池希敏｜厦门大学｜学者主页

2026

Structure Basis for Chloride Recognition and Transport by Human Kidney Brain Anion Transporter (KBAT)

Yurou Wang, Tengyu Xie, Songyue Wu, Anxin Wang, Wentao Cheng, Jing Huang, Renhong Yan, Ximin Chi

Biomolecules

DOI

2026

Molecular basis of metal transport by human ZnT10

Hongchen Mu, Chengyu Yang, Ruoyang Feng, Ding Song, Hai Jing Yu, Ximin Chi

Structure

DOI

2026

Structural insights into ligand recognition and activation of the human oxoglutarate receptor OXGR1

Tingshuai Ma, Ziyan Chen, Liang Enyuan, Xiufei Tang, Ximin Chi, Quanchang Gu, Qiang Su

Nature Communications

DOI

2025

A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2

Yankai Chu, Shishuang Chen, Mingyang Yang, Yin Chen, Huiling Fang, Pinyu Huang, Yueru Xie, Chi‐Chin Sun, Yun Chen, Baoding Zhang, Li Li, Hongchen Mu, Song Z. Ding, Wentao Cheng, Chao Wang, Wei Jiang, Xiaolan Xu, Zhengjin He, Shuo Chen, Mingxian Liu, Jingchuan Ma, Man Gil Yang, Jiaqi Cao, Jing Gao, Jiali Shen, Lulu Zhang, Yu Bai, Zheyi Liu, Jingyao Chen, Siqi Dai, Yi Arial Zeng, Yun Zhao, Hu Zhou, Chong Chen, Huan-wei Ru, Li Tan, Ximin Chi, Fangjun Wang, Daming Gao, Moubin Lin, Xianming Deng, Hai Jiang

Nature Biotechnology

DOI

2025

Structural basis for substrate recognition mechanism of human SLC26A7

Xiaorong Li, Xiaoxu Yang, Xiaoli Lu, Bingqian Lin, Yuanyuan Zhang, Bangdong Huang, Yutong Zhou, Jing Huang, Kun Wu, Qiang Zhou, Ximin Chi

Nature Communications

DOI

2025

Targeting oncogenic K-RAS mutants with small-molecule degrader XMU-MP-9 through NEDD4-1

Taoling Zeng, Tingting Jiang, Baoding Zhang, Ting Zhang, Wanjun Dai, Xun Yin, Yunzhan Li, Zhuoran Yu, Caiming Wu, Yaying Wu, Ximin Chi, Xianming Deng, Hongrui Wang

Acta Pharmaceutica Sinica B

DOI

2024

Structures of human γδ T cell receptor–CD3 complex

Weizhi Xin, Bangdong Huang, Ximin Chi, Yuehua Liu, Mengjiao Xu, Yuanyuan Zhang, Xu Li, Qiang Su, Qiang Zhou

Nature

DOI

2024

Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism

Ximin Chi, Yiming Chen, Yiming Chen, Yaning Li, Lu Dai, Yuanyuan Zhang, Yaping Shen, Yun Chen, Yun Chen, Tianhao Shi, Haonan Yang, Zilong Wang, Renhong Yan

Science Advances

DOI

2023

人源硫酸盐转运蛋白DTDST的结构生物学研究

池希敏，李晓荣，黄邦栋，周强

《电子显微学报》

2023

Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants

Xiang-Yang Chi, Lingyun Xia, Guan-Ying Zhang, Ximin Chi, Bangdong Huang, Yuan-Yuan Zhang, Zheng-Shan Chen, Jin Han, Liushu Wu, Ze-Ya Li, Han Sun, Ping Huang, Chang-Ming Yu, Wei Chen, Qiang Zhou

Cell Discovery

DOI

2022

The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis

R. Yan, En-Jun Xie, Ya-Ning Li, Jin Li, Yuan-Yuan Zhang, Ximin Chi, Xueping Hu, Lei Xu, Tingjun Hou, B. Stockwell, Jun-Xia Min, Qiang Zhou, Fu-Di Wang

Cell Research

DOI

2022

Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states

Yingying Guo, Yuan-Yuan Zhang, R. Yan, Bangdong Huang, F. Ye, Liushu Wu, Ximin Chi, Yi Shi, Qiang Zhou

Nature Communications

DOI

2021

Rational Exploration of Fold Atlas for Human Solute Carrier Proteins

Teng-Yu Xie, Ximin Chi, Bangdong Huang, F. Ye, Qiang Zhou, Jing Huang

bioRxiv

DOI

2021

S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 1 (1 up RBD and no PD bound)

R. Yan, Y.-Y. Zhang, Y.-N. Li, F. Ye, Y.-Y. Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Q. Zhou

DOI

2021

S protein of SARS-CoV-2 in the locked conformation

R. Yan, Y.-Y. Zhang, Y.-N. Li, F. Ye, Y.-Y. Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Q. Zhou

DOI

2021

Cryo-EM structures of the human sodium-potassium pump revealing the gating mechanism on the cytoplasmic side

Yingying Guo, Yuan-Yuan Zhang, R. Yan, Bangdong Huang, F. Ye, Liushu Wu, Ximin Chi, Qiang Zhou

DOI

2021

S protein of SARS-CoV-2 in the active conformation

R. Yan, Y.-Y. Zhang, Y.-N. Li, F. Ye, Y.-Y. Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Q. Zhou

DOI

2021

Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 1 (1 up RBD and 1 PD bound)

R. Yan, Y.-Y. Zhang, Y.-N. Li, F. Ye, Y.-Y. Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Q. Zhou

DOI

2021

Conformation 1 of S-ACE2-B0AT1 ternary complex

R. Yan, Y.-Y. Zhang, Y.-N. Li, F. Ye, Y.-Y. Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Q. Zhou

DOI

2021

S(p) protein of SARS-CoV-2

R. Yan, Y.-Y. Zhang, Y.-N. Li, F. Ye, Y.-Y. Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Q. Zhou

DOI

2021

Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2

R. Yan, Yuan-Yuan Zhang, Ya-Ning Li, F. Ye, Ying-Ying Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Qiang Zhou

Cell Research

DOI

2021

S(p,D614G) protein of SARS-CoV-2

R. Yan, Y.-Y. Zhang, Y.-N. Li, F. Ye, Y.-Y. Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Q. Zhou

DOI

2021

Trypsin-digested S protein of SARS-CoV-2 D614G mutant

R. Yan, Y.-Y. Zhang, Y.-N. Li, F. Ye, Y.-Y. Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Q. Zhou

DOI

2021

Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 2 (2 up RBD and 2 PD bound)

R. Yan, Y.-Y. Zhang, Y.-N. Li, F. Ye, Y.-Y. Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Q. Zhou

DOI

2021

Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 3 (3 up RBD and 2 PD bound)

R. Yan, Y.-Y. Zhang, Y.-N. Li, F. Ye, Y.-Y. Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Q. Zhou

DOI

2021

Author Correction: Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters

Ximin Chi, Xiaorong Li, Yun Chen, Yuan-Yuan Zhang, Q. Su, Qiang Zhou

Cell Research

DOI

2020

Acinetobacter MlaFEDB complex in ADP-vanadate trapped Vclose conformation

Y.-Y. Zhang, Qiong-Xuan Fan, Ximin Chi, Q. Zhou, Y.-Y. Li

DOI

2020

Molecular basis for regulation of human potassium chloride cotransporters

Ximin Chi, Xiaorong Li, Yun Chen, Yuan-Yuan Zhang, Q. Su, Qiang Zhou

bioRxiv

DOI

2020

Acinetobacter MlaFEDB complex in ATP-bound Vtrans1 conformation

Y.-Y. Zhang, Qiong-Xuan Fan, Ximin Chi, Q. Zhou, Y.-Y. Li

DOI

2020

The overall structure of SLC26A9

Ximin Chi, Y. Chen, X.-R. Li, Y.-Y. Zhang, Q. Zhou

DOI

2020

KCC3 bound with DIOA

Ximin Chi, X.-R. Li, Y. Chen, Y.-Y. Zhang, Q. Su, Q. Zhou

DOI

2020

The overall structure of KCC3

Ximin Chi, X.-R. Li, Y. Chen, Y.-Y. Zhang, Q. Su, Q. Zhou

DOI

2020

Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters

Ximin Chi, Xiaorong Li, Yun Chen, Yuan-Yuan Zhang, Q. Su, Qiang Zhou

Cell Research

DOI

2020

The overall structure of nucleotide free MlaFEDB complex

Ximin Chi, Qiong-Xuan Fan, Y.-Y. Zhang, K. Liang, Q. Zhou, Y.-Y. Li

DOI

2020

Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence

Ximin Chi, Xueqin Jin, Yun Chen, Xiaoli Lu, Xinyu Tu, Xiaorong Li, Yuan-Yuan Zhang, Jianlin Lei, Jing Huang, Zhuo Huang, Qiang Zhou, Xiaojing Pan

Cell Discovery

DOI

2020

The overall structure of the MlaFEDB complex in ATP-bound EQclose conformation (Mutation of E170Q on MlaF)

Ximin Chi, Qiong-Xuan Fan, Y.-Y. Zhang, K. Liang, Q. Zhou, Y.-Y. Li

DOI

2020

Structural mechanism of phospholipids translocation by MlaFEDB complex

Ximin Chi, Qiong-Xuan Fan, Yuan-Yuan Zhang, K. Liang, L. Wan, Qiang Zhou, Yanyan Li

Cell Research

DOI

2020

Cryo EM structure of the nucleotide free Acinetobacter MlaFEDB complex

Y.-Y. Zhang, Qiong-Xuan Fan, Ximin Chi, Q. Zhou, Y.-Y. Li

DOI

2020

Acinetobacter MlaFEDB complex in ATP-bound Vtrans2 conformation

Y.-Y. Zhang, Qiong-Xuan Fan, Ximin Chi, Q. Zhou, Y.-Y. Li

DOI

2020

Overall structure of KCC2

Ximin Chi, X.-R. Li, Y. Chen, Y.-Y. Zhang, Q. Su, Q. Zhou

DOI

2020

Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter

Yuan-Yuan Zhang, Qiong-Xuan Fan, Ximin Chi, Qiang Zhou, Yanyan Li

Cell Discovery

DOI

2020

The overall structure of the MlaFEDB complex in ATP-bound EQtall conformation (Mutation of E170Q on MlaF)

Ximin Chi, Qiong-Xuan Fan, Y.-Y. Zhang, K. Liang, Q. Zhou, Y.-Y. Li

DOI

2019

Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators

Ximin Chi, D. Gong, K. Ren, Gewei Zhou, Gaoxingyu Huang, Jianlin Lei, Qiang Zhou, N. Yan

Proceedings of the National Academy of Sciences of the United States of America

DOI

2019

Cryo-EM structure of RyR2 (Ca2+ alone dataset)

Ximin Chi, D. Gong, K. Ren, G.-W. Zhou, G.-X.-Y. Huang, J. Lei, Q. Zhou, N. Yan

DOI

2019

Structure of RyR2 (*F/A/C/L-Ca2+ dataset)

D. Gong, Ximin Chi, G.-W. Zhou, G.-X.-Y. Huang, J. Lei, N. Yan

DOI

2019

Structure of RyR2 (F/P/Ca2+ dataset)

Ximin Chi, D. Gong, K. Ren, Gewei Zhou, Gaoxingyu Huang, J. Lei, Qiang Zhou, N. Yan

DOI

2019

Structure of RyR2 (F/A/C/H-Ca2+/Ca2+CaM dataset)

D. Gong, Ximin Chi, G.-W. Zhou, G.-X.-Y. Huang, J. Lei, N. Yan

DOI

2019

Structure of RyR2 (F/A/C/L-Ca2+/Ca2+CaM dataset)

D. Gong, Ximin Chi, G.-W. Zhou, G.-X.-Y. Huang, J. Lei, N. Yan

DOI

2019

Structure of RyR2 (F/apoCaM dataset)

D. Gong, Ximin Chi, G.-W. Zhou, G.-X.-Y. Huang, J. Lei, N. Yan

DOI

2019

Structure of RyR2 (F/A/C/L-Ca2+/apo-CaM-M dataset)

D. Gong, Ximin Chi, G.-W. Zhou, G.-X.-Y. Huang, J. Lei, N. Yan

DOI

2019

Modulation of cardiac ryanodine receptor 2 by calmodulin

D. Gong, Ximin Chi, Jin-Hong Wei, Gewei Zhou, Gaoxingyu Huang, Lin Zhang, Rui-Wu Wang, Jianlin Lei, S. R. Wayne Chen, N. Yan

Nature

DOI

2019

Structure of RyR2 (P/L-Ca2+/Ca2+-CaM dataset)

D. Gong, Ximin Chi, G.-W. Zhou, G.-X.-Y. Huang, J. Lei, N. Yan

DOI

2018

Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin

D. Gong, Ximin Chi, K. Ren, Gaoxingyu Huang, Gewei Zhou, N. Yan, Jianlin Lei, Qiang Zhou

Nature Communications

DOI

2018

Cryo-EM structure of a P-type ATPase

D. Gong, Ximin Chi, K. Ren, G.-X.-Y. Huang, G.-W. Zhou, N. Yan, J. Lei, Q. Zhou

DOI

S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 2 (1 up RBD and 1 PD bound)

R. Yan, Y.-Y. Zhang, Y.-N. Li, F. Ye, Y.-Y. Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Q. Zhou

DOI

S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 3 (2 up RBD and 1 PD bound)

R. Yan, Y.-Y. Zhang, Y.-N. Li, F. Ye, Y.-Y. Guo, L. Xia, Xin-Yue Zhong, Ximin Chi, Q. Zhou

DOI

精选作品

期刊论文

Structure Basis for Chloride Recognition and Transport by Human Kidney Brain Anion Transporter (KBAT)

Molecular basis of metal transport by human ZnT10

Structural insights into ligand recognition and activation of the human oxoglutarate receptor OXGR1

A rapid imaging-based screen for induced-proximity degraders identifies a potent degrader of oncoprotein SKP2

Structural basis for substrate recognition mechanism of human SLC26A7

Targeting oncogenic K-RAS mutants with small-molecule degrader XMU-MP-9 through NEDD4-1

Structures of human γδ T cell receptor–CD3 complex

Cryo-EM structures of the human NaS1 and NaDC1 transporters revealed the elevator transport and allosteric regulation mechanism

人源硫酸盐转运蛋白DTDST的结构生物学研究

Comprehensive structural analysis reveals broad-spectrum neutralizing antibodies against SARS-CoV-2 Omicron variants

The structure of erastin-bound xCT–4F2hc complex reveals molecular mechanisms underlying erastin-induced ferroptosis

Cryo-EM structures of recombinant human sodium-potassium pump determined in three different states

Rational Exploration of Fold Atlas for Human Solute Carrier Proteins

S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 1 (1 up RBD and no PD bound)

S protein of SARS-CoV-2 in the locked conformation

Cryo-EM structures of the human sodium-potassium pump revealing the gating mechanism on the cytoplasmic side

S protein of SARS-CoV-2 in the active conformation

Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 1 (1 up RBD and 1 PD bound)

Conformation 1 of S-ACE2-B0AT1 ternary complex

S(p) protein of SARS-CoV-2

Structural basis for the different states of the spike protein of SARS-CoV-2 in complex with ACE2

S(p,D614G) protein of SARS-CoV-2

Trypsin-digested S protein of SARS-CoV-2 D614G mutant

Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 2 (2 up RBD and 2 PD bound)

Trypsin-digested S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 3 (3 up RBD and 2 PD bound)

Author Correction: Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters

Acinetobacter MlaFEDB complex in ADP-vanadate trapped Vclose conformation

Molecular basis for regulation of human potassium chloride cotransporters

Acinetobacter MlaFEDB complex in ATP-bound Vtrans1 conformation

The overall structure of SLC26A9

KCC3 bound with DIOA

The overall structure of KCC3

Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters

The overall structure of nucleotide free MlaFEDB complex

Structural insights into the gating mechanism of human SLC26A9 mediated by its C-terminal sequence

The overall structure of the MlaFEDB complex in ATP-bound EQclose conformation (Mutation of E170Q on MlaF)

Structural mechanism of phospholipids translocation by MlaFEDB complex

Cryo EM structure of the nucleotide free Acinetobacter MlaFEDB complex

Acinetobacter MlaFEDB complex in ATP-bound Vtrans2 conformation

Overall structure of KCC2

Cryo-EM structures of Acinetobacter baumannii glycerophospholipid transporter

The overall structure of the MlaFEDB complex in ATP-bound EQtall conformation (Mutation of E170Q on MlaF)

Molecular basis for allosteric regulation of the type 2 ryanodine receptor channel gating by key modulators

Cryo-EM structure of RyR2 (Ca2+ alone dataset)

Structure of RyR2 (*F/A/C/L-Ca2+ dataset)

Structure of RyR2 (F/P/Ca2+ dataset)

Structure of RyR2 (F/A/C/H-Ca2+/Ca2+CaM dataset)

Structure of RyR2 (F/A/C/L-Ca2+/Ca2+CaM dataset)

Structure of RyR2 (F/apoCaM dataset)

Structure of RyR2 (F/A/C/L-Ca2+/apo-CaM-M dataset)

Modulation of cardiac ryanodine receptor 2 by calmodulin

Structure of RyR2 (P/L-Ca2+/Ca2+-CaM dataset)

Structure of the human plasma membrane Ca2+-ATPase 1 in complex with its obligatory subunit neuroplastin

Cryo-EM structure of a P-type ATPase

S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 2 (1 up RBD and 1 PD bound)

S protein of SARS-CoV-2 bound with PD of ACE2 in the conformation 3 (2 up RBD and 1 PD bound)

预印本

A sequence–structure dual-match logic enables target recognition fidelity by an IS110 transposon