刘磊｜哈尔滨医科大学｜学者主页

2026

VIPR2作为食管腺癌免疫浸润及预后生物标志物的生物信息学分析

赵珂，刘磊，王桂阁，张家齐，杨丽冰，郭超，黄诚，陈野野，李单青

《肿瘤防治研究》

2026

FUNDC1-dependent mitophagy determines axon regeneration capacity

Wenlei Li, Yujiao Liu, Rui-Xuan Liu, Yuyuan Fan, Jinming Liu, Yingjie Guo, Zeping Hu, Lei Liu, Quan Chen, Bing Zhou

Autophagy

DOI

2026

GRIP-Lung: Generative Model of Response to Drug-Induced Perturbation in Lung Cancer

Zhijin Fu, Yanjiao Li, Zhenshun Du, D. X. Zhang, Lei Liu, Qing Jin, Xiujie Chen, Hongbo Xie

International Journal of Molecular Sciences

DOI

2025

HSF4基因在肝细胞癌中表达的生物信息学分析及体外细胞功能学实验验证

梁伦慧，陶顺华，刘磊，黄军，朱湘南

《江西医药》

2025

基于网络药理学和生物信息分析法研究二甲双胍对血管性痴呆的神经保护作用

马宇莘，冯禧轩，刘磊，冯天保，殷秀梅，车晓宁，王璐，刘晓琴

《延安大学学报(医学科学版)》

DOI

2025

Mechanisms of organotropism in breast cancer and predicting metastasis to distant organs using deep learning

Meizhu Xiao, Zhijin Fu, Yanjiao Li, Min Zhang, Denan Zhang, Lei Liu, Qing Jin, Xiujie Chen, Hongbo Xie

Discover Oncology

DOI

2025

Integrating Hypoxia Signatures from scRNA-seq and Bulk Transcriptomes for Prognosis Prediction and Precision Therapy in Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma

Kexin Yu, S Zhang, Jiali Shen, Meini Yu, Yangguang Su, Ying Wang, Kun Zhou, Lei Liu, Xiujie Chen

International Journal of Molecular Sciences

DOI

2024

Identifying a survival-associated cell type based on multi-level transcriptome analysis in idiopathic pulmonary fibrosis

Fei Xu, Yun Tong, Wenjun Yang, Yiyang Cai, Meini Yu, Lei Liu, Qingkang Meng

Respiratory Research

DOI

2024

Predicting drug synergy using a network propagation inspired machine learning framework

Qing Jin, Xianze Zhang, Diwei Huo, Hongbo Xie, Denan Zhang, Lei Liu, Yashuang Zhao, Xiujie Chen

Briefings in Functional Genomics

DOI

2023

中国蛋白质、核酸与糖类等的合成、修饰、功能与调控领域发展现状和未来挑战

周翔，俞飚，刘磊

《科学观察》，Vol. 18, No. 5

下载原文

2023

Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis

Lei Liu, Yan-Jun Li, Guo Chen, Quan Chen

Journal of Biomedical Sciences

DOI

2023

Integration of FUNDC1-associated mitochondrial protein import and mitochondrial quality control contributes to TDP-43 degradation

Jinfa Ma, Lei Liu, Lu Song, Jianghong Liu, Lingyao Yang, Quan Chen, Jane Y. Wu, Li Zhu

Cell Death and Disease

DOI

2023

Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function

Lin-Bo Chen, Qianping Zhang, Yuan-Yuan Meng, Tian Zhao, Cheng-Long Mu, Chang-Ying Fu, Caijuan Deng, Jianyu Feng, Siling Du, Wei Liu, Guang-Feng Geng, K. Ma, Hong-Cheng Cheng, Qiang-Qiang Liu, Qian Luo, Jiao-Jiao Zhang, Zhanqiang Du, Lin Cao, Hui Wang, Yong Liu, Jianping Lin, Guo Chen, Lei Liu, S. Lam, Guang-Hou Shui, Yu-Shan Zhu, Quan Chen

EMBO Reports

DOI

2023

Publisher Correction: Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Yingjie Guo, Huan Zhang, Chen-Xi Yan, B. Shen, Yue Zhang, Xiangyang Guo, Sha Sun, Fan Yu, Jiayun Yan, Ronghe Liu, Qianping Zhang, Di Zhang, Haiyang Liu, Yang Liu, Yaoyao Zhang, Wenlei Li, Jiangyu Qin, H. Lv, Zhao-Xia Wang, Yun Yuan, Jie Yang, Y. Zhong, Song Gao, Bing Zhou, Lei Liu, Deling Kong, Xiao-Jiang Hao, Jun-Jie Hu, Quan Chen

Nature Chemical Biology

DOI

2023

Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Nature Chemical Biology

DOI

2023

Network Propagation-based Identification of Oligometastatic Biomarkers in Metastatic Colorectal Cancer

Qing Jin, Ke‐Xin Yu, Xianze Zhang, Diwei Huo, Denan Zhang, Lei Liu, Hongbo Xie, Binhua Liang, Xiujie Chen

Current Bioinformatics

DOI

2022

New Metabolic Alterations and A Predictive Marker Pipecolic Acid in Sera for Esophageal Squamous Cell Carcinoma

Lei Liu, Jia Wu, Minxin Shi, Fengying Wang, Haimin Lu, Jibing Liu, Weiqin Chen, Guanzhen Yu, Dan Liu, Jing Yang, Qin Luo, Yan Ni, Xing Jin, Xiaoxia Jin, Wen-Lian Chen

Genomics,Proteomics & Bioinformatics

2022

LGR4 cooperates with PrPc to endow the stemness of colorectal cancer stem cells contributing to tumorigenesis and liver metastasis.

Qi Cheng, Hao Zheng, Ming Li, Hongyi Wang, Xiao-Xia Guo, Zhibo Zheng, Chuyan Chen, Jinming Liu, Tian-Cheng Zhan, Zhaowei Li, Hao Wu, Jing-Dong Han, Lei Liu, T. Tang, Quan Chen, Lei Du

Cancer Letters

DOI

2022

FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia

Ruxia Liu, Chunling Xu, Wei-Lin Zhang, Yangpo Cao, Jingjing Ye, Bo Li, Shi Jia, Lin Weng, Yingying Liu, Lei Liu, Ming-Fei Zheng

Cell Death and Disease

DOI

2022

FUNDC1 Promotes Mitochondrial Translocation of TDP-43 and Modulates TDP-43 Induced Neurotoxicity

Jinfa Ma, Lei Liu, Lu Song, Jianghong Liu, Lingyao Yang, Quan Chen, Jane Y. Wu, Li Zhu

Social Science Research Network

DOI

2022

Exploring Precise Medication Strategies for OSCC Based on Single-Cell Transcriptome Analysis from a Dynamic Perspective

Qingkang Meng, Feng Wu, Guoqi Li, Fei Xu, Lei Liu, Denan Zhang, Yangxu Lu, Hongbo Xie, Xiujie Chen

Cancers

DOI

2022

Identification of Warning Transition Points from Hepatitis B to Hepatocellular Carcinoma Based on Mutation Accumulation for the Early Diagnosis and Potential Drug Treatment of HBV‐HCC

Fei Xu, Qingkang Meng, Feng Wu, Yakun Wang, Wenjun Yang, Yun Tong, Lei Liu, Xiujie Chen

Oxidative Medicine and Cellular Longevity

DOI

2021

The Emerging Role of FUNDC1-Mediated Mitophagy in Cardiovascular Diseases

Lei Liu, Yimei Li, Quan Chen

Frontiers in Physiology

DOI

2021

Molecular regulation of mitochondrial autophagy and cellular fate

K. Ma, Hao Wu, Lei Liu, Yu-Shan Zhu, Quan Chen

DOI

2021

Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis

Lei Liu, Yan-Jun Li, Jia-Ni Wang, Di Zhang, Hao Wu, Wenhui Li, Huifang Wei, Nan Ta, Yuyuan Fan, Yujiao Liu, Xiaohui Wang, Jun Wang, Xin Pan, Xudong Liao, Yu-Shan Zhu, Quan Chen

EMBO Reports

DOI

2020

Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy

Hao Wu, Huifang Wei, Di Zhang, S. A. Sehgal, De-Jiu Zhang, Xiaohui Wang, Yan Qin, Lei Liu, Quan Chen

Redox Biology

DOI

2020

Mitophagy and Its Contribution to Metabolic and Aging-Associated Disorders

Lei Liu, Xudong Liao, Hao Wu, Yan-Jun Li, Yu-Shan Zhu, Quan Chen

Antioxidants and Redox Signaling

DOI

2020

Computational drug repositioning based on the relationships between substructure–indication

Jingbo Yang, Denan Zhang, Lei Liu, Guoqi Li, Yiyang Cai, Yan Zhang, Hongbo Jin, Xiujie Chen

Briefings in Bioinformatics

DOI

2020

Identification of Early Warning Signals at the Critical Transition Point of Colorectal Cancer Based on Dynamic Network Analysis

Lei Liu, Zhuo Shao, Jiaxuan Lv, Fei Xu, Sibo Ren, Qing Jin, Jingbo Yang, Weifang Ma, Hongbo Xie, Denan Zhang, Xiujie Chen

Frontiers in Bioengineering and Biotechnology

DOI

2019

Mitochondria organize the cellular proteostatic response and promote cellular senescence

Yan-Jun Li, Lei Liu, Yu-Shan Zhu, Quan Chen

Cell Stress

DOI

2019

FUN14 Domain‐Containing 1–Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice

Wenhui Li, Yan-Jun Li, Sami Siraj, Haojie Jin, Yuyuan Fan, Xin-Rong Yang, Xiao-Wu Huang, Xiaohui Wang, Jun Wang, Lei Liu, Lei Du, Quan Chen

Hepatology

DOI

2019

Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome

Hao Wu, You Wang, Wenhui Li, Hui Chen, Lei Du, Dong Liu, Xiaohui Wang, Tao Xu, Lei Liu, Quan Chen

Autophagy

DOI

2018

A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity

Yan-Jun Li, Yanhong Xue, Xiao-Jun Xu, Guopeng Wang, Yi-Qun Liu, Hao Wu, Wenhui Li, Yueying Wang, Zi-Heng Chen, Wei-Lin Zhang, Yu-Shan Zhu, Wei Ji, Tao Xu, Lei Liu, Quan Chen

EMBO Journal

DOI

2018

Predicting hepatocellular carcinoma through cross-talk genes identified by risk pathways

Lei Liu, Lin Pang, Yunfeng Wang, Ming Hu, Zhuo Shao, Diwei Huo, Denan Zhang, Hongbo Xie, Jingbo Yang, Qiuqi Liu, Xiujie Chen

Oncotarget

DOI

2018

Synthetic Lethality-based Identification of Targets for Anticancer Drugs in the Human Signaling Network

Lei Liu, Xiujie Chen, Chunyu Hu, Denan Zhang, Zhuo Shao, Qing Jin, Jingbo Yang, Hongbo Xie, Bo Liu, Mingming Hu, Kehui Ke

Scientific Reports

DOI

2017

MARCH5-FUNDC1 axis fine-tunes hypoxia-induced mitophagy

Zi-Heng Chen, Sami Siraj, Lei Liu, Quan Chen

Autophagy

DOI

2017

Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine‐tune hypoxic mitophagy

Zi-Heng Chen, Lei Liu, Qi Cheng, Yan-Jun Li, Hao Wu, Wei-Lin Zhang, Yueying Wang, S. A. Sehgal, Sami Siraj, Xiaohui Wang, Jun Wang, Yu-Shan Zhu, Quan Chen

EMBO Reports

DOI

2017

Prediction on the risk population of idiosyncratic adverse reactions based on molecular docking with mutant proteins

Hongbo Xie, Diheng Zeng, Xiujie Chen, Diwei Huo, Lei Liu, Denan Zhang, Qing Jin, Kehui Ke, Ming Hu

Oncotarget

DOI

2017

Large-Scale Analysis of Drug Side Effects via Complex Regulatory Modules Composed of microRNAs, Transcription Factors and Gene Sets

Xiaodong Jia, Qing Jin, Xiangqiong Liu, Xiusen Bian, Yunfeng Wang, Lei Liu, Hongzhe Ma, Fujian Tan, Mingliang Gu, Xiujie Chen

Scientific Reports

DOI

2017

Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening andin vitrobiological activities study

Hongbo Xie, Haixia Wen, Denan Zhang, Lei Liu, Bo Liu, Qiuqi Liu, Qing Jin, Kehui Ke, Ming Hu, Xiujie Chen

Oncotarget

DOI

2016

IGSA: Individual Gene Sets Analysis, including Enrichment and Clustering

Lingxiang Wu, Xiujie Chen, Denan Zhang, Wubing Zhang, Lei Liu, Hongzhe Ma, Jingbo Yang, Hongbo Xie, Бо Лю, Qing Jin

PLoS ONE

DOI

2016

Identification of breast cancer recurrence risk factors based on functional pathways in tumor and normal tissues

Xiujie Chen, Lei Liu, Yunfeng Wang, Bo Liu, Diheng Zeng, Qing Jin, Mengjian Li, Denan Zhang, Qiuqi Liu, Hongbo Xie

Oncotarget

DOI

2016

In silico drug repositioning for the treatment of Alzheimer's disease using molecular docking and gene expression data

Hongbo Xie, Haixia Wen, Mingze Qin, Jie Xia, Denan Zhang, Lei Liu, Бо Лю, Qiuqi Liu, Qing Jin, Xiujie Chen

RSC Advances

DOI

2014

Drug repositioning by applying ‘expression profiles’ generated by integrating chemical structure similarity and gene semantic similarity

Fujian Tan, Ruizhi Yang, Xiaoxue Xu, Xiujie Chen, Yunfeng Wang, Hongzhe Ma, Xiangqiong Liu, Xin Wu, Yuelong Chen, Lei Liu, Xiaodong Jia

Molecular BioSystems

DOI

2012

A sensitive method for computing GO-based functional similarities among genes with ‘shallow annotation’

Xiujie Chen, Ruizhi Yang, Jiankai Xu, Hongzhe Ma, Sheng Chen, Xiusen Bian, Lei Liu

Gene

DOI

2010

A sub-pathway-based approach for identifying drug response principal network

Xiujie Chen, Jiankai Xu, Bangqing Huang, Jin Li, Xin Wu, Ling Ma, Xiaodong Jia, Xiusen Bian, Fujian Tan, Lei Liu, Sheng Chen, Xia Li

Bioinformatics

DOI

精选作品

期刊论文

VIPR2作为食管腺癌免疫浸润及预后生物标志物的生物信息学分析

FUNDC1-dependent mitophagy determines axon regeneration capacity

GRIP-Lung: Generative Model of Response to Drug-Induced Perturbation in Lung Cancer

HSF4基因在肝细胞癌中表达的生物信息学分析及体外细胞功能学实验验证

基于网络药理学和生物信息分析法研究二甲双胍对血管性痴呆的神经保护作用

Mechanisms of organotropism in breast cancer and predicting metastasis to distant organs using deep learning

Integrating Hypoxia Signatures from scRNA-seq and Bulk Transcriptomes for Prognosis Prediction and Precision Therapy in Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma

Identifying a survival-associated cell type based on multi-level transcriptome analysis in idiopathic pulmonary fibrosis

Predicting drug synergy using a network propagation inspired machine learning framework

中国蛋白质、核酸与糖类等的合成、修饰、功能与调控领域发展现状和未来挑战

Crosstalk between mitochondrial biogenesis and mitophagy to maintain mitochondrial homeostasis

Integration of FUNDC1-associated mitochondrial protein import and mitochondrial quality control contributes to TDP-43 degradation

Saturated fatty acids increase LPI to reduce FUNDC1 dimerization and stability and mitochondrial function

Publisher Correction: Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Small molecule agonist of mitochondrial fusion repairs mitochondrial dysfunction

Network Propagation-based Identification of Oligometastatic Biomarkers in Metastatic Colorectal Cancer

New Metabolic Alterations and A Predictive Marker Pipecolic Acid in Sera for Esophageal Squamous Cell Carcinoma

LGR4 cooperates with PrPc to endow the stemness of colorectal cancer stem cells contributing to tumorigenesis and liver metastasis.

FUNDC1-mediated mitophagy and HIF1α activation drives pulmonary hypertension during hypoxia

FUNDC1 Promotes Mitochondrial Translocation of TDP-43 and Modulates TDP-43 Induced Neurotoxicity

Exploring Precise Medication Strategies for OSCC Based on Single-Cell Transcriptome Analysis from a Dynamic Perspective

Identification of Warning Transition Points from Hepatitis B to Hepatocellular Carcinoma Based on Mutation Accumulation for the Early Diagnosis and Potential Drug Treatment of HBV‐HCC

The Emerging Role of FUNDC1-Mediated Mitophagy in Cardiovascular Diseases

Molecular regulation of mitochondrial autophagy and cellular fate

Mitophagy receptor FUNDC1 is regulated by PGC‐1α/NRF1 to fine tune mitochondrial homeostasis

Defective mitochondrial ISCs biogenesis switches on IRP1 to fine tune selective mitophagy

Mitophagy and Its Contribution to Metabolic and Aging-Associated Disorders

Computational drug repositioning based on the relationships between substructure–indication

Identification of Early Warning Signals at the Critical Transition Point of Colorectal Cancer Based on Dynamic Network Analysis

Mitochondria organize the cellular proteostatic response and promote cellular senescence

FUN14 Domain‐Containing 1–Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice

Deficiency of mitophagy receptor FUNDC1 impairs mitochondrial quality and aggravates dietary-induced obesity and metabolic syndrome

A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity

Predicting hepatocellular carcinoma through cross-talk genes identified by risk pathways

Synthetic Lethality-based Identification of Targets for Anticancer Drugs in the Human Signaling Network

MARCH5-FUNDC1 axis fine-tunes hypoxia-induced mitophagy

Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine‐tune hypoxic mitophagy

Prediction on the risk population of idiosyncratic adverse reactions based on molecular docking with mutant proteins

Large-Scale Analysis of Drug Side Effects via Complex Regulatory Modules Composed of microRNAs, Transcription Factors and Gene Sets

Designing of dual inhibitors for GSK-3β and CDK5: Virtual screening andin vitrobiological activities study

IGSA: Individual Gene Sets Analysis, including Enrichment and Clustering

Identification of breast cancer recurrence risk factors based on functional pathways in tumor and normal tissues

In silico drug repositioning for the treatment of Alzheimer's disease using molecular docking and gene expression data

Drug repositioning by applying ‘expression profiles’ generated by integrating chemical structure similarity and gene semantic similarity

A sensitive method for computing GO-based functional similarities among genes with ‘shallow annotation’

A sub-pathway-based approach for identifying drug response principal network

研究方向