百晓学者学者目录

洪泂

副教授、博士生导师、教授、研究员，中国科学技术大学

精选作品

期刊论文

2026

Valorization of xylose mother liquor into salidroside by engineered Kluyveromyces marxianus

Lingya Wang, Dongmei Wang, Jiong Hong

Synthetic and Systems Biotechnology

DOI

2026

Production of mannitol from molasses and Jerusalem artichoke tubers at elevated temperatures using engineered Kluyveromyces marxianus through consolidated bioprocessing

Feier Wang, Dongmei Wang, Shenglin Hu, Xingjiang Li, Jiong Hong

Current Research in Food Science

DOI

2025

Gene disruption via a transient hypercompact CRISPR-AsCas12f1 system in Kluyveromyces marxianus

Kehui Zhang, Dongmei Wang, Shenglin Hu, Xingjiang Li, Jiong Hong

Biotechnology Letters

DOI

2025

MutS-mediated rapid and cost-effective error correction in in vitro DNA synthesis

Liting Jia, Shuang Wang, Dongmei Wang, Xingjiang Li, Jiong Hong

New Biotechnology

DOI

2025

From genetic constraints to process hurdles: A review of Kluyveromyces marxianus for efficient bio-manufacturing and bio-processing in food industry

Huan Wang, Zhongke Sun, Zifu Ni, Yanli Qi, Xianyang Feng, Hongkun Xiao, Le Wang, Jiong Hong, Yongheng Liang, Chengwei Li

Current Research in Food Science

DOI

2024

促进拔尖创新人才培养的合成生物学课程体系建设与实践

王冬梅，洪泂

《生物学杂志》

2024

Enhancing simultaneous saccharification and co-fermentation of corncob by Kluyveromyces marxianus through overexpression of putative transcription regulator

Kehui Zhang, Ziyun Jiang, Xingjiang Li, Dongmei Wang, Jiong Hong

Bioresource Technology

DOI

2023

合成生物学课程思政元素的挖掘与实践

王冬梅，洪泂

《生物学杂志》

2023

Unveiling malic acid biorefinery: Comprehensive insights into feedstocks, microbial strains, and metabolic pathways

Boyang Xu, Wang-Wei Zhang, Eryong Zhao, Jiong Hong, Xiangsong Chen, Zhao‐Jun Wei, Xingjiang Li

Bioresource Technology

DOI

2023

Enhancing tolerance of Kluyveromyces marxianus to lignocellulose-derived inhibitors and its ethanol production from corn cob via overexpression of a nitroreductase gene

Nini Zhang, Feier Wang, Feier Wang, Marknoah Chinenye Nwamba, Dongmei Wang, Jiong Hong

Industrial Crops and Products

DOI

2023

The novel properties of Kluyveromyces marxianus glucose sensor/receptor repressor pathway and the construction of glucose repression-released strains

Lingya Wang, Anran Wang, Dongmei Wang, Jiong Hong

Microbial Cell Factories

DOI

2022

Lignocellulosic xylitol production from corncob using engineered Kluyveromycesmarxianus

Jia Zhang, Teng Xu, Xiaohang Wang, Xiaoyan Jing, Jia Zhang, Jiong Hong, Jian Xu, Jichao Wang

Frontiers in Bioengineering and Biotechnology

DOI

2022

Carotenoid production from nondetoxified xylose mother liquid or corncob hydrolysate with engineered Kluyveromyces marxianus

Xiaoxue Yang, Dongmei Wang, Jiong Hong

Bioresource Technology

DOI

2021

Influence of prefoldin subunit 4 on the tolerance of Kluyveromyces marxianus to lignocellulosic biomass-derived inhibitors

Nini Zhang, Yingying Shang, Feier Wang, Dongmei Wang, Jiong Hong

Microbial Cell Factories

DOI

2021

The development of a heterologous gene expression system in thermophilic fungus Thermoascus aurantiacus

Shenglin Hu, Zhefan Wang, Dongmei Wang, Jichao Wang, Jiong Hong

3 Biotech

DOI

2020

微课教学设计:以“从碱基到人造生命——大规模DNA的从头合成”为例

王冬梅，洪泂

《生物学杂志》

2020

在耐热的马克斯克鲁维酵母中构建微生物细胞工厂

王冬梅，洪泂

《生物学杂志》

2020

Effect of a Novel Alpha/Beta Hydrolase Domain Protein on Tolerance of K. marxianus to Lignocellulosic Biomass Derived Inhibitors

Dan Wu, Dongmei Wang, Jiong Hong

Frontiers in Bioengineering and Biotechnology

DOI

2019

Release of glucose repression on xylose utilization in Kluyveromyces marxianus to enhance glucose-xylose co-utilization and xylitol production from corncob hydrolysate

Yan Hua, Jichao Wang, Yelin Zhu, Biao Zhang, Xin Kong, Wenjie Li, Dongmei Wang, Jiong Hong

Microbial Cell Factories

DOI

2018

Efficient l-lactic acid production from corncob residue using metabolically engineered thermo-tolerant yeast

Xin Kong, Biao Zhang, Yan Hua, Yelin Zhu, Wenjie Li, Dongmei Wang, Jiong Hong

Bioresource Technology

DOI

2018

Efficient purification of a recombinant tag-free thermostable Kluyveromyces marxianus uricase by pH-induced self-cleavage of intein and expression in Escherichia coli

Bangchun Wang, Laipeng Luo, Dongmei Wang, Rui Ding, Jiong Hong

3 Biotech

DOI

2018

Transcriptomic analysis of thermotolerant yeast Kluyveromyces marxianus in multiple inhibitors tolerance

Dongmei Wang, Dan Wu, Xiaoxue Yang, Jiong Hong

RSC Advances

DOI

2017

High-fidelity de novo synthesis of pathways using microchip-synthesized oligonucleotides and general molecular biology equipment

Wen Wan, Min Lü, Dongmei Wang, Xiaolian Gao, Jiong Hong

Scientific Reports

DOI

2017

Identification of hexose kinase genes in Kluyveromyces marxianus and thermo-tolerant one step producing glucose-free fructose strain construction

Guorong Zhang, Min Lu, Jichao Wang, Dongmei Wang, Xiaolian Gao, Jiong Hong

Scientific Reports

DOI

2017

キシロースとグルコースの同時消費による高温での工学的生産Kluyveromyces marxianusピルビン酸【Powered by NICT】

Biao Zhang, Yelin Zhu, Jia Zhang, Dong-Mei Wang, Lianhong Sun, Jiong Hong

2016

系统生物学实验系列课程之一——不同强度启动子调控基因表达的研究

王冬梅，洪泂

《生命的化学》

2016

Engineered Kluyveromyces marxianus for pyruvate production at elevated temperature with simultaneous consumption of xylose and glucose

Biao Zhang, Yelin Zhu, Jia Zhang, Dongmei Wang, Lianhong Sun, Jiong Hong

Bioresource Technology

DOI

2016

Simultaneous fermentation of glucose and xylose at elevated temperatures co-produces ethanol and xylitol through overexpression of a xylose-specific transporter in engineered Kluyveromyces marxianus

Biao Zhang, Jia Zhang, Dongmei Wang, Ruixiang Han, Rui Ding, Xiaolian Gao, Lianhong Sun, Jiong Hong

Bioresource Technology

DOI

2016

システム生物学実験シリーズの一つである異なる強度プロモーターによる遺伝子発現の制御に関する研究【JST・京大機械翻訳】

Dong-Mei Wang, Jiong Hong

2015

Data for rapid ethanol production at elevated temperatures by engineered thermotolerant Kluyveromyces marxianus via the NADP(H)-preferring xylose reductase–xylitol dehydrogenase pathway

Biao Zhang, Jia Zhang, Dongmei Wang, Xiaolian Gao, Lianhong Sun, Jiong Hong

Data in Brief

DOI

2015

Rapid ethanol production at elevated temperatures by engineered thermotolerant Kluyveromyces marxianus via the NADP(H)-preferring xylose reductase-xylitol dehydrogenase pathway

Jia Zhang, Biao Zhang, Dongmei Wang, Xiaolian Gao, Lianhong Sun, Jiong Hong

Metabolic Engineering

DOI

2015

Characterizing yeast promoters used in Kluyveromyces marxianus

Chun Xia Yang, Shenglin Hu, Songli Zhu, Dongmei Wang, Xiaolian Gao, Jiong Hong

World Journal of Microbiology and Biotechnology

DOI

2015

Effective Optimization of Antibody Affinity by Phage Display Integrated with High-Throughput DNA Synthesis and Sequencing Technologies

Dongmei Hu, Siyi Hu, Wen Wan, Man Xu, Ruikai Du, Wei Hong Zhao, Xiaolian Gao, Jing L. Liu, Haiyan Liu, Jiong Hong

PLoS ONE

DOI

2015

Construction and engineering application of high-temperature high-yielding strains of xylitol and ethanol at the same time

Jiong Hong, Biao Zhang, Jia Zhang

2015

Building and application of engineered strains capable of producing xylitol and ethanol at high temperature simultaneously with high yield

Jiong Hong, Biao Zhang, Jia Zhang

2014

合成生物学中的正交遗传系统

葛永斌，洪泂，王冬梅

《生命的化学》

2014

Design and construction of small perturbation mutagenesis libraries for antibody affinity maturation using massive microchip-synthesized oligonucleotides

Man Xu, Siyi Hu, Bo Ding, Caiyi Fei, Wen Wan, Dongmei Hu, Ruikai Du, Xiaochuan Zhou, Jiong Hong, Haiyan Liu, Xiaolian Gao, Jing L. Liu

Journal of Biotechnology

DOI

2014

Improving xylitol production at elevated temperature with engineered Kluyveromyces marxianus through over-expressing transporters

Jia Zhang, Biao Zhang, Dongmei Wang, Xiaolian Gao, Jiong Hong

Bioresource Technology

DOI

2014

Error removal in microchip-synthesized DNA using immobilized MutS

Wen Wan, Lulu Li, Qianqian Xu, Zhefan Wang, Yuan Yao, Rongliang Wang, Jia Zhang, Haiyan Liu, Xiaolian Gao, Jiong Hong

Nucleic Acids Research

DOI

2014

Direct fermentation of raw starch using a Kluyveromyces marxianus strain that expresses glucoamylase and Alpha‐amylase to produce ethanol

Rongliang Wang, Dongmei Wang, Xiaolian Gao, Jiong Hong

Biotechnology Progress

DOI

2014

Orthogonal genetic system in synthetic biology

Yong Ge, Jiong Hong, Dong-Mei Wang

2013

Xylitol production at high temperature by engineered Kluyveromyces marxianus

Jia Zhang, Biao Zhang, Dongmei Wang, Xiaolian Gao, Jiong Hong

Bioresource Technology

DOI

2013

Erratum to: Improved xylose fermentation of Kluyveromyces marxianus at elevated temperature through construction of a xylose isomerase pathway

Rongliang Wang, Lulu Li, Biao Zhang, Xiaolian Gao, Dongmei Wang, Jiong Hong

Journal of Industrial Microbiology & Biotechnology

DOI

2013

Improved xylose fermentation ofKluyveromyces marxianusat elevated temperature through construction of a xylose isomerase pathway

Rongliang Wang, Lulu Li, Biao Zhang, Xiaolian Gao, Dongmei Wang, Jiong Hong

Journal of Industrial Microbiology & Biotechnology

DOI

2013

Improving ethanol and xylitol fermentation at elevated temperature through substitution of xylose reductase inKluyveromyces marxianus

Biao Zhang, Lulu Li, Jia Zhang, Xiaolian Gao, Dongmei Wang, Jiong Hong

Journal of Industrial Microbiology & Biotechnology

DOI

2013

Construction and application of high-temperature high-yield xylitol engineering strains

Jiong Hong, Jia Zhang

2012

高水平国际学术竞赛在大学生创新能力培养中的作用

洪泂，罗昭峰，梁志，吴家睿，刘海燕

《高校生物学教学研究(电子版)》

2012

DNA化学合成中的错误去除

王冬梅，宛雯，洪泂

《生命的化学》

2012

Identification of a Xylitol Dehydrogenase Gene from Kluyveromyces marxianus NBRC1777

Lulu Li, Ling Zhang, Wang Dongmei, Xiaolian Gao, Hisanori Tamaki, Hidehiko Kumagai, Jiong Hong

Molecular Biotechnology

DOI

2012

Correction of the error in chemical DNA synthesis

Jiong Hong

2011

探索生化实验教学方法,增强教学效果

王冬梅，洪泂，王秀海

《生物学杂志》

2011

从碱基到人造生命——基因组的从头合成

王冬梅，洪泂

《生命的化学》

2011

Expression of family 3 cellulose-binding module (CBM3) as an affinity tag for recombinant proteins in yeast

Wen Wan, Dongmei Wang, Xiaolian Gao, Jiong Hong

Applied Microbiology and Biotechnology

DOI

2011

Identification of a xylose reductase gene in the xylose metabolic pathway of Kluyveromyces marxianus NBRC1777

Biao Zhang, Ling Zhang, Dongmei Wang, Xiaolian Gao, Jiong Hong

Journal of Industrial Microbiology & Biotechnology

DOI

2011

MRSD: a web server for Metabolic Route Search and Design

Deguo Xia, Haoran Zheng, Zhiqiang Liu, Guisheng Li, Jinlong Li, Jiong Hong, Kai Zhao

Bioinformatics

DOI

2011

Identification of a xylulokinase catalyzing xylulose phosphorylation in the xylose metabolic pathway of Kluyveromyces marxianus NBRC1777

Rongliang Wang, Ling Zhang, Dongmei Wang, Xiaolian Gao, Jiong Hong

Journal of Industrial Microbiology & Biotechnology

DOI

2011

From base to artificial life—chemical synthesis of genome

Jiong Hong

2009

Fast identification of thermostable beta‐glucosidase mutants on cellobiose by a novel combinatorial selection/screening approach

Wenjin Liu, Jiong Hong, David R. Bevan, Y.‐H. Percival Zhang

Biotechnology and Bioengineering

DOI

2008

Bioseparation of recombinant cellulose-binding module-proteins by affinity adsorption on an ultra-high-capacity cellulosic adsorbent

Jiong Hong, Xinhao Ye, Yiran Wang, Y.‐H. Percival Zhang

Analytica Chimica Acta

DOI

2008

Simple protein purification through affinity adsorption on regenerated amorphous cellulose followed by intein self-cleavage

Jiong Hong, Yiran Wang, Xinhao Ye, Y.‐H. Percival Zhang

Journal of Chromatography A

DOI

2007

Cloning and functional expression of thermostable β-glucosidase gene from Thermoascus aurantiacus

Jiong Hong, H. Tamaki, H. Kumagai

Applied Microbiology and Biotechnology

DOI

2007

Construction of thermotolerant yeast expressing thermostable cellulase genes.

Jiong Hong, Yong-Hong Wang, H. Kumagai, H. Tamaki

Journal of Biotechnology

DOI

2006

Unusual hydrophobic linker region of β-glucosidase (BGLII) from Thermoascus aurantiacus is required for hyper-activation by organic solvents

Jiong Hong, H. Tamaki, H. Kumagai

Applied Microbiology and Biotechnology

DOI

2003

Cloning of a gene encoding a thermo-stable endo-β-1,4-glucanase from Thermoascus aurantiacus and its expression in yeast

Jiong Hong, H. Tamaki, Kenji Yamamoto, H. Kumagai

Biotechnology Letters

DOI

2003

Studies on Thermostable Cellulases from Fungi

Jiong Hong

2001

Cloning of a gene encoding a highly stable endo-beta-1,4-glucanase from Aspergillus niger and its expression in yeast.

Jiong Hong, Hisanori Tamaki, Shunichi Akiba, Kenji Yamamoto, H. Kumagai

Journal of Bioscience and Bioengineering

DOI

会议论文

2019

构建同步糖化和共发酵利用玉米芯高效生产L-乳酸的耐热酵母

孔昕，张标，王冬梅，洪泂

《第十二届中国酶工程学术研讨会》

2016

Low cost and high efficient hydrolysis of soybean isoflavone glycosides by a fast and simple immobilized beta-glucosidase

Shenglin Hu, Dongmei Wang, Jiong Hong

The 14th China-Japan-Korea Joint Symposium on Enzyme Engineering

2013

Affinity Maturation of a Humanized Anti-ErbB2 Antibody Using Parallel Microarray-synthesized Oligonucleotides by Phage Display and Next Generation Sequencing Analysis

Dongmei Hu, Wen Wan, Man Xu, Ruikai Du, Wei Zhao, Xiaolian Gao, Jing Liu, Haiyan Liu, Jiong Hong, Siyi Hu

《抗体研发与人类健康——2013第五届国际抗体大会》

2012

Construction of the isomerase pathway for xylose assimilation in Kluyveromyces marxianus

Rongliang Wang, Lulu Li, Biao Zhang, Dongmei Wang, Xiaolian Gao, Jiong Hong

Proceedings of the 12th Japan-China-Korea joint symposium on enzyme engineering

书籍章节

2018

Expression of Cellulolytic Enzymes in Yeast

Dongmei Wang, Jiong Hong

Springer eBooks

DOI

2016

Immobilized MutS-Mediated Error Removal of Microchip-Synthesized DNA

Wen Wan, Dongmei Wang, Xiaolian Gao, Jiong Hong

Methods in molecular biology

DOI

2014

Purification of a Recombinant Protein with Cellulose-Binding Module 3 as the Affinity Tag

Dongmei Wang, Jiong Hong

Methods in molecular biology

DOI

研究方向

微流控芯片高通量基因合成生物质转化化学品的耐热工程酵母重组蛋白高温表达系统

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