吴川六｜厦门大学｜学者主页

2026

Disulfide-Directed Multicyclic Peptides for Chimeric Antigen Receptors Targeting Solid Tumors.

Xiaoting Meng, Keke Fu, Ya-Wei Liu, Yuan Liu, Joe Z. Zhang, Xi Kang, Chuan-Liu Wu, Yu-Hsuan Tsai

Journal of the American Chemical Society

DOI

2026

Thiol-Retaining N‑Terminal Cysteine Chemistry for Dual Modification and Bicyclic Peptide Construction

Junjie Liu, Shixiang Duan, Yang Huang, Ming-Yi Jian, Hsuan-Suan Lee, Gaocan Dai, Chuan-Liu Wu, Yi-Lin Wu, Yu-Hsuan Tsai

Journal of the American Chemical Society

DOI

2026

ICOS-Targeted Peptide Imaging Informs Therapeutic Response of STING Agonist in Lung Adenocarcinoma

Shao Duan, Bo-Yu Tan, Yuqiang Mao, Yue Zhang, Hongyue Lou, Xiao-Nan Wei, Chun-Rong Qu, Chao Li, Cheng-Wei Jing, Yifei Xia, Zengping Duan, Zhen Cheng, Chuanliu Wu, Zunyu Xiao

Journal of Nuclear Medicine

DOI

2026

Disulfide-Directed Multicylic Peptides for Targeting and Radionuclide Imaging of HER2 Expressing Tumors.

Jie Zhuang, Xue-Yao Chen, Si-Qi Zhang, Qianqian Lyu, Shihui Fan, Shuo Jiang, Xueting Cheng, Xin Gao, Chao-Ying Xu, Rui Wang, Kuan Hu, Chuan-Liu Wu

Journal of Medicinal Chemistry

DOI

2026

TROP2-targeted NIR-II fluorescence imaging for visualizing surgical margins and metastatic sentinel lymph nodes in breast cancers

Kang-Liang Lou, J. Bai, Hongtan Liu, Lin Lin, Cheng-Xi Li, Yiyang Gao, Sheng Lin, Yifei Pei, Xiao-Long Wei, Yi-Xin Chen, Yi Tang, Hong-Yu Chen, Zhi-yao Li, Rong Guo, Shicong Tang, Chuan-Liu Wu, Guo-Jun Zhang

Proceedings of the National Academy of Sciences of the United States of America

DOI

2026

pH-Controlled Stepwise Cyclization Enables Phage Display of Heterobridged Bicyclic Peptide Libraries

Ming-Jing Ye, Ranfeng Ye, Lin Pan, Junjie Liu, Shuaimin Lu, Chuan-Liu Wu

ACS Chemical Biology

DOI

2025

Biphenyl-dihydrothiazole-cyclized peptide libraries for peptide ligand and drug discovery

Junjie Liu, Xiangnan Sun, Jie Zhuang, Zi-Yan Liu, Chao-Ying Xu, Dalei Wu, Chuan-Liu Wu

Science China Chemistry

DOI

2025

Proline-Mediated Enhancement in Evolvability of Disulfide-Rich Peptides for Discovering Protein Binders.

Hongtan Liu, Lulu Song, Xiaoting Meng, Jinjing Li, Shihui Fan, Huilei Dong, Xiao-Ran Wang, Maolin Li, Hai-Peng Yu, Yu-Hsuan Tsai, Yi-Zhen Yin, Chuan-Liu Wu

Journal of the American Chemical Society

DOI

2025

Shaping Peptide Assemblies Using Multifaceted Cyclic Tectons.

Chenru Wang, Dexin Lu, Jia-Kang Li, Lin-Yuan Chen, Xiao-Bing Zuo, Chuan-Liu Wu, Xian-Kui Wei, Bin-Ju Wang, Yun-Bao Jiang, Tao Jiang

Journal of the American Chemical Society

DOI

2025

Directing the oxidative folding of disulfide-rich peptides for enhanced engineering and applications

Xueting Cheng, Chuan-Liu Wu

Chemical Science

DOI

2025

A Single Bioorthogonal Reaction for Multiplex Cell Surface Protein Labeling

Yang Huang, Cheng-Yang Wu, An-Jing Lu, Jingzhe Wang, Jian Liang, Han Sun, Li-Qing Yang, Shixiang Duan, Andrey A Berezin, Chuan-Liu Wu, Bo Zhang, Yi-Lin Wu, Yu-Hsuan Tsai

Journal of the American Chemical Society

DOI

2025

Directed Evolution of Multicyclic Peptides Using Yeast Display for Sensitive and Selective Fluorescent Analysis of CD28 on the Cell Surface.

Chao-Ying Xu, Xiaoting Meng, P. Chai, Hongtan Liu, Zengping Duan, Yu-Hsuan Tsai, Chuan-Liu Wu

Analytical Chemistry

DOI

2025

Multicyclic Peptides Targeting PD-L1 for Radiotheranostics: From Discovery to Clinical Proof-of-Concept.

Xueting Cheng, Shuo Jiang, Xingtong Peng, Pan Yang, Si-Qi Zhang, Chao-Ying Xu, Xin Gao, Shihui Fan, Hongtan Liu, Jie Zhuang, Xue-Yao Chen, Naixin Liang, Bingni Lin, Qing-Shuang Lu, Meirong Chen, Yibei Xiao, Zhao-Hui Zhu, Rui Wang, Kuan Hu, Chuan-Liu Wu

Journal of the American Chemical Society

DOI

2025

Motif-Directed Oxidative Folding to Design and Discover Multicyclic Peptides for Protein Recognition.

Chuan-Liu Wu

Accounts of Chemical Research

DOI

2025

Specifically targeted antimicrobial cyclic peptide to staphylococcal protein A for the treatment of S. aureus infection

Xiao‐Ling Lei, Yong Li, Xue-Ting Cheng, Jie Zhuang, Fang Zhang, Xiao-Ting Xie, Lin-Fang Tan, Jin-Xuan Fan, Yuan-Di Zhao, Chuan-Liu Wu, Kai Cheng

Chemical Engineering Journal

DOI

2025

Decoupling sequence and structure

Chuan-Liu Wu

Nature Reviews Chemistry

DOI

2024

Recent advances in chemical protein synthesis: method developments and biological applications

Suwei Dong, Ji-Shen Zheng, Yi-Ming Li, Huan Wang, Gong Chen, Yongxiang Chen, Ge-Min Fang, Jun Guo, Chunmao He, Honggang Hu, Xuechen Li, Yan-Mei Li, Zi-Gang Li, Man Pan, Shan Tang, Chang-Lin Tian, Ping Wang, Bian Wu, Chuan-Liu Wu, Jun-Feng Zhao, Lei Liu

Science China Chemistry

DOI

2024

Ribosomal translation of fluorinated non-canonical amino acids for de novo biologically active fluorinated macrocyclic peptides

Jun-Jie Wu, Yu-Chan Wang, Wenfeng Cai, Danyan Chen, Xiangda Peng, Huilei Dong, Jinjing Li, Hongtan Liu, Shuting Shi, Sen Tang, Zhifeng Li, Haiyan Sui, Yan Wang, Chuan-Liu Wu, Youming Zhang, Xinmiao Fu, Yi-Lun Yin

Chemical Science

DOI

2024

Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-XL by engaging a single-residue discrepancy

Fengwei Li, Junjie Liu, Chao Liu, Zi-Yan Liu, Xiangda Peng, Yinyue Huang, Xiaoyu Chen, Xiangnan Sun, Sen Wang, Wei Chen, Dan Xiong, X. Diao, Sheng Wang, Jingjing Zhuang, Chuan-Liu Wu, Dalei Wu

Nature Communications

DOI

2024

Triscysteine disulfide-directing motifs enabling design and discovery of multicyclic peptide binders

Zengping Duan, Chuilian Kong, Shihui Fan, Chuan-Liu Wu

Nature Communications

DOI

2024

Disulfide-Directed Multicyclic Peptides with N-Terminally Extendable α-Helices for Recognition and Activation of G-Protein-Coupled Receptors.

Shihui Fan, Jie Li, Jie Zhuang, Qingtong Zhou, Yiting Mai, Bingni Lin, Ming-Wei Wang, Chuan-Liu Wu

Journal of the American Chemical Society

DOI

2024

Ribosomal Incorporation of Lithocholic Acid into Peptides for the De Novo Discovery Of Peptide-Lithocholic Acid Hybrid Macrocyclic Peptides.

Lulu Song, Hongtan Liu, Maolin Li, Ya-Wen Yang, Huilei Dong, Jinjing Li, Jiaqi Shao, Lixu Zhi, Hao Sun, Zhifeng Li, Haiyan Sui, Youming Zhang, Chuan-Liu Wu, Yi-Zhen Yin

ACS Chemical Biology

DOI

2023

De Novo Discovery of Cysteine Frameworks for Developing Multicyclic Peptide Libraries for Ligand Discovery.

Jinjing Li, Hongtan Liu, Shuling Xiao, Shihui Fan, Xueting Cheng, Chuan-Liu Wu

Journal of the American Chemical Society

DOI

2023

Disulfide-Directed Multicyclic Peptide Libraries for the Discovery of Peptide Ligands and Drugs.

Shuaimin Lu, Shihui Fan, Shuling Xiao, Jinjing Li, Shilong Zhang, Yapei Wu, Chuilian Kong, Jie Zhuang, Hongtan Liu, Yi-Bing Zhao, Chuan-Liu Wu

Journal of the American Chemical Society

DOI

2023

Selection and evolution of disulfide-rich peptides via cellular protein quality control

Xiaoting Meng, Chaoying Xu, Shihui Fan, Dong Meng, Jie Zhuang, Zengping Duan, Yibing Zhao, Chuanliu Wu

Chemical Science

DOI

2023

Deciphering the Synthetic and Refolding Strategy of a Cysteine-Rich Domain in the Tumor Necrosis Factor Receptor (TNF-R) for Racemic Crystallography Analysis and d-Peptide Ligand Discovery

Alexander J. Lander, Yifu Kong, Yi Jin, Chuan-Liu Wu, Louis Y. P. Luk

ACS Bio & Med Chem Au

DOI

2022

Redox-Regulated Conformational Change of Disulfide-Rich Assembling Peptides.

Huilei Dong, Mingshui Wang, Shihui Fan, Chuan-Liu Wu, Chunhui Zhang, Xia Wu, Bin Xue, Yi Cao, Junjie Deng, Dan Yuan, Jun-Feng Shi

Angewandte Chemie

DOI

2022

Structure-guided design of CPPC-paired disulfide-rich peptide libraries for ligand and drug discovery

Yapei Wu, Shihui Fan, Meng Dong, Jinjing Li, Chuilian Kong, Jie Zhuang, Xiaoting Meng, Shuaimin Lu, Yi-Bing Zhao, Chuan-Liu Wu

Chemical Science

DOI

2022

De novo design and directed folding of disulfide-bridged peptide heterodimers

Si-Cong Yao, A. Moyer, Yi-Wu Zheng, Yang Shen, Xiaoting Meng, Chong Yuan, Yi-Bing Zhao, H. Yao, D. Baker, Chuan-Liu Wu

Nature Communications

DOI

2022

Design and Ribosomal Incorporation of Noncanonical Disulfide-Directing Motifs for the Development of Multicyclic Peptide Libraries.

Huilei Dong, Jinjing Li, Hong-Tan Liu, Shuaimin Lu, Jun-Jie Wu, You-Ming Zhang, Yizhen Yin, Yi-Bing Zhao, Chuan-Liu Wu

Journal of the American Chemical Society

DOI

2021

An evolution-inspired strategy to design disulfide-rich peptides tolerant to extensive sequence manipulation

J. Zha, Jinjing Li, Shihui Fan, Zengping Duan, Yi-Bing Zhao, Chuan-Liu Wu

Chemical Science

DOI

2021

Fast and Selective Reaction of 2-Benzylacrylaldehyde with 1,2-Aminothiol for Stable N-Terminal Cysteine Modification and Peptide Cyclization.

Ya-Qi Wu, Cong Li, Shihui Fan, Yi-Bing Zhao, Chuan-Liu Wu

Bioconjugate chemistry

DOI

2020

Directed Disulfide Pairing and Folding of Peptides for the De Novo Development of Multicyclic Peptide Libraries

Shuaimin Lu, Yapei Wu, Jinjing Li, Xiaoting Meng, Chenliang Hu, Yibing Zhao, Chuanliu Wu

Journal of the American Chemical Society

DOI

2020

Condensation of 2-((Alkylthio)(aryl)methylene)malononitrile with 1,2-Aminothiol as a Novel Bioorthogonal Reaction for Site-Specific Protein Modification and Peptide Cyclization

Xiaoli Zheng, Zhuoru Li, Wei Gao, Xiaoting Meng, Xuefei Li, Louis Y. P. Luk, Yibing Zhao, Yu‐Hsuan Tsai, Chuanliu Wu

Journal of the American Chemical Society

DOI

2020

Biocompatible and Rapid Cyclization of Peptides with 2,4-Difluoro-6-hydroxy-1,3,5-benzenetricarbonitrile for the Development of Cyclic Peptide Libraries

Xuejun Zheng, Weidong Liu, Ziyan Liu, Yibing Zhao, Chuanliu Wu

Bioconjugate Chemistry

DOI

2020

Design and Synthesis of Disulfide-Rich Peptides with Orthogonal Disulfide Pairing Motifs

Zirong Huang, Yapei Wu, Huilei Dong, Yibing Zhao, Chuanliu Wu

The Journal of Organic Chemistry

DOI

2019

Interchain doubly-bridged α-helical peptides for the development of protein binders

Yaqi Chen, Jingjing Liang, Tao Li, Ping J. Lin, Yibing Zhao, Chuanliu Wu

Chinese Chemical Letters

DOI

2019

A Doubly-Quenched Fluorescent Probe for Low-Background Detection of Mitochondrial H2O2

Jun Liu, Jingjing Liang, Chuanliu Wu, Yibing Zhao

Analytical Chemistry

DOI

2019

Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation

Yizhen Yin, Qianran Fei, Weidong Liu, Zhuoru Li, Hiroaki Suga, Chuanliu Wu

Angewandte Chemie

DOI

2019

Cover Feature: Ordered and Isomerically Stable Bicyclic Peptide Scaffolds Constrained through Cystine Bridges and Proline Turns (ChemBioChem 12/2019)

Ping J. Lin, Hongwei Yao, Jun Zha, Yibing Zhao, Chuanliu Wu

ChemBioChem

DOI

2019

Stabilizing p‐Dithiobenzyl Urethane Linkers without Rate‐Limiting Self‐Immolation for Traceless Drug Release

Yiwu Zheng, Yang Shen, Xiaoting Meng, Yaqi Wu, Yibing Zhao, Chuanliu Wu

ChemMedChem

DOI

2019

Design and Synthesis of Cross-Link-Dense Peptides by Manipulating Regioselective Bisthioether Cross-Linking and Orthogonal Disulfide Pairing

Huilei Dong, Xiaoting Meng, Xiaoli Zheng, Xueting Cheng, Yiwu Zheng, Yibing Zhao, Chuanliu Wu

The Journal of Organic Chemistry

DOI

2019

Ordered and Isomerically Stable Bicyclic Peptide Scaffolds Constrained through Cystine Bridges and Proline Turns

Ping J. Lin, Hongwei Yao, Jun Zha, Yibing Zhao, Chuanliu Wu

ChemBioChem

DOI

2018

A mini-review and perspective on multicyclic peptide mimics of antibodies

Weidong Liu, Chuanliu Wu

Chinese Chemical Letters

DOI

2018

CXC-Mediated Cellular Uptake of Miniproteins: Forsaking “Arginine Magic”

Xiaoting Meng, Tao Li, Yibing Zhao, Chuanliu Wu

ACS Chemical Biology

DOI

2018

A phage display-based strategy for the de novo creation of disulfide-constrained and isomer-free bicyclic peptide affinity reagents

Mirao Zha, Ping J. Lin, Hongwei Yao, Yibing Zhao, Chuanliu Wu

Chemical Communications

DOI

2017

Artificial disulfide-rich peptide scaffolds with precisely defined disulfide patterns and a minimized number of isomers

Yi-Wu Zheng, Zhuo-Ru Li, Jing Ren, Wei-Dong Liu, Ya-Qi Wu, Yi-Bing Zhao, Chuan-Liu Wu

Chemical Science

DOI

2017

正確に定義されたジスルフィドパターンを用いた人工ジスルフィド豊富なペプチド足場と最小数異性体【Powered by NICT】

Yi-Wu Zheng, Zhuo-Ru Li, Jing Ren, Wei-Dong Liu, Ya-Qi Wu, Yi-Bing Zhao, Chuan-Liu Wu

2017

De novo design of constrained and sequence-independent peptide scaffolds with topologically-formidable disulfide connectivities

Yiwu Zheng, Xiaoting Meng, Yaqi Wu, Yibing Zhao, Chuanliu Wu

Chemical Science

DOI

2017

Biscysteine-Bearing Peptide Probes To Reveal Extracellular Thiol–Disulfide Exchange Reactions Promoting Cellular Uptake

Tao Li, Wei Gao, Jingjing Liang, Mirao Zha, Yaqi Chen, Yibing Zhao, Chuanliu Wu

Analytical Chemistry

DOI

2017

Innenrücktitelbild: Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One‐Pot Reaction (Angew. Chem. 16/2017)

Weidong Liu, Yiwu Zheng, Xu‐Dong Kong, Christian Heinis, Yibing Zhao, Chuanliu Wu

Angewandte Chemie

DOI

2017

Inside Back Cover: Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One‐Pot Reaction (Angew. Chem. Int. Ed. 16/2017)

Weidong Liu, Yiwu Zheng, Xu‐Dong Kong, Christian Heinis, Yibing Zhao, Chuanliu Wu

Angewandte Chemie International Edition

DOI

2017

Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One‐Pot Reaction

Weidong Liu, Yiwu Zheng, Xu‐Dong Kong, Christian Heinis, Yibing Zhao, Chuanliu Wu

Angewandte Chemie

DOI

2017

Proteolytic Unlocking of Ultrastable Twin-Acylhydrazone Linkers for Lysosomal Acid-Triggered Release of Anticancer Drugs

Yiwu Zheng, Jing Ming Ren, Yaqi Wu, Xiaoting Meng, Yibing Zhao, Chuanliu Wu

Bioconjugate Chemistry

DOI

2017

Peptide Macrocycles Developed from Precisely Regulated Multiple Cyclization of Unprotected Peptides

Jinghui Wang, Mirao Zha, Qianran Fei, Weidong Liu, Yibing Zhao, Chuanliu Wu

Chemistry - A European Journal

DOI

2017

A lysosome-locating and acidic pH-activatable fluorescent probe for visualizing endogenous H 2 O 2 in lysosomes

Jun Liu, Shunqing Zhou, Jing Ming Ren, Chuanliu Wu, Yibing Zhao

The Analyst

DOI

2017

Stabilization of peptides against proteolysis through disulfide-bridged conjugation with synthetic aromatics

Yaqi Chen, Tao Li, Jianguo Li, Shiyan Cheng, Jinghui Wang, Chandra Shekhar Verma, Yibing Zhao, Chuanliu Wu

Organic & Biomolecular Chemistry

DOI

2017

Tunable accessibility of dye-doped liposomes towards gold nanoparticles for fluorescence sensing of lipopolysaccharide

Jinhong Gao, Zhuoru Li, Ouyang Zhang, Chuanliu Wu, Yibing Zhao

The Analyst

DOI

2016

Thioether-Bonded Fluorescent Probes for Deciphering Thiol-Mediated Exchange Reactions on the Cell Surface

Wei Gao, Tao Li, Jinghui Wang, Yibing Zhao, Chuanliu Wu

Analytical Chemistry

DOI

2016

pH-Switchable Fluorescent Probe for Spatially-Confined Visualization of Intracellular Hydrogen Peroxide

Jun Liu, Jing Ming Ren, Xiaojia Bao, Wei Gao, Chuanliu Wu, Yibing Zhao

Analytical Chemistry

DOI

2016

Inside Cover: Metal–Organic‐Framework‐Templated Polyelectrolyte Nanocapsules for the Encapsulation and Delivery of Small‐Molecule–Polymer Conjugates (Chem. Asian J. 12/2016)

Shuo Liu, Jianbin Chen, Xiaojia Bao, Tao Li, Yun-Yang Ling, Chunxiang Li, Chuanliu Wu, Yibing Zhao

Chemistry - An Asian Journal

DOI

2016

Metal–Organic‐Framework‐Templated Polyelectrolyte Nanocapsules for the Encapsulation and Delivery of Small‐Molecule–Polymer Conjugates

Shuo Liu, Jianbin Chen, Xiaojia Bao, Tao Li, Yun-Yang Ling, Chunxiang Li, Chuanliu Wu, Yibing Zhao

Chemistry - An Asian Journal

DOI

2016

Disulfide‐Linked/Peptide‐Incorporated Macrocycles: Unique Redox‐Responsiveness and Application for Intracellular Cargo‐Delivery

Jingjing Liang, Tao Li, Xiaojia Bao, Jing Ming Ren, Yibing Zhao, Chuanliu Wu

ChemistrySelect

DOI

2016

Aromaticity/Bulkiness of Surface Ligands to Promote the Interaction of Anionic Amphiphilic Gold Nanoparticles with Lipid Bilayers

Jinhong Gao, Ouyang Zhang, Jing Ming Ren, Chuanliu Wu, Yibing Zhao

Langmuir

DOI

2016

POEGMA-based disulfide-containing fluorescent probes for imitating and tracing noninternalization-based intracellular drug delivery

Yun-Yang Ling, Jing Ming Ren, Tao Li, Yibing Zhao, Chuanliu Wu

Chemical Communications

DOI

2015

Developing orthogonal disulfide pairing technology to direct peptide folding and cyclization

Chuan-Liu Wu, Ya-Qi Chen, Yi-Wu Zheng

2015

Orthogonal Cysteine–Penicillamine Disulfide Pairing for Directing the Oxidative Folding of Peptides

Yiwu Zheng, Linxiang Zhai, Yibing Zhao, Chuanliu Wu

Journal of the American Chemical Society

DOI

2015

The Interplay of Disulfide Bonds, α-Helicity, and Hydrophobic Interactions Leads to Ultrahigh Proteolytic Stability of Peptides

Yaqi Chen, Chaoqiong Yang, Tao Li, Miao Zhang, Yang Liu, Marc Andre Gauthier, Yibing Zhao, Chuanliu Wu

Biomacromolecules

DOI

2015

Multivalent peptides displayed on OEGMA-based copolymers for the modulation of protein–protein interactions

Yujie Li, Tao Li, Jinghui Wang, Xiaojia Bao, Yibing Zhao, Chuanliu Wu

Polymer Chemistry

DOI

2014

Extraordinary Modulation of Disulfide Redox‐Responsiveness by Cooperativity of Twin‐Disulfide Bonds

Linxiang Zhai, Jingjing Liang, Xiang-Qun Guo, Yibing Zhao, Chuanliu Wu

Chemistry - A European Journal

DOI

2014

Exploring and Exploiting Dynamic Noncovalent Chemistry for Effective Surface Modification of Nanoscale Metal–Organic Frameworks

Shuo Liu, Linxiang Zhai, Chunxiang Li, Yujie Li, Xiang-Qun Guo, Yibing Zhao, Chuanliu Wu

ACS Applied Materials & Interfaces

DOI

2013

Exploring and exploiting the synergy of non-covalent interactions on the surface of gold nanoparticles for fluorescent turn-on sensing of bacterial lipopolysaccharide

Jinhong Gao, Yangwei Lai, Chuanliu Wu, Yibing Zhao

Nanoscale

DOI

2011

A facile and general approach for the synthesis of fluorescent silica nanoparticles doped with inert dyes

Xue Mu, Chuanliu Wu, JinPing Lai, JianBin Chen, JinSheng Zheng, Chong Li, YiBing Zhao

Chinese Science Bulletin

DOI

2010

LSPR Sensing of Molecular Biothiols Based on Noncoupled Gold Nanorods

Chong Li, Chuanliu Wu, Jinsheng Zheng, Jinping Lai, Chenlong Zhang, Yibing Zhao

Langmuir

DOI

2010

Light-responsive nanogated ensemble based on polymer grafted mesoporous silica hybrid nanoparticles

Jinping Lai, Xue Mu, Yun‐Yan Xu, Xiaoli Wu, Chuanliu Wu, Chong Li, Jianbin Chen, Yibing Zhao

Chemical Communications

DOI

2009

Extracting fluorescence signal due to direct excitation of the energy acceptor from quantum dot-based FRET

Chaobiao Huang, Chuanliu Wu, Yibing Zhao

Journal of Nanoparticle Research

DOI

2008

CdS Quantum Dots as Fluorescence Probes for the Detection of Selenite

Chaobiao Huang, Chuanliu Wu, Jinping Lai, Shuyan Li, Jinsheng Zhen, Yibing Zhao

Analytical Letters

DOI

2008

Molecule-scale controlled-release system based on light-responsive silica nanoparticles

Chuanliu Wu, Chen Chen, Jinping Lai, Jianbin Chen, Xue Mu, Jinsheng Zheng, Yibing Zhao

Chemical Communications

DOI

2007

Hybrid Silica–Nanocrystal–Organic Dye Superstructures as Post‐Encoding Fluorescent Probes

Chuanliu Wu, Jinsheng Zheng, Chaobiao Huang, Jinping Lai, Shuyan Li, Chen Chen, Yibing Zhao

Angewandte Chemie

DOI

2007

Fluorescent core-shell silicananoparticles as tunable precursors: towards encoding and multifunctional nano-probes

Chuanliu Wu, Jinqing Hong, Xiang-Qun Guo, Chaobiao Huang, Jinping Lai, Jinsheng Zheng, Jianbin Chen, Xue Mu, Yibing Zhao

Chemical Communications

DOI

精选作品

期刊论文

Disulfide-Directed Multicyclic Peptides for Chimeric Antigen Receptors Targeting Solid Tumors.

Thiol-Retaining N‑Terminal Cysteine Chemistry for Dual Modification and Bicyclic Peptide Construction

ICOS-Targeted Peptide Imaging Informs Therapeutic Response of STING Agonist in Lung Adenocarcinoma

Disulfide-Directed Multicylic Peptides for Targeting and Radionuclide Imaging of HER2 Expressing Tumors.

TROP2-targeted NIR-II fluorescence imaging for visualizing surgical margins and metastatic sentinel lymph nodes in breast cancers

pH-Controlled Stepwise Cyclization Enables Phage Display of Heterobridged Bicyclic Peptide Libraries

Biphenyl-dihydrothiazole-cyclized peptide libraries for peptide ligand and drug discovery

Proline-Mediated Enhancement in Evolvability of Disulfide-Rich Peptides for Discovering Protein Binders.

Shaping Peptide Assemblies Using Multifaceted Cyclic Tectons.

Directing the oxidative folding of disulfide-rich peptides for enhanced engineering and applications

A Single Bioorthogonal Reaction for Multiplex Cell Surface Protein Labeling

Directed Evolution of Multicyclic Peptides Using Yeast Display for Sensitive and Selective Fluorescent Analysis of CD28 on the Cell Surface.

Multicyclic Peptides Targeting PD-L1 for Radiotheranostics: From Discovery to Clinical Proof-of-Concept.

Motif-Directed Oxidative Folding to Design and Discover Multicyclic Peptides for Protein Recognition.

Specifically targeted antimicrobial cyclic peptide to staphylococcal protein A for the treatment of S. aureus infection

Decoupling sequence and structure

Recent advances in chemical protein synthesis: method developments and biological applications

Ribosomal translation of fluorinated non-canonical amino acids for de novo biologically active fluorinated macrocyclic peptides

Cyclic peptides discriminate BCL-2 and its clinical mutants from BCL-XL by engaging a single-residue discrepancy

Triscysteine disulfide-directing motifs enabling design and discovery of multicyclic peptide binders

Disulfide-Directed Multicyclic Peptides with N-Terminally Extendable α-Helices for Recognition and Activation of G-Protein-Coupled Receptors.

Ribosomal Incorporation of Lithocholic Acid into Peptides for the De Novo Discovery Of Peptide-Lithocholic Acid Hybrid Macrocyclic Peptides.

De Novo Discovery of Cysteine Frameworks for Developing Multicyclic Peptide Libraries for Ligand Discovery.

Disulfide-Directed Multicyclic Peptide Libraries for the Discovery of Peptide Ligands and Drugs.

Selection and evolution of disulfide-rich peptides via cellular protein quality control

Deciphering the Synthetic and Refolding Strategy of a Cysteine-Rich Domain in the Tumor Necrosis Factor Receptor (TNF-R) for Racemic Crystallography Analysis and d-Peptide Ligand Discovery

Redox-Regulated Conformational Change of Disulfide-Rich Assembling Peptides.

Structure-guided design of CPPC-paired disulfide-rich peptide libraries for ligand and drug discovery

De novo design and directed folding of disulfide-bridged peptide heterodimers

Design and Ribosomal Incorporation of Noncanonical Disulfide-Directing Motifs for the Development of Multicyclic Peptide Libraries.

An evolution-inspired strategy to design disulfide-rich peptides tolerant to extensive sequence manipulation

Fast and Selective Reaction of 2-Benzylacrylaldehyde with 1,2-Aminothiol for Stable N-Terminal Cysteine Modification and Peptide Cyclization.

Directed Disulfide Pairing and Folding of Peptides for the De Novo Development of Multicyclic Peptide Libraries

Condensation of 2-((Alkylthio)(aryl)methylene)malononitrile with 1,2-Aminothiol as a Novel Bioorthogonal Reaction for Site-Specific Protein Modification and Peptide Cyclization

Biocompatible and Rapid Cyclization of Peptides with 2,4-Difluoro-6-hydroxy-1,3,5-benzenetricarbonitrile for the Development of Cyclic Peptide Libraries

Design and Synthesis of Disulfide-Rich Peptides with Orthogonal Disulfide Pairing Motifs

Interchain doubly-bridged α-helical peptides for the development of protein binders

A Doubly-Quenched Fluorescent Probe for Low-Background Detection of Mitochondrial H2O2

Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation

Cover Feature: Ordered and Isomerically Stable Bicyclic Peptide Scaffolds Constrained through Cystine Bridges and Proline Turns (ChemBioChem 12/2019)

Stabilizing p‐Dithiobenzyl Urethane Linkers without Rate‐Limiting Self‐Immolation for Traceless Drug Release

Design and Synthesis of Cross-Link-Dense Peptides by Manipulating Regioselective Bisthioether Cross-Linking and Orthogonal Disulfide Pairing

Ordered and Isomerically Stable Bicyclic Peptide Scaffolds Constrained through Cystine Bridges and Proline Turns

A mini-review and perspective on multicyclic peptide mimics of antibodies

CXC-Mediated Cellular Uptake of Miniproteins: Forsaking “Arginine Magic”

A phage display-based strategy for the de novo creation of disulfide-constrained and isomer-free bicyclic peptide affinity reagents

Artificial disulfide-rich peptide scaffolds with precisely defined disulfide patterns and a minimized number of isomers

正確に定義されたジスルフィドパターンを用いた人工ジスルフィド豊富なペプチド足場と最小数異性体【Powered by NICT】

De novo design of constrained and sequence-independent peptide scaffolds with topologically-formidable disulfide connectivities

Biscysteine-Bearing Peptide Probes To Reveal Extracellular Thiol–Disulfide Exchange Reactions Promoting Cellular Uptake

Innenrücktitelbild: Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One‐Pot Reaction (Angew. Chem. 16/2017)

Inside Back Cover: Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One‐Pot Reaction (Angew. Chem. Int. Ed. 16/2017)

Precisely Regulated and Efficient Locking of Linear Peptides into Stable Multicyclic Topologies through a One‐Pot Reaction

Proteolytic Unlocking of Ultrastable Twin-Acylhydrazone Linkers for Lysosomal Acid-Triggered Release of Anticancer Drugs

Peptide Macrocycles Developed from Precisely Regulated Multiple Cyclization of Unprotected Peptides

A lysosome-locating and acidic pH-activatable fluorescent probe for visualizing endogenous H 2 O 2 in lysosomes

Stabilization of peptides against proteolysis through disulfide-bridged conjugation with synthetic aromatics

Tunable accessibility of dye-doped liposomes towards gold nanoparticles for fluorescence sensing of lipopolysaccharide

Thioether-Bonded Fluorescent Probes for Deciphering Thiol-Mediated Exchange Reactions on the Cell Surface

pH-Switchable Fluorescent Probe for Spatially-Confined Visualization of Intracellular Hydrogen Peroxide

Inside Cover: Metal–Organic‐Framework‐Templated Polyelectrolyte Nanocapsules for the Encapsulation and Delivery of Small‐Molecule–Polymer Conjugates (Chem. Asian J. 12/2016)

Metal–Organic‐Framework‐Templated Polyelectrolyte Nanocapsules for the Encapsulation and Delivery of Small‐Molecule–Polymer Conjugates

Disulfide‐Linked/Peptide‐Incorporated Macrocycles: Unique Redox‐Responsiveness and Application for Intracellular Cargo‐Delivery

Aromaticity/Bulkiness of Surface Ligands to Promote the Interaction of Anionic Amphiphilic Gold Nanoparticles with Lipid Bilayers

POEGMA-based disulfide-containing fluorescent probes for imitating and tracing noninternalization-based intracellular drug delivery

Developing orthogonal disulfide pairing technology to direct peptide folding and cyclization

Orthogonal Cysteine–Penicillamine Disulfide Pairing for Directing the Oxidative Folding of Peptides

The Interplay of Disulfide Bonds, α-Helicity, and Hydrophobic Interactions Leads to Ultrahigh Proteolytic Stability of Peptides

Multivalent peptides displayed on OEGMA-based copolymers for the modulation of protein–protein interactions

Extraordinary Modulation of Disulfide Redox‐Responsiveness by Cooperativity of Twin‐Disulfide Bonds

Exploring and Exploiting Dynamic Noncovalent Chemistry for Effective Surface Modification of Nanoscale Metal–Organic Frameworks

Exploring and exploiting the synergy of non-covalent interactions on the surface of gold nanoparticles for fluorescent turn-on sensing of bacterial lipopolysaccharide

A facile and general approach for the synthesis of fluorescent silica nanoparticles doped with inert dyes

LSPR Sensing of Molecular Biothiols Based on Noncoupled Gold Nanorods

Light-responsive nanogated ensemble based on polymer grafted mesoporous silica hybrid nanoparticles

Extracting fluorescence signal due to direct excitation of the energy acceptor from quantum dot-based FRET

CdS Quantum Dots as Fluorescence Probes for the Detection of Selenite

Molecule-scale controlled-release system based on light-responsive silica nanoparticles