庆宏｜中央民族大学｜学者主页

2026

位置细胞与神经振荡功能异常介导阿尔茨海默病空间记忆障碍

黄倩，庆宏，全贞贞

《中国病理生理杂志》

2026

The PPC neurons modulate memory generalization via NR2B-type NMDA receptors in mice.

Yujun Deng, Da Song, Tao Huang, Chunjian Wang, Yun-Jie Qiu, Hui Li, Hong Qing, Zhen-Zhen Quan

Physiology and Behavior

DOI

2026

Mutagenesis-guided modeling of the Lynx1-α7 nicotinic acetylcholine receptor complex: An iterative feedback-driven approach.

M. Zaigraev, E. A. Zhivov, Timofey R. Chelyadinskii, M. Shulepko, D. Kulbatskii, Hong Qing, Zhen-Zhen Quan, M. Kirpichnikov, Z. Shenkarev, A. Chugunov, E. Lyukmanova

International Journal of Biological Macromolecules

DOI

2026

Effects of different exercise modalities on four major neurodegenerative diseases and their molecular mechanisms.

Shuo Wang, Yuqing Wei, Yongbiao Li, Hong Qing, Yan Yan, Yong Cheng

Neuroscience

DOI

2026

Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons

Qing-Yu Bai, Yan Yan, Chao-Wen Zeng, Xue Li, Gui-Hua Zeng, A. Saidova, Hui Li, Hong Qing

Frontiers in Aging Neuroscience

DOI

2026

Macrophage-Derived, Rather Than Microglial, Cathepsin B Exacerbates Brain Injury After Ischemic Stroke.

Wei Kong, Hui Li, Zhou Wu, Yoshinori Hayashi, Hiroshi Nakanishi, Juan Zhao, Yu-Tong Zhang, Hong Qing, Zhen-Zhen Quan, Jun-Jun Ni

Glia

DOI

2026

Multiple neural networks from cognition to motivation of prosocial behaviour in rodents: Potential mechanism between empathy and autism spectrum disorder.

Chen-Chen Lv, Da Song, Jun-Jun Ni, Hong Qing, Zhen-Zhen Quan

Progress in neurobiology

DOI

2026

Key circuits through which sleep affects memory and their role in Alzheimer's disease

Bing-Xin Shen, Zi-Lu Zhu, Hong Qing, Zhen-Zhen Quan

Journal of Alzheimer's Disease

DOI

2026

A working feedback-based framework for goal-directed spatial memory deficits in Alzheimer's disease: Feedforward and feedback interactions along the RSC–MEC–CA1–RSC axis

Yao-Yao Tian, Hong Qing, Zhen-Zhen Quan

Journal of Alzheimer's Disease

DOI

2026

Tau phosphorylation in Alzheimer’s disease: emerging mechanisms, network interactions, and therapeutic implications

Xue Li, Lei-Han Zhang, Li-Jun Zhao, Lang Qin, Qing-Yu Bai, Chao-Wen Zeng, Zhen-Bo Gao, Jun-Jun Ni, Gui-Hua Zeng, A. Saidova, Hong Qing, Hui Li

Journal of Translational Medicine

DOI

2026

Cathepsins in Ischemic Stroke: Unveiling Neuropharmacological Roles and Therapeutic Potential.

Rui Meng, Xin Zhong, Si-Meng Zhang, Yun-Jie Qiu, Zhen-Zhen Quan, Hong Qing, Hui Li, Jun-Jun Ni

Current Neuropharmacology

DOI

2026

Experience‐Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization

Da Song, Zi-Lu Zhu, Yujun Deng, Yujie Song, Hui Li, Jun-Jun Ni, Zhen-Zhen Quan, Yan Yan, Hong Qing

Advancement of science

DOI

2026

Intermittent hypoxia training alleviates cerebral hypoperfusion and amyloid-β deposition in a mixed dementia model established by bilateral common carotid artery stenosis in early-stage 5xFAD mice.

Chen-Chen Lv, Qiong-Fang Luo, Fei-Yang Jin, Qian-Qian Shao, Yun-Jie Qiu, Jun-Jun Ni, Jia Liu, Hong Qing, Zhen-Zhen Quan

Journal of Alzheimer's Disease

DOI

2025

Role of Peripheral NLRP3 Inflammasome in Cognitive Impairments: Insights of Non-central Factors

Meng-Fan Qiao, Jun-Jun Ni, Hong Qing, Yun-Jie Qiu, Zhen-Zhen Quan

Molecular Neurobiology

DOI

2025

The medial septum-hippocampus-lateral septum circuitry in spatial memory: linking healthy function to early Alzheimer’s disease and translational opportunities

Yujie Song, Jun-Jun Ni, Hong Qing, Zhen-Zhen Quan

Translational Neurodegeneration

DOI

2025

Cathepsin B deficiency disrupts cortical development via PEG3, leading to depression-like behavior

Zhen Xie, Qinghu Yang, Fei Lan, Wei Kong, Shuxuan Zhao, Jinyi Sun, Yan Yan, Zhen-Zhen Quan, Zhan-Tao Bai, Hong Qing, Jian Mao, Jun-Jun Ni

Communications Biology

DOI

2025

Deciphering T Cell Dynamics in Alzheimer's Disease Pathogenesis: Insights and Implications

Qi-Qi Yang, Yun-Jie Qiu, Jun-Jun Ni, Hui Li, Hong Qing

Current Neuropharmacology

DOI

2025

Machine-learning based strategy identifies a robust protein biomarker panel for Alzheimer’s disease in cerebrospinal fluid

Xiaosen Hou, Yun-Jie Qiu, Hui Li, Yan Yan, Dongxu Zhao, Simei Ji, Jun-Jun Ni, Jun Zhang, Kefu Liu, Hong Qing, Zhen-Zhen Quan

Alzheimer's Research & Therapy

DOI

2025

Neural mechanisms of cognitive generalization across species: From hippocampus to cortex

Zhen-Zhen Quan, Da Song, Hong Qing

Brain Medicine

DOI

2025

Targeted delivery of BACE1 siRNA for synergistic treatment of Alzheimer's disease

Zhaohan Li, Jun Yang, Jianan Li, Shuxuan Zhao, Shaoping Jiang, Weimin Liu, Xinjian Li, Si-Meng Zhang, Haiyan Du, Junjun Ni, Yuanyu Huang, Hong Qing, Shaobo Ruan

Translational Neurodegeneration

DOI

2024

Neural Network Excitation/Inhibition: A Key to Empathy and Empathy Impairment

Yuanhong Tang, Chunjian Wang, Qingquan Li, Gang Liu, Da Song, Zhen-Zhen Quan, Yan Yan, Hong Qing

The Neuroscientist

DOI

2024

Discovery of Novel Diphenyl Acrylonitrile Derivatives That Promote Adult Rats’ Hippocampal Neurogenesis

Si-Jia Liu, Cong-Xuan Ma, Zhengyang Quan, Jing Ding, Liang Yang, Si-Meng Liu, He-Ao Zhang, Hong Qing, Jianhuai Liang

International Journal of Molecular Sciences

DOI

2024

Extracellular vesicle-packed microRNAs profiling in Alzheimer's disease: The molecular intermediary between pathology and diagnosis.

Sandila Arif, T. J. Qazi, Zhen-Zhen Quan, Jun-Jun Ni, Zhaohan Li, Yun-Jie Qiu, Hong Qing

Ageing Research Reviews

DOI

2024

The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s disease

Kefu Liu, Ailikemu Aierken, Meng-Yao Liu, Nazakat Parhat, Wei Kong, Xingyu Yin, Gang Liu, Ding Yu, Jie Hong, Jun-Jun Ni, Zhen-Zhen Quan, Xiao-Yun Liu, Simei Ji, Jian Mao, Wei-Jun Peng, Chao Chen, Yan Yan, Hong Qing

iScience

DOI

2023

T细胞跨血脑屏障入脑促进阿尔茨海默病的研究进展

寇薛帅，谢真，庆宏，倪军军

《生命科学》

2023

Microglial zinc finger protein 335 mediates LPS‐induced neurodegeneration and memory loss as a transcriptional factor for lymphocyte antigen‐6M

Jun-Jun Ni, Zhen-Zhen Quan, Hong Qing

Alzheimer's & Dementia

DOI

2023

The Role of Oxytocin in Early-Life-Stress-Related Neuropsychiatric Disorders

Yue Jin, Da Song, Yan Yan, Zhen-Zhen Quan, Hong Qing

International Journal of Molecular Sciences

DOI

2023

In silico identification of novel stilbenes analogs for potential multi-targeted drugs against Alzheimer’s disease

Sundas Firdoos, R. Dai, R. Tahir, Z. Khan, Hui Li, Jun Zhang, Jun-Jun Ni, Zhen-Zhen Quan, Hong Qing

Journal of Molecular Modeling

DOI

2023

How brain ‘cleaners’ fail: Mechanisms and therapeutic value of microglial phagocytosis in Alzheimer's disease

Jun-Jun Ni, Zhen Xie, Zhen-Zhen Quan, J. Meng, Hong Qing

Glia

DOI

2023

Clusterin is a Potential Therapeutic Target in Alzheimer’s Disease

Nazhakaiti Palihati, Yuanhong Tang, Ya-Juan Yin, Ding Yu, Gang Liu, Zhen-Zhen Quan, Jun-Jun Ni, Yan Yan, Hong Qing

Molecular Neurobiology

DOI

2023

Reward prediction error in learning-related behaviors

Yujun Deng, Da Song, Jun-Jun Ni, Hong Qing, Zhen-Zhen Quan

Frontiers in Neuroscience

DOI

2023

Mediodorsal thalamus-projecting anterior cingulate cortex neurons modulate helping behavior in mice.

Da Song, Chunjian Wang, Yue Jin, Yujun Deng, Yan Yan, Deheng Wang, Zi-Lu Zhu, Zun-Ji Ke, Zhe Wang, Yi-Li Wu, Jun-Jun Ni, Hong Qing, Zhen-Zhen Quan

Current Biology

DOI

2023

The many faces of the zinc finger protein 335 in brain development and immune system.

Danyang Li, Zhen-Zhen Quan, Jun-Jun Ni, Hui Li, Hong Qing

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI

2022

抑制α-突触核蛋白聚集化合物的研究进展

王朝阳，王源浩，杨吉霞，庆宏，温鸿亮

《中国药物化学杂志》

2021

Rab蛋白家族在神经类疾病中的作用

吴安平，庆宏，全贞贞

《遗传》

DOI

2021

阿尔茨海默症生物标志物在脑脊液和血液中的研究

艾力克木·艾尔肯，全贞贞，庆宏

《生命科学》

DOI

2019

二苯乙烯酰胺衍生物类化合物促进大鼠海马神经发生的适合剂量研究

相林，杨亮，庆宏，安宜

《生命科学仪器》

2017

阿尔茨海默症发病机制及治疗方法研究进展

张贺奡，庆宏

《科技导报》

2017

1-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉的神经生物学功能研究进展

郑晓彤，陈薛钗，陈姿喧，庆宏，邓玉林，钟儒刚，郭敏军

《生物医学工程学杂志》

2017

[P3–157]: RAB21, A NOVEL PS1 INTERACTION PROTEIN, REGULATES G‐SECRETASE ACTIVITY VIA PS1 SUBCELLULAR DISTRIBUTION

Hong Qing, Zhen-Zhen Quan, Zhenzhen Sun, Qinghu Yang

DOI

2016

早衰因子及其突变对BACE1活性调控的研究

李诺敏，邱云洁，庆宏

《生命科学仪器》

2016

促海马区成体神经发生药物的研究进展

吴思，庆宏，梁建华

《药学学报》

DOI

2016

Advance in the study of compounds with potential activities in promotion of adult hippocampal neurogenesis

Si Wu, Hong Qing, Jian-Hua Liang

2015

Salsolinol合成酶的克隆和表达

冯程程，陈薛钗，刘可夫，曾凡，庆宏，邓玉林

《科技导报》

2015

儿茶酚异喹啉类物质Salsolinol(Sal)对α-Syn纤维化程度的影响

段晋燕，刘可夫，庆宏，邓玉林

《生命科学仪器》

2014

神经免疫相互作用对帕金森病发病机制的影响研究

孙飞一，王馥丽，庆宏，邓玉林，马宏

《国际神经病学神经外科学杂志》

2014

α-Synuclein蛋白过表达对小鼠纹状体的影响

段晋燕，刘可夫，张永谦，张彦彦，庆宏，邓玉林

《科技导报》

2013

阿尔茨海默症的诊断与治疗研究进展

尹雅菲，童贻刚，庆宏

《生物技术通讯》

2013

改进重叠延伸PCR克隆tau基因6种同工异构体

李诺敏，刘可夫，李灵芸，何放，顾文彬，董一名，邓玉林，庆宏

《北京理工大学学报》

2012

蛋白-脂质体复合物毛细管电泳筛选单胺氧化酶抑制剂

李冰，吕雪飞，庆宏，邓玉林

《分析化学》

2012

Lys(203) and Lys(382) are essential for the proteasomal degradation of BACE1.

Rong Wang, Zhengxin Ying, Juan Zhao, Yan-Yan Zhang, Ran Wang, Hong Lu, Yu-Lin Deng, Wei-Hong Song, Hong Qing

Current Alzheimer Research

DOI

2008

亨廷顿舞蹈症发病机制的研究进展

刘畅，吕晓菁，郑秀玉，庆宏

《生物技术通讯》

2008

内源性儿茶酚异喹啉神经毒性物质参与帕金森病的研究进展

王冉，庆宏，邓玉林

《神经解剖学杂志》

2008

铁离子促进过量多巴胺引起SH-SY5Y细胞儿茶酚异喹啉物质生成和氧化损伤(英文)

王冉，庆宏，刘晓茜，郑晓琳，邓玉林

Neuroscience Bulletin

2008

醋酸锰对PC12细胞损伤作用的研究

栾玉静，庆宏，卢剑清，谢海燕，林凡凯，毛健，邓玉林

《中国药理学通报》

2008

NF-κB在学习记忆以及神经变性性疾病中的分子作用机制

苏旸，邓玉林，庆宏

《医学分子生物学杂志》

2008

Molecular Mechanism of NF-κB in Learning,Memory and Neurodegenerative Diseases

Hong Qing

2000

纹状体源性神经营养因子治疗帕金森病大鼠模型的实验研究

郭畹华，贺江海，庆宏

《中山大学学报(医学科学版)》

精选作品

期刊论文

位置细胞与神经振荡功能异常介导阿尔茨海默病空间记忆障碍

The PPC neurons modulate memory generalization via NR2B-type NMDA receptors in mice.

Mutagenesis-guided modeling of the Lynx1-α7 nicotinic acetylcholine receptor complex: An iterative feedback-driven approach.

Effects of different exercise modalities on four major neurodegenerative diseases and their molecular mechanisms.

Engram cell vulnerability in neurodegeneration: from mechanistic insights to therapeutic horizons

Macrophage-Derived, Rather Than Microglial, Cathepsin B Exacerbates Brain Injury After Ischemic Stroke.

Multiple neural networks from cognition to motivation of prosocial behaviour in rodents: Potential mechanism between empathy and autism spectrum disorder.

Key circuits through which sleep affects memory and their role in Alzheimer's disease

A working feedback-based framework for goal-directed spatial memory deficits in Alzheimer's disease: Feedforward and feedback interactions along the RSC–MEC–CA1–RSC axis

Tau phosphorylation in Alzheimer’s disease: emerging mechanisms, network interactions, and therapeutic implications

Cathepsins in Ischemic Stroke: Unveiling Neuropharmacological Roles and Therapeutic Potential.

Experience‐Dependent Reorganization of Hippocampal CA3 Neuronal Ensembles Associates With Memory Generalization

Intermittent hypoxia training alleviates cerebral hypoperfusion and amyloid-β deposition in a mixed dementia model established by bilateral common carotid artery stenosis in early-stage 5xFAD mice.

Role of Peripheral NLRP3 Inflammasome in Cognitive Impairments: Insights of Non-central Factors

The medial septum-hippocampus-lateral septum circuitry in spatial memory: linking healthy function to early Alzheimer’s disease and translational opportunities

Cathepsin B deficiency disrupts cortical development via PEG3, leading to depression-like behavior

Deciphering T Cell Dynamics in Alzheimer's Disease Pathogenesis: Insights and Implications

Machine-learning based strategy identifies a robust protein biomarker panel for Alzheimer’s disease in cerebrospinal fluid

Neural mechanisms of cognitive generalization across species: From hippocampus to cortex

Targeted delivery of BACE1 siRNA for synergistic treatment of Alzheimer's disease

Neural Network Excitation/Inhibition: A Key to Empathy and Empathy Impairment

Discovery of Novel Diphenyl Acrylonitrile Derivatives That Promote Adult Rats’ Hippocampal Neurogenesis

Extracellular vesicle-packed microRNAs profiling in Alzheimer's disease: The molecular intermediary between pathology and diagnosis.

The decreased astrocyte-microglia interaction reflects the early characteristics of Alzheimer’s disease

T细胞跨血脑屏障入脑促进阿尔茨海默病的研究进展

Microglial zinc finger protein 335 mediates LPS‐induced neurodegeneration and memory loss as a transcriptional factor for lymphocyte antigen‐6M

The Role of Oxytocin in Early-Life-Stress-Related Neuropsychiatric Disorders

In silico identification of novel stilbenes analogs for potential multi-targeted drugs against Alzheimer’s disease

How brain ‘cleaners’ fail: Mechanisms and therapeutic value of microglial phagocytosis in Alzheimer's disease

Clusterin is a Potential Therapeutic Target in Alzheimer’s Disease

Reward prediction error in learning-related behaviors

Mediodorsal thalamus-projecting anterior cingulate cortex neurons modulate helping behavior in mice.

The many faces of the zinc finger protein 335 in brain development and immune system.

抑制α-突触核蛋白聚集化合物的研究进展

Rab蛋白家族在神经类疾病中的作用

阿尔茨海默症生物标志物在脑脊液和血液中的研究

二苯乙烯酰胺衍生物类化合物促进大鼠海马神经发生的适合剂量研究

阿尔茨海默症发病机制及治疗方法研究进展

1-甲基-6,7-二羟基-1,2,3,4-四氢异喹啉的神经生物学功能研究进展

[P3–157]: RAB21, A NOVEL PS1 INTERACTION PROTEIN, REGULATES G‐SECRETASE ACTIVITY VIA PS1 SUBCELLULAR DISTRIBUTION

早衰因子及其突变对BACE1活性调控的研究

促海马区成体神经发生药物的研究进展

Advance in the study of compounds with potential activities in promotion of adult hippocampal neurogenesis

Salsolinol合成酶的克隆和表达

儿茶酚异喹啉类物质Salsolinol(Sal)对α-Syn纤维化程度的影响

神经免疫相互作用对帕金森病发病机制的影响研究

α-Synuclein蛋白过表达对小鼠纹状体的影响

阿尔茨海默症的诊断与治疗研究进展

改进重叠延伸PCR克隆tau基因6种同工异构体

蛋白-脂质体复合物毛细管电泳筛选单胺氧化酶抑制剂

Lys(203) and Lys(382) are essential for the proteasomal degradation of BACE1.

亨廷顿舞蹈症发病机制的研究进展

内源性儿茶酚异喹啉神经毒性物质参与帕金森病的研究进展

铁离子促进过量多巴胺引起SH-SY5Y细胞儿茶酚异喹啉物质生成和氧化损伤(英文)

醋酸锰对PC12细胞损伤作用的研究

NF-κB在学习记忆以及神经变性性疾病中的分子作用机制

Molecular Mechanism of NF-κB in Learning,Memory and Neurodegenerative Diseases

纹状体源性神经营养因子治疗帕金森病大鼠模型的实验研究

会议论文

BACE1泛素化位点的研究

LRRK2参与帕金森病中α-Synuclein的聚集

泛素调控BACE1蛋白水解淀粉样蛋白前体的途径的研究

LC-MS用于检测鼠脑微血管中SSAO活性的研究

研究方向