甘建华｜复旦大学｜学者主页

2026

Mechanism and plasticity of primitive pyroptosis

Su Zhi, Man Huang, Jianhua Gan, Zhaoxiang He, Yuanyuan Wang, Yuanwei Zhang, Jiuxin Qu, Long Zhou, Changbin Chen, Yu Feng, Zheng‐Guo He, Youjun Feng

Science Advances

DOI

2026

Phage-encoded NARP3 system rebuilds NAD + to subvert bacterial immunity

Jia Yan, Siyu Liu, Zhaorong Luo, Zhi Su, Gaoqin Teng, Mengyuan Li, Jian‐Gang Ma, Rongsui Gao, Jiuxin Qu, Man Huang, Jianhua Gan, Youjun Feng

Science Advances

DOI

2026

H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants

Jiabing Wu, Jiachen Wang, Kangxi Du, Yingping Li, Wenhao Xie, Chenxi He, Qidan Xing, Xiang Li, Xiaoyu Zhu, Zhen Wu, Xiaolong Wu, Linghao Zhang, Wen‐Hui Shen, Fei Lan, Jianhua Gan, Bing Liu, Aiwu Dong

Nature Communications

DOI

2026

Targeting transthyretin by one Cas9 variant with superfidelity and broad compatibility

Sixian Qi, Lifan Wei, Zhan Ding, Feiya Zhong, Sicong Yang, Leibin Wu, Xuan Yang, Bin Kang, Mo Dan, Jianhua Gan, Chunlei Li, Xiaoye Su

Science Advances

DOI

2025

原核生物pre-tRNA 5'末端剪切酶的结构和功能研究

邵齐源，李洋洋，张威振，甘建华

《复旦学报(自然科学版)》

DOI

2025

Structure-based development of a covalent inhibitor targeting Streptococcus pyogenes over Staphylococcus aureus sortase A.

Hailing Zhou, Ziqi Yuan, Xiang-Na Guan, Chuan Yue, Wei Wu, Lefu Lan, Jianhua Gan, Tao Zhang, Caiguang Yang

Chemistry

DOI

2025

Selenium-derivatized Nucleic Acids for Phasing, Crystal Growth, Structure Determination and Beyond

Zhen Huang, Hehua Liu, Jianhua Gan

Structural Dynamics

DOI

2025

Crystal Engineering of Nucleic Acid Macro-molecules using Selenium Atoms

Zhen Huang, Hehua Liu, Jianhua Gan

Structural Dynamics

DOI

2025

Structural insight into polymerase mechanism via a chiral center generated with a single selenium atom

Tong Qin, B. Hu, Yiqing Chen, Jianhua Gan, Zhen Huang

Structural Dynamics

DOI

2025

Author Correction: Cryo-EM structure of a natural RNA nanocage

Xiaobin Ling, Dmitrij Golovenko, Jianhua Gan, Jinbiao Ma, Andrei A. Korostelev, Wenwen Fang

Nature

DOI

2025

Catalytic-state structure of Candidatus Hydrogenedentes Cas12b revealed by cryo-EM studies

Ye Li, Jian Jian Li, Xiaotong Pei, Jingjing Wei, Jianhua Gan, Jinzhong Lin

Nucleic Acids Research

DOI

2025

Structural and functional studies of the main replication protein NS1 of human parvovirus B19

Yixi Zhang, Boming Fan, Yanqing Gao, Jie Yang, Weizhen Zhang, Shichen Su, Linxi Li, Huili Li, Zhaorong Luo, Guangli Tang, Chenxi Wang, Xueting Zhang, Hehua Liu, Jianhua Gan

Nucleic Acids Research

DOI

2025

Cryo-EM structure of a natural RNA nanocage

Xiaobin Ling, Dmitrij Golovenko, Jianhua Gan, Jinbiao Ma, Andrei A. Korostelev, Wenwen Fang

Nature

DOI

2025

Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD+

Chulei Cao, Jie Yang, Weizhen Zhang, Jiaqin Chen, Yanqing Gao, Yuqi Yao, Yixi Zhang, Huili Li, Linxi Li, Zhaorong Luo, Chenxi Wang, Guangli Tang, Cui Ruixue, Hehua Liu, Qiyao Wang, Zhen Huang, Jinbiao Ma, Jianhua Gan

Nature Communications

DOI

2025

Assembly and inhibition of transferable TMexCD1-TOprJ1 efflux pump

Yu Shi, Mengyuan Li, Tao Cui, Jianhua Gan, Haomin Huang, Zhi Su, Runshi Yang, Xing Zhang, Huimin Zhang, Yu Feng, Youjun Feng

Nature Communications

DOI

2025

Mechanisms and engineering of a miniature type V-N CRISPR-Cas12 effector enzyme

Wenhan Fu, Jiacheng Ma, Zhipeng Wang, Na Tang, Deng Pan, Mengjiao Su, Zhaowei Wu, Jianhua Gan, Quanjiang Ji

Nature Communications

DOI

2025

Development of Orally Bioavailable FTO Inhibitors with Potent Antileukemia Efficacy

Teng Yang, Ze Dong, Rong Du, Yiqing Wang, Lu Liu, Yangyang Xue, Xi Zhang, Yonggang Liao, Jianhua Gan, Xiaoxuan Yu, Yue Huang, Cai‐Guang Yang

Journal of Medicinal Chemistry

DOI

2025

Megavirus baoshanense Mb0671 modulates host translation and increases viral fitness

Wenya Bian, Jie Yang, Yucheng Xia, Yun Li, Yanjin Cheng, Yu-Chen Wu, Jianhua Gan, Jiang F. Zhong

Frontiers in Microbiology

DOI

2025

Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection

Tao Zhang, Wei Dong Wu, Yanling Zhao, Ziang Ding, Bingyan Wei, Teng Yang, Jiahui Li, Pengyu Wang, Lefu Lan, Jianhua Gan, Cai‐Guang Yang

Journal of Medicinal Chemistry

DOI

2024

Cofactor binding triggers rapid conformational remodelling of the active site of a methyltransferase ribozyme

Hengyi Jiang, Getong Liu, Yanqing Gao, Jianhua Gan, Dongrong Chen, A. Murchie

Journal of Biological Chemistry

DOI

2024

Structural insights into the biosynthetic mechanism of Nα-GlyT and 5-NmdU hypermodifications of DNA

Yan Wen, Wenting Guo, Chunyan Meng, Jie Yang, Sha Xu, Haitao Chen, Jianhua Gan, Baixing Wu

Nucleic Acids Research

DOI

2024

A bacterial methyltransferase that initiates biotin synthesis, an attractive anti-ESKAPE druggable pathway

Su Zhi, Weizhen Zhang, Yu Shi, Tao Cui, Yongchang Xu, Runshi Yang, Man Huang, Chun Zhou, Huimin Zhang, Ting Lu, Jiuxin Qu, Zheng‐Guo He, Jianhua Gan, Youjun Feng

Science Advances

DOI

2024

Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents

Tao Zhang, Pengyu Wang, Hailing Zhou, Bingyan Wei, Yanling Zhao, Jiahui Li, Min Zhang, Wenjuan Wu, Lefu Lan, Jianhua Gan, Cai‐Guang Yang

Cell Reports Medicine

DOI

2024

Structures of African swine fever virus topoisomerase complex and their implications

Jie Yang, Zhiwei Shao, Xin Zhao, Weizhen Zhang, Yixi Zhang, Linxi Li, Yanqing Gao, Qiyuan Shao, Chulei Cao, Huili Li, Ruixue Cui, Hehua Liu, Jianhua Gan

Nature Communications

DOI

2024

Structural and functional insights into the helicase protein E5 of Mpox virus

Weizhen Zhang, Yusong Liu, Mengquan Yang, Jie Yang, Zhiwei Shao, Yanqing Gao, Xinran Jiang, Cui Ruixue, Yixi Zhang, Xin Zhao, Qiyuan Shao, Chulei Cao, Huili Li, Linxi Li, Hehua Liu, Haishan Gao, Jianhua Gan

Cell Discovery

DOI

2024

High-resolution crystal structure of RNA kinase ArK1 from G. acetivorans

Chulei Cao, Weizhen Zhang, Yanqing Gao, Jie Yang, Hehua Liu, Jianhua Gan

Biochemical and Biophysical Research Communications

DOI

2023

Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom

Tong Qin, B. Hu, Qianwei Zhao, Yali Wang, Shaoxin Wang, Danyan Luo, J. Lyu, Yiqing Chen, Jianhua Gan, Zhen Huang

International Journal of Molecular Sciences

DOI

2023

Structures and implications of the C962R protein of African swine fever virus

Zhiwei Shao, Shichen Su, Jie Yang, Weizhen Zhang, Yanqing Gao, Xin Zhao, Yixi Zhang, Qiyuan Shao, Chulei Cao, Huili Li, Hehua Liu, Jinru Zhang, Jinzhong Lin, Jinbiao Ma, Jianhua Gan

Nucleic Acids Research

DOI

2023

Crystal structures and identification of novel Cd2+-specific DNA aptamer

Hehua Liu, Yanqing Gao, Johnsi Mathivanan, Zev Armour-Garb, Zhiwei Shao, Yixi Zhang, Xin Zhao, Qiyuan Shao, Weizhen Zhang, Jie Yang, Chulei Cao, Huili Li, Jia Sheng, Jianhua Gan

Nucleic Acids Research

DOI

2023

Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma

Linlin Zhou, Tao Zhang, Yun Xue, Chuan Yue, Yihui Pan, Pengyu Wang, Teng Yang, Meixia Li, Hu Zhou, Kan Ding, Jianhua Gan, Hongbin Ji, Cai‐Guang Yang

Nature Communications

DOI

2023

Shade-induced RTFL/DVL peptides negatively regulate the shade response by directly interacting with BSKs in Arabidopsis

Sha Huang, Yu Ma, Yitian Xu, Pengfei Lu, Jie Yang, Yu Huan Xie, Jianhua Gan, Lin Li

Nature Communications

DOI

2023

Molecular basis and engineering of miniature Cas12f with C-rich PAM specificity

Mengjiao Su, Fan Li, Yujue Wang, Yan Gao, Weiqi Lan, Zhiwei Shao, Chen Zhu, Na Tang, Jianhua Gan, Zhaowei Wu, Quanjiang Ji

Nature Chemical Biology

DOI

2023

Structural and functional studies of PCNA from African swine fever virus

Zhiwei Shao, Jie Yang, Yanqing Gao, Yixi Zhang, Xin Zhao, Qiyuan Shao, Weizhen Zhang, Chulei Cao, Hehua Liu, Jianhua Gan

Journal of Virology

DOI

2023

Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties

Pan Xiao, Zongliang Duan, Zeyu Liu, Liang Chen, Deyan Zhang, Lu Liu, Chen Zhou, Jianhua Gan, Ze Dong, Cai‐Guang Yang

Journal of Medicinal Chemistry

DOI

2023

Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists

Ranran Zhang, Pengyu Wang, Bingyan Wei, Liang Chen, Xiaomin Song, Yihui Pan, Jiahui Li, Jianhua Gan, Tao Zhang, Cai‐Guang Yang

European Journal of Medicinal Chemistry

DOI

2023

Structure-based insights into mechanism of endoperoxidase FtmOx1 catalyzed reactions

Fei Wang, Yanqing Gao, Chunxi Wang, Wenxian Lan, Jianhua Gan, Chunyang Cao

Catalysis Science & Technology

DOI

2022

Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1

Ruixue Cui, Hao Li, Jin Zhao, Xuhang Li, Jianhua Gan, Jinbiao Ma

Nucleic Acids Research

DOI

2022

Xenogeneic nucleoid-associated EnrR thwarts H-NS silencing of bacterial virulence with unique DNA binding

Ruiqing Ma, Yabo Liu, Jianhua Gan, Haoxian Qiao, Jiabao Ma, Yi Zhang, Yifan Bu, Shuai Shao, Yuanxing Zhang, Qiyao Wang

Nucleic Acids Research

DOI

2022

PmiR senses 2-methylisocitrate levels to regulate bacterial virulence in Pseudomonas aeruginosa

Guoyan Cui, Yixi Zhang, Xuejie Xu, Yingying Liu, Zhuang Li, Min Wu, Jianling Liu, Jianhua Gan, Haihua Liang

Science Advances

DOI

2022

Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP

Bingyan Wei, Tao Zhang, Pengyu Wang, Yihui Pan, Jiahui Li, Weizhong Chen, Min Zhang, Quanjiang Ji, Wenjuan Wu, Lefu Lan, Jianhua Gan, Cai‐Guang Yang

Nature Communications

DOI

2022

Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis

Bowen Zhan, Yanqing Gao, Wenqing Gao, Ye Li, Zhengyang Li, Qi Qi, Xin Lan, Hongbo Shen, Jianhua Gan, Guoping Zhao, Jixi Li

Communications Biology

DOI

2022

Structural insights into partner selection for MYB and bHLH transcription factor complexes

Baihui Wang, Qiang Luo, Yingping Li, Kangxi Du, Zhen Wu, Tianyang Li, Wen‐Hui Shen, Chien‐Hsun Huang, Jianhua Gan, Aiwu Dong

Nature Plants

DOI

2022

Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma

Pengyu Wang, Tao Zhang, Xinjing Wang, Hongying Xiao, Huiti Li, Linlin Zhou, Teng Yang, Bingyan Wei, Zeyun Zhu, Lu Zhou, Song Yang, Xiongxiong Lu, Yonghui Zhang, Yue Huang, Jianhua Gan, Cai‐Guang Yang

Cell chemical biology

DOI

2022

Three enigmatic BioH isoenzymes are programmed in the early stage of mycobacterial biotin synthesis, an attractive anti-TB drug target

Yongchang Xu, Jie Yang, Weihui Li, Shuaijie Song, Yu Shi, Lihan Wu, Jingdu Sun, Mengyun Hou, Jinzi Wang, Xu Jia, Huimin Zhang, Man Huang, Ting Lu, Jianhua Gan, Youjun Feng

PLoS Pathogens

DOI

2022

Structure–Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors

Zeyu Liu, Zongliang Duan, Deyan Zhang, Pan Xiao, Tao Zhang, Hongjiao Xu, Chuan-Hui Wang, Guo-Wu Rao, Jianhua Gan, Yue Huang, Cai‐Guang Yang, Ze Dong

Journal of Medicinal Chemistry

DOI

2022

Fluorescent Aptaswitch for Detection of Lead Ions

Johnsi Mathivanan, Hehua Liu, Jianhua Gan, Arun Richard Chandrasekaran, Jia Sheng

ACS Applied Bio Materials

DOI

2022

Crystal structures and insights into precursor tRNA 5’-end processing by prokaryotic minimal protein-only RNase P

Yangyang Li, Shichen Su, Yanqing Gao, Guoliang Lu, Hehua Liu, Xi Chen, Zhiwei Shao, Yixi Zhang, Qiyuan Shao, Xin Zhao, Jie Yang, Chulei Cao, Jinzhong Lin, Jinbiao Ma, Jianhua Gan

Nature Communications

DOI

2022

Structures and implications of the nuclease domain of human parvovirus B19 NS1 protein

Yixi Zhang, Zhiwei Shao, Yanqing Gao, Boming Fan, Jie Yang, Xi Chen, Xin Zhao, Qiyuan Shao, Weizhen Zhang, Chulei Cao, Hehua Liu, Jianhua Gan

Computational and Structural Biotechnology Journal

DOI

2021

铜绿假单胞菌利用HinK感知组胺并控制细菌的致病力（英文）

王娅娅，曹荞，曹芹，甘建华，孙宁，杨财广，Taeok Bae，吴敏，蓝乐夫

Science Bulletin

2021

Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa

Yaya Wang, Qiao Cao, Qin Cao, Jianhua Gan, Ning Sun, Cai‐Guang Yang, Taeok Bae, Min Wu, Lefu Lan

《中国科学通报：英文版》

DOI

2021

Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella

Xiang‐Na Guan, Tao Zhang, Teng Yang, Ze Dong, Song Yang, Lefu Lan, Jianhua Gan, Cai‐Guang Yang

RSC Medicinal Chemistry

DOI

2021

The identification and characterization of a selected SAM-dependent methyltransferase ribozyme that is present in natural sequences

Hengyi Jiang, Yanqing Gao, Lei Zhang, Dongrong Chen, Jianhua Gan, Alastair I.H. Murchie

Nature Catalysis

DOI

2021

Structural analysis and functional study of phosphofructokinase B (PfkB) from Mycobacterium marinum

Baocai Gao, Rui Ji, Zhengyang Li, Xiaoqin Su, Hongyong Li, Yicheng Sun, Chaoneng Ji, Jianhua Gan, Jixi Li

Biochemical and Biophysical Research Communications

DOI

2021

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

Wenqing Gao, Yuanyuan Li, Xuehe Liu, Sen Wang, Pucheng Mei, Zijun Chen, Kewei Liu, Suhua Li, Xue‐Wei Xu, Jianhua Gan, Jiaxue Wu, Chaoneng Ji, Chen Ding, Xing Liu, Yuping Lai, Housheng Hansen He, Judy Lieberman, Hao Wu, Xiangjun Chen, Jixi Li

Cell Death and Differentiation

DOI

2021

Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections

Teng Yang, Tao Zhang, Xiang Zhou, Pengyu Wang, Jianhua Gan, Baoan Song, Song Yang, Cai‐Guang Yang

Journal of Agricultural and Food Chemistry

DOI

2020

结核分枝杆菌RNA解旋酶RhlE的蛋白表达、纯化及结构性质研究

刘雪鹤，李正阳，高文青，洪利国，甘建华，李继喜

《复旦学报(自然科学版)》

DOI

2020

Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei

Yanqing Gao, Hehua Liu, Chong Zhang, Shichen Su, Yiqing Chen, Xi Chen, Yangyang Li, Zhiwei Shao, Yixi Zhang, Qiyuan Shao, Jixi Li, Zhen Huang, Jinbiao Ma, Jianhua Gan

Nucleic Acids Research

DOI

2020

NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B

Qiang Luo, Baihui Wang, Zhen Wu, Wen Jiang, Yueyue Wang, Kangxi Du, Nana Zhou, Lina Zheng, Jianhua Gan, Wen‐Hui Shen, Jinbiao Ma, Aiwu Dong

Proceedings of the National Academy of Sciences

DOI

2020

DNA backbone interactions impact the sequence specificity of DNA sulfur-binding domains: revelations from structural analyses

Hao Yu, Jiayi Li, Guang Liu, Gong Zhao, Yuli Wang, Wenyue Hu, Zixin Deng, Geng Wu, Jianhua Gan, Yi‐Lei Zhao, Xinyi He

Nucleic Acids Research

DOI

2020

Structural studies reveal a ring-shaped architecture of deep-sea vent phage NrS-1 polymerase

Xi Chen, Shichen Su, Yiqing Chen, Yanqing Gao, Yangyang Li, Zhiwei Shao, Yixi Zhang, Qiyuan Shao, Hehua Liu, Jixi Li, Jinbiao Ma, Jianhua Gan

Nucleic Acids Research

DOI

2020

OsChz1 acts as a histone chaperone in modulating chromatin organization and genome function in rice

Kangxi Du, Qiang Luo, Liufan Yin, Jiabing Wu, Yuhao Liu, Jianhua Gan, Aiwu Dong, Wen‐Hui Shen

Nature Communications

DOI

2020

Short DNA Oligonucleotide as a Ag+ Binding Detector

Fusheng Shen, Song Mao, Johnsi Mathivanan, Ying Wu, Arun Richard Chandrasekaran, Hehua Liu, Jianhua Gan, Jia Sheng

ACS Omega

DOI

2020

A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP‐Protein Interactions in Kidney Cancer Cells

Zhen Wang, Hao Zhang, Baoen Chen, Sisheng Ouyang, Tong Zheng, Ran Zhou, Ze Dong, Yue Huang, Tao Zhang, Hualiang Jiang, Jianhua Gan, Cheng Luo, Cai‐Guang Yang

Chinese Journal of Chemistry

DOI

2020

Catalytic-state structure and engineering of Streptococcus thermophilus Cas9

Yifei Zhang, Hongyuan Zhang, Xuexia Xu, Yujue Wang, Weizhong Chen, Yannan Wang, Zhaowei Wu, Na Tang, Yu Wang, Suwen Zhao, Jianhua Gan, Quanjiang Ji

Nature Catalysis

DOI

2020

Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases

Zhengyang Li, Long Li, Ying‐Yi Huo, Zijun Chen, Yu Zhao, Jing Huang, Shu-Ling Jian, Zhen Rong, Di Wu, Jianhua Gan, Xiaojian Hu, Jixi Li, Xue‐Wei Xu

Biotechnology for Biofuels

DOI

2020

Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

Zijun Chen, Zhengyang Li, Xiaojian Hu, Feiyan Xie, Siyun Kuang, Bowen Zhan, Wenqing Gao, Xiangjun Chen, Siqi Gao, Yang Li, Yongming Wang, Feng Qian, Chen Ding, Jianhua Gan, Chaoneng Ji, Xue‐Wei Xu, Zheng Zhou, Jinqing Huang, Housheng Hansen He, Jixi Li

Advanced Science

DOI

2020

Crystal structure of human archease, a key cofactor of tRNA splicing ligase complex

Shuyan Duan, Wenqing Gao, Zijun Chen, Zhengyang Li, Suhua Li, Jianhua Gan, Xiangjun Chen, Jixi Li

The International Journal of Biochemistry & Cell Biology

DOI

2020

A unique DNA-binding mode of African swine fever virus AP endonuclease

Yiqing Chen, Xi Chen, Qi Zhong Huang, Zhiwei Shao, Yanqing Gao, Yangyang Li, Chun Yang, Hehua Liu, Jixi Li, Qiyao Wang, Jinbiao Ma, Yong‐Zhen Zhang, Yijun Gu, Jianhua Gan

Cell Discovery

DOI

2020

The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa

Gukui Chen, Jianhua Gan, Chun Yang, Yili Zuo, Juan Peng, Meng Li, Weiping Huo, Yingpeng Xie, Yani Zhang, Tietao Wang, Xin Deng, Haihua Liang

The EMBO Journal

DOI

2019

Structural insights into target DNA recognition by R2R3-MYB transcription factors

Baihui Wang, Qiang Luo, Yingping Li, Liufan Yin, Nana Zhou, Xiangnan Li, Jianhua Gan, Aiwu Dong

Nucleic Acids Research

DOI

2019

Selective cadmium regulation mediated by a cooperative binding mechanism in CadR

Xichun Liu, Qingyuan Hu, Jinmei Yang, Shanqing Huang, Tianbiao Wei, Weizhong Chen, Yafeng He, Dan Wang, Zhijun Liu, Kang Wang, Jianhua Gan, Hao Chen

Proceedings of the National Academy of Sciences

DOI

2019

Toxin–antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA–KacT complex

Hongliang Qian, Hao Yu, Peifei Li, Eric Zhu, Qingqing Yao, Cui Tai, Zixin Deng, Kenn Gerdes, Xinyi He, Jianhua Gan, Hong‐Yu Ou

Nucleic Acids Research

DOI

2019

Structural analysis of Phytophthora suppressor of RNA silencing 2 (PSR2) reveals a conserved modular fold contributing to virulence

Jinqiu He, Wenwu Ye, Du Seok Choi, Baixing Wu, Yi Zhai, Baodian Guo, Shuyi Duan, Yuanchao Wang, Jianhua Gan, Wenbo Ma, Jinbiao Ma

Proceedings of the National Academy of Sciences

DOI

2019

Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease

Weizhong Chen, Hongyuan Zhang, Yifei Zhang, Yu Wang, Jianhua Gan, Quanjiang Ji

PLoS Biology

DOI

2019

Purification and enzymatic characterization of the RNA ligase RTCB from Thermus thermophilus

Shuyan Duan, Zijun Chen, Zhengyang Li, Rui Ji, Jianhua Gan, Jixi Li

Biotechnology Letters

DOI

2019

The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment

Bing Liu, Yuhao Liu, Baihui Wang, Qiang Luo, Jinlei Shi, Jianhua Gan, Wen‐Hui Shen, Yu Yu, Aiwu Dong

Nature Communications

DOI

2019

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

Yue Huang, Rui Jun Su, Yue Sheng, Lei Dong, Ze Dong, Hongjiao Xu, Tengfeng Ni, Zijie Scott Zhang, Tao Zhang, Chenying Li, Li Han, Zhenyun Zhu, Fulin Lian, Jiangbo Wei, Qiangqiang Deng, Yungui Wang, Mark Wunderlich, Zhiwei Gao, Guoyu Pan, Dafang Zhong, Hu Zhou, Naixia Zhang, Jianhua Gan, Hualiang Jiang, James C. Mulloy, Zhijian Qian, Jianjun Chen, Cai‐Guang Yang

Cancer Cell

DOI

2019

Structural insights into the complex of trigger factor chaperone and ribosomal protein S7 from Mycobacterium tuberculosis

Zhengyang Li, Di Wu, Bowen Zhan, Xiaojian Hu, Jianhua Gan, Chaoneng Ji, Jixi Li

Biochemical and Biophysical Research Communications

DOI

2019

Structural Insight into the Mechanism of Staphylococcus aureus Stp1 Phosphatase

Teng Yang, Tingting Liu, Jianhua Gan, Kunqian Yu, Kaixian Chen, Wei Xue, Lefu Lan, Song Yang, Cai‐Guang Yang

ACS Infectious Diseases

DOI

2019

Structure of the error-prone DNA ligase of African swine fever virus identifies critical active site residues

Yiqing Chen, Hehua Liu, Chun Yang, Yanqing Gao, Xiang Yu, Xi Chen, Ruixue Cui, Lina Zheng, Suhua Li, Xuhang Li, Jinbiao Ma, Zhen Huang, Jixi Li, Jianhua Gan

Nature Communications

DOI

2019

Molecular insights into the master regulator CysB‐mediated bacterial virulence in Pseudomonas aeruginosa

Yaqin Song, Chun Yang, Gukui Chen, Yixi Zhang, Zijing Seng, Zhao Cai, Chao Zhang, Liang Yang, Jianhua Gan, Haihua Liang

Molecular Microbiology

DOI

2018

大肠杆菌GhoS的纯化及X射线衍射分析（英文）

程云珊，李继喜，甘建华

《复旦学报(自然科学版)》

2018

High-resolution DNA quadruplex structure containing all the A-, G-, C-, T-tetrads

Hehua Liu, Rui Wang, Xiang Yu, Fusheng Shen, Wenxian Lan, Phensinee Haruehanroengra, Qingqing Yao, Jing Zhang, Yiqing Chen, Suhua Li, Baixing Wu, Lina Zheng, Jinbiao Ma, Jinzhong Lin, Chunyang Cao, Jixi Li, Jia Sheng, Jianhua Gan

Nucleic Acids Research

DOI

2018

Structural insights into DNA degradation by human mitochondrial nuclease MGME1

Chun Yang, Ruiqi Wu, Hehua Liu, Yiqing Chen, Yanqing Gao, Xi Chen, Yangyang Li, Jinbiao Ma, Jixi Li, Jianhua Gan

Nucleic Acids Research

DOI

2018

Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action

Yan Yan, Qikun Liu, Xin Zang, Shuguang Yuan, Undramaa Bat-Erdene, Calvin Nguyen, Jianhua Gan, Jiahai Zhou, Steven E. Jacobsen, Yi Tang

Nature

DOI

2018

Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA

Rui Wang, Srivathsan V. Ranganathan, Phensinee Haruehanroengra, Song Mao, Matteo Scalabrin, Daniele Fabris, Alan A. Chen, Hehua Liu, Abdalla E. A. Hassan, Jianhua Gan, Jia Sheng

Journal of Biomolecular Structure and Dynamics

DOI

2018

Structural basis for multiple gene regulation by human DUX4

Yangyang Li, Baixing Wu, Hehua Liu, Yanqing Gao, Chun Yang, Xi Xian Chen, Jing Zhang, Yiqing Chen, Yijun Gu, Jixi Li, Jinbiao Ma, Jianhua Gan

Biochemical and Biophysical Research Communications

DOI

2018

Structural and biochemical insights into small RNA 3′ end trimming by Arabidopsis SDN1

Jiayi Chen, Li Liu, Chenjiang You, Jiaqi Gu, Wenjie Ruan, Lu Zhang, Jianhua Gan, Chunyang Cao, Ying Huang, Xuemei Chen, Jinbiao Ma

Nature Communications

DOI

2018

Acetylation of lysine 182 inhibits the ability of Mycobacterium tuberculosis DosR to bind DNA and regulate gene expression during hypoxia

Jing Bi, Zongchao Gou, Fengzhu Zhou, Yiqing Chen, Jianhua Gan, Jun Liu, Honghai Wang, Xuelian Zhang

Emerging Microbes & Infections

DOI

2018

Structural insight into the role of VAL1 B3 domain for targeting to FLC locus in Arabidopsis thaliana

Baixing Wu, Mengmeng Zhang, Shichen Su, Hehua Liu, Jianhua Gan, Jinbiao Ma

Biochemical and Biophysical Research Communications

DOI

2018

Competition between Supramolecular Interaction and Protein–Protein Interaction in Protein Crystallization: Effects of Crystallization Method and Small Molecular Bridge

Rongting Hu, Guang Yang, Hong‐Ming Ding, Jinbiao Ma, Yu‐qiang Ma, Jianhua Gan, Guosong Chen

Industrial & Engineering Chemistry Research

DOI

2018

Identification and characterization of acetyltransferase‐type toxin‐antitoxin locus in Klebsiella pneumoniae

Hongliang Qian, Qingqing Yao, Cui Tai, Zixin Deng, Jianhua Gan, Hong‐Yu Ou

Molecular Microbiology

DOI

2018

Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

Baixing Wu, Shichen Su, Deepak P. Patil, Hehua Liu, Jianhua Gan, Samie R. Jaffrey, Jinbiao Ma

Nature Communications

DOI

2017

Structure insight of GSDMD reveals the basis of GSDMD autoinhibition in cell pyroptosis

Siyun Kuang, Jun Zheng, Hui Yang, Suhua Li, Shuyan Duan, Yanfang Shen, Chaoneng Ji, Jianhua Gan, Xue‐Wei Xu, Jixi Li

Proceedings of the National Academy of Sciences

DOI

2017

Crystal structure of an RNA-cleaving DNAzyme

Hehua Liu, Yu Xiang, Yiqing Chen, Jing Zhang, Baixing Wu, Lina Zheng, Phensinee Haruehanroengra, Rui Wang, Suhua Li, Jinzhong Lin, Jixi Li, Jia Sheng, Zhen Huang, Jinbiao Ma, Jianhua Gan

Nature Communications

DOI

2017

Structural basis of Zn(II) induced metal detoxification and antibiotic resistance by histidine kinase CzcS in Pseudomonas aeruginosa

Dan Wang, Weizhong Chen, Shanqing Huang, Yafeng He, Xichun Liu, Qingyuan Hu, Tianbiao Wei, Hong Sang, Jianhua Gan, Hao Chen

PLoS Pathogens

DOI

2017

Structural insights into the specific recognition of DSR by the YTH domain containing protein Mmi1

Baixing Wu, Jinhao Xu, Shichen Su, Hehua Liu, Jianhua Gan, Jinbiao Ma

Biochemical and Biophysical Research Communications

DOI

2017

A DNA Structure Containing AgI‐Mediated G:G and C:C Base Pairs

Hehua Liu, Fusheng Shen, Phensinee Haruehanroengra, Qingqing Yao, Yunshan Cheng, Yiqing Chen, Chun Yang, Jing Zhang, Baixing Wu, Qiang Luo, Ruixue Cui, Jixi Li, Jinbiao Ma, Jia Sheng, Jianhua Gan

Angewandte Chemie

DOI

2017

Structural and functional studies of a noncanonical Dicer from Entamoeba histolytica

Xiang Yu, Xuhang Li, Lina Zheng, Jinbiao Ma, Jianhua Gan

Scientific Reports

DOI

2017

Unique 5′-P recognition and basis for dG:dGTP misincorporation of ASFV DNA polymerase X

Yiqing Chen, Jing Zhang, Hehua Liu, Yanqing Gao, Xuhang Li, Lina Zheng, Ruixue Cui, Qingqing Yao, Liang Rong, Jixi Li, Zhen Huang, Jinbiao Ma, Jianhua Gan

PLoS Biology

DOI

2017

Structural Insights into the Redox-Sensing Mechanism of MarR-Type Regulator AbfR

Guijie Liu, Xing Liu, Hongjiao Xu, Xichun Liu, Hu Zhou, Zhen Huang, Jianhua Gan, Hao Chen, Lefu Lan, Cai‐Guang Yang

Journal of the American Chemical Society

DOI

2016

Structural insights into RNA duplexes with multiple 2′-5′-linkages

Fusheng Shen, Zhipu Luo, Hehua Liu, Rui Wang, Shenglong Zhang, Jianhua Gan, Jia Sheng

Nucleic Acids Research

DOI

2016

Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex

Hehua Liu, Chen Cai, Phensinee Haruehanroengra, Qingqing Yao, Yiqing Chen, Chun Yang, Qiang Luo, Baixing Wu, Jixi Li, Jinbiao Ma, Jia Sheng, Jianhua Gan

Nucleic Acids Research

DOI

2016

Crystal structure ofPseudomonas aeruginosaRsaL bound to promoter DNA reaffirms its role as a global regulator involved in quorum-sensing

Huaping Kang, Jianhua Gan, Jingru Zhao, Weina Kong, Jing Zhang, Miao Zhu, Fan Li, Yaqin Song, Jin Qin, Haihua Liang

Nucleic Acids Research

DOI

2016

Structural basis for single-stranded RNA recognition and cleavage by C3PO

Jing Zhang, Hehua Liu, Qingqing Yao, Xiang Yu, Yiqing Chen, Ruixue Cui, Baixing Wu, Lina Zheng, Junjun Zuo, Zhen Huang, Jinbiao Ma, Jianhua Gan

Nucleic Acids Research

DOI

2016

Rhein Inhibits AlkB Repair Enzymes and Sensitizes Cells to Methylated DNA Damage

Qi Li, Yue Huang, Xichun Liu, Jianhua Gan, Hao Chen, Cai‐Guang Yang

Journal of Biological Chemistry

DOI

2016

Structural Basis for the Selective Pb(II) Recognition of Metalloregulatory Protein PbrR691

Shanqing Huang, Xichun Liu, Dan Wang, Weizhong Chen, Qingyuan Hu, Tianbiao Wei, Wenquan Zhou, Jianhua Gan, Hao Chen

Inorganic Chemistry

DOI

2016

Structural Analysis of the Hg(II)-Regulatory Protein Tn501 MerR from Pseudomonas aeruginosa

Dan Wang, Shanqing Huang, Pingying Liu, Xichun Liu, Yafeng He, Weizhong Chen, Qingyuan Hu, Tianbiao Wei, Jianhua Gan, Jing Ma, Hao Chen

Scientific Reports

DOI

2016

Identification and characterization of chromosomal relBE toxin-antitoxin locus in Streptomyces cattleya DSM46488

Peng Li, Cui Tai, Zixin Deng, Jianhua Gan, Marco Rinaldo Oggioni, Hong‐Yu Ou

Scientific Reports

DOI

2016

Characterization of Gain-of-Function Mutant Provides New Insights into ClpP Structure

Tengfeng Ni, Fei Ye, Xing Liu, Jie Zhang, Hongchuan Liu, Jiahui Li, Yingyi Zhang, Yin-Qiang Sun, Meining Wang, Cheng Luo, Hualiang Jiang, Lefu Lan, Jianhua Gan, Ao Zhang, Hu Zhou, Cai‐Guang Yang

ACS Chemical Biology

DOI

2016

Structural and Molecular Mechanism of CdpR Involved in Quorum-Sensing and Bacterial Virulence in Pseudomonas aeruginosa

Jingru Zhao, Xiang Yu, Miao Zhu, Huaping Kang, Jinbiao Ma, Min Wu, Jianhua Gan, Xin Deng, Haihua Liang

PLoS Biology

DOI

2015

Identification and Characterization of a Novel Prokaryotic Peptide

Guiqin Sun, Xiang Yu, Celimuge Bao, Lei Wang, Meng Li, Jianhua Gan, Di Qu, Jinbiao Ma, Li Chen

Journal of Biological Chemistry

DOI

2015

Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein

Tianlu Wang, Tingting Hong, Yue Huang, Haomiao Su, Fan Wu, Yi Chen, Lai Wei, Wei Huang, Xiaoluan Hua, Xia Yu, Jinglei Xu, Jianhua Gan, Bi‐Feng Yuan, Yuqi Feng, Xiao‐Lian Zhang, Cai‐Guang Yang, Xiang Yu Zhou

Journal of the American Chemical Society

DOI

2014

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

Yue Huang, Jingli Yan, Qi Li, Jiafei Li, Shouzhe Gong, Hu Zhou, Jianhua Gan, Hualiang Jiang, Guifang Jia, Cheng Luo, Cai‐Guang Yang

Nucleic Acids Research

DOI

2014

Structural insights into the effects of 2′-5′ linkages on the RNA duplex

Jia Sheng, Li Li, Aaron E. Engelhart, Jianhua Gan, Jiawei Wang, Jack W. Szostak

Proceedings of the National Academy of Sciences

DOI

2013

The complex structures of ALKBH2 mutants cross-linked to dsDNA reveal the conformational swing of β-hairpin

Baoen Chen, Jianhua Gan, Cai‐Guang Yang

Science China Chemistry

DOI

2013

RNase III: Genetics and Function; Structure and Mechanism

Donald L. Court, Jianhua Gan, Yu‐He Liang, Gary X. Shaw, Joseph E. Tropea, Nina Costantino, David S. Waugh, Xinhua Ji

Annual Review of Genetics

DOI

2012

Oxidation-sensing Regulator AbfR Regulates Oxidative Stress Responses, Bacterial Aggregation, and Biofilm Formation in Staphylococcus epidermidis

Xing Liu, Xiaoxu Sun, Youcong Wu, Cen Xie, Wenru Zhang, Dan Wang, Xiaoyan Chen, Di Qu, Jianhua Gan, Hao Chen, Hualiang Jiang, Lefu Lan, Cai‐Guang Yang

Journal of Biological Chemistry

DOI

精选作品

期刊论文

Mechanism and plasticity of primitive pyroptosis

Phage-encoded NARP3 system rebuilds NAD + to subvert bacterial immunity

H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants

Targeting transthyretin by one Cas9 variant with superfidelity and broad compatibility

原核生物pre-tRNA 5'末端剪切酶的结构和功能研究

Structure-based development of a covalent inhibitor targeting Streptococcus pyogenes over Staphylococcus aureus sortase A.

Selenium-derivatized Nucleic Acids for Phasing, Crystal Growth, Structure Determination and Beyond

Crystal Engineering of Nucleic Acid Macro-molecules using Selenium Atoms

Structural insight into polymerase mechanism via a chiral center generated with a single selenium atom

Author Correction: Cryo-EM structure of a natural RNA nanocage

Catalytic-state structure of Candidatus Hydrogenedentes Cas12b revealed by cryo-EM studies

Structural and functional studies of the main replication protein NS1 of human parvovirus B19

Cryo-EM structure of a natural RNA nanocage

Crystal structures and snapshots along Tpt1-catalyzed phosphate transfer from nucleic acid to NAD+

Assembly and inhibition of transferable TMexCD1-TOprJ1 efflux pump

Mechanisms and engineering of a miniature type V-N CRISPR-Cas12 effector enzyme

Development of Orally Bioavailable FTO Inhibitors with Potent Antileukemia Efficacy

Megavirus baoshanense Mb0671 modulates host translation and increases viral fitness

Structure-Guided Development of ClpP Agonists with Potent Therapeutic Activities against Staphylococcus aureus Infection

Cofactor binding triggers rapid conformational remodelling of the active site of a methyltransferase ribozyme

Structural insights into the biosynthetic mechanism of Nα-GlyT and 5-NmdU hypermodifications of DNA

A bacterial methyltransferase that initiates biotin synthesis, an attractive anti-ESKAPE druggable pathway

Structure-guided development of selective caseinolytic protease P agonists as antistaphylococcal agents

Structures of African swine fever virus topoisomerase complex and their implications

Structural and functional insights into the helicase protein E5 of Mpox virus

High-resolution crystal structure of RNA kinase ArK1 from G. acetivorans

Structural Insight into Polymerase Mechanism via a Chiral Center Generated with a Single Selenium Atom

Structures and implications of the C962R protein of African swine fever virus

Crystal structures and identification of novel Cd2+-specific DNA aptamer

Selective activator of human ClpP triggers cell cycle arrest to inhibit lung squamous cell carcinoma

Shade-induced RTFL/DVL peptides negatively regulate the shade response by directly interacting with BSKs in Arabidopsis

Molecular basis and engineering of miniature Cas12f with C-rich PAM specificity

Structural and functional studies of PCNA from African swine fever virus

Rational Design of RNA Demethylase FTO Inhibitors with Enhanced Antileukemia Drug-Like Properties

Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists

Structure-based insights into mechanism of endoperoxidase FtmOx1 catalyzed reactions

Structural insights into the dual activities of the two-barrel RNA polymerase QDE-1

Xenogeneic nucleoid-associated EnrR thwarts H-NS silencing of bacterial virulence with unique DNA binding

PmiR senses 2-methylisocitrate levels to regulate bacterial virulence in Pseudomonas aeruginosa

Anti-infective therapy using species-specific activators of Staphylococcus aureus ClpP

Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis

Structural insights into partner selection for MYB and bHLH transcription factor complexes

Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma

Three enigmatic BioH isoenzymes are programmed in the early stage of mycobacterial biotin synthesis, an attractive anti-TB drug target

Structure–Activity Relationships and Antileukemia Effects of the Tricyclic Benzoic Acid FTO Inhibitors

Fluorescent Aptaswitch for Detection of Lead Ions

Crystal structures and insights into precursor tRNA 5’-end processing by prokaryotic minimal protein-only RNase P

Structures and implications of the nuclease domain of human parvovirus B19 NS1 protein

铜绿假单胞菌利用HinK感知组胺并控制细菌的致病力（英文）

Histamine activates HinK to promote the virulence of Pseudomonas aeruginosa

Covalent sortase A inhibitor ML346 prevents Staphylococcus aureus infection of Galleria mellonella

The identification and characterization of a selected SAM-dependent methyltransferase ribozyme that is present in natural sequences

Structural analysis and functional study of phosphofructokinase B (PfkB) from Mycobacterium marinum

TRIM21 regulates pyroptotic cell death by promoting Gasdermin D oligomerization

Dysregulation of ClpP by Small-Molecule Activators Used Against Xanthomonas oryzae pv. oryzae Infections

结核分枝杆菌RNA解旋酶RhlE的蛋白表达、纯化及结构性质研究

Structural basis for guide RNA trimming by RNase D ribonuclease in Trypanosoma brucei

NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B

DNA backbone interactions impact the sequence specificity of DNA sulfur-binding domains: revelations from structural analyses

Structural studies reveal a ring-shaped architecture of deep-sea vent phage NrS-1 polymerase

OsChz1 acts as a histone chaperone in modulating chromatin organization and genome function in rice

Short DNA Oligonucleotide as a Ag+ Binding Detector

A Peptide Binder of E3 Ligase Adaptor SPOP Disrupts Oncogenic SPOP‐Protein Interactions in Kidney Cancer Cells

Catalytic-state structure and engineering of Streptococcus thermophilus Cas9

Structure-guided protein engineering increases enzymatic activities of the SGNH family esterases

Structural Basis of Human Helicase DDX21 in RNA Binding, Unwinding, and Antiviral Signal Activation

Crystal structure of human archease, a key cofactor of tRNA splicing ligase complex

A unique DNA-binding mode of African swine fever virus AP endonuclease

The SiaA/B/C/D signaling network regulates biofilm formation in Pseudomonas aeruginosa

Structural insights into target DNA recognition by R2R3-MYB transcription factors

Selective cadmium regulation mediated by a cooperative binding mechanism in CadR

Toxin–antitoxin operon kacAT of Klebsiella pneumoniae is regulated by conditional cooperativity via a W-shaped KacA–KacT complex

Structural analysis of Phytophthora suppressor of RNA silencing 2 (PSR2) reveals a conserved modular fold contributing to virulence

Molecular basis for the PAM expansion and fidelity enhancement of an evolved Cas9 nuclease

Purification and enzymatic characterization of the RNA ligase RTCB from Thermus thermophilus

The transcription factor OsSUF4 interacts with SDG725 in promoting H3K36me3 establishment

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

Structural insights into the complex of trigger factor chaperone and ribosomal protein S7 from Mycobacterium tuberculosis