王举波｜中国药科大学｜学者主页

2026

Discovery of Novel Glutaminase (GLS1) and Histone Deacetylase (HDAC) Dual Inhibitors as a Promising Strategy for Cancer Therapy

Zhisheng Zhang, Xuan Zhang, Yinan Jiang, Manqi Zhang, Juan Zhao, Tianxin Li, Jiani Yang, Shengnan Shi, Xueling Cao, Lingxiang Jiang, Zihan Tian, Yongsheng Wu, Jiawen Ru, Liuxiang Zhu, Qianming Du, Jinlei Bian, Zhiyu Li, Xi Jin Xu, Jubo Wang

Journal of Medicinal Chemistry

DOI

2026

A Scalable and Safe Synthesis of Ramelteon: Integrating Batch Steps with Asymmetric Hydrogenation and Microreactor Technology

Renbing Wang, Wenjie Yu, Chen Yang, Kaiyu Gao, Jiale Hu, Rui Zhang, Junyin Liu, Ruitong Zhao, Lexi Niao, Chengyang Li, Liuxiang Zhu, Zhiyu Li, Xi Xu, Zhisheng Zhang, Jubo Wang

Organic Process Research & Development

DOI

2026

Wogonin-derived chemotype enables discovery of novel GLS1 inhibitors with potent antitumor activity

Xuhong Li, Yan Liang, Xiaoyu Zhang, Yibing Wu, Tizhi Wu, Yucheng Tian, Cheng Tang, Zhixia Qiu, Hongxi Wu, Jinlei Bian, Zhiyu Li, Xiaoming Xu, Jubo Wang

Future Medicinal Chemistry

DOI

2025

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Qiqi Lin, Wenjing Liu, Wenjia Lu, Monong Zhao, Lin Cao, Zhiyu Li, Jubo Wang, Xi Jin Xu, Hongxi Wu

Advanced Science

DOI

2025

Design, Synthesis, and Biological Evaluation of Sulfonamide Derivatives as Potent CDK9 Inhibitors

Yifang Liu, Zexu Wang, Yifan Xu, Liyan Yang, Xiaolei Yang, Zhiyu Li, Jinlei Bian, Jubo Wang, Lixia Pan, Tizhi Wu

ACS Medicinal Chemistry Letters

DOI

2025

Design and Discovery of Preclinical Candidate LYG-409 as a Highly Potent and Selective GSPT1 Molecular Glue Degraders

Yanqing Zhang, Wenjing Liu, Chao Tong, Xinhong Wang, Xiujin Chang, Fangui Qu, Zhiming Zhang, Zhongpen Fan, Monong Zhao, Cheng Tang, Beichen Song, Ming Ruo Ding, Zhixia Qiu, Jubo Wang, Jinlei Bian, Zhiyu Li, Hongxi Wu, Xi Jin Xu

Journal of Medicinal Chemistry

DOI

2024

细胞周期蛋白依赖性激酶9抑制剂研究进展

曹志豪，曾扬杰，李文欣，张瑞，王举波，任晓东

《中国新药杂志》

2024

STNGS: a deep scaffold learning-driven generation and screening framework for discovering potential novel psychoactive substances

Dongping Liu, Dinghao Liu, Kewei Sheng, Zhiyong Cheng, Zixuan Liu, Yanling Qiao, Shangxuan Cai, Yulong Li, Jubo Wang, Hongyang Chen, Chi Hu, Peng Xu, Bin Di, Jun Liao

Briefings in Bioinformatics

DOI

2024

Practical, Facile, and Efficient Approach to Scalable Synthesis of the Flavonoid Derivative GL-V9

Pei Shen, Yezhi Wang, Sixian Yu, Yu Du, Zhiyu Li, Jubo Wang

Organic Process Research & Development

DOI

2024

Inhibitors and PROTACs of CDK2: challenges and opportunities

Yangjie Zeng, Xiaodong Ren, Pengyao Jin, Zhida Fan, Mengguang Liu, Yali Zhang, Linzhao Li, Ming Zhuo, Jubo Wang, Zhiyu Li, Min Wu

Expert Opinion on Drug Discovery

DOI

2024

Overview of the development of protein arginine methyltransferase modulators: Achievements and future directions

Chao Tong, Xiujin Chang, Fangui Qu, Jinlei Bian, Jubo Wang, Zhiyu Li, Xi Jin Xu

European Journal of Medicinal Chemistry

DOI

2024

Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective

Xiujin Chang, Fangui Qu, Chunxiao Li, Jingtian Zhang, Yanqing Zhang, Yuanyuan Xie, Zhongpeng Fan, Jinlei Bian, Jubo Wang, Zhiyu Li, Xi Jin Xu

Medicinal Research Reviews

DOI

2023

他汀类药物抗肿瘤作用机制的研究进展

曹志豪，金鹏耀，曾扬杰，任晓东，王举波

《现代药物与临床》

2023

Development of MPS1 Inhibitors: Recent Advances and Perspectives

Yangjie Zeng, Xiaodong Ren, Pengyao Jin, Yali Zhang, Ming Zhuo, Jubo Wang

Journal of Medicinal Chemistry

DOI

2023

Discovery of Selective and Potent Macrocyclic CDK9 Inhibitors for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer

Tizhi Wu, Bin Yu, Yifan Xu, Zekun Du, Zhiming Zhang, Yuxiao Wang, Haoming Chen, Li′ao Zhang, Rui Chen, Feihai Ma, Weihong Gong, Sixian Yu, Zhixia Qiu, Hongxi Wu, Xi Xu, Jubo Wang, Zhiyu Li, Jinlei Bian

Journal of Medicinal Chemistry

DOI

2023

Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy

Tizhi Wu, Tizhi Wu, Zhiming Zhang, Guangyue Gong, Yifan Xu, Yifan Xu, Sixian Yu, Feihai Ma, Xuan Zhang, Yuxiao Wang, Yuxiao Wang, Haoming Chen, Shiqi Wu, Shiqi Wu, Hongxi Wu, Zhixia Qiu, Zhiyu Li, Hongxi Wu, Jinlei Bian, Jubo Wang

European Journal of Medicinal Chemistry

DOI

2023

Design and optimization of selective and potent CDK9 inhibitors with flavonoid scaffold for the treatment of acute myeloid leukemia

Tizhi Wu, Bin Yu, Weihong Gong, Jing Zhang, Sixian Yu, Yucheng Tian, Tengteng Zhao, Zhiyu Li, Jubo Wang, Jinlei Bian

European Journal of Medicinal Chemistry

DOI

2023

Discovery of thiohydantoin based antagonists of androgen receptor with efficient degradation for the treatment of prostate cancer

Xiujin Chang, Di Zhang, Fangui Qu, Youquan Xie, Tian Chen, Yuqing Zhang, Qianming Du, Jinlei Bian, Zhiyu Li, Jubo Wang, Xi Jin Xu

European Journal of Medicinal Chemistry

DOI

2023

A patent review of selective CDK9 inhibitors in treating cancer

Tizhi Wu, Xiaowei Wu, Yifan Xu, Rui Chen, Jubo Wang, Zhiyu Li, Jinlei Bian

Expert Opinion on Therapeutic Patents

DOI

2022

Design, synthesis, and biological evaluation of novel glutaminase 1 allosteric inhibitors with an alkane chain tail group

Xiujin Chang, Min Wang, Di Zhang, Yuqing Zhang, Jubo Wang, Zhiyu Li, Jinlei Bian, Xi Jin Xu

European Journal of Medicinal Chemistry

DOI

2022

Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression

Yucheng Tian, Kang Liu, Ruoyi Liu, Zhixia Qiu, Yifan Xu, Wei Wei, Xi Jin Xu, Jubo Wang, Hong Ding, Zhiyu Li, Jinlei Bian

Journal of Medicinal Chemistry

DOI

2022

Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles

Xi Jin Xu, Xiujin Chang, Jingxuan Huang, Di Zhang, Min Wang, Tian Jing, Yu Zhuang, Junping Kou, Zhixia Qiu, Jubo Wang, Zhiyu Li, Jinlei Bian

European Journal of Medicinal Chemistry

DOI

2021

Preparing anti-SARS-CoV-2 agent EIDD-2801 by a practical and scalable approach, and quick evaluation via machine learning

Zhen Qin, Bin Dong, Renbing Wang, Dechun Huang, Jubo Wang, Xi Feng, Jinlei Bian, Zhiyu Li

Acta Pharmaceutica Sinica B

DOI

2021

CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma

Jingyue Yao, Jubo Wang, Ye Xu, Qinglong Guo, Yuening Sun, Jian Liu, Sichan Li, Yongjian Guo, Libin Wei

Autophagy

DOI

2021

Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site

Xi Jin Xu, Jubo Wang, Min Wang, Xinyu Yuan, Lei Li, Chao Zhang, Huidan Huang, Tian Jing, Chenchen Wang, Chao Tong, Liwen Zhou, Ying Meng, Pengfei Xu, Junping Kou, Zhixia Qiu, Zhiyu Li, Jinlei Bian

Journal of Medicinal Chemistry

DOI

2021

Identification of novel androgen receptor degrading agents to treat advanced prostate cancer

Hongxi Wu, Jie Ren, Lulu Zhao, Zhiyu Li, Wanli Ye, Yong Yang, Jubo Wang, Jinlei Bian

European Journal of Medicinal Chemistry

DOI

2021

FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation

Po Hu, Jubo Wang, Yingjie Qing, Hui Li, Wenzhuo Sun, Xiaoxuan Yu, Hui Hui, Qinglong Guo, Jingyan Xu

Cell Death and Disease

DOI

2020

Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion

Xiaqiu Qiu, Yuan‐Qing Li, Bin Yu, Jie Ren, Huidan Huang, Min Wang, Hong Ding, Zhiyu Li, Jubo Wang, Jinlei Bian

European Journal of Medicinal Chemistry

DOI

2020

Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update

Tizhi Wu, Zhen Qin, Yucheng Tian, Jubo Wang, Chenxi Xu, Zhiyu Li, Jinlei Bian

Journal of Medicinal Chemistry

DOI

2020

Practical and Efficient Approach to the Preparation of Diquafosol Tetrasodium

Pengfei Xu, Hai Wang, Pei Shen, Peng Peng, Yongrui Tu, Yongqiang Sun, Jubo Wang, Chenxi Xu, Zhixia Qiu, Raoling Ge, Zhiyu Li, Jinlei Bian

Organic Process Research & Development

DOI

2020

Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening

Jie Han, Yucheng Tian, Liang Yu, Qilin Zhang, Xi Jin Xu, Yichao Zhang, Jubo Wang, Zengyi Ma, Jinlei Bian, Cheng Luo, Hualiang Jiang, Kaixian Chen, Yao Zhao, Zhiyu Li, Hong Ding

Bioorganic Chemistry

DOI

2020

Microwave-assisted unprotected Sonogashira reaction in water for the synthesis of polysubstituted aromatic acetylene compounds

Yucheng Tian, Jubo Wang, Xinying Cheng, Kang Liu, Tizhi Wu, Xiaqiu Qiu, Zijian Kuang, Zhiyu Li, Jinlei Bian

Green Chemistry

DOI

2019

Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors

Xi Jin Xu, Zijian Kuang, Jie Han, Ying Meng, Lei Li, Hongyu Luan, Pengfei Xu, Jubo Wang, Cheng Luo, Hong Ding, Zhiyu Li, Jinlei Bian

Journal of Medicinal Chemistry

DOI

2019

Synthesis and characterization of potential stereoisomeric and degradation impurities of ulipristal acetate

Pengfei Xu, Hongyu Luan, Bin Yu, Yongrui Tu, Yongqiang Sun, Wei Chen, Xi Jin Xu, Raoling Ge, Jubo Wang, Zhiyu Li, Jinlei Bian

Organic Chemistry Frontiers

DOI

2018

Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity

Jinlei Bian, Jie Ren, Yongren Li, Jubo Wang, Xi Jin Xu, Yifan Feng, Hui Tang, Yajing Wang, Zhiyu Li

Bioorganic Chemistry

DOI

2018

Palladium(II)-Catalyzed Reaction of Lawsones and Propargyl Carbonates: Construction of 2,3-Furanonaphthoquinones and Evaluation as Potential Indoleamine 2,3-Dioxygenase Inhibitors

Xi Feng, Xiaqiu Qiu, Huidan Huang, Jubo Wang, Xi Jin Xu, Pengfei Xu, Ruijia Ge, Xiaojin Liu, Zhiyu Li, Jinlei Bian

The Journal of Organic Chemistry

DOI

2017

Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro

Jubo Wang, Raoling Ge, Xiaqiu Qiu, Xi Jin Xu, Libin Wei, Zhiyu Li, Jinlei Bian

European Journal of Medicinal Chemistry

DOI

2017

Current knowledge on the nucleotide agonists for the P2Y2 receptor

Pengfei Xu, Xi Feng, Hongyu Luan, Jubo Wang, Raoling Ge, Zhiyu Li, Jinlei Bian

Bioorganic & Medicinal Chemistry

DOI

2017

A Practical and Efficient Approach to the Preparation of Bioactive Natural Product Wogonin

Tinghan Li, Tianwei Weng, Jubo Wang, Zhihui Wei, Zhao Lu, Zhiyu Li

Organic Process Research & Development

DOI

2012

G蛋白偶联受体119激动剂的研究进展

蒋坤，江程，王举波，宋丽君，李志裕

《中国新药杂志》

2012

用于治疗前列腺癌的雄激素受体拮抗剂

王飏，宋丽君，王举波，胡珀，李志裕

《药学进展》

2012

聚腺苷二磷酸核糖聚合酶抑制剂的临床研究进展

胡珀，宋丽君，王飏，王举波，李志裕

《中国新药与临床杂志》

2011

Synthesis and biological evaluation of 7-O-modified oroxylin A derivatives

Wei Fu, Jubo Wang, Li‐Qin Yu, Li Zhao, Na Lu, Qidong You, Qinglong Guo, Zhiyu Li

Bioorganic & Medicinal Chemistry Letters

DOI

精选作品

期刊论文

Discovery of Novel Glutaminase (GLS1) and Histone Deacetylase (HDAC) Dual Inhibitors as a Promising Strategy for Cancer Therapy

A Scalable and Safe Synthesis of Ramelteon: Integrating Batch Steps with Asymmetric Hydrogenation and Microreactor Technology

Wogonin-derived chemotype enables discovery of novel GLS1 inhibitors with potent antitumor activity

Cancer Biology of GSPT1: Mechanisms and Targeted Therapy Opportunities of Molecular Glue Degraders

Design, Synthesis, and Biological Evaluation of Sulfonamide Derivatives as Potent CDK9 Inhibitors

Design and Discovery of Preclinical Candidate LYG-409 as a Highly Potent and Selective GSPT1 Molecular Glue Degraders

细胞周期蛋白依赖性激酶9抑制剂研究进展

STNGS: a deep scaffold learning-driven generation and screening framework for discovering potential novel psychoactive substances

Practical, Facile, and Efficient Approach to Scalable Synthesis of the Flavonoid Derivative GL-V9

Inhibitors and PROTACs of CDK2: challenges and opportunities

Overview of the development of protein arginine methyltransferase modulators: Achievements and future directions

Development and therapeutic potential of GSPT1 molecular glue degraders: A medicinal chemistry perspective

他汀类药物抗肿瘤作用机制的研究进展

Development of MPS1 Inhibitors: Recent Advances and Perspectives

Discovery of Selective and Potent Macrocyclic CDK9 Inhibitors for the Treatment of Osimertinib-Resistant Non-Small-Cell Lung Cancer

Discovery of novel flavonoid-based CDK9 degraders for prostate cancer treatment via a PROTAC strategy

Design and optimization of selective and potent CDK9 inhibitors with flavonoid scaffold for the treatment of acute myeloid leukemia

Discovery of thiohydantoin based antagonists of androgen receptor with efficient degradation for the treatment of prostate cancer

A patent review of selective CDK9 inhibitors in treating cancer

Design, synthesis, and biological evaluation of novel glutaminase 1 allosteric inhibitors with an alkane chain tail group

Discovery of Potent Small-Molecule USP8 Inhibitors for the Treatment of Breast Cancer through Regulating ERα Expression

Discovery of novel glutaminase 1 allosteric inhibitor with 4-piperidinamine linker and aromatic heterocycles

Preparing anti-SARS-CoV-2 agent EIDD-2801 by a practical and scalable approach, and quick evaluation via machine learning

CDK9 inhibition blocks the initiation of PINK1-PRKN-mediated mitophagy by regulating the SIRT1-FOXO3-BNIP3 axis and enhances the therapeutic effects involving mitochondrial dysfunction in hepatocellular carcinoma

Structure-Enabled Discovery of Novel Macrocyclic Inhibitors Targeting Glutaminase 1 Allosteric Binding Site

Identification of novel androgen receptor degrading agents to treat advanced prostate cancer

FV-429 induces autophagy blockage and lysosome-dependent cell death of T-cell malignancies via lysosomal dysregulation

Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion

Recent Developments in the Biology and Medicinal Chemistry of CDK9 Inhibitors: An Update

Practical and Efficient Approach to the Preparation of Diquafosol Tetrasodium

Discovery of novel USP8 inhibitors via Ubiquitin-Rho-110 fluorometric assay based high throughput screening

Microwave-assisted unprotected Sonogashira reaction in water for the synthesis of polysubstituted aromatic acetylene compounds

Development and Characterization of a Fluorescent Probe for GLS1 and the Application for High-Throughput Screening of Allosteric Inhibitors

Synthesis and characterization of potential stereoisomeric and degradation impurities of ulipristal acetate

Discovery of Wogonin-based PROTACs against CDK9 and capable of achieving antitumor activity

Palladium(II)-Catalyzed Reaction of Lawsones and Propargyl Carbonates: Construction of 2,3-Furanonaphthoquinones and Evaluation as Potential Indoleamine 2,3-Dioxygenase Inhibitors

Discovery and synthesis of novel Wogonin derivatives with potent antitumor activity in vitro

Current knowledge on the nucleotide agonists for the P2Y2 receptor

A Practical and Efficient Approach to the Preparation of Bioactive Natural Product Wogonin

G蛋白偶联受体119激动剂的研究进展

用于治疗前列腺癌的雄激素受体拮抗剂

聚腺苷二磷酸核糖聚合酶抑制剂的临床研究进展

Synthesis and biological evaluation of 7-O-modified oroxylin A derivatives

预印本

Discovery of Novel Thiohydantoin Derivatives as Full Antagonists and Efficient Degraders of Androgen Receptor