiers in Cellular and Infection Microbiology

DOI

2023

Structural insights into the interaction of three Y-shaped ligands with PI3Kα

Qingtong Zhou, Xiao Liu, Dario Neri, Wen-Xin Li, N. Favalli, G. Bassi, Su Yang, De-Hua Yang, Peter K. Vogt, Ming-Wei Wang

Proceedings of the National Academy of Sciences of the United States of America

DOI

2023

Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors

Wenbo Feng, Qingtong Zhou, Xianyue Chen, A. Dai, Xiao-qing Cai, Xiao Liu, Feng-Hui Zhao, Yan Chen, C. Ye, Ying-Na Xu, Z. Cong, Hao Li, Shi Lin, De-Hua Yang, Ming-Wei Wang

Cell Discovery

DOI

2023

Structural and mechanistic insights provided by single particle cryo-EM analysis of phosphoinositide 3-kinase (PI3Kα)

P. Vogt, J. Hart, Su Yang, Qingtong Zhou, De-Hua Yang, Ming-Wei Wang

Biochimica et biophysica acta. Reviews on cancer

DOI

2023

A potentially serious adverse effect of GLP-1 receptor agonists

Jinmiao Lu, Hao Liu, Qingtong Zhou, Ming-Wei Wang, Zhiping Li

Acta Pharmaceutica Sinica B

DOI

2023

GPCRana: A web server for quantitative analysis of GPCR structures.

Yu Guo, Qingtong Zhou, Bin Wei, Ming-Wei Wang, Su-Wen Zhao

Structure

DOI

2023

High expression of GPR160 in prostate cancer is unrelated to CARTp-mediated signaling pathways

Chenyu Ye, Qingtong Zhou, Shi Lin, Wen-Sheng Yang, Xiao-qing Cai, Yiting Mai, Yan-Yan Chen, De-Hua Yang, Ming-Wei Wang

Acta Pharmaceutica Sinica B

DOI

2023

Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)

Yan Chen, Qingtong Zhou, Jiang Wang, Youwei Xu, Yun Wang, Jiahui Yan, Yi-Bing Wang, Qi Zhu, Feng-Hui Zhao, Cheng-Hao Li, Chuan-Wei Chen, Xiao-qing Cai, Ross A. .d. Bathgate, Chun Shen, H. Eric Xu, De-Hua Yang, Hong Liu, Ming-Wei Wang

Nature Communications

DOI

2023

Molecular basis of signal transduction mediated by the human GIPR splice variants

Fenghui Zhao, Kaini Hang, Qingtong Zhou, Lijun Shao, Hao Li, Wenzhuo Li, Shi Lin, Antao Dai, Xiaoqing Cai, Yan‐Yun Liu, Yingna Xu, Wenbo Feng, Dehua Yang, Ming‐Wei Wang

Proceedings of the National Academy of Sciences

DOI

2023

Structural analysis of the dual agonism at GLP-1R and GCGR

Yang Li, Qingtong Zhou, Antao Dai, Fenghui Zhao, Rulue Chang, Tianlei Ying, Beili Wu, Dehua Yang, Ming‐Wei Wang, Zhaotong Cong

Proceedings of the National Academy of Sciences

DOI

2022

Formyl peptide receptor 2 as a potential therapeutic target for inflammatory bowel disease

Wen-sheng Yang, Jing-lin Wang, Wei Wu, Guangxing Wang, Jun Yan, Qing Liu, Xiao-yan Wu, Qingtong Zhou, De-Hua Yang, Ming-Wei Wang, Zhiping Li

Acta Pharmacologica Sinica

DOI

2022

Abstract 671: Cryo-electronmicroscopy of PI3K reveals additional regulatory features

J. Hart, Su Yang, Xiao Liu, Ying-Na Xu, X. Zou, Huibing Zhang, Qingtong Zhou, T. Xia, Yan Zhang, De-Hua Yang, Ming-Wei Wang, Peter K. Vogt

Cancer Research

DOI

2022

Structural perspective of class B1 GPCR signaling.

Z. Cong, Yi-Lynn Liang, Qingtong Zhou, Sanaz Darbalaei, Feng-Hui Zhao, Wenbo Feng, Li-Hua Zhao, H. Xu, De-Hua Yang, Ming-Wei Wang

TIPS - Trends in Pharmacological Sciences

DOI

2022

Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα

J. Hart, Xiao Liu, Chen Pan, Anyi Liang, Lynn Ueno, Ying-Na Xu, Alexa Quezada, X. Zou, Su Yang, Qingtong Zhou, S. Schoonooghe, Gholamreza Hassanzadeh-Ghassabeh, T. Xia, W. Shui, De-Hua Yang, P. Vogt, Ming-Wei Wang

Proceedings of the National Academy of Sciences of the United States of America

DOI

2022

Structural insights into ligand recognition and selectivity of somatostatin receptors

Wenli Zhao, Shuo Han, Na Qiu, Wenbo Feng, Mengjie Lu, Wenru Zhang, Mu Wang, Qingtong Zhou, Shutian Chen, Wei Xu, Juan Du, Xiaojing Chu, C. Yi, A. Dai, Liaoyuan A. Hu, Michelle Shen, Yaping Sun, Qing Zhang, Ying-Li Ma, W. Zhong, De-Hua Yang, Ming-Wei Wang, Beili Wu, Qiang Zhao

Cell Research

DOI

2022

Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors

Feng-Hui Zhao, Qingtong Zhou, Z. Cong, K. Hang, X. Zou, Chao Zhang, Yan Chen, A. Dai, Anyi Liang, Q. Ming, Mu Wang, Li-Nan Chen, P. Xu, Rulve Chang, Wenbo Feng, T. Xia, Yan Zhang, Beili Wu, De-Hua Yang, Li-Hua Zhao, H. Xu, Ming-Wei Wang

Nature Communications

DOI

2022

Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα

Xiao Liu, Qingtong Zhou, J. Hart, Ying-Na Xu, Su Yang, De-Hua Yang, P. Vogt, Ming-Wei Wang

Proceedings of the National Academy of Sciences of the United States of America

DOI

2022

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor.

Y. Zhuang, Yue Wang, Bingqing He, Xin-Heng He, X. E. Zhou, Shimeng Guo, Qi-Di Rao, Jiaqi Yang, Jinyu Liu, Qingtong Zhou, Xiaoxi Wang, Mingliang Liu, Weiyi Liu, Xiang-Rui Jiang, De-Hua Yang, Hualiang Jiang, Jingshan Shen, K. Melcher, Hong Chen, Yi Jiang, Xi Cheng, Ming-Wei Wang, Xin Xie, H. Xu

Cell

DOI

2022

Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24

Z. Cong, Qingtong Zhou, Yang Li, Li-Nan Chen, Zichen Zhang, Anyi Liang, Qing Liu, Xiao-yan Wu, A. Dai, T. Xia, Wei Wu, Yan Zhang, De-Hua Yang, Ming-Wei Wang

bioRxiv

DOI

2022

Ligand-independent modulation of GIPR signaling by splice variants

K. Hang, Li-Jun Shao, Qingtong Zhou, Feng-Hui Zhao, A. Dai, Xiao-qing Cai, R. Stevens, De-Hua Yang, Ming-Wei Wang

bioRxiv

DOI

2022

A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds

Jie Li, Yan Zhou, G. Eelen, Qingtong Zhou, Wenbo Feng, Viktorija Labroska, F. Ma, Hui-ping Lu, M. Dewerchin, P. Carmeliet, Ming-Wei Wang, De-Hua Yang

Acta Pharmacologica Sinica

DOI

2022

Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists

Sanaz Darbalaei, Rulue Chang, Qingtong Zhou, Yan Chen, A. Dai, Ming-Wei Wang, De-Hua Yang

Acta Pharmacologica Sinica

DOI

2021

G蛋白偶联受体的共同激活机制

周庆同，戴之卓，赵素文

《自然杂志》

2021

High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist

G. Lin, Yang Feng, Xiao-qing Cai, Cai-Hong Zhou, Li-Jun Shao, Yan Chen, Lin-Hai Chen, Qing Liu, Qingtong Zhou, R. Bathgate, De-Hua Yang, Ming-Wei Wang

Molecules

DOI

2021

Constitutive signal bias mediated by the human GHRHR splice variant 1

Zhaotong Cong, Fulai Zhou, Chao Zhang, Xinyu Zou, Huibing Zhang, Yuzhe Wang, Qingtong Zhou, Xiaoqing Cai, Qiaofeng Liu, Jie Li, Lijun Shao, Chunyou Mao, Xi Wang, Jihong Wu, Tian Xia, Lihua Zhao, Hualiang Jiang, Yan Zhang, H. Eric Xu, Xi Cheng, Dehua Yang, Ming‐Wei Wang

Proceedings of the National Academy of Sciences

DOI

2021

Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening

Qingtong Zhou, Wan-Jing Guo, A. Dai, Xiao-qing Cai, Márton Vass, C. de Graaf, W. Shui, Su-Wen Zhao, De-Hua Yang, Ming-Wei Wang

Biomolecules

DOI

2021

Author response: Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

Fenghui Zhao, Chao Zhang, Qingtong Zhou, Kaini Hang, Xinyu Zou, Yan Chen, Fan Wu, Qidi Rao, Antao Dai, Wanchao Yin, Dandan Shen, Yan Zhang, Tian Xia, Raymond C. Stevens, H. Eric Xu, Dehua Yang, Lihua Zhao, Ming‐Wei Wang

DOI

2021

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

Ying-Na Xu, Wenbo Feng, Qingtong Zhou, Anyi Liang, Jie Li, A. Dai, Feng-Hui Zhao, Jiahui Yan, Chuan-Wei Chen, Hao Li, Li-Hua Zhao, T. Xia, Yi Jiang, H. Xu, De-Hua Yang, Ming-Wei Wang

Nature Communications

DOI

2021

Structures of the human cholecystokinin receptors bound to agonists and antagonists

Xue-Feng Zhang, Cheng-Lin He, Mu Wang, Qingtong Zhou, De-Hua Yang, Ya Zhu, Wenbo Feng, Hui Zhang, A. Dai, Xiaojing Chu, Jia Wang, Zhen-Lin Yang, Yi Jiang, U. Sensfuss, Q. Tan, Shuo Han, S. Reedtz-Runge, H. Xu, Su-Wen Zhao, Ming-Wei Wang, Beili Wu, Qiang Zhao

Nature Chemical Biology

DOI

2021

Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists.

Lin Lin, G. Lin, Qingtong Zhou, R. Bathgate, G. Q. Gong, De-Hua Yang, Qing Liu, Ming-Wei Wang

Bioorganic chemistry (Print)

DOI

2021

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

Z. Cong, Li-Nan Chen, Honglei Ma, Qingtong Zhou, X. Zou, C. Ye, A. Dai, Qing Liu, Wei Huang, Xian-Qiang Sun, Xi Wang, P. Xu, Li-Hua Zhao, T. Xia, W. Zhong, De-Hua Yang, H. Eric Xu, Yan Zhang, Ming-Wei Wang

Nature Communications

DOI

2021

Molecular basis of ligand recognition and activation of human V2 vasopressin receptor

Fulai Zhou, Chenyu Ye, Xiaomin Ma, Wanchao Yin, Tristan Ian Croll, Qingtong Zhou, Xinheng He, Xiaokang Zhang, Dehua Yang, Peiyi Wang, H. Eric Xu, Ming‐Wei Wang, Yi Jiang

Cell Research

DOI

2021

Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A2A Receptor Targeting the Sodium Ion Pocket.

Yan Lu, Hongyue Liu, De-Hua Yang, Li Zhong, Ye Xin, Su-Wen Zhao, Ming-Wei Wang, Qingtong Zhou, W. Shui

ACS Chemical Biology

DOI

2021

Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2

Xi Wang, Xi Cheng, Li-Hua Zhao, Yu-zhe Wang, Chenyu Ye, X. Zou, A. Dai, Z. Cong, Jian Chen, Qingtong Zhou, T. Xia, Hualiang Jiang, H. E. Xu, De-Hua Yang, Ming-Wei Wang

Proceedings of the National Academy of Sciences of the United States of America

DOI

2021

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

Feng-Hui Zhao, Qingtong Zhou, Z. Cong, K. Hang, X. Zou, Chao Zhang, Yan Chen, A. Dai, Anyi Liang, Q. Ming, Mu Wang, Li-Nan Chen, P. Xu, Rulue Chang, Wenbo Feng, T. Xia, Yan Zhang, Beili Wu, De-Hua Yang, Li-Hua Zhao, H. Xu, Ming-Wei Wang

bioRxiv

DOI

2021

Crystal structure of a constitutive active mutant of adenosine A2A receptor

M. Cui, Qingtong Zhou, Yue-Ming Xu, Yuan C. Weng, D. Yao, Su-Wen Zhao, Gaojie Song

bioRxiv

DOI

2021

G protein-coupled receptors: structure- and function-based drug discovery

De-Hua Yang, Qingtong Zhou, Viktorija Labroska, Shanshan Qin, Sanaz Darbalaei, Yi-Ran Wu, Elita Yuliantie, Linshan Xie, Hou-Chao Tao, Jianjun Cheng, Qing Liu, Su-Wen Zhao, W. Shui, Yi Jiang, Ming-Wei Wang

Signal Transduction and Targeted Therapy

DOI

2021

GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis

Yan Chen, Ying-Na Xu, C. Ye, Wenbo Feng, Qingtong Zhou, De-Hua Yang, Ming-Wei Wang

Acta Pharmacologica Sinica

DOI

2021

Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation

Xiao Liu, Su Yang, J. Hart, Ying-Na Xu, X. Zou, Huibing Zhang, Qingtong Zhou, T. Xia, Yan Zhang, De-Hua Yang, Ming-Wei Wang, P. Vogt

Proceedings of the National Academy of Sciences of the United States of America

DOI

2021

Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor.

Elita Yuliantie, W. V. D. van der Velden, Viktorija Labroska, A. Dai, Feng-Hui Zhao, Sanaz Darbalaei, Giuseppe Deganutti, Tongyang Xu, Qingtong Zhou, De-Hua Yang, M. Rosenkilde, P. Sexton, Ming-Wei Wang, D. Wootten

Biochemical Pharmacology

DOI

2020

Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders.

G. Lin, Qiao-Feng Liu, A. Dai, Xiao-qing Cai, Qingtong Zhou, Xi Wang, Yan Chen, C. Ye, Jie Li, De-Hua Yang, Ming-Wei Wang

Biochemical Journal

DOI

2020

Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands.

L. Tan, Qingtong Zhou, Wenzhong Yan, Jian Sun, A. Kozikowski, Su-Wen Zhao, Xi-Ping Huang, Jianjun Cheng

Journal of Medicinal Chemistry

DOI

2020

An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9

Yu-zhe Wang, Xiao Liu, George Way, Vipul Madarha, Qingtong Zhou, De-Hua Yang, Jia-yu Liao, Ming-Wei Wang

Acta Pharmacologica Sinica

DOI

2020

Structural basis for activation of the growth hormone-releasing hormone receptor

Fu-Lai Zhou, Huibing Zhang, Z. Cong, Li-Hua Zhao, Qingtong Zhou, C. Mao, Xi Cheng, D. Shen, Xiao-qing Cai, Cheng Ma, Yu-zhe Wang, A. Dai, Yan Zhou, Wen Sun, Feng-Hui Zhao, Su-Wen Zhao, Hua-Liang Jiang, Yi Jiang, De-Hua Yang, H. Eric Xu, Yan Zhang, Ming-Wei Wang

Nature Communications

DOI

2020

A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor

Wen Sun, Li-Nan Chen, Qingtong Zhou, Li-Hua Zhao, De-Hua Yang, Huibing Zhang, Z. Cong, D. Shen, Feng-Hui Zhao, Fu-Lai Zhou, Xiao-qing Cai, Yan Chen, Yan Zhou, S. Gadgaard, W. V. D. van der Velden, Su-Wen Zhao, Yi Jiang, M. Rosenkilde, H. E. Xu, Yan Zhang, Ming-Wei Wang

Cell Research

DOI

2019

A Chemical Strategy for Amphiphile Replacement in Membrane Protein Research.

Dongxiang Xue, Jing-Jing Wang, Xi-Yong Song, Wei Wang, Tao Hu, Lintao Ye, Yang Liu, Qingtong Zhou, F. Zhou, Zhong-Xing Jiang, Zhi-Jie Liu, Hou-Chao Tao

Langmuir

DOI

2019

Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α2C Adrenergic Receptor.

Xiaoyu Chen, Yueming Xu, L. Qu, Lijie Wu, G. Han, Yu Guo, Yi-Ran Wu, Qingtong Zhou, Qian-Qian Sun, Cenfeng Chu, Jie Yang, Liu Yang, Quan Wang, S. Yuan, Ling Wang, Tao Hu, Hou-Chao Tao, Yaping Sun, Yunpeng Song, Liaoyuan A. Hu, Zhi-Jie Liu, R. Stevens, Su-Wen Zhao, Dong Wu, Gui-Sheng Zhong

Cell Reports

DOI

2019

Common activation mechanism of class A GPCRs

Qingtong Zhou, De-Hua Yang, Meng Wu, Yu Guo, Wan-Jing Guo, Li Zhong, Xiao-qing Cai, A. Dai, Wonjo Jang, E. Shakhnovich, Zhi-Jie Liu, R. Stevens, N. Lambert, M. Babu, Ming-Wei Wang, Su-Wen Zhao

eLife

DOI

2019

GPCR Allosteric Modulator Discovery.

Yi-Ran Wu, Jiahui Tong, K. Ding, Qingtong Zhou, Su-Wen Zhao

Advances in Experimental Medicine and Biology

DOI

2019

Structural Basis of the Diversity of Adrenergic Receptors.

L. Qu, Qingtong Zhou, Yueming Xu, Yu Guo, Xiaoyu Chen, D. Yao, G. Han, Zhi-Jie Liu, R. Stevens, Gui-Sheng Zhong, Dong Wu, Su-Wen Zhao

Cell Reports

DOI

2018

人源Apelin受体与天然配体Apelin的多肽类似物的复合物晶体结构

马英利，岳洋，马彦彬，Qing Zhang，周庆同，Yunpeng Song，Yuqing Shen，Xun Li，Xiaochuan Ma，李超，Michael A.Hanson，Gye Won Han，E.Allen Sickmier，Gayathri Swaminath，赵素文，Raymond C.Stevens，Liaoyuan A.Hu，Wenge Zhong，张明强，徐菲

《科学新闻》

2018

High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening

Shanshan Qin, Mengmeng Meng, De-Hua Yang, Wenwen Bai, Yan Lu, Yao Peng, Gaojie Song, Yi-Ran Wu, Qingtong Zhou, Su-Wen Zhao, Xi-Ping Huang, J. McCorvy, Xiao-qing Cai, A. Dai, B. Roth, M. Hanson, Zhi-Jie Liu, Ming-Wei Wang, R. Stevens, W. Shui

Chemical Science

DOI

2017

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

Gaojie Song, De-Hua Yang, Yu-Xia Wang, C. de Graaf, Qingtong Zhou, Shan Jiang, Kaiwen Liu, Xiao-qing Cai, A. Dai, G. Lin, Dong-Sheng Liu, Fan Wu, Yi-Ran Wu, Su-Wen Zhao, Lintao Ye, G. Han, J. Lau, Beili Wu, M. Hanson, Zhi-Jie Liu, Ming-Wei Wang, R. Stevens

Nature

DOI

2017

Structure of apelin receptor in complex with agonist peptide

Y. Ma, Yang Yue, Qing Zhang, Qingtong Zhou, Yunpeng Song, Yuqing Shen, Xun Li, Xiao-Chuan Ma, C. Li, M. Hanson, G. Han, E. Sickmier, G. Swaminath, Su-Wen Zhao, R. C. Stevems, Liaoyuan A. Hu, W. Zhong, Ming-Qiang Zhang, Fei Xu

DOI

2017

Structure of the human GLP-1 receptor complex with NNC0640

DOI

2017

Structural Basis for Apelin Control of the Human Apelin Receptor.

Ying-Li Ma, Yang Yue, Yan-Bin Ma, Qing Zhang, Qingtong Zhou, Yunpeng Song, Yuqing Shen, Xun Li, Xiao-Chuan Ma, Chao Li, M. Hanson, Gye Won Han, E. Sickmier, G. Swaminath, Su-Wen Zhao, Raymond C. Stevens, Liaoyuan A. Hu, W. Zhong, Ming-Qiang Zhang, Fei Xu

Structure

DOI

2017

Structure of the human GLP-1 receptor complex with PF-06372222

DOI

2016

基于结构的O-GlcNAc转移酶抑制剂的虚拟筛选（英文）

周庆同，梁好均，Eugene Shakhnovich

Chinese Journal of Chemical Physics

2015

生物相空间中的适配体和药物虚拟筛选

周庆同

《中国科学技术大学》

精选作品

期刊论文

Amoebicidal action of isoliquiritigenin and glabridin from Glycyrrhiza species: Mechanisms and effects against Acanthamoeba castellanii

Molecular mechanism underlying non-discriminatory recognition of relaxin-3 by RXFP3 and RXFP4

Relief of loperamide-induced constipation by peptidic and small molecule RXFP4 agonists in mice

Oral FPR2/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease

Computation-Enabled Structure-Based Discovery of Potent Binders for Small-Molecule Aptamers

Nitroxoline evidence amoebicidal activity against Acanthamoeba castellanii through DNA damage and the stress response pathways

gmx_RRCS: A Precision Tool for Detecting Subtle Conformational Dynamics in Molecular Simulations

Structural basis for the constitutive activity of the melanocortin receptor family

A homotrimeric GPCR architecture of the human cytomegalovirus revealed by cryo-EM

Absence of PNET formation and normal longevity in a mouse model of Mahvash disease

Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide

Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9–36) in conjunction with LSN3318839

Correction to "Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor".

Distinct roles of the extracellular surface residues of glucagon-like peptide-1 receptor in β-arrestin 1/2 signaling.

Structural Mass Spectrometry Captures Residue-Resolved Comprehensive Conformational Rearrangements of a G Protein-Coupled Receptor.

Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with Gs proteins

Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology.

Disulfide-Directed Multicyclic Peptides with N-Terminally Extendable α-Helices for Recognition and Activation of G Protein-Coupled Receptors

Visualizing the dual interaction of calcineurin with PI4KA and FAM126A

Structural insights into human zinc transporter ZnT1 mediated Zn2+ efflux

Novel anti-Acanthamoeba effects elicited by a repurposed poly (ADP-ribose) polymerase inhibitor AZ9482

Structural insights into the interaction of three Y-shaped ligands with PI3Kα

Structural insights into ligand recognition and subtype selectivity of the human melanocortin-3 and melanocortin-5 receptors

Structural and mechanistic insights provided by single particle cryo-EM analysis of phosphoinositide 3-kinase (PI3Kα)

A potentially serious adverse effect of GLP-1 receptor agonists

GPCRana: A web server for quantitative analysis of GPCR structures.

High expression of GPR160 in prostate cancer is unrelated to CARTp-mediated signaling pathways

Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)

Molecular basis of signal transduction mediated by the human GIPR splice variants

Structural analysis of the dual agonism at GLP-1R and GCGR

Formyl peptide receptor 2 as a potential therapeutic target for inflammatory bowel disease

Abstract 671: Cryo-electronmicroscopy of PI3K reveals additional regulatory features

Structural perspective of class B1 GPCR signaling.

Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα

Structural insights into ligand recognition and selectivity of somatostatin receptors

Structural insights into multiplexed pharmacological actions of tirzepatide and peptide 20 at the GIP, GLP-1 or glucagon receptors

Cryo-EM structures of cancer-specific helical and kinase domain mutations of PI3Kα

Molecular recognition of morphine and fentanyl by the human μ-opioid receptor.

Structural basis of peptidomimetic agonism revealed by small-molecule GLP-1R agonists Boc5 and WB4-24

Ligand-independent modulation of GIPR signaling by splice variants

A high-throughput screening campaign against PFKFB3 identified potential inhibitors with novel scaffolds

Effects of site-directed mutagenesis of GLP-1 and glucagon receptors on signal transduction activated by dual and triple agonists

G蛋白偶联受体的共同激活机制

High-Throughput Screening Campaign Identified a Potential Small Molecule RXFP3/4 Agonist

Constitutive signal bias mediated by the human GHRHR splice variant 1

Discovery of Novel Allosteric Modulators Targeting an Extra-Helical Binding Site of GLP-1R Using Structure- and Ligand-Based Virtual Screening

Author response: Structural insights into hormone recognition by the human glucose-dependent insulinotropic polypeptide receptor

A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2

Structures of the human cholecystokinin receptors bound to agonists and antagonists

Design, synthesis and pharmacological evaluation of tricyclic derivatives as selective RXFP4 agonists.

Molecular insights into ago-allosteric modulation of the human glucagon-like peptide-1 receptor

Molecular basis of ligand recognition and activation of human V2 vasopressin receptor

Affinity Mass Spectrometry-Based Fragment Screening Identified a New Negative Allosteric Modulator of the Adenosine A2A Receptor Targeting the Sodium Ion Pocket.

Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2

Structural basis for the therapeutic advantage of dual and triple agonists at the human GIP, GLP-1 or GCG receptors

Crystal structure of a constitutive active mutant of adenosine A2A receptor

G protein-coupled receptors: structure- and function-based drug discovery

GLP-1 mimetics as a potential therapy for nonalcoholic steatohepatitis

Cryo-EM structures of PI3Kα reveal conformational changes during inhibition and activation

Insights into agonist-elicited activation of the human glucose-dependent insulinotropic polypeptide receptor.

Characterization of a naturally occurring mutation V368M in the human glucagon receptor and its association with metabolic disorders.

Design and Synthesis of Bitopic 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as Selective Dopamine D3 Receptor Ligands.

An in vitro Förster resonance energy transfer-based high-throughput screening assay identifies inhibitors of SUMOylation E2 Ubc9

Structural basis for activation of the growth hormone-releasing hormone receptor

A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor

A Chemical Strategy for Amphiphile Replacement in Membrane Protein Research.

Molecular Mechanism for Ligand Recognition and Subtype Selectivity of α2C Adrenergic Receptor.

Common activation mechanism of class A GPCRs

GPCR Allosteric Modulator Discovery.

Structural Basis of the Diversity of Adrenergic Receptors.

人源Apelin受体与天然配体Apelin的多肽类似物的复合物晶体结构

High-throughput identification of G protein-coupled receptor modulators through affinity mass spectrometry screening

Human GLP-1 receptor transmembrane domain structure in complex with allosteric modulators

Structure of apelin receptor in complex with agonist peptide

Structure of the human GLP-1 receptor complex with NNC0640

Structural Basis for Apelin Control of the Human Apelin Receptor.

Structure of the human GLP-1 receptor complex with PF-06372222

基于结构的O-GlcNAc转移酶抑制剂的虚拟筛选（英文）