王晓飞｜郑州大学｜学者主页

期刊论文

2025

PXR-CYP3A4轴通过触发内质网应激介导利托那韦肝毒性的机制研究

王晓飞，熊在欢，常琦，余怡杭，王沛，张莉蓉

《药学学报》

2025

METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA

Jingya Wang, Jingya Wang, Yihang Yu, Zaihuan Xiong, Pei Wang, Pei Wang, Zijing Wang, Zijing Wang, Anqi Du, Shengna Han, Xiaofei Wang, Lirong Zhang

Biochemical Pharmacology

DOI

2025

Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity

Xiaofei Wang, Zijing Wang, Jingya Wang, Yihang Yu, Yiting Wang, Zaihuan Xiong, Shengna Han, Xiao‐bo Zhong, Pei Wang, Lirong Zhang

Molecular Pharmacology

DOI

2024

The long noncoding RNA HNF1A-AS1 with dual functions in the regulation of cytochrome P450 3A4

Yiting Wang, Pei Wang, Qi Wang, Shitong Chen, Xiaofei Wang, Xiao‐bo Zhong, Wanglai Hu, Rick Francis Thorne, Shengna Han, Mian Wu, Lirong Zhang

Biochemical Pharmacology

DOI

2023

HNF4A-AS1 Alleviates Ritonavir-induced Liver Injury via HNRNPC-mediated HNF4A Degradation

Xiaofei Wang, Jingya Wang, Pei Wang, Yihang Yu, Yiting Wang, Mengyao Yan, Shengna Han, Lirong Zhang

Journal of Pharmacology and Experimental Therapeutics

DOI

2022

HNF4A-AS1负调控HNF4A/PXR/CYP3A4通路参与利托那韦致肝损伤的作用及机制

王晓飞

《郑州大学》

2022

Long Noncoding RNAs Hepatocyte Nuclear Factor 4A Antisense RNA 1 and Hepatocyte Nuclear Factor 1A Antisense RNA 1 are Involved in Ritonavir‐induced Cytotoxicity in Hepatoma Cells

Xiaofei Wang, Yihang Yu, Pei Wang, Kun Yang, Mengyao Yan, Yiting Wang, Liang Yan, Xiao‐bo Zhong, Lirong Zhang

The FASEB Journal

DOI

2021

Long Noncoding RNAs Hepatocyte Nuclear Factor 4A Antisense RNA 1 and Hepatocyte Nuclear Factor 1A Antisense RNA 1 Are Involved in Ritonavir-Induced Cytotoxicity in Hepatoma Cells

Xiaofei Wang, Yihang Yu, Pei Wang, Kun Yang, Yiting Wang, Yan Liang, Xiao‐bo Zhong, Lirong Zhang

Drug Metabolism and Disposition

DOI

2021

The Long Noncoding RNA Hepatocyte Nuclear Factor 4α Antisense RNA 1 Negatively Regulates Cytochrome P450 Enzymes in Huh7 Cells via Histone Modifications

Pei Wang, Shitong Chen, Yiting Wang, Xiaofei Wang, Yan Liang, Kun Yang, Xiao‐bo Zhong, Shengna Han, Lirong Zhang

Drug Metabolism and Disposition

DOI

2016

河南汉族CYP2C19基因多态性对氯吡格雷药物代谢动力学的影响

申明惠，王晓飞，刘敏，杨卫红，黄晨征，张胜军，张莉蓉

《郑州大学学报(医学版)》

2013

人肝脏组织CYP3A4酶活性的高效液相色谱法测定

张海朋，赵杰，张莉蓉，王晓飞，薛文华

《郑州大学学报(医学版)》

2013

Hsa-miR-660负调控人类肝脏组织中药物代谢酶CYP3A4的表达

张艺婷，王晓飞，魏之昀，陈铭杰，邢清和

《复旦学报(医学版)》

会议论文

2024

N 6 -腺酸甲基化修饰调控肝脏药物代谢个体差异的新进展

仇艳娇，侯晓阳，杜安琪，王晓飞，张莉蓉，王沛

《2024医药前沿—第九届表观遗传药物研发与交叉学科学术大会》

DOI

2013

UGT1A1和ABCB1基因多态性与伊立替康化疗不良反应的关系

张睿喆，闫良，刘晓嘉，王晓飞，宋敏，刘会范，张莉蓉

《2013医学前沿论坛暨第十三届全国肿瘤药理与化疗学术会议》

2012

CYP3A41G和CYP3A53基因多态性对硝苯地平在健康人体内药动学的影响

王晓飞，张莉蓉

《2012年中美临床和转化医学国际论坛心脑血管病分会论坛（延吉）暨第十二届全国心血管药理学术会议和中俄药理国际研讨会论文集》

王晓飞

精选作品

期刊论文

PXR-CYP3A4轴通过触发内质网应激介导利托那韦肝毒性的机制研究

METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA

Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity

The long noncoding RNA HNF1A-AS1 with dual functions in the regulation of cytochrome P450 3A4

HNF4A-AS1 Alleviates Ritonavir-induced Liver Injury via HNRNPC-mediated HNF4A Degradation

HNF4A-AS1负调控HNF4A/PXR/CYP3A4通路参与利托那韦致肝损伤的作用及机制

Long Noncoding RNAs Hepatocyte Nuclear Factor 4A Antisense RNA 1 and Hepatocyte Nuclear Factor 1A Antisense RNA 1 are Involved in Ritonavir‐induced Cytotoxicity in Hepatoma Cells

Long Noncoding RNAs Hepatocyte Nuclear Factor 4A Antisense RNA 1 and Hepatocyte Nuclear Factor 1A Antisense RNA 1 Are Involved in Ritonavir-Induced Cytotoxicity in Hepatoma Cells

The Long Noncoding RNA Hepatocyte Nuclear Factor 4α Antisense RNA 1 Negatively Regulates Cytochrome P450 Enzymes in Huh7 Cells via Histone Modifications

河南汉族CYP2C19基因多态性对氯吡格雷药物代谢动力学的影响

人肝脏组织CYP3A4酶活性的高效液相色谱法测定

Hsa-miR-660负调控人类肝脏组织中药物代谢酶CYP3A4的表达

会议论文

N 6 -腺酸甲基化修饰调控肝脏药物代谢个体差异的新进展

UGT1A1和ABCB1基因多态性与伊立替康化疗不良反应的关系

CYP3A41G和CYP3A53基因多态性对硝苯地平在健康人体内药动学的影响

研究方向

精选作品

期刊论文

PXR-CYP3A4轴通过触发内质网应激介导利托那韦肝毒性的机制研究

METTL3 regulates rifampicin-induced CYP3A4 expression by activating PXR translation and nuclear import and stabilizing CYP3A4 mRNA

Role of HNF4A-AS1/HNRNPC-mediated HNF4A ubiquitination protection against ritonavir-induced hepatotoxicity

The long noncoding RNA HNF1A-AS1 with dual functions in the regulation of cytochrome P450 3A4

HNF4A-AS1 Alleviates Ritonavir-induced Liver Injury via HNRNPC-mediated HNF4A Degradation

HNF4A-AS1负调控HNF4A/PXR/CYP3A4通路参与利托那韦致肝损伤的作用及机制

Long Noncoding RNAs Hepatocyte Nuclear Factor 4A Antisense RNA 1 and Hepatocyte Nuclear Factor 1A Antisense RNA 1 are Involved in Ritonavir‐induced Cytotoxicity in Hepatoma Cells

Long Noncoding RNAs Hepatocyte Nuclear Factor 4A Antisense RNA 1 and Hepatocyte Nuclear Factor 1A Antisense RNA 1 Are Involved in Ritonavir-Induced Cytotoxicity in Hepatoma Cells

The Long Noncoding RNA Hepatocyte Nuclear Factor 4α Antisense RNA 1 Negatively Regulates Cytochrome P450 Enzymes in Huh7 Cells via Histone Modifications

河南汉族CYP2C19基因多态性对氯吡格雷药物代谢动力学的影响

人肝脏组织CYP3A4酶活性的高效液相色谱法测定

Hsa-miR-660负调控人类肝脏组织中药物代谢酶CYP3A4的表达

会议论文

N 6 -腺酸甲基化修饰调控肝脏药物代谢个体差异的新进展

UGT1A1和ABCB1基因多态性与伊立替康化疗不良反应的关系

CYP3A4*1G和CYP3A5*3基因多态性对硝苯地平在健康人体内药动学的影响

研究方向

CYP3A41G和CYP3A53基因多态性对硝苯地平在健康人体内药动学的影响