王纲｜复旦大学｜学者主页

期刊论文

2025

Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice

Bing-Yao Zhou, Ze-Xuan Li, Yi-Wei Li, Jin-Nan Li, Wei-Tang Liu, Xi-Yue Liu, Zhi-Bin Hu, Li Zhao, Jia-Yin Chen, Ling Hu, Ning-Ning Song, Xue Feng, Gang Wang, Lin Xu, Yu-Qiang Ding

Neuropsychopharmacology，Vol. 500, No. 8

DOI

2025

Nucleolar MED19 regulates 2′-O-methylation of rRNA in supporting cancer cell growth

Yang Ming, Zhao Jiamin, Peng Fei Yu, Lu Chengjiang, Zhang Yiyang, Zhang Hanqing, Qiang Zhou, Gang Wang

Nucleic Acids Research

DOI

2025

A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline

Haozheng Li, Yuanming Zheng, Chunlei Yuan, Jiayi Wang, Xiaying Zhao, Min Yang, Defei Xiong, Yenan Yang, Yunpeng Dai, Yiming Gao, Yuqi Wang, Lei Xue, Gang Wang

Cell Discovery

DOI

2025

Mediator complex subunit MED23 dampens antiviral innate immunity by restricting RIG-I expression

De-fei Xiong, Yi-yang Zhang, Zhichao Wang, Yuan-ming Zheng, Hanqing Zhang, Gang Wang

PLoS Biology

DOI

2025

Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3′ end processing factors

Chengjiang Lu, Xue Hui Bai, Hanqing Zhang, Yiyang Zhang, Yiyang Zhang, Yiyang Zhang, Ming Yang, Yuanming Zheng, Zhaohui Jin, Wancheng Yang, Gaoxing Guo, Qiang Huang, Ying Huang, Ligang Wu, Xiang‐Dong Fu, Zhihua Zhang, Gang Wang

Molecular Cell

DOI

2025

Phosphorylation of MSX1 controls tumorigenesis and bone development through targeting FBXW7 degradation

Yenan Yang, Xiang Jia, Peng Yu, Si-Hong Lu, Chen Wang, Heng Zhang, Xuefei Wang, Qiang Zhou, Yihong Sun, Gang Wang

Cancer Letters

DOI

2025

RYBP promotes HIV-1 latency through promoting H2AK119ub and decreasing H3K4me3

Xinyi Yang, Yuqi Zhu, Xiaying Zhao, Jingna Xun, Xingyu Wang, Yipeng Cheng, Si Xiong, Xiaocong Yu, Suixiang Li, Dan Wang, Zhiliang Hu, Yinzhong Shen, Shibo Jiang, Hongzhou Lu, Gang Wang, Huanzhang Zhu

Cell Communication and Signaling

DOI

2024

Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs

Shuai Zhang, Xue Feng, Chonghui Li, Yuan-Ming Zheng, Mengya Wang, Junjie Li, Yunpeng Dai, Naihe Jing, Jiawei Zhou, Gang Wang

Cell Discovery

DOI

2024

The Mediator Med23 controls a transcriptional switch for muscle stem cell proliferation and differentiation in muscle regeneration

Yi Fang, Chunlei Yuan, Chonghui Li, Chengjiang Lu, Wei Yu, Gang Wang

Cell Reports

DOI

2024

Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis

Xiaobo Fu, Siming Liu, Dan Cao, Chonghui Li, Hongbin Ji, Gang Wang

British Journal of Cancer

DOI

2023

Author Correction: Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury

Xiaoli Sun, Jingwen Yin, Yan Liang, Chonghui Li, Pingjin Gao, Ying Yu, Gang Wang

Cell Discovery

DOI

2023

An intellectual disability-related MED23 mutation dysregulates gene expression by altering chromatin conformation and enhancer activities

Yenan Yang, Chonghui Li, Ziyin Chen, Yiyang Zhang, Qing Tian, Meiling Sun, Shuai Zhang, Miao Yu, Gang Wang

Nucleic Acids Research

DOI

2023

Correction: Emerin anchors Msx1 and its protein partners at the nuclear periphery to inhibit myogenesis

Zhangjing Ma, Huiyuan Shi, Yi Shen, Huixia Li, Yu Yang, Jiange Yang, Hui Zhao, Gang Wang, Jingqiang Wang

Cell & Bioscience

DOI

2022

Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression

Yenan Yang, Qi Xiao, Jingwen Yin, Chonghui Li, Decai Yu, Yulong He, Zhongzhou Yang, Gang Wang

Communications Biology

DOI

2021

Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury

Xiaoli Sun, Jingwen Yin, Yan Liang, Chonghui Li, Pingjin Gao, Ying Yu, Gang Wang

Cell Discovery

DOI

2021

Insulin signaling establishes a developmental trajectory of adipose regulatory T cells

Yangyang Li, Ying Lu, Shuhai Lin, Ning Li, Yichao Han, Qianru Huang, Yi Zhao, Feng Xie, Yixian Guo, Biaolong Deng, Andy Tsun, Juan Du, Dan Li, Joanne Sun, Guochao Shi, Fang Zheng, Xiao Su, Sheng‐Zhong Duan, Song Guo Zheng, Gang Wang, Xuemei Tong, Bin Li

Nature Immunology

DOI

2020

Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development

Yenan Yang, Xiaoli Zhu, Xiang Jia, Wanwan Hou, Guoqiang Zhou, Zhangjing Ma, Bin Yu, Yan Pi ., Xumin Zhang, Jingqiang Wang, Gang Wang

Nucleic Acids Research

DOI

2020

Mediator Med23 Regulates Adult Hippocampal Neurogenesis

Guoyan Chen, Shuai Zhang, Chonghui Li, Congcong Qi, Yazhou Wang, Jia‐Yin Chen, Gang Wang, Yu‐Qiang Ding, Changjun Su

Frontiers in Cell and Developmental Biology

DOI

2019

转录中介体复合物与转录及表观遗传调控

李重辉，曹丹，王纲

《中国细胞生物学学报》

2019

Mediator MED23 regulates inflammatory responses and liver fibrosis

Zhichao Wang, Dan Cao, Chonghui Li, Lihua Min, Gang Wang

PLoS Biology

DOI

2019

Loss of homeoprotein Msx1 and Msx2 leading to athletic and kinematic impairment related to the increasing neural excitability of neurons in aberrant neocortex in mice

Bin Yu, Yuqing Jin, Yi Shen, Yenan Yang, Gang Wang, Haiying Zhu, Yuguo Yu, Jingqiang Wang

Biochemical and Biophysical Research Communications

DOI

2019

Emerin anchors Msx1 and its protein partners at the nuclear periphery to inhibit myogenesis

Zhangjing Ma, Huiyuan Shi, Yi Shen, Huixia Li, Yu Yang, Jiange Yang, Hui Zhao, Gang Wang, Jingqiang Wang

Cell & Bioscience

DOI

2019

The homeoprotein Msx1 cooperates with Pkn1 to prevent terminal differentiation in myogenic precursor cells

Xiaoli Zhu, Mingrui Li, Xiang Jia, Wanwan Hou, Jiange Yang, Hui Zhao, Gang Wang, Jingqiang Wang

Biochimie

DOI

2018

转录中介体MED23亚基通过MITF协调控制黑色素细胞的颜色与DNA损伤修复

Min Xia, Kun Chen, Xiao Yao, Yichi Xu, Jiaying Yao, Jun Yan, Zhen Shao, 王纲

《科学新闻》

会议论文

2019

Adipocyte MED23 regulates adipose development and liver growth hormone resistance via NAMPT-NAD+-STAT5-IGF1 axis in mice

Zhichao Wang, Qijiang Li, Leonardo Gomez Rosso, Gang Wang

《第三届中国生物物理学会代谢生物学分会学术研讨会论文集》

DOI

2017

Mediator Subunit MED23 Is an Essential Regulator of Hepatic Cancer

Zhichao Wang, Lihua Min, Yajing Chu, Dan Cao, Gang Wang

《全球华人生物学家大会暨第十六届美洲华人生物科学学会学术研讨会摘要集》

2015

The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination

Xiao Yao, Zhanyun Tang, Xing Fu, Jingwen Yin, Yan Liang, Chonghui Li, Huayun Li, Qing Tian, Robert G.Roeder, Gang Wang

《第十一次全国基因功能与表观遗传调控学术研讨会摘要集》

预印本

2026

Mediator subunit MED16 cooperates with UBP1-TFCP2 to control the promoter context-dependent transcriptional activity

Yuan-Ming Zheng, Xiaying Zhao, Ming Yang, Xinyi Yang, Huanzhang Zhu, Xiaofei Yu, Qiang Zhou, Gang Wang

eLife

DOI

王纲

精选作品

期刊论文

Central Med23 deficiency leads to malformation of dentate gyrus and ADHD-like behaviors in mice

Nucleolar MED19 regulates 2′-O-methylation of rRNA in supporting cancer cell growth

A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline

Mediator complex subunit MED23 dampens antiviral innate immunity by restricting RIG-I expression

Mediator regulates transcriptional termination through crosstalk with pre-mRNA 3′ end processing factors

Phosphorylation of MSX1 controls tumorigenesis and bone development through targeting FBXW7 degradation

RYBP promotes HIV-1 latency through promoting H2AK119ub and decreasing H3K4me3

Mediator MED23 controls oligodendrogenesis and myelination by modulating Sp1/P300-directed gene programs

The Mediator Med23 controls a transcriptional switch for muscle stem cell proliferation and differentiation in muscle regeneration

Med23 deficiency reprograms the tumor microenvironment to promote lung tumorigenesis

Author Correction: Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury

An intellectual disability-related MED23 mutation dysregulates gene expression by altering chromatin conformation and enhancer activities

Correction: Emerin anchors Msx1 and its protein partners at the nuclear periphery to inhibit myogenesis

Med23 supports angiogenesis and maintains vascular integrity through negative regulation of angiopoietin2 expression

Mediator Med23 deficiency in smooth muscle cells prevents neointima formation after arterial injury

Insulin signaling establishes a developmental trajectory of adipose regulatory T cells

Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development

Mediator Med23 Regulates Adult Hippocampal Neurogenesis

转录中介体复合物与转录及表观遗传调控

Mediator MED23 regulates inflammatory responses and liver fibrosis

Loss of homeoprotein Msx1 and Msx2 leading to athletic and kinematic impairment related to the increasing neural excitability of neurons in aberrant neocortex in mice

Emerin anchors Msx1 and its protein partners at the nuclear periphery to inhibit myogenesis

The homeoprotein Msx1 cooperates with Pkn1 to prevent terminal differentiation in myogenic precursor cells

转录中介体MED23亚基通过MITF协调控制黑色素细胞的颜色与DNA损伤修复

会议论文

Adipocyte MED23 regulates adipose development and liver growth hormone resistance via NAMPT-NAD+-STAT5-IGF1 axis in mice

Mediator Subunit MED23 Is an Essential Regulator of Hepatic Cancer

The Mediator subunit MED23 couples H2B mono-ubiquitination to transcriptional control and cell fate determination

预印本

Mediator subunit MED16 cooperates with UBP1-TFCP2 to control the promoter context-dependent transcriptional activity

研究方向