郭祖奉｜重庆医科大学｜学者主页

期刊论文

2026

Structure-Guided Discovery of Novel Dual-Site FEM1B Ligands and Assessment of Their Use in Targeted Protein Degradation

Lingbo Xu, Ruyi Huang, Yuying Ma, Li Yang, Yueying Li, Chengping He, Zhenhao Zhang, Yang Teng, Wei Li, Zan Chen, Yue Wei, Zufeng Guo, Linfeng Li

Journal of Medicinal Chemistry

DOI

2026

High-throughput ligand discovery in living cells using the cellular protein stability enhancement assay

Yue Wei, Yunyun Gao, Ruijie Li, Yao Chen, Wenjing Bai, Peirui Zhao, Junchi Hu, Linfeng Li, Xing Yun Wang, Guobing Yin, Yongjun Dang, Xiangqian Kong, Zufeng Guo

Acta Pharmaceutica Sinica B

DOI

2026

High‐throughput identification of carboxylate‐free ligands for the E3 ligase Kelch domain‐containing protein 2

Yao Chen, Ruichen Gao, Jiajia Li, Ruijie Li, Xinyu Wang, Xi Tang, Xing Wang, Yue Wei, Linfeng Li, Yuying Ma, Zufeng Guo

Protein Science

DOI

2026

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong

Advanced Science

DOI

2026

Systematic Optimization of Proteolysis-Targeting Chimeras for PIN1 Enables Selective Degradation and Antitumor Activity In Vivo

Yuying Ma, Yang Teng, Jiayi Liu, Yuke Deng, Lingbo Xu, Ruichen Gao, Tingyu Peng, Wei Li, Yue Wei, Linfeng Li, Zufeng Guo

Pharmaceutics

DOI

2025

G蛋白偶联受体的化学动态修饰和化学干预

徐萍，胡骏驰，高玉婷，文鑫，曹玉婷，郭祖奉，易文，杨帆，李亦舟，党永军，张岩

《中国科学:化学》

2025

GLUTs-Facilitated Targeting BRD4 Degradation in Breast Cancer through Carbohydrate-Conjugated PROTACs

Yunyun Gao, Dan Ni, Yueying Li, Jia Zheng, Ke Zhang, Yijie Xiao, Xi Tang, Linfeng Li, Xing Wang, Yue Wei, Yi He, Zufeng Guo, Shenyou Nie

Journal of Medicinal Chemistry

DOI

2025

Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry

Jia He, Haibo Yu, Kunling Song, Ailong Huang, Yongjun Dang, Juan Chen, Zufeng Guo

Signal Transduction and Targeted Therapy

DOI

2025

LigDockTailor: Ligand-specific docking tool matching using multidimensional descriptors

Kai Zhang, Yunmei Zhu, Wei Zhang, Yanghan Sun, Ziheng Zhang, Yueyang Wang, Yixian Tan, Linyu Yu, Sirui Chen, Shiyong Ma, Kongkai Zhu, Bowen Ke, Jiaxue Wu, Zufeng Guo, Ling Zhang, Yongjun Dang, Junchi Hu

Computational Biology and Chemistry

DOI

2024

Design, Synthesis, and Biological Evaluation of 3-Amino-pyrazine-2-carboxamide Derivatives as Novel FGFR Inhibitors

Jia Zheng, Wei Zhang, Dan Ni, Shuang Zhao, Yi He, Junchi Hu, Linfeng Li, Yongjun Dang, Zufeng Guo, Shenyou Nie

ACS Medicinal Chemistry Letters

DOI

2024

Design, synthesis and anticancer activity of β-carboline based pseudo-natural products by inhibiting AKT/mTOR signaling pathway

Lijie Lv, Kunlin Song, Yijie Xiao, Jia Zheng, Wei Zhang, Linfeng Li, Yue Wei, Hao Chen, Yi He, Zufeng Guo, Shenyou Nie

Bioorganic Chemistry

DOI

2024

Neuropilin-1 is a novel host factor modulating the entry of hepatitis B virus

Haibo Yu, Jihua Ren, Haijun Deng, Linfeng Li, Zhenzhen Zhang, Shengtao Cheng, Zufeng Guo, Ailong Huang, Yongjun Dang, Kunling Song, Daiqing Wu, Xinyan Yao, Yiping Qin, Zhen Yang, Kexin Xu, Xin He, Juan Chen

Journal of Hepatology

DOI

2024

A rapid and simple non-radioactive assay for measuring uptake by solute carrier transporters

Kunling Song, Longbin Zhang, Xi’an Fu, Linfeng Li, Gaolin Zhu, Mingjun Wu, Wei Zhang, Jia He, Sanyong Zhu, Yongjun Dang, Jun‐Yan Liu, Chang Chen, Zufeng Guo

Frontiers in Pharmacology

DOI

2023

Corrigendum: Prostaglandin reductase 1 as a potential therapeutic target for cancer therapy

Xing Wang, Guobing Yin, Wei Zhang, Kunling Song, Longbin Zhang, Zufeng Guo

Frontiers in Pharmacology

DOI

2023

Rapid access to C2-quaternary 3-methyleneindolines via base-mediated post-Ugi Conia-ene cyclization

Shuang Zhao, Yi He, Feiyu Gao, Yue Wei, Jiawei Zhang, Mengxiao Chen, Yunyun Gao, Yuan Zhang, Jun‐Yan Liu, Zufeng Guo, Zhenghua Li, Shenyou Nie

Chemical Communications

DOI

2022

基于天然产物及其衍生物的分子胶水的研究进展

何佳，宋坤玲，郭祖奉，党永军

《药学学报》

2022

Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review

Jia Zheng, Wei Zhang, Linfeng Li, Yi He, Yue Wei, Yongjun Dang, Shenyou Nie, Zufeng Guo

Frontiers in Chemistry

DOI

2021

Prostaglandin Reductase 1 as a Potential Therapeutic Target for Cancer Therapy

Xing Wang, Guobing Yin, Wei Zhang, Kunling Song, Longbin Zhang, Zufeng Guo

Frontiers in Pharmacology

DOI

2021

Influence of stereochemistry on the activity of rapadocin, an isoform-specific inhibitor of the nucleoside transporter ENT1

Yuefan Wang, Hanjing Peng, Zufeng Guo, Brett R. Ullman, Kana Yamamoto, Sam Y. Hong, Jun O. Liu

Chemical Science

DOI

数据集

2026

EPIC Array and RNA-seq raw data for the article "Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition"

Cuicui Xia, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Qin, Bing, Xintong Cai, Jie Wang, Jing Huang, Zufeng Guo, S B Baylin, Xiangqian Kong

ScienceDB

DOI

郭祖奉

精选作品

期刊论文

Structure-Guided Discovery of Novel Dual-Site FEM1B Ligands and Assessment of Their Use in Targeted Protein Degradation

High-throughput ligand discovery in living cells using the cellular protein stability enhancement assay

High‐throughput identification of carboxylate‐free ligands for the E3 ligase Kelch domain‐containing protein 2

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Systematic Optimization of Proteolysis-Targeting Chimeras for PIN1 Enables Selective Degradation and Antitumor Activity In Vivo

G蛋白偶联受体的化学动态修饰和化学干预

GLUTs-Facilitated Targeting BRD4 Degradation in Breast Cancer through Carbohydrate-Conjugated PROTACs

Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry

LigDockTailor: Ligand-specific docking tool matching using multidimensional descriptors

Design, Synthesis, and Biological Evaluation of 3-Amino-pyrazine-2-carboxamide Derivatives as Novel FGFR Inhibitors

Design, synthesis and anticancer activity of β-carboline based pseudo-natural products by inhibiting AKT/mTOR signaling pathway

Neuropilin-1 is a novel host factor modulating the entry of hepatitis B virus

A rapid and simple non-radioactive assay for measuring uptake by solute carrier transporters

Corrigendum: Prostaglandin reductase 1 as a potential therapeutic target for cancer therapy

Rapid access to C2-quaternary 3-methyleneindolines via base-mediated post-Ugi Conia-ene cyclization

基于天然产物及其衍生物的分子胶水的研究进展

Signaling Pathway and Small-Molecule Drug Discovery of FGFR: A Comprehensive Review

Prostaglandin Reductase 1 as a Potential Therapeutic Target for Cancer Therapy

Influence of stereochemistry on the activity of rapadocin, an isoform-specific inhibitor of the nucleoside transporter ENT1

数据集

EPIC Array and RNA-seq raw data for the article "Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition"

研究方向