金丽华｜东北林业大学｜学者主页

2026

Schisandrin A ameliorates obesity and MAFLD through bile acid context-dependent modulation of intestinal FXR signaling.

Xu Wang, Yaping Jiang, Lian-Shun Feng, Yi-Xuan Luo, Jia-Li Zhang, Xun-Jiang Wang, Yan-Fei Wang, Yujie Ma, Meng-Die Hua, Lihua Jin, Wei'an Yuan, Zheng-Tao Wang, Wen-Dong Huang, Dong Liu, Li Yang, Wei Liu, Mingming Li, Lili Ding

Phytomedicine

DOI

2026

Pharmacology and therapeutics of bile acid synthesis and modification enzymes in metabolic diseases.

Lili Ding, Lihua Jin, Wen-Dong Huang

Pharmacological Reviews

DOI

2026

Bile acid signaling, metabolism, and aging

Ji Sun, Shili Zhang, Lihua Jin, Wen-Dong Huang

Liver Research

DOI

2025

基于非靶向代谢组学的红景天和麦冬代谢途径及代谢产物差异分析

于然，金丽华，李敬慈，王子豪

《食品研究与开发》

2025

Differential roles of individual bile acid in physiology and disease

M. Fan, Zhiyu Yang, Lihua Jin, Wen-Dong Huang

Pharmacological Research

DOI

2025

De Novo Hepatic Pyrimidine Synthesis Regulates Systemic Energy Homeostasis

L. Fu, Pradnya H Patil, Pengfei Zhang, Ignacio Norambuena-Soto, Qiu-Tang Xiong, Yin Wang, Chelsea Jang, Kevin Wang, Yun-Qian Peng, Lu Ding, Patrick T. Fueger, Lihua Jin, Wen-Dong Huang, P. Lorenzi, Lin Tan, Markus Kalkum, Philipp E. Scherer, Zhao V. Wang, Ying-Feng Deng

bioRxiv

DOI

2025

Schisantherin A interacts with gut bacteria to stimulate adipose tissue thermogenesis in obese mice via a TGR5‒p-CREB‒STAT6 signaling pathway

Xun-Jiang Wang, Xu Wang, Shenglan Yu, Lu-Yao Huang, Qiongwen Xue, Xinru Yang, Zi-Xuan Wang, Wenyuan Lin, Yaping Jiang, Ying Xu, Qi Liao, Lihua Jin, Zheng-Tao Wang, Feng Tao, Li Yang, Wen-Dong Huang, Lili Ding

Nature Communications

DOI

2025

Hepatic and intestinal tissue-specific Fxr deficiency alters bile acid homeostasis in female mice.

Jiarui Jiang, M. Fan, Wei'an Yuan, Dawei Yue, Zheng-Tao Wang, Li Yang, Wen-Dong Huang, Lihua Jin, Xu Wang, Lili Ding

American Journal of Physiology - Gastrointestinal and Liver Physiology

DOI

2025

CO-PERK-IRG1 axis attenuates oxidative stress and ferroptosis in hepatic ischemia-reperfusion injury.

Jeongmin Park, Min Zheng, J. Gong, Lihua Jin, Stefan W. Ryter, Yeonsoo Joe, Hun Taeg Chung

Free Radical Biology & Medicine

DOI

2025

CO confers neuroprotection via activating the PERK-calcineurin pathway and inhibiting necroptosis

Jeongmin Park, Lihua Jin, Hyun-Chul Song, Ying-Qing Chen, Eun Young Jang, Gyu Hwan Park, C. Yang, Stefan W. Ryter, J. Park, Min Zheng, Yeonsoo Joe, Hun Taeg Chung

Cell Death Discovery

DOI

2024

The role of bile acids in human aging

Lihua Jin, Linsen Shi, Wen-Dong Huang

Medical Review

DOI

2023

BMP信号影响黑腹果蝇浆细胞的吞噬功能

张文豪，金丽华

《昆虫学报》

2023

CYP8B1 downregulation mediates the metabolic effects of vertical sleeve gastrectomy in mice

Yanjun Liu, Jui Tu, Linsen Shi, Zhipeng Fang, Mingjie Fan, Jianyin Zhang, Lili Ding, Yiqiang Chen, Yangmeng Wang, E. Zhang, Senlin Xu, Nisha Sharma, J. Gillece, Laurens Reining, Lihua Jin, Wen-Dong Huang

Hepatology

DOI

2023

Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Linsen Shi, Lihua Jin, Wen-Dong Huang

Cells

DOI

2023

Pharmacological profiling of a berbamine derivative for lymphoma treatment

Senlin Xu, Shunquan Wu, Mingfeng Zhang, Jun Xie, Mingsheng Lin, Lihua Jin, Jiawei Zhang, Yangmeng Wang, Mingjie Fan, Zhipeng Fang, Wei-Ni Li, Ching Ouyang, David Kwon, N. Que, Zhi-Rou Li, Jin-Ge Mao, Hao-Nan Chen, J. Harris, Xi-Wei Wu, Jun Wu, Hong-Wei Yin, Wing C. Chan, David Horne, Wen-Dong Huang

Blood Advances

DOI

2023

Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice

Zhipeng Fang, M. Fan, Dongqiang Yuan, Lihua Jin, Yangmeng Wang, Li-Li Ding, Senlin Xu, Jui Tu, E. Zhang, Xi-Wei Wu, Z. Chen, Wen-Dong Huang

Communications Biology

DOI

2022

八宝景天对果蝇肠道损伤的缓解作用研究

臧铭圻，刘彤宇，王思宏，金丽华

《辽宁林业科技》

2022

果蝇造血器官淋巴腺的研究进展

李坤，金丽华

《生物技术进展》

2022

中药提取物对高糖饮食诱导的果蝇异常生长发育的缓解作用

邵佳瑶，白野，金丽华

《林业科技通讯》

2022

Bile acids, gut microbiota and metabolic surgery

Jui Tu, Yangmeng Wang, Lihua Jin, Wen-Dong Huang

Frontiers in Endocrinology

DOI

2022

Bile acid‐mediated activation of brown fat protects from alcohol‐induced steatosis and liver injury

M. Fan, M. Fan, Yangmeng Wang, Lihua Jin, Zhao-Li Sun, Wen-Xing Ding, Wen-Dong Huang

The FASEB Journal

DOI

2022

Intestinal AMPK modulation of gut microbiota mediates cross‐talk with brown fat to control metabolism

Wen-Dong Huang, E. Zhang, Lihua Jin, Yangmeng Wang, Zhipeng Fang, I. Al-Abdullah, S. Shuck

The FASEB Journal

DOI

2021

果蝇肠道干细胞及肠道菌群的研究进展

金秋霞，王思宏，金丽华

《生物技术通报》

DOI

2021

钝叶瓦松对SDS诱导的果蝇肠道损伤修复作用

陈麒名，印涵，王思宏，金丽华

《林业科技通讯》

DOI

2021

金银花提取物对高糖饮食诱导的果蝇代谢紊乱影响研究

元哲进，金丽华，白野

《中医药学报》

DOI

2021

Bile Acid–Mediated Activation of Brown Fat Protects From Alcohol-Induced Steatosis and Liver Injury in Mice

M. Fan, Yangmeng Wang, Lihua Jin, Zhipeng Fang, Jiangling Peng, Jui Tu, Yanjun Liu, E. Zhang, Senlin Xu, Xiaoqian Liu, Yuqing Huo, Zhao-Li Sun, Xiao-Juan Chao, Wen-Xing Ding, Qing-Feng Yan, Wen-Dong Huang

Cellular and Molecular Gastroenterology and Hepatology

DOI

2021

Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis

E. Zhang, Lihua Jin, Yangmeng Wang, Jui Tu, Rui-Rong Zheng, Li-Li Ding, Zhipeng Fang, M. Fan, I. Al-Abdullah, R. Natarajan, K. Ma, Zheng-Tao Wang, A. Riggs, Sarah C. Shuck, Li Yang, Wen-Dong Huang

Nature Communications

DOI

2021

Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice

Li-Li Ding, E. Zhang, Qiao-Ling Yang, Lihua Jin, K. Sousa, B. Dong, Yangmeng Wang, Jui Tu, Xiao-Xiao Ma, Jing-Yan Tian, Hongli Zhang, Zhipeng Fang, Ana Guan, Yi-Xin Zhang, Zheng-Tao Wang, D. Moore, Li Yang, Wen-Dong Huang

Proceedings of the National Academy of Sciences of the United States of America

DOI

2020

Bile Acid Composition Contributes to Metabolic Improvements after Sleeve Gastrectomy in Mice

Jui Tu, Yanjun Liu, Li-Li Ding, E. Zhang, Lihua Jin, Wen-Dong Huang

The FASEB Journal

DOI

2020

Bile Acid Membrane Receptor TGR5 Inhibits Alcohol‐Induced Liver Steatosis

M. Fan, Yanjun Liu, Jui Tu, Yangmeng Wang, Lihua Jin, Wen-Dong Huang

The FASEB Journal

DOI

2017

CAMK2γ in Intestinal Epithelial Cells Modulates Colitis-Associated Colorectal Carcinogenesis via Enhancing STAT3 Activation

Xiao-Xiao Ma, Zhi-Peng Meng, Lihua Jin, Zhen-Zhou Xiao, Xiao-Qiong Wang, W. Tsark, Li-Li Ding, Ying Gu, Jia-Wei Zhang, Byung-wook Kim, Min He, X. Gan, J. Shively, Hua Yu, Rong-Zhen Xu, Wen-Dong Huang

Oncogene

DOI

2016

工布乌头提取物提高果蝇肠道免疫功能的实验研究

陈羽臣，柳宗琳，张宏，王超，关法春，金丽华

《中草药》

2016

Vertical Sleeve Gastrectomy Activates GPBAR-1/TGR5 to Sustain Weight Loss, Improve Fatty Liver, and Remit Insulin Resistance in Mice

Li-Li Ding, K. Sousa, Lihua Jin, B. Dong, Byung-wook Kim, R. Ramírez, Zhen-Zhou Xiao, Ying Gu, Qiao-Ling Yang, Jie Wang, Donna D. Yu, A. Pigazzi, Dustin E. Schones, Li Yang, D. Moore, Zheng-Tao Wang, Wen-Dong Huang

Hepatology

DOI

2015

果蝇再生蛋白(rgn)多克隆抗体的制备及鉴定

李哲，柳宗琳，金丽华

《细胞与分子免疫学杂志》

2015

果蝇肠道干细胞增殖与分化机制及其研究进展

刘强，金丽华

《生物化学与生物物理进展》

2015

果蝇Rab蛋白在天然免疫中的作用

于世超，金丽华

《免疫学杂志》

2014

红景天提高黑腹果蝇肠道免疫功能研究

左占广，朱彩霞，鲁东立，金丽华

《中草药》

2014

Notch信号途径中的Su(H)和E(spl)基因对果蝇天然免疫的影响

汪晓纯，金丽华

《生物化学与生物物理进展》

2013

果蝇肠道免疫的研究进展

郝阳光，张玮钰，金丽华

《免疫学杂志》

2012

刺五加提取物对果蝇免疫功能的影响

李文佳，刘强，金丽华

《中草药》

2012

果蝇polycomblike蛋白多克隆抗体的制备及纯化

张晴，汪晓纯，金丽华

《免疫学杂志》

2011

果蝇jumeaux蛋白多克隆抗体的制备及鉴定

郝阳光，张晴，金丽华

《免疫学杂志》

2011

果蝇spen蛋白的抗体制备、组织特异性表达及功能分析

金丽华，齐卓

《遗传》

精选作品

期刊论文

Schisandrin A ameliorates obesity and MAFLD through bile acid context-dependent modulation of intestinal FXR signaling.

Pharmacology and therapeutics of bile acid synthesis and modification enzymes in metabolic diseases.

Bile acid signaling, metabolism, and aging

基于非靶向代谢组学的红景天和麦冬代谢途径及代谢产物差异分析

Differential roles of individual bile acid in physiology and disease

De Novo Hepatic Pyrimidine Synthesis Regulates Systemic Energy Homeostasis

Schisantherin A interacts with gut bacteria to stimulate adipose tissue thermogenesis in obese mice via a TGR5‒p-CREB‒STAT6 signaling pathway

Hepatic and intestinal tissue-specific Fxr deficiency alters bile acid homeostasis in female mice.

CO-PERK-IRG1 axis attenuates oxidative stress and ferroptosis in hepatic ischemia-reperfusion injury.

CO confers neuroprotection via activating the PERK-calcineurin pathway and inhibiting necroptosis

The role of bile acids in human aging

BMP信号影响黑腹果蝇浆细胞的吞噬功能

CYP8B1 downregulation mediates the metabolic effects of vertical sleeve gastrectomy in mice

Bile Acids, Intestinal Barrier Dysfunction, and Related Diseases

Pharmacological profiling of a berbamine derivative for lymphoma treatment

Downregulation of hepatic lncRNA Gm19619 improves gluconeogenesis and lipogenesis following vertical sleeve gastrectomy in mice

八宝景天对果蝇肠道损伤的缓解作用研究

果蝇造血器官淋巴腺的研究进展

中药提取物对高糖饮食诱导的果蝇异常生长发育的缓解作用

Bile acids, gut microbiota and metabolic surgery

Bile acid‐mediated activation of brown fat protects from alcohol‐induced steatosis and liver injury

Intestinal AMPK modulation of gut microbiota mediates cross‐talk with brown fat to control metabolism

果蝇肠道干细胞及肠道菌群的研究进展

钝叶瓦松对SDS诱导的果蝇肠道损伤修复作用

金银花提取物对高糖饮食诱导的果蝇代谢紊乱影响研究

Bile Acid–Mediated Activation of Brown Fat Protects From Alcohol-Induced Steatosis and Liver Injury in Mice

Intestinal AMPK modulation of microbiota mediates crosstalk with brown fat to control thermogenesis

Vertical sleeve gastrectomy confers metabolic improvements by reducing intestinal bile acids and lipid absorption in mice

Bile Acid Composition Contributes to Metabolic Improvements after Sleeve Gastrectomy in Mice

Bile Acid Membrane Receptor TGR5 Inhibits Alcohol‐Induced Liver Steatosis

CAMK2γ in Intestinal Epithelial Cells Modulates Colitis-Associated Colorectal Carcinogenesis via Enhancing STAT3 Activation

工布乌头提取物提高果蝇肠道免疫功能的实验研究

Vertical Sleeve Gastrectomy Activates GPBAR-1/TGR5 to Sustain Weight Loss, Improve Fatty Liver, and Remit Insulin Resistance in Mice

果蝇再生蛋白(rgn)多克隆抗体的制备及鉴定

果蝇肠道干细胞增殖与分化机制及其研究进展

果蝇Rab蛋白在天然免疫中的作用

红景天提高黑腹果蝇肠道免疫功能研究

Notch信号途径中的Su(H)和E(spl)基因对果蝇天然免疫的影响

果蝇肠道免疫的研究进展

刺五加提取物对果蝇免疫功能的影响

果蝇polycomblike蛋白多克隆抗体的制备及纯化

果蝇jumeaux蛋白多克隆抗体的制备及鉴定

果蝇spen蛋白的抗体制备、组织特异性表达及功能分析

会议论文

果蝇天然免疫相关基因的功能及作用机制

研究方向