邓恋｜复旦大学｜学者主页

2026

Genomic insights into the admixture history and adaptive evolution of the Zhuang people

Chuangxue Mao, Songyang Li, Yan Lu, Qi Liu, Lian Deng, Gao Y, Xiaoxi Zhang, Hao Chen, Yajun Yang, Shuhua Xu

Molecular Biology and Evolution

DOI

2026

Gene-culture coevolution shapes olfactory receptor gene diversity in Orang Asli populations

Yueyang Ma, Boon‐Peng Hoh, Shuhua Xu, Lian Deng

Cell Reports

DOI

2025

Expression quantitative trait loci (eQTL): from population genetics to precision medicine.

Zhi-Qi Wong, Lian Deng, Alvin Cengnata, Thuhairah Abdul Rahman, A. Ismail, Renee Lay Hong Lim, Shu-Hua Xu, B. Hoh

Journal of genetics and genomics = Yi chuan xue bao

DOI

2025

Multi-centric origins and gene flow shape the diversity of β-thalassemia mutations in Southern East Asia

Qian-Qian Zhang, Jialong Li, Haoyang Huang, Xuan Shang, Yu-Hua Ye, Wei Zhang, Peng Lin, Yi Gong, B. Hoh, Qingming Luo, Ti-Zhen Yan, Xinghua Pan, M. Stoneking, Shu-Hua Xu, Xiangmin Xu, Lian Deng

Nature Communications

DOI

2025

Dissecting the Genetic Affinity Between the Orang Asli and Southeast Asian Native Populations

Cengnata Alvin, Tham Pei-Mei, Foo Hoi-Thung, Chan Calista Zhe-Qing, Xin Lee, R. Lim, Lian Deng, Shu-Hua Xu, H. Boon-Peng

Annals of Human Genetics

DOI

2024

Asian-European differentiation of schizophrenia-associated genes driven by admixture and natural selection

Si-Han Chen, D. Tang, Lian Deng, Shu-Hua Xu

iScience

DOI

2024

A genotype imputation reference panel specific for native Southeast Asian populations

Alvin Cengnata, Lian Deng, Wai-Sum Yap, Lay-Hong Renee Lim, C. Leong, Shu-Hua Xu, B. Hoh

npj Genomic Medicine

DOI

2023

A pangenome reference of 36 Chinese populations

Yang Gao, Xiao-Fei Yang, Hao Chen, Xinjiang Tan, Zhao-Qing Yang, Lian Deng, Baoxun Wang, Shuang Kong, Song Li, Yuhang Cui, Chang Lei, Yimin Wang, Yuwen Pan, Sen Ma, Hao Sun, Xiao-Han Zhao, Yingbing Shi, Zi-Yi Yang, Dongdong Wu, Shaoyuan Wu, Xing-Ming Zhao, Binyin Shi, Li Jin, Z. Hu, Chuang-Xue Mao, Shao-Hua Fan, Qiang Gao, Jun-Cheng Dai, Feng-Xiao Bu, Guang-Lin He, Yang Wu, Hui-Jun Yuan, Jin-Chen Li, Chao Chen, Jian Yang, Chao-Chun Wei, Xin Jin, Xia Shen, Yan Lu, Jiayou Chu, Kai Ye, Shu-Hua Xu

Nature

DOI

2022

A protocol for applying a population-specific reference genome assembly to population genetics and medical studies

Lian Deng, B. Xie, Yimin Wang, Xiaoxi Zhang, Shu-Hua Xu

STAR Protocols

DOI

2022

The Peopling and Migration History of the Natives in Peninsular Malaysia and Borneo: A Glimpse on the Studies Over the Past 100 years

B. Hoh, Lian Deng, Shu-Hua Xu

Frontiers in Genetics

DOI

2022

Genetic adaptation of skin pigmentation in highland Tibetans

Zhaohui Yang, Caijuan Bai, Youwei Pu, Qing-Hong Kong, Yongbo Guo, X. Liu, Qi Zhao, Zhichao Qiu, Wang-Shan Zheng, Yao-Xi He, Yi-Han Lin, Lian Deng, Chao Zhang, Shu-Hua Xu, Yi Peng, Kun Xiang, Xiao-Ming Zhang, Chaoying Cui, Yongyue Pan, Jingxue Xin, Yong Wang, Shi-Ming Liu, Liangbang Wang, Heng-Liang Guo, Zhenzhen Feng, Shao-Bo Wang, Hong Shi, Bing-Hua Jiang, Tian-Yi Wu, Xuebin Qi, Bing Su

Proceedings of the National Academy of Sciences of the United States of America

DOI

2021

Population Genomics of High-Altitude Adaptation

Lian Deng, Shu-Hua Xu

DOI

2021

Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia

Lian Deng, Yuwen Pan, Yi-Nan Wang, Hao Chen, Kai Yuan, Sihan Chen, Dong-Sheng Lu, Yan Lu, S. S. Mokhtar, T. Rahman, B. Hoh, Shu-Hua Xu

Molecular biology and evolution

DOI

2021

Refining models of archaic admixture in Eurasia with ArchaicSeeker 2.0

Kai Yuan, Xu-Min Ni, Chang Liu, Yuwen Pan, Lian Deng, Rui Zhang, Yang Gao, Xue-Ling Ge, Jiaojiao Liu, Xi-Xian Ma, Haiyi Lou, Tao-Yang Wu, Shu-Hua Xu

Nature Communications

DOI

2020

Shared Signature of Recent Positive Selection on the TSBP1–BTNL2–HLA-DRA Genes in Five Native Populations from North Borneo

B. Hoh, Xiaoxi Zhang, Lian Deng, Kai Yuan, C. Yew, Woei-Yuh Saw, M. Hoque, F. Aghakhanian, M. Phipps, Yik Y. Teo, V. Subbiah, Shu-Hua Xu

Genome Biology and Evolution

DOI

2020

De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation

Ouzhuluobu, Yaoxi He, Haiyi Lou, Chaoying Cui, Lian Deng, Yang Gao, Wangshan Zheng, Yongbo Guo, Xiaoji Wang, Zhilin Ning, Jun Li, Bin Li, Caijuan Bai, Baimakangzhuo, Gonggalanzi, Dejiquzong, Bianba, Duojizhuoma, Shiming Liu, Tianyi Wu, Shuhua Xu, Xuebin Qi, Bing Su

National Science Review

2019

Analysis of five deep-sequenced trio-genomes of the Peninsular Malaysia Orang Asli and North Borneo populations

Lian Deng, Haiyi Lou, Xiaoxi Zhang, B. Thiruvahindrapuram, Dong-Sheng Lu, C. Marshall, Chang Liu, B. Xie, Wan-Xing Xu, Lai-Ping Wong, C. Yew, A. Farhang, R. Ong, M. Hoque, A. Thuhairah, Bhak Jong, M. Phipps, S. Scherer, Yik Y. Teo, S. V. Kumar, B. Hoh, Shu-Hua Xu

BMC Genomics

DOI

2019

Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders

Lian Deng, Chao Zhang, Kai Yuan, Yang Gao, Yuwen Pan, Xue-Ling Ge, Yao-Xi He, Yuan Yuan, Yan Lu, Xiaoxi Zhang, Hao Chen, Haiyi Lou, Xiaoji Wang, Dong-Sheng Lu, Jiaojiao Liu, L. Tian, Qidi Feng, Asifullah Khan, Ya-Jun Yang, Zi-Bing Jin, Jian Yang, F. Lu, Jia Qu, L. Kang, B. Su, Shu-Hua Xu

National Science Review

DOI

2018

Genomic structure of the native inhabitants of Peninsular Malaysia and North Borneo suggests complex human population history in Southeast Asia

C. Yew, Dong-Sheng Lu, Lian Deng, Lai-Ping Wong, R. Ong, Yan Lu, Xiaoji Wang, Y. Yunus, F. Aghakhanian, S. S. Mokhtar, M. Hoque, C. L. Voo, T. A. Abdul Rahman, J. Bhak, M. Phipps, Shu-Hua Xu, Yik Y. Teo, S. V. Kumar, B. Hoh

Human Genetics

DOI

2017

Adaptation of human skin color in various populations

Lian Deng, Shu-Hua Xu

Hereditas

DOI

2017

Differentiated demographic histories and local adaptations between Sherpas and Tibetans

Chao Zhang, Yan Lu, Qidi Feng, Xiaoji Wang, Haiyi Lou, Jiaojiao Liu, Zhilin Ning, Kai Yuan, Yuchen Wang, Ying Zhou, Lian Deng, Li-Jun Liu, Ya-Jun Yang, Shi-Lin Li, Lifeng Ma, Zhiying Zhang, Li Jin, B. Su, L. Kang, Shu-Hua Xu

Genome Biology

DOI

2017

PGG.Population: a database for understanding the genomic diversity and genetic ancestry of human populations

Chao Zhang, Yang Gao, Jiaojiao Liu, Zhe Xue, Yan Lu, Lian Deng, L. Tian, Qidi Feng, Shu-Hua Xu

Nucleic Acids Res.

DOI

2016

Ancestral Origins and Genetic History of Tibetan Highlanders.

Dong-Sheng Lu, Haiyi Lou, Kai Yuan, Xiaoji Wang, Yuchen Wang, Chao Zhang, Yan Lu, Xiong Yang, Lian Deng, Ying Zhou, Qidi Feng, Ya Hu, Qiliang Ding, Ya-Jun Yang, Shi-Lin Li, Li Jin, Ya-Qun Guan, B. Su, L. Kang, Shu-Hua Xu

American Journal of Human Genetics

DOI

2016

Ancestry variation and footprints of natural selection along the genome in Latin American populations

Lian Deng, A. Ruiz-Linares, Shu-Hua Xu, Sijia Wang

Scientific Reports

DOI

2015

Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia

Xuan-Yao Liu, Y. Yunus, Dong-Sheng Lu, F. Aghakhanian, Woei-Yuh Saw, Lian Deng, Mohammad Ali, Xu Wang, Fadzilah Ghazali, T. A. Abdul Rahman, Shahrul Azlin Shaari, M. Z. Salleh, M. Phipps, R. Ong, Shu-Hua Xu, Yik Y. Teo, B. Hoh

Human Genetics

DOI

2015

Erratum to: Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia

Xuan-Yao Liu, Y. Yunus, Dong-Sheng Lu, F. Aghakhanian, Woei-Yuh Saw, Lian Deng, Mohammad Ali, Xu Wang, Fadzilah Mohd Nor, T. A. Abdul Rahman, Shahrul Azlin Shaari, M. Z. Salleh, M. Phipps, R. Ong, Shu-Hua Xu, Yik Y. Teo, B. Hoh

Human Genetics

DOI

2015

Dissecting the genetic structure and admixture of four geographical Malay populations

Lian Deng, B. Hoh, Dong-Sheng Lu, Woei-Yuh Saw, Rick Twee-Hee Ong, A. Kasturiratne, H. D. de Silva, B. Zilfalil, N. Kato, A. R. Wickremasinghe, Yik Y. Teo, Shu-Hua Xu

Scientific Reports

DOI

2015

Fine-scale population structure of Malays in Peninsular Malaysia and Singapore and implications for association studies

B. Hoh, Lian Deng, Mat Jusoh Julia-Ashazila, Z. Zuraihan, Ma’amor Nur-Hasnah, Ab Rajab Nur‐Shafawati, Wan Isa Hatin, I. Endom, B. Zilfalil, Yusoff Khalid, Shu-Hua Xu

Human Genomics

DOI

2014

The population genomic landscape of human genetic structure, admixture history and local adaptation in Peninsular Malaysia

Lian Deng, B. Hoh, Dong-Sheng Lu, Rui-Qing Fu, M. Phipps, Shi-Lin Li, Ab Rajab Nur‐Shafawati, Wan Isa Hatin, E. Ismail, S. S. Mokhtar, Li-Rong Jin, B. Zilfalil, C. Marshall, S. Scherer, F. Al-Mulla, Shu-Hua Xu

Human Genetics

DOI

2013

Genome-Wide Landscapes of Human Local Adaptation in Asia

Wei Qian, Lian Deng, Dong-Sheng Lu, Shu-Hua Xu

PLoS ONE

DOI

邓恋

精选作品

期刊论文

Genomic insights into the admixture history and adaptive evolution of the Zhuang people

Gene-culture coevolution shapes olfactory receptor gene diversity in Orang Asli populations

Expression quantitative trait loci (eQTL): from population genetics to precision medicine.

Multi-centric origins and gene flow shape the diversity of β-thalassemia mutations in Southern East Asia

Dissecting the Genetic Affinity Between the Orang Asli and Southeast Asian Native Populations

Asian-European differentiation of schizophrenia-associated genes driven by admixture and natural selection

A genotype imputation reference panel specific for native Southeast Asian populations

A pangenome reference of 36 Chinese populations

A protocol for applying a population-specific reference genome assembly to population genetics and medical studies

The Peopling and Migration History of the Natives in Peninsular Malaysia and Borneo: A Glimpse on the Studies Over the Past 100 years

Genetic adaptation of skin pigmentation in highland Tibetans

Population Genomics of High-Altitude Adaptation

Genetic Connections and Convergent Evolution of Tropical Indigenous Peoples in Asia

Refining models of archaic admixture in Eurasia with ArchaicSeeker 2.0

Shared Signature of Recent Positive Selection on the TSBP1–BTNL2–HLA-DRA Genes in Five Native Populations from North Borneo

De novo assembly of a Tibetan genome and identification of novel structural variants associated with high-altitude adaptation

Analysis of five deep-sequenced trio-genomes of the Peninsular Malaysia Orang Asli and North Borneo populations

Prioritizing natural-selection signals from the deep-sequencing genomic data suggests multi-variant adaptation in Tibetan highlanders

Genomic structure of the native inhabitants of Peninsular Malaysia and North Borneo suggests complex human population history in Southeast Asia

Adaptation of human skin color in various populations

Differentiated demographic histories and local adaptations between Sherpas and Tibetans

PGG.Population: a database for understanding the genomic diversity and genetic ancestry of human populations

Ancestral Origins and Genetic History of Tibetan Highlanders.

Ancestry variation and footprints of natural selection along the genome in Latin American populations

Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia

Erratum to: Differential positive selection of malaria resistance genes in three indigenous populations of Peninsular Malaysia

Dissecting the genetic structure and admixture of four geographical Malay populations

Fine-scale population structure of Malays in Peninsular Malaysia and Singapore and implications for association studies

The population genomic landscape of human genetic structure, admixture history and local adaptation in Peninsular Malaysia

Genome-Wide Landscapes of Human Local Adaptation in Asia

预印本

Adaptive introgression in Tibetans spans focal and distributed architectures

研究方向