李剑｜昆明理工大学｜学者主页

2026

哈巴俄苷改善小鼠代谢功能障碍相关脂肪性肝炎的研究

王筱懿，王可可，贾王雅，李剑，徐红，季莉莉

《药学学报》

DOI

2026

PDE4 inhibitor DC591017 ameliorates pulmonary fibrosis through modulating fibroblasts-epithelial cells-alternatively activated macrophages crosstalk.

Shuyue Lei, Jian Li, Tao Yang, Ziyi Peng, Yousheng Xu, Zhizhen Hui, Meng Yan, Chunlan Feng, Hong Liu, Wei-xue Tang

European Journal of Pharmacology

DOI

2026

Electrochemical C–H Nitration of N ‐Substituted Anilines With Sodium Nitrite

Chunping Dong, Qiaoting Zhang, Wenqian Qin, Caijuan Hu, Xiaojiao Du, Jian Li

European Journal of Organic Chemistry

DOI

2026

Acetic Acid-Assisted Electrochemical Ipso -Nitration of Aryl Borides Using Ferric Nitrate Nonahydrate

Chunping Dong, Qiaoting Zhang, Wenqian Qin, Caijuan Hu, Xiaojiao Du, Jian Li

The Journal of Organic Chemistry

DOI

2025

Iodine‐Catalyzed Aerobic Oxidative Domino Cyclization of Methyl N‐Heteroarenes with 6‐Aminopyrimidine‐2,4‐Dione and Pyrazol‐5‐Amine

Chunping Dong, Yue Zhang, Caijuan Hu, Yongsheng Zhou, Jian Li

Asian Journal of Organic Chemistry

DOI

2025

Iodine-Mediated Oxidative Cyclization of Amino-heteroaromatics with Allylic Alcohols and Propene Derivatives: Access to Pyrazolo[3,4- b ]pyridines

Chunping Dong, Wenqian Qin, Mei Hua Xin, Qiaoting Zhang, Caijuan Hu, Xiaojiao Du, Jian Li

Organic Letters

DOI

2024

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

Xiong Xie, Qiao-Shuai Lan, Jinyi Zhao, Su-Lin Zhang, Lu Liu, Yu-Min Zhang, Wei Xu, Maolin Shao, Jing-Jing Peng, S. Xia, Yan Zhu, Keke Zhang, Xiang-Lei Zhang, Ruxue Zhang, Jian Li, Wen-Hao Dai, Zhen Ge, Shulei Hu, C. Yu, Jiang Wang, Dakota Ma, Ming-Yue Zheng, Hai-Tao Yang, Gengfu Xiao, Zi-He Rao, Lu Lu, Leike Zhang, Fang Bai, Yao Zhao, Shi-Bo Jiang, Hong Liu

Signal Transduction and Targeted Therapy

DOI

2024

Bicyclic peptide-enhanced covalent inhibitor of SARS-CoV-2 3CL protease

Qian Wang, Yanhui Wang, Jian Li, Hong Liu, Shi-Yu Chen

Exploration of Drug Science

DOI

2023

Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group.

Pengxuan Ren, Hui Li, Tianqing Nie, Xiaoqin Jian, C. Yu, Jian Li, H. Su, Xiang-Lei Zhang, Shiwei Li, Xin Yang, Chao Peng, Yue Yin, Leike Zhang, Yechun Xu, Hong Liu, Fang Bai

Journal of Medicinal Chemistry

DOI

2023

Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2

Pengxuan Ren, C. Yu, Ruxue Zhang, Tianqing Nie, Qiaoyu Hu, Hui Li, Xiang-Lei Zhang, Xue-Yuan Zhang, Shiwei Li, Lu Liu, Wen-Hao Dai, Jian Li, Yechun Xu, H. Su, Leike Zhang, Hong Liu, Fang Bai

European journal of medicinal chemistry

DOI

2022

Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability.

Xiong Xie, Yu-Gui Zheng, Huan Chen, Jian Li, Rong-Hua Luo, Liang-zhong Chen, Chang-Bo Zheng, Shurui Zhang, Pan-Feng Peng, Dakota Ma, Liu-Meng Yang, Yong-Tang Zheng, Hong Liu, Jiang Wang

Journal of Medicinal Chemistry

DOI

2022

In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2

W. Shang, Wen-Hao Dai, Cheng Yao, Ling Xu, Xiang-Ming Tao, H. Su, Jian Li, Xiong Xie, Yechun Xu, Min-yi Hu, Dong Xie, Hua-Liang Jiang, Leike Zhang, Hong Liu

Antiviral Research

DOI

2022

Synthesis of maleimide-braced peptide macrocycles and their potential anti-SARS-CoV-2 mechanisms.

Jian Li, Ji-Na Sun, Xiang-Lei Zhang, Ruxue Zhang, Qian Wang, Lin Wang, Leike Zhang, Xiong Xie, Chun-Pu Li, Yu Zhou, Jiang Wang, Geng-Fu Xiao, Fang Bai, Hong Liu

Chemical Communications

DOI

2021

Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

Wen-Hao Dai, Dirk Jochmans, Hang Xie, Hang Yang, Jian Li, H. Su, Di Chang, Jiang Wang, Jing-Jing Peng, Li-Li Zhu, Nian Yong, R. Hilgenfeld, Hua-Liang Jiang, Kaixian Chen, Leike Zhang, Yechun Xu, J. Neyts, Hong Liu

Journal of Medicinal Chemistry

DOI

2021

Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.

Yu Zhou, Yan Fu, W. Yin, Jian Li, Wei Wang, Fang Bai, Sheng-Tao Xu, Qi Gong, Tao Peng, Yu Hong, Dong Zhang, Dan Zhang, Qiufeng Liu, Yechun Xu, H. Xu, Hai-Yan Zhang, Hua-Liang Jiang, Hong Liu

Journal of Medicinal Chemistry

DOI

2021

A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo

Jana Van Dycke, Wen-Hao Dai, Zoe Stylianidou, Jian Li, Arno Cuvry, E. Roux, Bing Li, Jasper Rymenants, Lindsey Bervoets, P. D. de Witte, Hong Liu, J. Neyts, J. Rocha-Pereira

Viruses

DOI

2020

DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling.

Heng Li, Jian Li, Xianglei Zhang, Chun-Lan Feng, Chen Fan, Xiaoqian Yang, Rui Zhang, Feng-hua Zhu, Yu Zhou, Yechun Xu, Hong Liu, Wei Tang

Biochemical Pharmacology

DOI

2020

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Wen-Hao Dai, Bing Zhang, Xia-Ming Jiang, H. Su, Jian Li, Yao Zhao, Xiong Xie, Zhenming Jin, Jing-Jing Peng, Fengjiang Liu, Chun-Pu Li, You Li, Fang Bai, Haofeng Wang, Xi Cheng, Xiaobo Cen, Shulei Hu, Xiuna Yang, Jiang Wang, Xiang Liu, Geng-Fu Xiao, Hua-Liang Jiang, Z. Rao, Leike Zhang, Yechun Xu, Haitao Yang, Hong Liu

Science

DOI

2020

Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.

Rui Zhang, Heng Li, Xianglei Zhang, Jian Li, H. Su, Q. Lu, Guangyu Dong, Huixia Dou, Chen Fan, Zhan-Ni Gu, Qian-Wen Mu, Wei Tang, Yechun Xu, Hong Liu

European journal of medicinal chemistry

DOI

2019

Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.

Xianglei Zhang, Guangyu Dong, Heng Li, Wuyan Chen, Jian Li, Chun-Lan Feng, Zhan-Ni Gu, Feng-hua Zhu, Rui Zhang, Min-Jun Li, Wei Tang, Hong Liu, Yechun Xu

Journal of Medicinal Chemistry

DOI

2018

Molecular binding mode of PF-232798, a clinical anti-HIV candidate, at chemokine receptor CCR5

Ya Zhu, Yan-long Zhao, Jian Li, Hong Liu, Qiang Zhao, Beili Wu, Zhen-Lin Yang

Acta Pharmacologica Sinica

DOI

2016

Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives

Guan-Nan Liu, Rong-Hua Luo, Yu Zhou, Xing-Jie Zhang, Jian Li, Liu-Meng Yang, Yong-Tang Zheng, Hong Liu

Molecules

DOI

2015

Aldehyde group compounds, as well as preparation method and application thereof

Hong Liu, Nian Yong, Jian Li, 饶福希尔根菲尔德, Dai-Zong Lin, Hai-Long Liu, Yu Zhou, Hua-Liang Jiang, Kai-Xian Chen

2015

5-aromatic alkynyl substituted benzamide compounds and preparation method, pharmaceutical compositions and use of same compounds

Hong Liu, Yu Zhou, Dong Zhang, Jian Li, Hua-Liang Jiang, Kai-Xian Chen

2015

Crystal form a of compound and preparation method thereof

Hong Liu, Jiang Wang, Jian Li, Jia Li, Jing-Ya Li, Sheng-Bin Zhou, Ming-Bo Su, Hua-Liang Jiang, Xiaomin Luo, Kai-Xian Chen

2015

C, O-spiro aryl glycoside compound and preparation and application thereof

Hong Liu, Jia Li, Jiang Wang, Jing-Ya Li, Hui Chen, Dan Li, Jian Li, Hua-Liang Jiang, Kai-Xian Chen

2014

Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors.

Xun Ji, Ting Peng, Xu Zhang, Jian Li, Wei Yang, Lin-jiang Tong, Rong Qu, H. Jiang, Jian Ding, Hua Xie, Hong Liu

Bioorganic & Medicinal Chemistry

DOI

2014

Synthesis and Evaluation of Anti-HIV-1 Activities of Novel 7-Hydroxy-1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-4-carboxylate Derivatives

Guan-Nan Liu, Rong-Hua Luo, Xing-Jie Zhang, Yu Zhou, Jian Li, Yong-Tang Zheng, Hong Liu

DOI

2013

Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor.

Xu Zhang, Ting Peng, Xun Ji, Jian Li, Lin-jiang Tong, Zeng Li, Wei Yang, Yun-Gen Xu, Meng-yuan Li, Jian Ding, Hua-Liang Jiang, Hua Xie, Hong Liu

Bioorganic & Medicinal Chemistry

DOI

2013

Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.

E. Feng, Woo-Jin Shin, Xuelian Zhu, Jian Li, Deju Ye, Jiang Wang, Mingyue Zheng, Jian-Ping Zuo, K. No, Xian Liu, Wei Zhu, Wei Tang, B. Seong, Hua-Liang Jiang, Hong Liu

Journal of Medicinal Chemistry

DOI

2013

Structure of the CCR5 chemokine receptor – HIV entry inhibitor Maraviroc complex

Q. Tan, Ya Zhu, Jian Li, Zhu-Xi Chen, G. Han, I. Kufareva, Tingting Li, Limin Ma, G. Fenalti, Jing Li, Wenru Zhang, Xin Xie, Huaiyu Yang, Hua-Liang Jiang, V. Cherezov, Hong Liu, R. Stevens, Qiang Zhao, Beili Wu

Science

DOI

2013

1-(3-amino propyl) substituted cyclic amine compound as well as preparation method, pharmaceutical composition and use thereof

Hong Liu, Beili Wu, Yong-Tang Zheng, Xin Xie, H. Jiang, Pan-Feng Peng, Rong-Hua Luo, Jing Li, Jian Li, Ya Zhu, Ying Chen, Hao-Nan Zhang, Liu-Meng Yang, Yu Zhou, Kai-xian Chen

2012

Recent Advances in Neuraminidase Inhibitor Development as Anti‐influenza Drugs

E. Feng, Deju Ye, Jian Li, Deng-You Zhang, Jin-Fang Wang, Fei Zhao, R. Hilgenfeld, Mingyue Zheng, Hua-Liang Jiang, Hong Liu

ChemMedChem

DOI

2012

Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.

Deju Ye, Woo-Jin Shin, Ning Li, Wei Tang, E. Feng, Jian Li, Pei-Lan He, Jian-Ping Zuo, Hanjo Kim, Ky-Youb Nam, Wei Zhu, B. Seong, K. No, Hua-Liang Jiang, Hong Liu

European journal of medicinal chemistry

DOI

2010

2,4-二取代氨基-6-取代-[1,3,5]三嗪或1,3-嘧啶类化合物、其制备方法、药物组合物及用途

Hua-Liang Jiang, Xu Shen, Yong-Tang Zheng, Jian Li, Hong Liu, Li Du, Liu-Meng Yang, Rui-Rui Wang, Yi-Ping Wang, Kai-xian Chen

2008

Antitumor Activity of a New N-Substituted Thiourea Derivative, an EGFR Signaling-Targeted Inhibitor against a Panel of Human Lung Cancer Cell Lines

Xishan Xiong, Hong Liu, Li-Li Fu, Lin Li, Jian Li, Xiaomin Luo, Chang-Lin Mei

Chemotherapy

DOI

2006

One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation

Jian Li, Jing Chen, Li Zhang, Feng Wang, C. Gui, Yu Qin, Qiang Xu, Hong Liu, F. Nan, Jing-Kang Shen, D. Bai, Kaixian Chen, Xu Shen, Hua-Liang Jiang

Bioorganic & Medicinal Chemistry

DOI

2006

Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities.

Jian Li, Mingyue Zheng, Wei Tang, Pei-Lan He, Weiliang Zhu, Tianxian Li, Jian-Ping Zuo, Hong Liu, Hua-Liang Jiang

Bioorganic & Medicinal Chemistry Letters

DOI

2006

Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features

Li-li Chen, Jian Li, Cheng Luo, Hong Liu, Weijun Xu, Gang Chen, O. Liew, Weiliang Zhu, C. Puah, Xu Shen, Hua-Liang Jiang

Bioorganic & Medicinal Chemistry

DOI

2006

Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay.

Jian Li, Jian Zhang, Jing Chen, Xiaomin Luo, Weiliang Zhu, Jianhua Shen, Hong Liu, Xu Shen, Hua-Liang Jiang

Journal of combinatorial chemistry

DOI

2006

Focused Library Design Based on Hit and Target Structures: Method and Application in Drug Discovery

Weiliang Zhu, Jian Li, Zhen Gong, Hong Liu, Hua-Liang Jiang

DOI

2005

Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay

Jian Li, Jing Chen, C. Gui, Li Zhang, Yu Qin, Qiang Xu, Jian Zhang, Hong Liu, Xu Shen, Hua-Liang Jiang

Bioorganic & Medicinal Chemistry

DOI

2005

3-alkoxy substituted-2, 5, 7-tri-substituted benzopyran-4-ketones compounds, preparing method thereof and pharmaceutical compounds containing same

Weiliang Zhu, Jian Li, Chun-Mu Pan, Li-li Chen, Gang Chen, Cheng Luo, Zhi-Li Zuo, Hong Liu, Xiaomin Luo, Kai-Xian Chen, Xu Shen, Hua-Liang Jiang

精选作品

期刊论文

哈巴俄苷改善小鼠代谢功能障碍相关脂肪性肝炎的研究

PDE4 inhibitor DC591017 ameliorates pulmonary fibrosis through modulating fibroblasts-epithelial cells-alternatively activated macrophages crosstalk.

Electrochemical C–H Nitration of N ‐Substituted Anilines With Sodium Nitrite

Acetic Acid-Assisted Electrochemical Ipso -Nitration of Aryl Borides Using Ferric Nitrate Nonahydrate

Iodine‐Catalyzed Aerobic Oxidative Domino Cyclization of Methyl N‐Heteroarenes with 6‐Aminopyrimidine‐2,4‐Dione and Pyrazol‐5‐Amine

Iodine-Mediated Oxidative Cyclization of Amino-heteroaromatics with Allylic Alcohols and Propene Derivatives: Access to Pyrazolo[3,4- b ]pyridines

Structure-based design of pan-coronavirus inhibitors targeting host cathepsin L and calpain-1

Bicyclic peptide-enhanced covalent inhibitor of SARS-CoV-2 3CL protease

Discovery and Mechanism Study of SARS-CoV-2 3C-like Protease Inhibitors with a New Reactive Group.

Discovery, synthesis and mechanism study of 2,3,5-substituted [1,2,4]-thiadiazoles as covalent inhibitors targeting 3C-Like protease of SARS-CoV-2

Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability.

In vitro and in vivo evaluation of the main protease inhibitor FB2001 against SARS-CoV-2

Synthesis of maleimide-braced peptide macrocycles and their potential anti-SARS-CoV-2 mechanisms.

Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2

Kinetics-Driven Drug Design Strategy for Next-Generation Acetylcholinesterase Inhibitors to Clinical Candidate.

A Novel Class of Norovirus Inhibitors Targeting the Viral Protease with Potent Antiviral Activity In Vitro and In Vivo

DC591017, a phosphodiesterase-4 (PDE4) inhibitor with robust anti-inflammation through regulating PKA-CREB signaling.

Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease

Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.

Structure-Aided Identification and Optimization of Tetrahydro-isoquinolines as Novel PDE4 Inhibitors Leading to Discovery of an Effective Antipsoriasis Agent.

Molecular binding mode of PF-232798, a clinical anti-HIV candidate, at chemokine receptor CCR5

Synthesis and Anti-HIV-1 Activity Evaluation for Novel 3a,6a-Dihydro-1H-pyrrolo[3,4-c]pyrazole-4,6-dione Derivatives

Aldehyde group compounds, as well as preparation method and application thereof

5-aromatic alkynyl substituted benzamide compounds and preparation method, pharmaceutical compositions and use of same compounds

Crystal form a of compound and preparation method thereof

C, O-spiro aryl glycoside compound and preparation and application thereof

Design, synthesis and biological evaluation of novel 6-alkenylamides substituted of 4-anilinothieno[2,3-d]pyrimidines as irreversible epidermal growth factor receptor inhibitors.

Synthesis and Evaluation of Anti-HIV-1 Activities of Novel 7-Hydroxy-1,3-dioxo-2,3-dihydro-1H-pyrrolo[3,4-c]pyridine-4-carboxylate Derivatives

Design, synthesis and biological evaluation of novel 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of the epidermal growth factor receptor.

Structure-based design and synthesis of C-1- and C-4-modified analogs of zanamivir as neuraminidase inhibitors.

Structure of the CCR5 chemokine receptor – HIV entry inhibitor Maraviroc complex

1-(3-amino propyl) substituted cyclic amine compound as well as preparation method, pharmaceutical composition and use thereof

Recent Advances in Neuraminidase Inhibitor Development as Anti‐influenza Drugs

Synthesis of C-4-modified zanamivir analogs as neuraminidase inhibitors and their anti-AIV activities.

2,4-二取代氨基-6-取代-[1,3,5]三嗪或1,3-嘧啶类化合物、其制备方法、药物组合物及用途

Antitumor Activity of a New N-Substituted Thiourea Derivative, an EGFR Signaling-Targeted Inhibitor against a Panel of Human Lung Cancer Cell Lines

One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation

Syntheses of triazole-modified zanamivir analogues via click chemistry and anti-AIV activities.

Binding interaction of quercetin-3-β-galactoside and its synthetic derivatives with SARS-CoV 3CLpro: Structure–activity relationship studies reveal salient pharmacophore features

Strategy for discovering chemical inhibitors of human cyclophilin a: focused library design, virtual screening, chemical synthesis and bioassay.

Focused Library Design Based on Hit and Target Structures: Method and Application in Drug Discovery

Discovering novel chemical inhibitors of human cyclophilin A: Virtual screening, synthesis, and bioassay

3-alkoxy substituted-2, 5, 7-tri-substituted benzopyran-4-ketones compounds, preparing method thereof and pharmaceutical compounds containing same

研究方向