李传海｜青岛大学｜学者主页

2026

The Association between Prenatal Quaternary Ammonium Compounds (QACs) Exposure and Neonatal Birth Obesity: Insights from Epidemiology and In Vitro Evidence

Yong-Feng Lin, Xiang-Yue Liu, Chun-Yan Deng, Rui Zhang, Xiao-Zun Liu, Wen-Xuan Li, Li-Qin Wang, Jing Yang, Chuanhai Li, Ming-Shu Li, Da-Wei Lu, Wei Gao, Yong Tian, Yuxin Zheng

Environmental Health

DOI

2025

Estrogenic and transgenerational effects of perfluorocarboxylic acids through estrogen-related receptor γ pathway.

Sha Shi, Wei Zheng, Xilong Zhang, Min-Jie Li, Cheng Ye, Lu Chen, Wen-Jun Hong, Chuanhai Li, Huiyu Chi, Fangfang Li, Liang-Qiang Guo

Journal of Hazardous Materials

DOI

2025

Medium-chain perfluoroalkyl carboxylic acids exert male reproductive toxicity at environmental and human exposure levels by antagonizing androgen receptor mediated pathways.

Wei Zheng, Mingliang Sun, Xinni Yao, Chuanhai Li, Min-Jie Li, Liang-Qiang Guo

Journal of Hazardous Materials

DOI

2025

2,4,6-Tri-tert-butylphenol Promoted Adipogenesis in 3T3-L1 Cells through a Retinoid X Receptor α-Dependent Mechanism.

Yinling He, Zhen-Dong Sun, Ning Wu, Chuanhai Li, Qun-Fang Zhou, Li-Gang Hu, Chun-Yang Liao, Gui-Bin Jiang

Environmental Research

DOI

2025

Effects of multiple novel bisphenol S analogs on adipogenesis in 3T3-L1 cells.

Zhen-Dong Sun, Shengnan Zhang, Jiefeng Liang, Chuanhai Li, Xiaoxi Yang, Qian S. Liu, Qun-Fang Zhou, Jian-Bo Shi, Bin Zhao, Gui-Bin Jiang

Journal of Hazardous Materials

DOI

2024

磷酸三苯酯及磷酸甲苯二苯酯的早期胚胎发育毒性：PPARγ的作用

黄静，翟雨诺，李博洋，纪静，李传海，刘世昕，刘议蔓，袁骏华，姜启晓

《环境与职业医学》

2024

Fine particulate matter disrupts bile acid homeostasis in hepatocytes via binding to and activating farnesoid X receptor

Donghui Zhang, Xinya Liu, Lanchao Sun, Daochuan Li, Jingyue Du, Huizi Yang, Dianke Yu, Chuanhai Li

Toxicology

DOI

2024

Adipogenic Effects of Cresyl Diphenyl Phosphate (Triphenyl Phosphate Alternative) through Peroxisome Proliferator-Activated Receptor Gamma Pathway: A Comprehensive Study Integrating In Vitro, In Vivo, and In Silico from Molecule to Health Risk

Lanchao Sun, Xinya Liu, Jingyue Du, Huizi Yang, Yongfeng Lin, Dianke Yu, Chuanhai Li, Yuxin Zheng

Environmental Science & Technology

DOI

2024

Cresyl diphenyl phosphate (a novel organophosphate ester) induces hepatic steatosis by directly binding to liver X receptor α: From molecule action to risk assessment

Xinya Liu, Lanchao Sun, Yongfeng Lin, Jingyue Du, Huizi Yang, Chuanhai Li

Environment International

DOI

2024

A High-Throughput Screening Approach for Evaluating the Binding Affinity of Environmental Pollutants to Nuclear Receptors

Lanchao Sun, Chuanhai Li

Journal of Visualized Experiments

DOI

2024

piR-27222 mediates PM2.5-induced lung cancer by resisting cell PANoptosis through the WTAP/m6A axis

Wan‐Li Ma, Lin Xu, Yixuan Wang, Shen Chen, Daochuan Li, Xiaoyu Huo, Ruoxi Li, Xiaoxiao Zhu, Ningning Chen, Yuan Jin, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Wei Han, Dianke Yu

Environment International

DOI

2023

Diesel exhaust particles exposure induces liver dysfunction: Exploring predictive potential of human circulating microRNAs signature relevant to liver injury risk

Lin Xu, Yanting Li, Wanli Ma, Xueying Sun, Rongrong Fan, Yuan Jin, Ningning Chen, Xiaoxiao Zhu, Huan Guo, Kunming Zhao, Jiao Luo, Chuanhai Li, Yuxin Zheng, Dianke Yu

Journal of Hazardous Materials

DOI

2023

Toxicity and risk priority ranking of polybrominated diphenyl ethers (PBDEs): A relative receptor-bound concentration approach

Xinya Liu, Lanchao Sun, Shangning Wu, Penghao Wang, Zhaoze Wang, Mengfan Zhai, Jiayi Xu, Donghui Zhang, Dianke Yu, Chuanhai Li

The Science of The Total Environment

DOI

2023

Binding, activity and risk assessment of bisphenols toward farnesoid X receptor pathway: In vitro and in silico study

Donghui Zhang, Xinya Liu, Yuan Qi, Yongfeng Lin, Kunming Zhao, Yuan Jin, Jiao Luo, Lin Xu, Dianke Yu, Chuanhai Li

The Science of The Total Environment

DOI

2023

Human health risk assessment of 6:2 Cl-PFESA through quantitative in vitro to in vivo extrapolation by integrating cell-based assays, an epigenetic key event, and physiologically based pharmacokinetic modeling

Chuanhai Li, Lidan Jiang, Donghui Zhang, Yuan Qi, Xinyi Wang, Yuan Jin, Xinya Liu, Yongfeng Lin, Jiao Luo, Lin Xu, Kunming Zhao, Dianke Yu

Environment International

DOI

2023

Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease

Ningning Chen, Jiao Luo, Tao Zhou, Yingqing Shou, Chenlong Du, Ge Song, Lin Xu, Kunming Zhao, Yuan Jin, Chuanhai Li, Dianke Yu

Biochemical Pharmacology

DOI

2023

Association of adverse fetal outcomes with placental inflammation after oral gestational exposure to hexafluoropropylene oxide dimer acid (GenX) in Sprague-Dawley rats.

D'iakonov Lv, Hongyun Liu, Qi An, Chengwei Lei, Yanxuan Wang, Jin Sun, Chuanhai Li, Yong-Feng Lin, Qing Dong, Zhugen Yang, K. Che, Wendong Liu, Wenchao Han

Journal of Hazardous Materials

DOI

2022

Using a human bronchial epithelial cell-based malignant transformation model to explore the function of hsa-miR-200 family in the progress of PM2.5-induced lung cancer development

Wanli Ma, Lin Xu, Xueying Sun, Yuan Qi, Shen Chen, Daochuan Li, Yuan Jin, Ningning Chen, Xiaoxiao Zhu, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Dianke Yu

Environmental Pollution

DOI

2022

N, N-dimethylformamide exposure induced liver abnormal mitophagy by targeting miR-92a-1-5p-BNIP3L pathway in vivo and vitro

Lin Xu, Wanli Ma, Yuan Jin, Xueying Sun, Ningning Chen, Xiaoxiao Zhu, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Dianke Yu

The Science of The Total Environment

DOI

2022

Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes

Chuanhai Li, Lidan Jiang, Yuan Qi, Donghui Zhang, Xinya Liu, Wenchao Han, Wanli Ma, Lin Xu, Yuan Jin, Jiao Luo, Kunming Zhao, Dianke Yu

Ecotoxicology and Environmental Safety

DOI

2022

Identifying microRNAs that drive BaP-induced pulmonary effects: Multiple patterns of mechanisms underlying activation of the toxicity pathways

Yuan Jin, Qianqian Zhang, Yuzhen Liu, Heyuan Guan, Yingqing Shou, Chenlong Du, Jiao Luo, Kunming Zhao, Chuanhai Li, Lin Xu, Wanli Ma, Ningning Chen, Yuxin Zheng, Dianke Yu

Environment International

DOI

2022

Human exposure to F-53B in China and the evaluation of its potential toxicity: An overview

Yanxia He, Di Lv, Chuanhai Li, Xiuqin Liu, Wendong Liu, Wenchao Han

Environment International

DOI

2021

High throughput data-based, toxicity pathway-oriented development of a quantitative adverse outcome pathway network linking AHR activation to lung damages

Yuan Jin, Guangshuai Qi, Yingqing Shou, Daochuan Li, Yuzhen Liu, Heyuan Guan, Qianqian Zhang, Shen Chen, Jiao Luo, Lin Xu, Chuanhai Li, Wanli Ma, Ningning Chen, Yuxin Zheng, Dianke Yu

Journal of Hazardous Materials

DOI

2021

Lipid metabolism disorders effects of 6:2 chlorinated polyfluorinated ether sulfonate through Hsa-miRNA-532–3p/Acyl-CoA oxidase 1(ACOX1) pathway

Chuanhai Li, Lidan Jiang, Yuan Jin, Donghui Zhang, Jing Chen, Yuan Qi, Rongrong Fan, Jiao Luo, Lin Xu, Wanli Ma, Kunming Zhao, Dianke Yu

Ecotoxicology and Environmental Safety

DOI

2021

MicroRNA-760 resists ambient PM2.5-induced apoptosis in human bronchial epithelial cells through elevating heme-oxygenase 1 expression

Lin Xu, Qianwen Zhao, Daochuan Li, Jiao Luo, Wanli Ma, Yuan Jin, Chuanhai Li, Jing Chen, Kunming Zhao, Yuxin Zheng, Dianke Yu

Environmental Pollution

DOI

2021

PIWI-interacting RNA-23210 protects against acetaminophen-induced liver injury by targeting HNF1A and HNF4A

Lin Xu, Wendi Chen, Jing Chen, Yuan Jin, Wanli Ma, Guangshuai Qi, Xueying Sun, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Dianke Yu

Biochemical Pharmacology

DOI

2021

miR-15a-3p Protects Against Isoniazid-Induced Liver Injury via Suppressing N-Acetyltransferase 2 Expression

Xinmei Li, Heng Zhang, Lin Xu, Yuan Jin, Jiao Luo, Chuanhai Li, Kunming Zhao, Yuxin Zheng, Dianke Yu, Yanjie Zhao

Frontiers in Molecular Biosciences

DOI

2021

A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease

Jiao Luo, Mengyue Xie, Yufei Hou, Wanli Ma, Yuan Jin, Jing Chen, Chuanhai Li, Kunming Zhao, Ningning Chen, Lin Xu, Yanan Ji, Qianqian Zhang, Yuxin Zheng, Dianke Yu

Biochemical Pharmacology

DOI

2021

A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells

Jiao Luo, Yufei Hou, Wanli Ma, Mengyue Xie, Yuan Jin, Lin Xu, Chuanhai Li, Ying Wang, Jing Chen, Wendi Chen, Yuxin Zheng, Dianke Yu

Biochemical Pharmacology

DOI

2020

A toxicity pathway-oriented approach to develop adverse outcome pathway: AHR activation as a case study

Yuan Jin, Meiyao Feng, Wanli Ma, Yanhong Wei, Guangshuai Qi, Jiao Luo, Lin Xu, Xinmei Li, Chuanhai Li, Wang Ying, Daochuan Li, Jing Chen, Yanjie Zhao, Yufei Hou, Qianwen Zhao, Lidan Jiang, Mengyue Xie, Yuxin Zheng, Dianke Yu

Environmental Pollution

DOI

2020

Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity

Lin Xu, Qianwen Zhao, Jiao Luo, Wanli Ma, Yuan Jin, Chuanhai Li, Yufei Hou, Meiyao Feng, Ying Wang, Jing Chen, Jinquan Zhao, Yuxin Zheng, Dianke Yu

Ecotoxicology and Environmental Safety

DOI

2020

MicroRNA hsa-miR-1301-3p Regulates Human ADH6, ALDH5A1 and ALDH8A1 in the Ethanol-Acetaldehyde-Acetate Metabolic Pathway

Xubing Wang, Yanjie Zhao, Jiao Min Luo, Lin Xu, Xinmei Li, Yuan Jin, Chuanhai Li, Meiyao Feng, Ying Wang, Jing Chen, Yufei Hou, Qianwen Zhao, Jinquan Zhao, Baitang Ning, Yuxin Zheng, Dianke Yu

Molecular Pharmacology

DOI

2019

Butylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells.

Zhen-Dong Sun, Xiaoxi Yang, Qian S. Liu, Chuanhai Li, Qun-Fang Zhou, H. Fiedler, Chunyang Liao, Jianqing Zhang, Guibin Jiang

Journal of Hazardous Materials

DOI

精选作品

期刊论文

The Association between Prenatal Quaternary Ammonium Compounds (QACs) Exposure and Neonatal Birth Obesity: Insights from Epidemiology and In Vitro Evidence

Estrogenic and transgenerational effects of perfluorocarboxylic acids through estrogen-related receptor γ pathway.

Medium-chain perfluoroalkyl carboxylic acids exert male reproductive toxicity at environmental and human exposure levels by antagonizing androgen receptor mediated pathways.

2,4,6-Tri-tert-butylphenol Promoted Adipogenesis in 3T3-L1 Cells through a Retinoid X Receptor α-Dependent Mechanism.

Effects of multiple novel bisphenol S analogs on adipogenesis in 3T3-L1 cells.

磷酸三苯酯及磷酸甲苯二苯酯的早期胚胎发育毒性：PPARγ的作用

Fine particulate matter disrupts bile acid homeostasis in hepatocytes via binding to and activating farnesoid X receptor

Adipogenic Effects of Cresyl Diphenyl Phosphate (Triphenyl Phosphate Alternative) through Peroxisome Proliferator-Activated Receptor Gamma Pathway: A Comprehensive Study Integrating In Vitro, In Vivo, and In Silico from Molecule to Health Risk

Cresyl diphenyl phosphate (a novel organophosphate ester) induces hepatic steatosis by directly binding to liver X receptor α: From molecule action to risk assessment

A High-Throughput Screening Approach for Evaluating the Binding Affinity of Environmental Pollutants to Nuclear Receptors

piR-27222 mediates PM2.5-induced lung cancer by resisting cell PANoptosis through the WTAP/m6A axis

Diesel exhaust particles exposure induces liver dysfunction: Exploring predictive potential of human circulating microRNAs signature relevant to liver injury risk

Toxicity and risk priority ranking of polybrominated diphenyl ethers (PBDEs): A relative receptor-bound concentration approach

Binding, activity and risk assessment of bisphenols toward farnesoid X receptor pathway: In vitro and in silico study

Human health risk assessment of 6:2 Cl-PFESA through quantitative in vitro to in vivo extrapolation by integrating cell-based assays, an epigenetic key event, and physiologically based pharmacokinetic modeling

Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease

Association of adverse fetal outcomes with placental inflammation after oral gestational exposure to hexafluoropropylene oxide dimer acid (GenX) in Sprague-Dawley rats.

Using a human bronchial epithelial cell-based malignant transformation model to explore the function of hsa-miR-200 family in the progress of PM2.5-induced lung cancer development

N, N-dimethylformamide exposure induced liver abnormal mitophagy by targeting miR-92a-1-5p-BNIP3L pathway in vivo and vitro

Integration of metabolomics and proteomics reveals the underlying hepatotoxic mechanism of perfluorooctane sulfonate (PFOS) and 6:2 chlorinated polyfluoroalkyl ether sulfonic acid (6:2 Cl-PFESA) in primary human hepatocytes

Identifying microRNAs that drive BaP-induced pulmonary effects: Multiple patterns of mechanisms underlying activation of the toxicity pathways

Human exposure to F-53B in China and the evaluation of its potential toxicity: An overview

High throughput data-based, toxicity pathway-oriented development of a quantitative adverse outcome pathway network linking AHR activation to lung damages

Lipid metabolism disorders effects of 6:2 chlorinated polyfluorinated ether sulfonate through Hsa-miRNA-532–3p/Acyl-CoA oxidase 1(ACOX1) pathway

MicroRNA-760 resists ambient PM2.5-induced apoptosis in human bronchial epithelial cells through elevating heme-oxygenase 1 expression

PIWI-interacting RNA-23210 protects against acetaminophen-induced liver injury by targeting HNF1A and HNF4A

miR-15a-3p Protects Against Isoniazid-Induced Liver Injury via Suppressing N-Acetyltransferase 2 Expression

A novel epigenetic mechanism unravels hsa-miR-148a-3p-mediated CYP2B6 downregulation in alcoholic hepatitis disease

A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells

A toxicity pathway-oriented approach to develop adverse outcome pathway: AHR activation as a case study

Integration of proteomics, lipidomics, and metabolomics reveals novel metabolic mechanisms underlying N, N-dimethylformamide induced hepatotoxicity

MicroRNA hsa-miR-1301-3p Regulates Human ADH6, ALDH5A1 and ALDH8A1 in the Ethanol-Acetaldehyde-Acetate Metabolic Pathway

Butylated hydroxyanisole isomers induce distinct adipogenesis in 3T3-L1 cells.

会议论文

基于生物活性等效浓度构建“体外-体内外推”模型及在新污染物毒性风险评估中的应用

预印本

MicroRNA-760 Resists Ambient PM2.5-induced Lung Injury Through Upregulating Heme-oxygenase 1 Expression

研究方向