金光辉｜厦门大学｜学者主页

期刊论文

2026

The tumor suppressor menin is a key scaffold mediator for homologous recombination repair

Aobo Lian, Xingwen Zhu, Bangming Jin, Guixin Gu, Bin Xu, Li Zhang, Xiao Lin, Xuan Zhu, Guang‐Hui Jin

Nucleic Acids Research

DOI

2025

Myeloid loss of scaffolding protein menin promotes liver fibrosis via H3K36me3 reprogramming

Qing Han, Yujun Chen, Jun-Bo Yuan, Li Zhang, Qi‐Fan Zheng, Guang‐Hui Jin

Journal of Biological Chemistry

DOI

2025

Menin maintains lysosomal and mitochondrial homeostasis through epigenetic mechanisms in lung cancer

Jun-Bo Yuan, Gui-Xin Gu, Bangming Jin, Qing Han, Bing-Hui Li, Li Zhang, Bin Xu, Xuan Zhu, Guang‐Hui Jin

Cell Death and Disease

DOI

2025

Menin orchestrates macrophage reprogramming to maintain the pulmonary immune homeostasis

Xingwen Zhu, Bin Xu, Aobo Lian, Xiaoqian Zhang, Yiting Wang, Yuan Zhang, Li Zhang, Jie Ma, Shu-Bin Gao, Guang‐Hui Jin

Cell Reports

DOI

2023

Author Correction: Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response

Weiwei Jiang, Guang‐Hui Jin, Fangfang Cai, Xiao Chen, Nini Cao, Xiangyu Zhang, Jia Liu, Fei Chen, Feng Wang, Wei Dong, Hongqin Zhuang, Zichun Hua

Experimental & Molecular Medicine

DOI

2023

Data from Loss of MLL Induces Epigenetic Dysregulation of Rasgrf1 to Attenuate Kras-Driven Lung Tumorigenesis

Ling-Yu Zhu, Jun-Bo Yuan, Li Zhang, Chun-Xiao He, Xiao Lin, Bin Xu, Guang‐Hui Jin

DOI

2022

Loss of MLL Induces Epigenetic Dysregulation of Rasgrf1 to Attenuate Kras-Driven Lung Tumorigenesis

Ling-Yu Zhu, Jun-Bo Yuan, Li Zhang, Chun-Xiao He, Xiao Lin, Bin Xu, Guang‐Hui Jin

Cancer Research

DOI

2020

MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response

Huan Qiu, Bangming Jin, Zhanfeng Wang, Bin Xu, Qi‐Fan Zheng, Li Zhang, Ling-Yu Zhu, Shuang Shi, Jun-Bo Yuan, Xiao Lin, Shu-Bin Gao, Guang‐Hui Jin

Nature Communications

DOI

2019

Abnormal expression of menin predicts the pathogenesis and poor prognosis of adult gliomas

Zhanfeng Wang, Xinyu Hong, Ling-Yu Zhu, Li Zhang, Huan Qiu, Yuanyuan Zhang, Ming-Cheng Yuan, Xingli Zhao, Qi‐Fan Zheng, Guang‐Hui Jin

Cancer Gene Therapy

DOI

2019

Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response

Weiwei Jiang, Guang‐Hui Jin, Fangfang Cai, Xiao Chen, Nini Cao, Xiangyu Zhang, Jia Liu, Fei Chen, Feng Wang, Wei Dong, Hongqin Zhuang, Zichun Hua

Experimental & Molecular Medicine

DOI

2018

Epigenetic alterations contribute to promoter activity of imprinting gene IGF2

Qi‐Fan Zheng, Bin Xu, Huimin Wang, Lihong Ding, Jinyang Liu, Ling-Yu Zhu, Huan Qiu, Li Zhang, Guang-Yi Ni, Jing Ye, Shu-Bin Gao, Guang‐Hui Jin

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

DOI

2017

Reprogramming of histone methylation controls the differentiation of monocytes into macrophages

Qi‐Fan Zheng, Huimin Wang, Zhanfeng Wang, Jinyang Liu, Qi Zhang, Li Zhang, Yuan‐Hua Lu, Han You, Guang‐Hui Jin

FEBS Journal

DOI

2017

Enhancing chemotherapy sensitivity by targeting PcG via the ATM/p53 pathway.

Shu-Bin Gao, Kang‐Li Li, Huan Qiu, Ling-Yu Zhu, Chang-Bao Pan, Yue Zhao, Shuhua Wei, Shi Shu, Guang‐Hui Jin, Lixiang Xue

PubMed

2016

Male Men1 heterozygous mice exhibit fasting hyperglycemia in the early stage of MEN1

Zhong‐Xiuzi Gao, Li Zhang, Wenting Xie, Siqi Wang, Xiaorui Bao, Yuli Guo, Houjian Zhang, Qingzhong Hu, Yi Chen, Zeen Wang, Maoqiang Xue, Guang‐Hui Jin

Journal of Endocrinology

DOI

2015

An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis

Smita S. Matkar, Paras Sharma, Shu-Bin Gao, Buddha Gurung, Bryson W. Katona, Jennifer Liao, Abdul Bari Muhammad, Xiang-Cheng Kong, Lei Wang, Guang‐Hui Jin, Chi Van Dang, Xianxin Hua

Cancer Cell

DOI

2015

Genetic alteration and misexpression of Polycomb group genes in hepatocellular carcinoma.

Shu-Bin Gao, Shilong Sun, Qilin Zheng, Li Zhang, Yuequan Zhu, Guang‐Hui Jin, Lixiang Xue

PubMed

2014

EZH2 Represses Target Genes through H3K27-Dependent and H3K27-Independent Mechanisms in Hepatocellular Carcinoma

Shu-Bin Gao, Qi‐Fan Zheng, Bin Xu, Chang-Bao Pan, Kang‐Li Li, Yue Zhao, Qilin Zheng, Xiao Lin, Lixiang Xue, Guang‐Hui Jin

Molecular Cancer Research

DOI

2014

The functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma

Shu-Bin Gao, Bin Xu, Lihong Ding, Qilin Zheng, Li Zhang, Qi‐Fan Zheng, Shan-Hua Li, Zi-Jie Feng, Jie Wei, Zhenyu Yin, Xianxin Hua, Guang‐Hui Jin

Journal of Hepatology

DOI

2013

Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription

Bin Xu, Shan-Hua Li, Rong Quan Zheng, Shu-Bin Gao, Lihong Ding, Zhenyu Yin, Xiao Lin, Zi-Jie Feng, Sheng Zhang, Xiaomin Wang, Guang‐Hui Jin

Proceedings of the National Academy of Sciences

DOI

2013

Menin Epigenetically Represses Hedgehog Signaling in MEN1 Tumor Syndrome

Buddha Gurung, Zijie Feng, Daniel V. Iwamoto, Austin T. Thiel, Guang‐Hui Jin, Chen-Min Fan, Jessica M.Y. Ng, Tom Curran, Xianxin Hua

Cancer Research

DOI

2012

Interplay between Menin and K-Ras in Regulating Lung Adenocarcinoma

Yuan Wu, Zi-Jie Feng, Shu-Bin Gao, Smita S. Matkar, Bin Xu, Hongbin Duan, Xiao Lin, Shan-Hua Li, Xianxin Hua, Guang‐Hui Jin

Journal of Biological Chemistry

DOI

2011

Tumor Suppressor Menin Represses Paired Box Gene 2 Expression via Wilms Tumor Suppressor Protein-Polycomb Group Complex

Bin Xu, Dequan Zeng, Yuan Wu, Rong Quan Zheng, Le Gu, Xiao Lin, Xianxin Hua, Guang‐Hui Jin

Journal of Biological Chemistry

DOI

2010

Menin represses malignant phenotypes of melanoma through regulating multiple pathways

Shu-Bin Gao, Zi-Jie Feng, Bin Xu, Yan Chen, Honghua Zheng, Ping Yin, Xianxin Hua, Guang‐Hui Jin

Journal of Cellular and Molecular Medicine

DOI

2008

Menin regulates endocrine diseases by controlling histone modification and gene transcription

Shaozhi Gao, Xianxin Hua, Guang‐Hui Jin

Annales d Endocrinologie

DOI

会议论文

2010

Menin associates with histone h3 lysine27 trimethylation and is essential for target gene transcription

Guanghui Jin, Bin Xu

《中国生物化学与分子生物学会第十届会员代表大会暨全国学术会议摘要集》

金光辉

精选作品

期刊论文

The tumor suppressor menin is a key scaffold mediator for homologous recombination repair

Myeloid loss of scaffolding protein menin promotes liver fibrosis via H3K36me3 reprogramming

Menin maintains lysosomal and mitochondrial homeostasis through epigenetic mechanisms in lung cancer

Menin orchestrates macrophage reprogramming to maintain the pulmonary immune homeostasis

Author Correction: Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response

Data from Loss of MLL Induces Epigenetic Dysregulation of Rasgrf1 to Attenuate Kras-Driven Lung Tumorigenesis

Loss of MLL Induces Epigenetic Dysregulation of Rasgrf1 to Attenuate Kras-Driven Lung Tumorigenesis

MEN1 deficiency leads to neuroendocrine differentiation of lung cancer and disrupts the DNA damage response

Abnormal expression of menin predicts the pathogenesis and poor prognosis of adult gliomas

Extracellular signal-regulated kinase 5 increases radioresistance of lung cancer cells by enhancing the DNA damage response

Epigenetic alterations contribute to promoter activity of imprinting gene IGF2

Reprogramming of histone methylation controls the differentiation of monocytes into macrophages

Enhancing chemotherapy sensitivity by targeting PcG via the ATM/p53 pathway.

Male Men1 heterozygous mice exhibit fasting hyperglycemia in the early stage of MEN1

An Epigenetic Pathway Regulates Sensitivity of Breast Cancer Cells to HER2 Inhibition via FOXO/c-Myc Axis

Genetic alteration and misexpression of Polycomb group genes in hepatocellular carcinoma.

EZH2 Represses Target Genes through H3K27-Dependent and H3K27-Independent Mechanisms in Hepatocellular Carcinoma

The functional and mechanistic relatedness of EZH2 and menin in hepatocellular carcinoma

Menin promotes hepatocellular carcinogenesis and epigenetically up-regulates Yap1 transcription

Menin Epigenetically Represses Hedgehog Signaling in MEN1 Tumor Syndrome

Interplay between Menin and K-Ras in Regulating Lung Adenocarcinoma

Tumor Suppressor Menin Represses Paired Box Gene 2 Expression via Wilms Tumor Suppressor Protein-Polycomb Group Complex

Menin represses malignant phenotypes of melanoma through regulating multiple pathways

Menin regulates endocrine diseases by controlling histone modification and gene transcription

会议论文

Menin associates with histone h3 lysine27 trimethylation and is essential for target gene transcription

研究方向