郭闯｜东北大学｜学者主页

2026

Detection of primary cancer types via fragment size selection in circulating cell-free extrachromosomal circular DNA

Jing-Wen Fang, Songwen Luo, Shou-Zhen Li, Ye-Hong Xu, Jing Wang, Benjie Shan, Mingjun Hu, Qiao-Ni Yu, Wen Zhang, Ke Liu, Y. Shao, Jia-Xuan Yang, You-Yang Zhou, Guang-Tao Xu, Xin-Feng Yao, Ruo-Ming Sun, Meng-Yuan Zhang, Kun Li, Xi-Hai Xu, Yongliang Zhang, Zhi-Hong Zhang, Xinghua Han, Yue-Yin Pan, Chuang Guo, Kun Qu

Genome Medicine

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期刊论文

Detection of primary cancer types via fragment size selection in circulating cell-free extrachromosomal circular DNA

A lifespan-scale single-cell atlas defines an early-childhood immunometabolic transition linked to age-referenced immune states

Parthenolide Ameliorates Alzheimer's Disease Pathology by Suppressing Microglial Inflammation and Inflammation-Driven Amyloidogenesis via the HIF1α/NF-κB Axis.

Lactoferrin alleviates LPS-induced neuroinflammation and depressive-like behavior in mice by regulating microglial M1/M2 polarization.

Exploratory Single-Nucleus RNA Sequencing Suggests Glial-Specific NPY Upregulation and Cell-Type-Specific Metabolic Alterations in Temporal Lobe Epilepsy

Bayesian age-period-cohort analysis and trend prediction of epilepsy disease burden in China, 1990-2021.

Multi-spectroscopic and molecular docking analysis of tiaprofenic acid-lactoferrin binding: Implications for neuroprotective strategies.

[Review] Cell-free DNA in extracellular vesicles: A candidate biomarker of schizophrenia

Landscape of extrachromosomal DNA characteristics in high-grade serous ovarian cancer via long-read sequencing.

Spatial Transcriptomics of Human Decidua Identifies Molecular Signatures in Recurrent Pregnancy Loss

Integrative spatial multiomics analysis reveals regulatory mechanisms of VCAM1+ proximal tubule cells in lupus nephritis.

Melatonin ameliorates tauopathy and ferroptosis in P301S Tau transgenic mice

Repurposing pharmaceuticals for Alzheimer's treatment via adjusting the lactoferrin interacting proteins.

Astrocyte lactoferrin deficiency affects the construction and function of spinal neurons by regulating cholesterol metabolism.

Biological relationship between Parkinson's disease and gallstone disease

Exploratory Single-Cell Transcriptomic Profiling Reveals Dysregulated Glial Populations and Pathways in Focal Cortical Dysplasia Epilepsy

Inflammatory proteins and hidradenitis suppurativa: Insights from genetic correlation and Mendelian randomization

Role of RNA-binding Proteins in Regulating Cell Adhesion and Progression of the Atherosclerotic Plaque and Plaque Erosion

eccDNA-pipe: an integrated pipeline for identification, analysis and visualization of extrachromosomal circular DNA from high-throughput sequencing data

Astrocytic lactoferrin deficiency augments MPTP-induced dopaminergic neuron loss by disturbing glutamate/calcium and ER-mitochondria signaling.

Astrocyte‐derived lactoferrin reduces β‐amyloid burden by promoting the interaction between p38 kinase and PP2A phosphatase in male APP/PS1 transgenic mice

The human islet amyloid polypeptide reduces hippocampal tauopathy and behavioral impairments in P301S mice without inducing neurotoxicity or seeding amyloid aggregation.

A single-cell landscape of pre- and post-menopausal high-grade serous ovarian cancer ascites

Single-cell transcriptomic analysis of immune cell dynamics in the healthy human endometrium

Dynamics and regulation of mitotic chromatin accessibility bookmarking at single-cell resolution

Comparative analysis of methodologies for detecting extrachromosomal circular DNA

Single-cell transcriptome profiling reveals immune and stromal cell heterogeneity in primary Sjögren’s syndrome

Astrocyte‐specific loss of lactoferrin influences neuronal structure and function by interfering with cholesterol synthesis

ATP13A2 Declines Zinc-Induced Accumulation of α-Synuclein in a Parkinson’s Disease Model

Single-cell transcriptomics reveal a unique memory-like NK cell subset that accumulates with ageing and correlates with disease severity in COVID-19

Novel melatonin-trientine conjugate as potential therapeutic agents for Alzheimer's disease.

A transcriptome atlas and interactive analysis platform for autoimmune disease

ScanTecc classifies primary cancers via cell-free extrachromosomal circular DNA in peripheral blood

Single-Cell Heterogeneity of the Liver-Infiltrating Lymphocytes in Individuals with Chronic Echinococcus multilocularis Infection

Single-cell transcriptome profiling and chromatin accessibility reveal an exhausted regulatory CD4+ T cell subset in systemic lupus erythematosus.

Benchmarking spatial and single-cell transcriptomics integration methods for transcript distribution prediction and cell type deconvolution

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

A Review on Lactoferrin and Central Nervous System Diseases

Chromatin accessibility landscapes of immune cells in rheumatoid arthritis nominate monocytes in disease pathogenesis

A Novel Cu(II)-Binding Peptide Identified by Phage Display Inhibits Cu2+-Mediated Aβ Aggregation

Intranasal administration of α-synuclein preformed fibrils triggers microglial iron deposition in the substantia nigra of Macaca fascicularis

Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss

Single-cell analysis of COVID-19, sepsis, and HIV infection reveals hyperinflammatory and immunosuppressive signatures in monocytes

Restoration of HBV-specific CD8+ T-cell responses by sequential low-dose IL-2 treatment in non-responder patients after IFN-α therapy

Nasal Delivery of D-Penicillamine Hydrogel Upregulates a Disintegrin and Metalloprotease 10 Expression via Melatonin Receptor 1 in Alzheimer’s Disease Models

Brain Targeting and Aβ Binding Bifunctional Nanoparticles Inhibit Amyloid Protein Aggregation in APP/PS1 Transgenic Mice.

Selection of a D-Enantiomeric Peptide Specifically Binding to PHF6 for Inhibiting Tau Aggregation in Transgenic Mice

Large-scale single-cell analysis reveals critical immune characteristics of COVID-19 patients

Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm

Single-cell analysis of severe COVID-19 patients reveals a monocyte-driven inflammatory storm attenuated by Tocilizumab

Vitamin D deficiency exacerbates Alzheimer-like pathologies by reducing antioxidant capacity.

Comparative analysis of single-cell RNA-seq cluster methods

Cynomolgus Monkeys With Spontaneous Type-2-Diabetes-Mellitus-Like Pathology Develop Alpha-Synuclein Alterations Reminiscent of Prodromal Parkinson’s Disease and Related Diseases

Recombinant human lactoferrin attenuates the progression of hepatosteatosis and hepatocellular death by regulating iron and lipid homeostasis in ob/ob mice.

α-Lipoic Acid Maintains Brain Glucose Metabolism via BDNF/TrkB/HIF-1α Signaling Pathway in P301S Mice

Author Correction: Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis

Immunomodulation Induced During Interferon-α Therapy Impairs the Anti-HBV Immune Response Through CD24+CD38hi B Cells

Chromatin accessibility landscapes of skin cells in systemic sclerosis nominate dendritic cells in disease pathogenesis

Paricalcitol accelerates BACE1 lysosomal degradation and inhibits calpain-1 dependent neuronal loss in APP/PS1 transgenic mice

Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis

Iron Exposure and the Cellular Mechanisms Linked to Neuron Degeneration in Adult Mice

Iron Pathophysiology in Alzheimer's Diseases.

Tetrathiomolybdate Treatment Leads to the Suppression of Inflammatory Responses through the TRAF6/NFκB Pathway in LPS-Stimulated BV-2 Microglia

Iron and Alzheimer’s Disease: From Pathogenesis to Therapeutic Implications

Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice

Deferoxamine ameliorates adipocyte dysfunction by modulating iron metabolism in ob/ob mice

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

Chronic diabetic states worsen Alzheimer neuropathology and cognitive deficits accompanying disruption of calcium signaling in leptin-deficient APP/PS1 mice

KIR3DS1/HLA-B Bw4-80Ile Genotype Is Correlated with the IFN-α Therapy Response in hepatitis B e antigen-Positive Chronic Hepatitis B

Deferoxamine-mediated up-regulation of HIF-1α prevents dopaminergic neuronal death via the activation of MAPK family proteins in MPTP-treated mice.

CD3brightCD56+ T cells associate with pegylated interferon-alpha treatment nonresponse in chronic hepatitis B patients

Deferoxamine ameliorates hepatosteatosis via several mechanisms in ob/ob mice

Chronic hyperglycemia induced via the heterozygous knockout of Pdx1 worsens neuropathological lesion in an Alzheimer mouse model

NKp30+ NK cells are associated with HBV control during pegylated-interferon-alpha-2b therapy of chronic hepatitis B

MicroRNA-362-5p promotes tumor growth and metastasis by targeting CYLD in hepatocellular carcinoma.

Intranasal deferoxamine attenuates synapse loss via up-regulating the P38/HIF-1α pathway on the brain of APP/PS1 transgenic mice

Fluid shear stress‐induced osteoarthritis: roles of cyclooxygenase‐2 and its metabolic products in inducing the expression of proinflammatory cytokines and matrix metalloproteinases

Methodological Limitations in Determining Astrocytic Gene Expression