陈娟｜重庆医科大学｜学者主页

2026

EGFR N-Glycosylation Catalyzed by NDST2 Promotes Lenvatinib Resistance in Hepatocellular Carcinoma

Huiying Gu, Fan Li, Yuehua Chen, Mengling Zhang, Qiumin Wu, Hongyun Zhao, Chong-Yang Zhou, Li Yan, Ruixi Xie, Xinchang Huang, Jihua Ren, Shengtao Cheng, Haibo Yu, Yuehua Chen, Zhenzhen Zhang, Juan Chen

Cancer Research

DOI

2025

免疫因子γ干扰素、肿瘤坏死因子α、甲胎蛋白异质体在肝细胞癌中的表达及与病理参数、预后的相关性

陈娟，朴瑛，高金平，郑振东

《安徽医药》

2025

The role of succinylation-mediated metabolic reprogramming in tumor progression

Siyi He, Chunduo Wang, Ranran Li, Kexin Xu, Wenjia Zhang, Binbin Feng, Sheng‐Tao Cheng, Ji‐Hua Ren, Juan Chen

Molecular Biology Reports

DOI

2025

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Minli Yang, Sheng‐Tao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Ji‐Hua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen

Advanced Science

DOI

2025

[Crosstalk and the progression of hepatocellular carcinoma].

Leirong Gu, Hui Zhang, Juan Chen, Sheng‐Tao Cheng

PubMed

DOI

2025

Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry

Jia He, Haibo Yu, Kunling Song, Ailong Huang, Yongjun Dang, Juan Chen, Zufeng Guo

Signal Transduction and Targeted Therapy

DOI

2025

Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome

Sheng‐Tao Cheng, Weixian Chen, Haijun Deng, Xin He, Hui Zhang, Ming Tan, Haibo Yu, Zhen-Zhen Zhang, Ji‐Hua Ren, Min-Li Yang, Dapeng Zhang, Zhi-Hong Li, Juan Chen

Clinical and Molecular Hepatology

DOI

2025

CRISPR/Cas13a combined with reverse transcription-multienzyme isothermal rapid amplification for hepatitis B virus RNA detection

Chuiyu Zhu, Junjie Li, Haibo Yu, Kexin Xu, Xiaomei He, Zhihao Liu, Juan Chen

Analytica Chimica Acta

DOI

2024

脂质代谢紊乱在非酒精性脂肪性肝病中的作用概述

谭明，张慧，任吉华，程胜桃，陈娟

《胃肠病学和肝病学杂志》

2024

氨基酸代谢在非酒精性脂肪性肝病中的作用机制

张慧，谭明，程胜桃，陈娟

《临床肝胆病杂志》

2024

Colchicine-mediated selective autophagic degradation of HBV core proteins inhibits HBV replication and HBV-related hepatocellular carcinoma progression

Hui Zhang, Xiameng Su, Leirong Gu, Ming Tan, Yuting Liu, Kexin Xu, Ji‐Hua Ren, Juan Chen, Zhihong Li, Sheng‐Tao Cheng

Cell Death Discovery

DOI

2024

HOXA‐AS2 Epigenetically Inhibits HBV Transcription by Recruiting the MTA1‐HDAC1/2 Deacetylase Complex to cccDNA Minichromosome

Yi-Ping Qin, Ji‐Hua Ren, Haibo Yu, Xin He, Sheng‐Tao Cheng, WeiXian Chen, Zhen Yang, Fengming Sun, Chunduo Wang, Si-Yu Yuan, Peng Chen, Daiqing Wu, Fang Ren, Ailong Huang, Juan Chen

Advanced Science

DOI

2024

Chromatin binding protein HMGN1 promotes HBV cccDNA transcription and replication by regulating the phosphorylation of histone 3

Tan Ming, Yuting Liu, Dong Meiling, Sheng‐Tao Cheng, Ren Jihua, Zhang Hui, Chen Wanjin, Dian Li, Gao Tingting, Juan Chen, Zhenzhen Zhang

Antiviral Research

DOI

2024

Signaling molecules in the microenvironment of hepatocellular carcinoma

Wan‐Jin Chen, Ming Tan, Hui Zhang, Tingting Gao, Ji‐Hua Ren, Sheng‐Tao Cheng, Juan Chen

Functional & Integrative Genomics

DOI

2024

KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B

Li Wang, Fangli Liao, Liping Yang, Linshan Jiang, Liang Duan, Bo Wang, Di Mu, Juan Chen, Ying Huang, Qin Hu, Weixian Chen

PLoS ONE

DOI

2024

Corrigendum: Ribosomal protein L23 drives the metastasis of hepatocellular carcinoma via upregulating MMP9

Min-Li Yang, Yujiao Zhou, Haijun Deng, Hongzhong Zhou, Sheng‐Tao Cheng, Dapeng Zhang, Xin He, Li Mai, Yao Chen, Juan Chen

Frontiers in Oncology

DOI

2024

RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling

Yujiao Zhou, Min-Li Yang, Xin He, Hui-Ying Gu, Ji‐Hua Ren, Sheng‐Tao Cheng, Zhou Fu, Zhenzhen Zhang, Juan Chen

Journal of Experimental & Clinical Cancer Research

DOI

2024

Epigenetic regulation and its therapeutic potential in hepatitis B virus covalently closed circular DNA

Ji‐Hua Ren, Sheng‐Tao Cheng, Fang Ren, Huiying Gu, Daiqing Wu, Xinyan Yao, Ming Tan, Ailong Huang, Juan Chen

Genes & Diseases

DOI

2024

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy

Kongying Hu, Wenjing Zai, Mingzhu Xu, Haiyu Wang, Xinluo Song, Chao Huang, Jiangxia Liu, Juan Chen, Qiang Deng, Zhenghong Yuan, Jieliang Chen

mBio

DOI

2024

Neuropilin-1 is a novel host factor modulating the entry of hepatitis B virus

Haibo Yu, Jihua Ren, Haijun Deng, Linfeng Li, Zhenzhen Zhang, Shengtao Cheng, Zufeng Guo, Ailong Huang, Yongjun Dang, Kunling Song, Daiqing Wu, Xinyan Yao, Yiping Qin, Zhen Yang, Kexin Xu, Xin He, Juan Chen

Journal of Hepatology

DOI

2023

肝喜合剂含药血清对人肝癌HepG2细胞增殖和凋亡的影响

罗燕，曾普华，奚剑敏，陈娟，李勇敏，周融融，吕元，罗吉

《中成药》

2023

CLEC1B在肝细胞癌中的表达及其对细胞恶性生物学行为的影响

陈娟，邓敏，程冬梅，陈濛濛

《长治医学院学报》

2023

Phosphorylation of UHRF2 affects malignant phenotypes of HCC and HBV replication by blocking DHX9 ubiquitylation

Kejia Wu, Yiqi Zhang, Yuxin Liu, Qingxiu Li, Yong Chen, Juan Chen, Chang-Zhu Duan

Cell Death Discovery

DOI

2023

Sphondin efficiently blocks HBsAg production and cccDNA transcription through promoting HBx degradation

Fang Ren, Jun-Chi Hu, Yong-Jun Dang, Hai-Jun Deng, Ji-Hua Ren, Sheng-Tao Cheng, Ming-dian Tan, Hui Zhang, Xin He, Haibo Yu, Juan Zhang, Zhen-Zhen Zhang, Wei-Xian Chen, Jie-Li Hu, Xue-fei Cai, Yuan Hu, Ai-Long Huang, Juan Chen

Journal of Medical Virology

DOI

2022

SIRT2 Promotes HBV Transcription and Replication by Targeting Transcription Factor p53 to Increase the Activities of HBV Enhancers and Promoters

Dai-Tze Wu, Qiuying Ding, Na-Na Tao, Ming-dian Tan, Yuan Zhang, Fangjiao Li, Yujiao Zhou, Mei-Ling Dong, Sheng-Tao Cheng, Fang Ren, Juan Chen, Ji-Hua Ren

Frontiers in Microbiology

DOI

2022

Pimobendan Inhibits HBV Transcription and Replication by Suppressing HBV Promoters Activity

Si-Yu Yuan, Hai-Ling Yu, Zhen Yang, Yi-Ping Qin, Ji-Hua Ren, Sheng-Tao Cheng, Fang Ren, B. Law, V. Wong, Jerome P. L. Ng, Yujiao Zhou, Xin He, Ming-dian Tan, Zhen-zhen Zhang, Juan Chen

Frontiers in Pharmacology

DOI

2022

Glutamate dehydrogenase 1 mediated glutaminolysis sustains HCC cells survival under glucose deprivation

Yujiao Zhou, Haibo Yu, Sheng-Tao Cheng, Yao Chen, Lin He, Ji-Hua Ren, Xin He, Juan Chen, Lu Zheng, Fangjiao Li

Journal of Cancer

DOI

2022

Case report: A case of severe acute hepatitis of unknown origin

Yujiao Zhou, Huiling Gu, Q. Tang, Fan Li, Jin Zhu, Ting Ai, Kun Zhu, Bin Xu, Qing Wang, Ai-Long Huang, Juan Chen, Zhen-zhen Zhang

Frontiers in Pediatrics

DOI

2022

Distinct immune responses in the early phase to natural SARS‐CoV‐2 infection or vaccination

Pai Peng, Hai-Jun Deng, Zhihong Li, Yao Chen, L. Fang, Jie-Li Hu, Kang Wu, Jian-Jiang Xue, De-Qiang Wang, Bei-zhong Liu, Quan-xin Long, Juan Chen, Kai Wang, N. Tang, Ai-Long Huang

Journal of Medical Virology

DOI

2022

Increased immune escape of the new SARS-CoV-2 variant of concern Omicron

Jie-Li Hu, Pai Peng, Xiaoxia Cao, Kang Wu, Juan Chen, Kai Wang, N. Tang, Ai-Long Huang

Cellular & Molecular Immunology

DOI

2022

Genome-wide association study of SARS-CoV-2 infection in Chinese population

Jie Fan, Quan-xin Long, Ji-Hua Ren, Hao Chen, Meng-meng Li, Zheng Cheng, Juan Chen, Li Zhou, Ai-Long Huang

European Journal of Clinical Microbiology and Infectious Diseases

DOI

2022

Rapamycin inhibits hepatitis B virus covalently closed circular DNA transcription by enhancing the ubiquitination of HBx

Yuan Zhang, Liang Li, Sheng-Tao Cheng, Yi-Ping Qin, Xin He, Fangjiao Li, Dai-Tze Wu, Fang Ren, Hai-Ling Yu, Jing Liu, Juan Chen, Ji-Hua Ren, Zhen-zhen Zhang

Frontiers in Microbiology

DOI

2022

KAT2A Promotes Hepatitis B Virus Transcription and Replication Through Epigenetic Regulation of cccDNA Minichromosome

Yi-Ping Qin, Hai-Ling Yu, Simin Yuan, Zhen Yang, Fang Ren, Qing Wang, Fan Li, Ji-Hua Ren, Sheng-Tao Cheng, Yujiao Zhou, Xin He, Hongzhong Zhou, Yuan Zhang, Ming-dian Tan, Min-Li Yang, Dapeng Zhang, Xu Wen, Mei-Ling Dong, Hui Zhang, Jing Liu, Zhi-Hong Li, Yao Chen, Ai-Long Huang, Wei-Xian Chen, Juan Chen

Frontiers in Microbiology

DOI

2022

HBx Mediated Increase of DDX17 Contributes to HBV-Related Hepatocellular Carcinoma Tumorigenesis

Mei-Ling Dong, Xu Wen, Xin He, Ji‐Hua Ren, Haibo Yu, Yi-Ping Qin, Zhen Yang, Min-Li Yang, Chong-Yang Zhou, Hui Zhang, Sheng‐Tao Cheng, Juan Chen

Frontiers in Immunology

DOI

2022

Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagy

Ren Fang, Tan Ming, Jerome P. L. Ng, Wu An Guo, Yuan Si Yu, Hui Zhang, Ren J. Hua, Cheng S. Tao, Juan Zhang, Hang Hong Lo, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Juan Chen

Antiviral Research

DOI

2022

Functional cure of hepatitis B from the perspective of hepatitis B virus covalently closed circular DNA

Juan Chen

DOAJ (DOAJ: Directory of Open Access Journals)

2021

醌氧化还原酶1抑制剂双香豆素促进HBV X蛋白降解进而抑制cccDNA转录的机制研究

CHENG ST, HU JL, REN JH, 陈娟, 黄爱龙

《临床肝胆病杂志》

2021

木犀草素抑制PKM2继而促进自噬诱导肝癌细胞凋亡

陈娟，邓敏，周焕，程冬梅

《中国医院药学杂志》

DOI

2021

双香豆素在HBx介导的肝癌细胞生长增殖中的作用及其机制研究

王晴，程胜桃，陈娟

《中国细胞生物学学报》

2021

SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome.

Hai-Ling Yu, Sheng-Tao Cheng, Fang Ren, Yong Chen, Xiao-feng Shi, V. Wong, B. Law, Ji-Hua Ren, Shan Zhong, Wei-Xian Chen, Hong-Mei Xu, Zhen-Zhen Zhang, Jie-Li Hu, Xue-fei Cai, Yuan Hu, Wen-lu Zhang, Quan-xin Long, Lin He, Zhong-Wen Hu, Hui Jiang, Hongzhong Zhou, Ai-Long Huang, Juan Chen

Clinical science

DOI

2021

DDX17‐regulated alternative splicing that produced an oncogenic isoform of PXN‐AS1 to promote HCC metastasis

Hongzhong Zhou, Fan Li, Sheng-Tao Cheng, Yong Xu, Hai-Jun Deng, Da-Yong Gu, Jin Wang, Wei-Xian Chen, Yujiao Zhou, Min-Li Yang, Ji-Hua Ren, Lu Zheng, Ai-Long Huang, Juan Chen

Hepatology

DOI

2021

Humoral responses in naive or SARS-CoV-2 experienced individuals vaccinated with an inactivated vaccine

Pai Peng, Hai-Jun Deng, Jie-Li Hu, Xiao-Yu Wei, Jian-jiang Xue, Ting-ting Li, L. Fang, Bei-zhong Liu, Ai-shun Jin, Feng-li Xu, Kang Wu, Quan-xin Long, Juan Chen, Kai Wang, N. Tang, Ai-long Huang

Cell Discovery

DOI

2021

Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9

Min-Li Yang, Yujiao Zhou, Hai-Jun Deng, Hongzhong Zhou, Sheng-Tao Cheng, Dapeng Zhang, Xinyunxi He, Li Mai, Yao Chen, Fan Li, Juan Chen

bioRxiv

DOI

2021

Immune memory in convalescent patients with asymptomatic or mild COVID-19

Quan-xin Long, Yangqing Jia, Xin Wang, Hai-Jun Deng, Xiao-Xia Cao, Jun Yuan, L. Fang, Xufei Cheng, C. Luo, A. He, Xiao-jun Tang, Jie Hu, Yuan Hu, N. Tang, Xue-fei Cai, De-Qiang Wang, Jie Hu, Jing-Fu Qiu, Bei-zhong Liu, Juan Chen, Ai-Long Huang

Cell Discovery

DOI

2021

Clinical features of Chinese children with COVID‐19 and other viral respiratory infections

Zhen-Zhen Zhang, Da-Peng Chen, Quan-Bo Liu, Chuan Gan, Li Jiang, Kun Zhu, Xiayi Zhang, Hong-Mei Xu, Ai-long Huang, Quan-xin Long, Hai-Jun Deng, Juan Chen

Pediatric Pulmonology

DOI

2021

HBx promotes hepatocarcinogenesis by enhancing phosphorylation and blocking ubiquitinylation of UHRF2

Fengjuan Cheng, Guanhua Qian, Xian-Yun Fang, Jingjie Sun, Siyuan Chen, Rongjuan Chen, Shangjing Liu, Zhaodi Li, Kejia Wu, Shiming Jiang, Yong Chen, Ni Tang, Juan Chen, Changzhu Duan

Hepatology International

DOI

2020

基于肠道微生态与内质网应激探讨虎掌菌多糖改善NAFLD的作用及机制

陈娟

《安徽大学》

2020

Patients with SARS-CoV-2 and HBV co-infection are at risk of greater liver injury

Yong Lin, Jun Yuan, Quan-xin Long, Jie-Li Hu, Hai-Jun Deng, Zhenyu Zhao, Juan Chen, Meng-Ji Lu, Ai-Long Huang

Genes and Diseases

DOI

2020

HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis

Qing Wang, Sheng-Tao Cheng, Juan Chen

International Journal of Medical Sciences

DOI

2020

DHX9 interacts with APOBEC3B and attenuates the anti-HBV effect of APOBEC3B

Yan-Meng Chen, B. Shen, Xiaochuan Zheng, Quan-xin Long, J. Xia, Yao Huang, Xue-fei Cai, De-Qiang Wang, Juan Chen, N. Tang, Ai-Long Huang, Yuan Hu

Emerging Microbes and Infections

DOI

2020

Antibody responses to SARS-CoV-2 in patients with COVID-19

Quan-xin Long, Bai-Zhong Liu, Hai-Jun Deng, Gui-cheng Wu, K. Deng, Yao-Kai Chen, P. Liao, Jing-Fu Qiu, Yong Lin, Xue-fei Cai, De-Qiang Wang, Yuan Hu, Ji-Hua Ren, N. Tang, Yin-yin Xu, Li-hua Yu, Zhan Mo, Fang Gong, Xiao-li Zhang, Wen-guang Tian, Li Hu, Xian-Xiang Zhang, Jiang-lin Xiang, Hong-xin Du, Hua-Wen Liu, Chun-Hui Lang, Xiao-he Luo, Shao-bo Wu, Xiao-Ping Cui, Zheng Zhou, Manxiang Zhu, Jing Wang, Cheng-jun Xue, Xiao-Feng Li, Li Wang, Zhi-jie Li, Kun Wang, Chang-Chun Niu, Qing-jun Yang, Xiao-jun Tang, Yong Zhang, Xia-mao Liu, Jin-jing Li, De-chun Zhang, Fan Zhang, Ping Liu, Jun Yuan, Qin Li, Jie-Li Hu, Juan Chen, Ai-Long Huang

Nature Medicine

DOI

2020

LncRNA HOTAIR Modulates Hepatitis B Virus Transcription and Replication by Enhancing SP1 Transcription Factor.

Fang Ren, Ji-Hua Ren, Chun-Li Song, M. Tan, Hai-Ling Yu, Yujiao Zhou, Yi-Ping Qin, Sheng-Tao Cheng, Yuan Zhang, Ai-Long Huang, Juan Chen, Xiao Yang

Clinical science

DOI

2020

The D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity and decreases neutralization sensitivity to individual convalescent sera

Jie-Li Hu, Chang-long He, Q. Gao, Guiji Zhang, Xiao-Xia Cao, Quan-xin Long, Hai-Jun Deng, Lu-yi Huang, Juan Chen, Kai Wang, N. Tang, Ai-Long Huang

DOI

2020

Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim.

Hong-Yan Xu, Ji-Hua Ren, Yu Su, Fang Ren, Yujiao Zhou, Hui Jiang, Sheng-Tao Cheng, Chuan-Rui Zhang, Juan Chen

Journal of Ethnopharmacology

DOI

2020

Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children

Yang Zhuo, Ya-Lan Yang, Ming-Jun Zhang, Ying Xu, Zhong-Ping Chen, L. Mu, Xiao-Jun Tang, Z. Zhong, Juan Chen, Li Zhou

The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale

DOI

2020

Longitudinal Dynamics of the Neutralizing Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

Kai Wang, Quan-xin Long, Hai-Jun Deng, Jie Hu, Q. Gao, Guiji Zhang, Chang-long He, Lu-yi Huang, Jie Hu, Juan Chen, N. Tang, Ai-Long Huang

medRxiv

DOI

2020

The clinical and immunological features of pediatric COVID-19 patients in China

Juan Chen, Zhen-Zhen Zhang, Yao-Kai Chen, Quan-xin Long, Wen-guang Tian, Hai-Jun Deng, Jie-Li Hu, Xian-Xiang Zhang, Pu-Liao, Jiang-lin Xiang, Dao-Xin Wang, P. Hu, Fa-Chun Zhou, Zhi-jie Li, Hong-Mei Xu, Xue-fei Cai, De-Qiang Wang, Yuan Hu, N. Tang, Bei-zhong Liu, Gui-cheng Wu, Ai-Long Huang

Genes and Diseases

DOI

2020

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

Quan-xin Long, Xiao-jun Tang, Qiuling Shi, Qin Li, Hai-Jun Deng, Jun Yuan, Jie-Li Hu, Wei Xu, Yong Zhang, Fa-Jin Lv, K. Su, Fan Zhang, Jiang Gong, Bo Wu, Xia-mao Liu, Jin-jing Li, Jing-Fu Qiu, Juan Chen, Ai-Long Huang

Nature Medicine

DOI

2020

A Peptide-based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Coronavirus Disease 2019 (COVID-19)

Xue-fei Cai, Juan Chen, Jie-Li Hu, Quan-xin Long, Hai-Jun Deng, Ping Liu, K. Fan, P. Liao, Bei-zhong Liu, Gui-cheng Wu, Yao-Kai Chen, Zhi-jie Li, Kun Wang, Xiao-li Zhang, Wen-guang Tian, Jiang-lin Xiang, Hong-xin Du, Jing Wang, Yuan Hu, N. Tang, Yong Lin, Ji-Hua Ren, Lu-yi Huang, Jie Wei, Chun-yang Gan, Yan-Meng Chen, Q. Gao, A-mei Chen, Chang-long He, Dao-Xin Wang, Peng Hu, Fa-Chun Zhou, Ai-Long Huang, De-Qiang Wang

medRxiv

DOI

2020

Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx.

Sheng-Tao Cheng, Jie-Li Hu, Ji-Hua Ren, Hai-Ling Yu, S. Zhong, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Wei-Xian Chen, Hong-Mei Xu, Zhen-Zhen Zhang, Xue-fei Cai, Yuan Hu, Wen-lu Zhang, Quan-xin Long, Fang Ren, Hongzhong Zhou, Ai-Long Huang, Juan Chen

Journal of Hepatology

DOI

2020

Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3β/p65 pathway.

Na-Na Tao, Zhen-Zhen Zhang, Ji-Hua Ren, Juan Zhang, Yujiao Zhou, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Sheng-Tao Cheng, Hongzhong Zhou, Wei-Xian Chen, Hong-Mei Xu, Juan Chen

Cancer Letters

DOI

2019

小檗碱调控线粒体功能改善2型糖尿病引起的肝脏脂质代谢紊乱

黄泽禹，陈娟，陈清杰

《华中科技大学学报(医学版)》

2019

HBV cccDNA转录调控机制与抗HBV治疗前景

陈娟，黄爱龙

《临床肝胆病杂志》

2019

泛素结合酶UBE2L3功能位点维持cccDNA稳定性并促进HBV复制的机制研究

陈娟，黄爱龙

《临床肝胆病杂志》

2019

A functional variant in UBE 2 L 3 contributes to HBV infection and maintains cccDNA stability by inducing degradation of APOBEC 3 A protein

Li Zhou, Ji-Hua Ren, Sheng-Tao Cheng, Hong-Mei Xu, Wei-Xian Chen, Dapeng, Chen, V. Wong, B. Law, Yi Liu, Xue-fei Cai, Hua Tang, Hai-Ling Yu, Jie-Li Hu, Yuan Hu, Hongzhong Zhou, Fang Ren, Lin He, Zhong-wen, Hu, Hui Jiang, Hong-Yan Xu, Ai-Long Huang, Juan Chen

2019

PBK overexpression promotes metastasis of hepatocellular carcinoma via activating ETV4-uPAR signaling pathway.

Qiu-Xia Yang, S. Zhong, Lin He, Xiao-Jiong Jia, Hua Tang, Sheng-Tao Cheng, Ji-Hua Ren, Hai-Ling Yu, Li Zhou, Hongzhong Zhou, Fang Ren, Zhong-Wen Hu, Rui Gong, Ai-Long Huang, Juan Chen

Cancer Letters

DOI

2019

NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma

Hongzhong Zhou, Han-qing Zeng, Ding Yuan, Ji-Hua Ren, Sheng-Tao Cheng, Hai-Ling Yu, Fang Ren, Qing Wang, Yi-Ping Qin, Ai-Long Huang, Juan Chen

Cell Communication and Signaling

DOI

2019

Niacin analogue, 6-Aminonicotinamide, a novel inhibitor of hepatitis B virus replication and HBsAg production

Fang Ren, Xiao Yang, Zhong-Wen Hu, V. Wong, Hong-Yan Xu, Ji-Hua Ren, S. Zhong, Xiao-Jiong Jia, Hui Jiang, Jie-Li Hu, Xue-fei Cai, Wen-lu Zhang, F. Yao, Hai-Ling Yu, Sheng-Tao Cheng, Hongzhong Zhou, Ai-Long Huang, B. Law, Juan Chen

EBioMedicine

DOI

2019

A Functional Variant in Ubiquitin Conjugating Enzyme E2 L3 Contributes to Hepatitis B Virus Infection and Maintains Covalently Closed Circular DNA Stability by Inducing Degradation of Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3A

Li Zhou, Ji-Hua Ren, Sheng-Tao Cheng, Hong-Mei Xu, Wei-Xian Chen, Da-Peng Chen, V. Wong, B. Law, Yi Liu, Xue-fei Cai, Hua Tang, Hai-Ling Yu, Jie-Li Hu, Yuan Hu, Hongzhong Zhou, Fang Ren, Lin He, Zhong-Wen Hu, Hui Jiang, Hong-Yan Xu, Ai-Long Huang, Juan Chen

Hepatology

DOI

2019

SIRT6 Inhibitor, OSS_128167 Restricts Hepatitis B Virus Transcription and Replication Through Targeting Transcription Factor Peroxisome Proliferator-Activated Receptors α

Hui Jiang, Sheng-Tao Cheng, Ji-Hua Ren, Fang Ren, Hai-Ling Yu, Qing Wang, Ai-Long Huang, Juan Chen

Frontiers in Pharmacology

DOI

2019

Decellularized human liver scaffold-based three-dimensional culture system facilitate hepatitis B virus infection.

Zhen-Zhen Zhang, Hong-Mei Xu, G. Mazza, Ming-Man Zhang, L. Frenguelli, Quan-Bo Liu, W. Al-Akkad, Ji-Hua Ren, Ruiqiu Zhao, Fang Ren, Xin Chen, Ai-Long Huang, Juan Chen

Journal of Biomedical Materials Research. Part A

DOI

2019

Ornithine transcarbamylase downregulation is associated with poor prognosis in hepatocellular carcinoma

Lin He, Xue-fei Cai, Sheng-Tao Cheng, Hongzhong Zhou, Zhen-Zhen Zhang, Ji-Hua Ren, Fang Ren, Qiu-Xia Yang, Na-Na Tao, Juan Chen

Oncology Letters

DOI

2019

NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.

Wan-yu Li, Hongzhong Zhou, Yao Chen, Xue-fei Cai, Hua Tang, Ji-Hua Ren, Vincent Kam Wai Wong, Betty Yuen Kwan Law, Yong Chen, Sheng-Tao Cheng, Hai-Ling Yu, Hao Cai, Wei-Xian Chen, N. Tang, Wen-lu Zhang, Na-Na Tao, Qiu-Xia Yang, Fang Ren, Lin He, Hui Jiang, Ai-Long Huang, Juan Chen

Cancer Letters

DOI

2019

Hepatitis B virus X protein modulates upregulation of DHX9 to promote viral DNA replication

B. Shen, Yan-Meng Chen, Jie-Li Hu, Miao Qiao, Ji-Hua Ren, Jie-Li Hu, Juan Chen, N. Tang, Ai-Long Huang, Yuan Hu

Cellular Microbiology

DOI

2019

SIP1 serves a role in HBx‑induced liver cancer growth and metastasis

Yuanyuan Ye, Jun Yang, Qin Hu, Jinju Mao, Qianfan Yang, Hong Chen, Dandan Li, Pu Li, Liang Duan, Bo Wang, Juan Chen, Weixian Chen

International Journal of Oncology

DOI

2019

Epigenetic regulation of hepatitis B virus cccDNA and related prospects for antiviral therapy

Juan Chen

DOAJ (DOAJ: Directory of Open Access Journals)

2018

SIRT2对裸鼠原位肝癌生长和肺转移的影响及其机制研究

杨秋霞，周洪钟，任吉华，李宛蔚，陶娜娜，程胜桃，何琳，余海波，龚蕊，陈娟

《中国细胞生物学学报》

2018

HBx-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis.

Sheng-Tao Cheng, Ji-Hua Ren, Xue-fei Cai, Hui Jiang, Juan Chen

Biochemical and Biophysical Research Communications - BBRC

DOI

2018

SIRT 3 restricts HBV transcription and replication via epigenetic regulation of cccDNA involving SUV 39 H 1 and SETD 1 A histone methyltransferases

Ji-Hua Ren, Jie-Li Hu, Sheng-Tao Cheng, Hai-Ling Yu, V. Wong, B. Law, Yong-Feng Yang, Ying K. Huang, Yi Liu, Wei-Xian Chen, Xue-fei Cai, Hua Tang, Yuan Hu, Wen-lu Zhang, Xiang Liu, Quan-xin Long, Li Zhou, Na-Na Tao, Hongzhong Zhou, Qiu-Xia Yang, Fang Ren, Lin He, Rui, Gong, Ai-Long Huang, Juan Chen

2018

Fluorescent protein tagged hepatitis B virus capsid protein with long glycine-serine linker that supports nucleocapsid formation.

Jiang-Yan Chen, Chun-yang Gan, Xue-fei Cai, Wen-lu Zhang, Quan-xin Long, Xia-Fei Wei, Yuan Hu, N. Tang, Juan Chen, Haitao Guo, Ai-Long Huang, Jie-Li Hu

Journal of Virological Methods

DOI

2018

Down-regulation of argininosuccinate lyase induces hepatoma cell apoptosis through activating Bax signaling pathway

Rui Gong, Lin He, Hongzhong Zhou, Sheng-Tao Cheng, Fang Ren, Juan Chen, Ji-Hua Ren

Genes and Diseases

DOI

2018

SIRT6 Depletion Sensitizes Human Hepatoma Cells to Chemotherapeutics by Downregulating MDR1 Expression

Xia Yang, Hua J. Ren, Juan Chen, Zhong H. Zhou, Tao S. Cheng, Fang Ren, Lin He, Rui Gong, Yong Chen

Frontiers in Pharmacology

DOI

2018

Cisplatin Enhances Hepatitis B Virus Replication and PGC-1α Expression through Endoplasmic Reticulum Stress

Xiaosong Li, E. Pan, Junke Zhu, Lei Xu, Xuemei Chen, Jingjing Li, L. Liang, Yuan Hu, J. Xia, Juan Chen, Wan-Nan Chen, Jie-Li Hu, Kai Wang, N. Tang, Ai-Long Huang

Scientific Reports

DOI

2018

AGK2, A SIRT2 Inhibitor, Inhibits Hepatitis B Virus Replication In Vitro And In Vivo

Hai-Ling Yu, Hui Jiang, Sheng-Tao Cheng, Zhong-Wen Hu, Ji-Hua Ren, Juan Chen

International Journal of Medical Sciences

DOI

2018

Rap1b enhances the invasion and migration of hepatocellular carcinoma cells by up‐regulating Twist 1

Zhenrong Tang, Hong Peng, Juan Chen, Yuyang Liu, Shaoying Yan, Gangfeng Yu, Qiuxu Chen, Hua Tang, Sheng-Chun Liu

Experimental Cell Research

DOI

2018

Interleukin-35 Level Is Reduced in Patients with Chronic Hepatitis B Virus Infection

Sheng-Tao Cheng, Ding Yuan, Yi Liu, Ying K. Huang, Xiang Chen, Hai-Ling Yu, Lin He, Hui Jiang, Ji-Hua Ren, Juan Chen

International Journal of Medical Sciences

DOI

2018

Research progress of chidamide in treatment of tumor diseases

Juan Chen, Xuemei Li

DOI

2018

SIRT3 restricts hepatitis B virus transcription and replication through epigenetic regulation of covalently closed circular DNA involving suppressor of variegation 3‐9 homolog 1 and SET domain containing 1A histone methyltransferases

Hepatology

DOI

2018

Interleukin-35 stimulates hepatitis B virus transcription and replication by targeting transcription factor HNF4α.

Na-Na Tao, Rui Gong, Xiang Chen, Lin He, Fang Ren, Hai-Ling Yu, Juan Chen, Ji-Hua Ren

Journal of General Virology

DOI

2018

Identification of Compounds Targeting Hepatitis B Virus Core Protein Dimerization through a Split Luciferase Complementation Assay

Xia-Fei Wei, Chun-yang Gan, Jing Cui, Ying-Ying Luo, Xue-fei Cai, Yi Yuan, Jing Shen, Zhiyong Li, Wen-lu Zhang, Quan-xin Long, Yuan Hu, Juan Chen, N. Tang, Haitao Guo, Ai-Long Huang, Jie-Li Hu

Antimicrobial Agents and Chemotherapy

DOI

2018

Long-Noncoding RNA Colorectal Neoplasia Differentially Expressed Gene as a Potential Target to Upregulate the Expression of IRX5 by miR-136-5P to Promote Oncogenic Properties in Hepatocellular Carcinoma

Liying Zhu, Yuyang Liu, Qiuxu Chen, Gangfeng Yu, Juan Chen, Ke Chen, N. Yang, T. Zeng, Shaoying Yan, Ai-Long Huang, Hua Tang

Cellular Physiology and Biochemistry

DOI

2017

Interleukin-34 inhibits hepatitis B virus replication in vitro and in vivo

Sheng-Tao Cheng, Hua Tang, Ji-Hua Ren, Xiang Chen, Ai-Long Huang, Juan Chen

PLoS ONE

DOI

2017

LINC00052 upregulates EPB41L3 to inhibit migration and invasion of hepatocellular carcinoma by binding miR-452-5p

Liying Zhu, N. Yang, Juan Chen, T. Zeng, Shaoying Yan, Yuyang Liu, Gangfeng Yu, Qiuxu Chen, Guiqin Du, W. Pan, Xing Li, Hui-Hao Zhou, Ai-Long Huang, Hua Tang

OncoTarget

DOI

2017

Deacetylation of Ku70 by SIRT6 attenuates Bax-mediated apoptosis in hepatocellular carcinoma.

Na-Na Tao, Ji-Hua Ren, Hua Tang, Long-kuan Ran, Hongzhong Zhou, Bo Liu, Ai-Long Huang, Juan Chen

Biochemical and Biophysical Research Communications - BBRC

DOI

2017

AF119895 regulates NXF3 expression to promote migration and invasion of hepatocellular carcinoma through an interaction with miR‐6508‐3p

T. Zeng, Dan Wang, Juan Chen, Ke Chen, Gangfeng Yu, Qiuxu Chen, Yuyang Liu, Shaoying Yan, Liying Zhu, Hui-Hao Zhou, Ai-Long Huang, Hua Tang

Experimental Cell Research

DOI

2017

Upregulation of UBE2Q1 via gene copy number gain in hepatocellular carcinoma promotes cancer progression through β‐catenin‐EGFR‐PI3K‐Akt‐mTOR signaling pathway

Bin Zhang, Chao Deng, Lei Wang, Fan Zhou, Shu Zhang, Wei Kang, Ping Zhan, Juan Chen, Shanshan Shen, Huimin Guo, Ming Zhang, Yi Wang, Feng Zhang, Wei Zhang, Jiangqiang Xiao, Bo Kong, Helmut Friess, Yuzheng Zhuge, Hongli Yan, Xiaoping Zou

Molecular Carcinogenesis

DOI

2016

热休克蛋白70对HBV复制的影响

周洪钟，刘波，任吉华，陶娜娜，陈祥，李宛蔚，陈娟

《中国病理生理杂志》

2016

Sirtuin 6对肝癌细胞增殖的影响

陶娜娜，周洪钟，任吉华，陈祥，李宛蔚，刘波，陈娟

《中国病理生理杂志》

2016

沉默信息调节因子3对肝癌细胞增殖的影响

陶颖，陈娟

《南方医科大学学报》

2016

SIRT6基因沉默对裸鼠异位移植人肝癌细胞增殖和凋亡的影响

周洪钟，陶娜娜，陈祥，任吉华，李宛蔚，刘波，陈娟

《中国细胞生物学学报》

2016

SIRT6基因沉默对人肝癌细胞凋亡的影响及其机制研究

周洪钟，陶娜娜，陈祥，任吉华，李宛蔚，刘波，陈娟

《中国细胞生物学学报》

2016

肝癌干细胞体外富集模式的构建

杨帅，陈娟，佘佐亚，陈相宜，蔡捷，邝晓聪

《山东医药》

2016

热休克蛋白B1抑制HBV复制的研究

程胜桃，任吉华，刘波，陈娟

《陆军军医大学学报》

2016

ZEB2 inhibits HBV transcription and replication by targeting its core promoter

Qiao He, Wan-yu Li, Ji-Hua Ren, Ye-Cai Huang, Ying K. Huang, Qin Hu, Juan Chen, Weixian Chen

OncoTarget

DOI

2016

熱ショック蛋白質B1によるHBV複製抑制の研究【JST・京大機械翻訳】

Sheng-Tao Cheng, Ji-Hua Ren, Bo Liu, Juan Chen

2016

LINC00052 regulates the expression of NTRK3 by miR-128 and miR-485-3p to strengthen HCC cells invasion and migration

Dong-mei Xiong, Yanrui Sheng, Shijia Ding, Juan Chen, Xixi Tan, T. Zeng, Dong-Dong Qin, Liying Zhu, Ai-Long Huang, Hua Tang

OncoTarget

DOI

2016

The SIRT1 inhibitor, nicotinamide, inhibits hepatitis B virus replication in vitro and in vivo

Wan-yu Li, Ji-Hua Ren, Na-Na Tao, Long-kuan Ran, Xiang Chen, Hongzhong Zhou, Bo Liu, Xiao-song Li, Ai-Long Huang, Juan Chen

Archives of Virology

DOI

2016

Protective Role of Sirtuin3 (SIRT3) in Oxidative Stress Mediated by Hepatitis B Virus X Protein Expression

Ji-Hua Ren, Xiang Chen, Li Zhou, Na-Na Tao, Hongzhong Zhou, Bo Liu, Wan-yu Li, Ai-Long Huang, Juan Chen

PLoS ONE

DOI

2016

Sirtuin 3 enhanced drug sensitivity of human hepatoma cells through glutathione S-transferase pi 1/JNK signaling pathway

Na-Na Tao, Hongzhong Zhou, Hua Tang, Xue-fei Cai, Wen-lu Zhang, Ji-Hua Ren, Li Zhou, Xiang Chen, Ke Chen, Wan-yu Li, Bo Liu, Qiu-Xia Yang, Sheng-Tao Cheng, Li-Xia Huang, Ai-Long Huang, Juan Chen

OncoTarget

DOI

2016

SIRT6 Overexpression Potentiates Apoptosis Evasion in Hepatocellular Carcinoma via BCL2-Associated X Protein–Dependent Apoptotic Pathway

Long-kuan Ran, Yong Chen, Zhen-Zhen Zhang, Na-Na Tao, Ji-Hua Ren, Li Zhou, Hua Tang, Xiang Chen, Ke Chen, Wan-yu Li, Ai-Long Huang, Juan Chen

Clinical Cancer Research

DOI

2016

AF 113014 inhibits proliferation and migration of hepatocellular carcinoma cells by binding eEF 1 A 1 protein

Dan-Dan Wang, Juan Chen, Ke Chen, Hong Peng, Liyong Zhu, T. Zeng, Ai-Long Huang, Wen-lu Zhang, Hua, Tang

2016

Host Genetic Variants in HLA Loci Influence Risk for Hepatitis B Virus Infection in Children

Jie Fan, Xin Huang, Juan Chen, Yi-Ling Cai, L. Xiong, L. Mu, Li Zhou

Hepatitis Monthly

DOI

2015

细胞周期蛋白D2对HBV复制的影响

任吉华，冉龙宽，李宛蔚，陶娜娜，陈祥，周洪钟，刘波，陈娟

《陆军军医大学学报》

2015

过表达SIRT3抑制裸鼠异位移植人肝细胞癌的生长及其机制研究

陈祥，任吉华，冉龙宽，陶娜娜，李宛蔚，周洪钟，刘波，陈娟

《中国细胞生物学学报》

2015

The Infection Efficiency and Replication Ability of Circularized HBV DNA Optimized the Linear HBV DNA in Vitro and in Vivo

Xiaosong Li, Junke Zhu, G. Lai, Lei Yan, Jie-Li Hu, Juan Chen, N. Tang, Ai-Long Huang

International Journal of Molecular Sciences

DOI

2015

Deep Sequencing Analysis of HBV Genotype Shift and Correlation with Antiviral Efficiency during Adefovir Dipivoxil Therapy

Yu-Wei Wang, X. Shan, Zhi Liang, Youlan Shan, Wen-Xiang Huang, Da-Zhi Zhang, Aizhong Zen, Xin Zhou, Yao Zhao, Xu-Yang Gong, Ge Xu, Xiu-Yu Zhang, Juan Chen, Ai-Long Huang

PLoS ONE

DOI

2015

Upregulated in Hepatitis B virus-associated hepatocellular carcinoma cells, miR-331-3p promotes proliferation of hepatocellular carcinoma cells by targeting ING5

Yiyi Cao, Juan Chen, Dan Wang, Hong Peng, Xixi Tan, Dong-mei Xiong, Ai-Long Huang, Hua Tang

OncoTarget

DOI

2015

S-phase arrest after vincristine treatment may promote hepatitis B virus replication.

Lei Xu, Z. Tu, Ge Xu, Jie-Li Hu, Xue-fei Cai, Xingxing Zhan, Yu-Wei Wang, Yuan Huang, Juan Chen, Ai-Long Huang

World Journal of Gastroenterology

DOI

2015

A novel baseline hepatitis B virus sequencing-based strategy for predicting adefovir antiviral response.

Yu-Wei Wang, X. Shan, Yao Huang, Hai-Jun Deng, Wen-Xiang Huang, Da-Zhi Zhang, Juan Chen, N. Tang, Youlan Shan, Jin-Jun Guo, Ai-Long Huang

Infection, Genetics and Evolution

DOI

2015

Functional analysis of miR-181a and Fas involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.

Chengcheng Zou, Juan Chen, Ke Chen, Sen Wang, Yiyi Cao, Jinnan Zhang, Yanrui Sheng, Ai-Long Huang, Hua Tang

Experimental Cell Research

DOI

2014

构建高比例肝癌干细胞克隆筛选模式

陈娟

《广西医科大学》

2014

慢性乙型肝炎患者血清CCL7与IL-6、TGF-β1表达的关系及其在肝脏炎症/纤维化进展中作用的研究

李德征，南月敏，闫有敏，王素格，石国晨，陈娟

《河北医药》

2014

组蛋白去乙酰化酶抑制剂对乙型肝炎病毒复制的影响

陈可，任吉华，宋春丽，冉龙宽，李宛蔚，陈娟

《重庆医科大学学报》

2014

SIRT2基因沉默后对肝癌细胞增殖的影响

冉龙宽，宋春丽，李宛蔚，任吉华，陈祥，陶娜娜，陈娟

《陆军军医大学学报》

2014

丹酚酸B对非酒精性脂肪性肝炎大鼠肝细胞凋亡的影响

王迎春，孔维宗，金青梅，陈娟

《临床肝胆病杂志》

2014

Epirubicin directly promotes hepatitis B virus (HBV) replication in stable HBV-expressing cell lines: a novel mechanism of HBV reactivation following anticancer chemotherapy.

Lei Xu, Z. Tu, Ge Xu, Yu-Wei Wang, W. Pan, Xingxing Zhan, Q. Luo, Yuan Huang, Juan Chen, Ai-Long Huang

Molecular Medicine Reports

DOI

2014

Cyclin D2 plays a regulatory role in HBV replication.

Chun-Li Song, Ji-Hua Ren, Long-kuan Ran, Yong-Guo Li, Xiao-song Li, Xiang Chen, Wan-yu Li, Ai-Long Huang, Juan Chen

Virology

DOI

2014

Functional analysis of miR-101-3p and Rap1b involved in hepatitis B virus-related hepatocellular carcinoma pathogenesis.

Yanrui Sheng, Shijia Ding, Ke Chen, Juan Chen, Sen Wang, Chengcheng Zou, Jing-Nan Zhang, Yiyi Cao, Ai-Long Huang, Hua Tang

Biochemistry and cell biology = Biochimie et biologie cellulaire

DOI

2014

miR-125b inhibits hepatitis B virus expression in vitro through targeting of the SCNN1A gene

Zhen-Zhen Zhang, Juan Chen, Yin He, Xue Zhan, Ruiqiu Zhao, Yan-Feng Huang, Hong-Mei Xu, Zhaomin Zhu, Quan-Bo Liu

Archives of Virology

DOI

2014

Depletion of Sirtuin 1 (SIRT1) Leads to Epigenetic Modifications of Telomerase (TERT) Gene in Hepatocellular Carcinoma Cells

Bin Zhang, Juan Chen, A. Cheng, Ben C. B. Ko

PLoS ONE

DOI

2013

Endoplasmic reticulum stress leads to lipid accumulation through upregulation of SREBP-1c in normal hepatic and hepatoma cells

Dian-Liang Fang, Ying Wan, W. Shen, Jie Cao, Zhongdong Sun, Hui-hong Yu, Qin Zhang, Wenbin Cheng, Juan Chen, Bo Ning

Molecular and Cellular Biochemistry

DOI

2013

Sirtuin 1 Regulates Hepatitis B Virus Transcription and Replication by Targeting Transcription Factor AP-1

Ji-Hua Ren, Ying Tao, Zhen-Zhen Zhang, Wei-Xian Chen, Xue-fei Cai, Ke Chen, Ben C. B. Ko, Chun-Li Song, Long-kuan Ran, Wan-yu Li, Ai-Long Huang, Juan Chen

Journal of Virology

DOI

2013

SIRT2 Overexpression in Hepatocellular Carcinoma Mediates Epithelial to Mesenchymal Transition via Akt/GSK‐3β/β‐catenin Signaling.

Ben C.B. Ko, Juan Chen, Anthony Chen, Paul B.S. Lai, Ailong Huang

The FASEB Journal

DOI

2013

SIRT2 overexpression in hepatocellular carcinoma mediates epithelial to mesenchymal transition by protein kinase B/glycogen synthase kinase‐3β/β‐catenin signaling

Juan Chen, A. Chan, Ka F. To, Wei-Xian Chen, Zhen-Zhen Zhang, Ji-Hua Ren, Chun-Li Song, Yue-Sun Cheung, P. Lai, Suk H. Cheng, M. Ng, Ai-Long Huang, Ben C. B. Ko

Hepatology

DOI

2012

受体来源转染pBLAST2-hHGF质粒肝卵圆细胞对大鼠移植肝肝功能的影响

李铸，陈娟，李学华，刘志恒，刘桂杰，张学利，高延超，孙会东，纪丕友，张金良，李立

《中国现代医学杂志》

2012

SIRT1基因沉默诱导肝癌细胞老化及其机制

宋春丽，任吉华，张祯祯，陶颖，陈娟

《陆军军医大学学报》

2012

应用SRY原位杂交技术检测肝脏干细胞移植肝内种植情况

李铸，陈娟，李学华，刘志恒，刘桂杰，张学利，高延超，孙会东，纪丕友，张金良，李立

《中国组织工程研究》

2012

慢病毒介导的靶向沉默信息调节因子1（SIRT1）的RNA干扰对肝癌细胞生长及凋亡的影响

Ji-Hua Ren, Chun-Li Song, Ying Tao, Juan Chen

2012

Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway

Jie Cao, Dong-Ling Dai, Long Yao, Hui-hong Yu, Bo Ning, Qin Zhang, Juan Chen, Wenbin Cheng, W. Shen, Zhao-Xia Yang

Molecular and Cellular Biochemistry

DOI

2012

[Hypoxia-induced alterations of lipid metabolism in the normal human hepatic L02 cell line].

Wenbin Cheng, W. Shen, Juan Chen

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

DOI

2011

移植途径对大鼠骨髓间充质干细胞归巢及肝功能恢复的影响

何秀华，李东良，江军，徐颖，范敬静，陈娟，陈胜平

《中华细胞与干细胞杂志(电子版)》

2011

Sirtuin 1 is upregulated in a subset of hepatocellular carcinomas where it is essential for telomere maintenance and tumor cell growth.

Juan Chen, Bin Zhang, N. Wong, A. Lo, Ka F. To, A. Chan, M. Ng, C. Y. Ho, Suk H. Cheng, P. Lai, Jun Yu, H. Ng, M. Ling, Ai-long Huang, Xue Cai, Ben C. B. Ko

Cancer Research

DOI

2011

[Effect of hepatitis B virus X protein on expression of lipid metabolism-related genes in HepG2 cells].

Juan Chen, W. Shen, Wenbin Cheng

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

DOI

2010

大鼠肝卵圆细胞的增殖模型建立和体外分离培养、诱导分化研究

李铸，李立，冉江华，张升宁，刘静，李来邦，陈娟

《中国现代医学杂志》

2010

实时荧光定量RT-PCR检测肝卵圆细胞Alb和CK-19 mRNA的表达

李铸，李立，冉江华，张升宁，刘静，刘滇生，陈娟

《中国现代医学杂志》

2010

Heparin sulphate D-glucosaminyl 3-O-sulfotransferase 3B1 plays a role in HBV replication.

Zhen-Zhen Zhang, Xiang Liu, Juan Chen, Huai-Bin Su, Q. Luo, Jianjiang Ye, N. Tang, Wen-lu Zhang, Wei-Xian Chen, Ben C. B. Ko, Ai-Long Huang

Virology

DOI

2008

O6-甲基鸟嘌呤-DNA甲基转移酶在肝癌组织中的表达及其意义

袁丁，陈治强，陈娟

《现代肿瘤医学》

2008

HCV core protein interacts with Dicer to antagonize RNA silencing.

Wei-Xian Chen, Zhen-Zhen Zhang, Juan Chen, Juan Zhang, Jun Zhang, Ying Wu, Ying K. Huang, Xue-fei Cai, Ai-Long Huang

Virus Research

DOI

2007

HCV 5'UTR启动子活性研究

陈娟

《重庆医科大学》

2007

HepG2细胞中HCV NS5A蛋白对HCV IRES启动蛋白翻译的影响

Juan Chen, Wei-Xian Chen, Zhen-Zhen Zhang, Ai-Long Huang

2007

[The effect of HCV NS5A protein on HCV IRES-dependent translation in HepG2 cells].

Juan Chen, Wei-Xian Chen, Zhen-Zhen Zhang, Ai-long Huang

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

2007

[The effect of HCV NS5A protein on HCV IRES-dependent translation in HepG2 cells].

Juan Chen, Weixian Chen, Zhenzhen Zhang, Ailong Huang

PubMed

2006

HCV核心蛋白影响细胞凋亡可能机制的研究进展

陈娟，黄爱龙

《国际病毒学杂志》

2006

丙型肝炎病毒5’非翻译区不同结构域对其启动子活性的影响

陈娟，陈维贤，慕生枝，张君，黄爱龙

Virologica Sinica

2006

短发夹状双链RNA抑制丙型肝炎病毒IRES介导的基因表达

陈维贤，单林娜，陈娟，张祯祯，张秉强，黄爱龙

《中华肝脏病杂志》

2006

The Effect of Various Domains of HCV 5’UTR on the Promoter Activity

Juan Chen, Weixian Chen, MU Sheng-zhi, Jun Zhang, Ailong Huang

Virologica Sinica

2006

[Inhibition of HCV IRES controlled reporter gene expression by RNA interference].

Wei-Xian Chen, Lin Shan, Juan Chen, Zhen-Zhen Zhang, Bing-qiang Zhang, Ai-long Huang

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology

1997

老化肝脏枯否细胞骨架结构及其对内毒素剂量耐受性的改变

孙文兵，韩本立，李昆，彭志明，段恒春，马瑞亮，陈娟，王槐志

《中华肝脏病杂志》

精选作品

期刊论文

EGFR N-Glycosylation Catalyzed by NDST2 Promotes Lenvatinib Resistance in Hepatocellular Carcinoma

免疫因子γ干扰素、肿瘤坏死因子α、甲胎蛋白异质体在肝细胞癌中的表达及与病理参数、预后的相关性

The role of succinylation-mediated metabolic reprogramming in tumor progression

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

[Crosstalk and the progression of hepatocellular carcinoma].

Rapavir, a novel inhibitor of sodium taurocholate cotransporting polypeptide, potently blocks hepatitis B virus entry

Glutamate dehydrogenase 1-dependent α-ketoglutarate promotes hepatitis B virus transcription by modulating histone methylations on the covalently closed circular DNA minichromosome

CRISPR/Cas13a combined with reverse transcription-multienzyme isothermal rapid amplification for hepatitis B virus RNA detection

脂质代谢紊乱在非酒精性脂肪性肝病中的作用概述

氨基酸代谢在非酒精性脂肪性肝病中的作用机制

Colchicine-mediated selective autophagic degradation of HBV core proteins inhibits HBV replication and HBV-related hepatocellular carcinoma progression

HOXA‐AS2 Epigenetically Inhibits HBV Transcription by Recruiting the MTA1‐HDAC1/2 Deacetylase Complex to cccDNA Minichromosome

Chromatin binding protein HMGN1 promotes HBV cccDNA transcription and replication by regulating the phosphorylation of histone 3

Signaling molecules in the microenvironment of hepatocellular carcinoma

KLRG1-expressing CD8+ T cells are exhausted and polyfunctional in patients with chronic hepatitis B

Corrigendum: Ribosomal protein L23 drives the metastasis of hepatocellular carcinoma via upregulating MMP9

RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling

Epigenetic regulation and its therapeutic potential in hepatitis B virus covalently closed circular DNA

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy

Neuropilin-1 is a novel host factor modulating the entry of hepatitis B virus

肝喜合剂含药血清对人肝癌HepG2细胞增殖和凋亡的影响

CLEC1B在肝细胞癌中的表达及其对细胞恶性生物学行为的影响

Phosphorylation of UHRF2 affects malignant phenotypes of HCC and HBV replication by blocking DHX9 ubiquitylation

Sphondin efficiently blocks HBsAg production and cccDNA transcription through promoting HBx degradation

SIRT2 Promotes HBV Transcription and Replication by Targeting Transcription Factor p53 to Increase the Activities of HBV Enhancers and Promoters

Pimobendan Inhibits HBV Transcription and Replication by Suppressing HBV Promoters Activity

Glutamate dehydrogenase 1 mediated glutaminolysis sustains HCC cells survival under glucose deprivation

Case report: A case of severe acute hepatitis of unknown origin

Distinct immune responses in the early phase to natural SARS‐CoV‐2 infection or vaccination

Increased immune escape of the new SARS-CoV-2 variant of concern Omicron

Genome-wide association study of SARS-CoV-2 infection in Chinese population

Rapamycin inhibits hepatitis B virus covalently closed circular DNA transcription by enhancing the ubiquitination of HBx

KAT2A Promotes Hepatitis B Virus Transcription and Replication Through Epigenetic Regulation of cccDNA Minichromosome

HBx Mediated Increase of DDX17 Contributes to HBV-Related Hepatocellular Carcinoma Tumorigenesis

Ciliatoside A, isolated from Peristrophe japonica, inhibits HBsAg expression and cccDNA transcription by inducing autophagy

Functional cure of hepatitis B from the perspective of hepatitis B virus covalently closed circular DNA

醌氧化还原酶1抑制剂双香豆素促进HBV X蛋白降解进而抑制cccDNA转录的机制研究

木犀草素抑制PKM2继而促进自噬诱导肝癌细胞凋亡

双香豆素在HBx介导的肝癌细胞生长增殖中的作用及其机制研究

SIRT7 restricts HBV transcription and replication through catalyzing desuccinylation of histone H3 associated with cccDNA minichromosome.

DDX17‐regulated alternative splicing that produced an oncogenic isoform of PXN‐AS1 to promote HCC metastasis

Humoral responses in naive or SARS-CoV-2 experienced individuals vaccinated with an inactivated vaccine

Ribosomal Protein L23 Drives the Metastasis of Hepatocellular Carcinoma via Upregulating MMP9

Immune memory in convalescent patients with asymptomatic or mild COVID-19

Clinical features of Chinese children with COVID‐19 and other viral respiratory infections

HBx promotes hepatocarcinogenesis by enhancing phosphorylation and blocking ubiquitinylation of UHRF2

基于肠道微生态与内质网应激探讨虎掌菌多糖改善NAFLD的作用及机制

Patients with SARS-CoV-2 and HBV co-infection are at risk of greater liver injury

HBx mediated Increase of SIRT1 Contributes to HBV-related Hepatocellular Carcinoma Tumorigenesis

DHX9 interacts with APOBEC3B and attenuates the anti-HBV effect of APOBEC3B

Antibody responses to SARS-CoV-2 in patients with COVID-19

LncRNA HOTAIR Modulates Hepatitis B Virus Transcription and Replication by Enhancing SP1 Transcription Factor.

The D614G mutation of SARS-CoV-2 spike protein enhances viral infectivity and decreases neutralization sensitivity to individual convalescent sera

Anti-hepatitis B virus activity of swertisin isolated from Iris tectorum Maxim.

Single Nucleotide Polymorphisms in IFN-γ Signaling Pathway Associated with Risk of Hepatitis B Virus Infection in Chinese Children

Longitudinal Dynamics of the Neutralizing Antibody Response to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

The clinical and immunological features of pediatric COVID-19 patients in China

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

A Peptide-based Magnetic Chemiluminescence Enzyme Immunoassay for Serological Diagnosis of Coronavirus Disease 2019 (COVID-19)

Dicoumarol, an NQO1 inhibitor, blocks cccDNA transcription by promoting degradation of HBx.

Overexpression of ubiquitin-conjugating enzyme E2 L3 in hepatocellular carcinoma potentiates apoptosis evasion by inhibiting the GSK3β/p65 pathway.

小檗碱调控线粒体功能改善2型糖尿病引起的肝脏脂质代谢紊乱

HBV cccDNA转录调控机制与抗HBV治疗前景

泛素结合酶UBE2L3功能位点维持cccDNA稳定性并促进HBV复制的机制研究

A functional variant in UBE 2 L 3 contributes to HBV infection and maintains cccDNA stability by inducing degradation of APOBEC 3 A protein

PBK overexpression promotes metastasis of hepatocellular carcinoma via activating ETV4-uPAR signaling pathway.

NQO1 potentiates apoptosis evasion and upregulates XIAP via inhibiting proteasome-mediated degradation SIRT6 in hepatocellular carcinoma

Niacin analogue, 6-Aminonicotinamide, a novel inhibitor of hepatitis B virus replication and HBsAg production

A Functional Variant in Ubiquitin Conjugating Enzyme E2 L3 Contributes to Hepatitis B Virus Infection and Maintains Covalently Closed Circular DNA Stability by Inducing Degradation of Apolipoprotein B mRNA Editing Enzyme Catalytic Subunit 3A

SIRT6 Inhibitor, OSS_128167 Restricts Hepatitis B Virus Transcription and Replication Through Targeting Transcription Factor Peroxisome Proliferator-Activated Receptors α

Decellularized human liver scaffold-based three-dimensional culture system facilitate hepatitis B virus infection.

Ornithine transcarbamylase downregulation is associated with poor prognosis in hepatocellular carcinoma

NAD(P)H: Quinone oxidoreductase 1 overexpression in hepatocellular carcinoma potentiates apoptosis evasion through regulating stabilization of X-linked inhibitor of apoptosis protein.

Hepatitis B virus X protein modulates upregulation of DHX9 to promote viral DNA replication

SIP1 serves a role in HBx‑induced liver cancer growth and metastasis

Epigenetic regulation of hepatitis B virus cccDNA and related prospects for antiviral therapy

SIRT2对裸鼠原位肝癌生长和肺转移的影响及其机制研究

HBx-elevated SIRT2 promotes HBV replication and hepatocarcinogenesis.