黄启来｜山东大学｜学者主页

2025

VSTM2L protects prostate cancer cells against ferroptosis via inhibiting VDAC1 oligomerization and maintaining mitochondria homeostasis

Juan Yang, Xiao Lu, Jing-Lan Hao, Lan Li, Yong-Tong Ruan, Xue-Ni An, Qilai Huang, Xiao-Ming Dong, Ping Gao

Nature Communications

2024

Temperature regulates negative supercoils to modulate meiotic crossovers and chromosome organization

Yingjin Tan, Tai-Cong Tan, Shuxian Zhang, Bo Li, Beiyi Chen, Xu Zhou, Ying Wang, Xiao Yang, B. Zhai, Qilai Huang, Liangran Zhang, Shunxin Wang

Science China Life Sciences

DOI

2023

A Digital PCR Method Based on Highly Specific Taq for Detecting Gene Editing and Mutations

Bo Li, Junhao Liu, Qilai Huang

International Journal of Molecular Sciences

DOI

2023

Dna2 removes toxic ssDNA-RPA filaments generated from meiotic recombination-associated DNA synthesis

B. Zhai, Shuxian Zhang, Bo Li, Jiaming Zhang, Xuan Yang, Yingjin Tan, Ying Wang, Tai-Cong Tan, X. Yang, Beiyi Chen, Zhongyu Tian, Yanding Cao, Qilai Huang, Jinmin Gao, Shunxin Wang, Liangran Zhang

Nucleic Acids Research

DOI

2022

Enhanced Taq Variant Enables Efficient Genome Editing Testing and Mutation Detection

Ping Du, Bo Li, Xiaodan Liu, Lele Yang, Naixia Ren, Ying-Ying Li, Qilai Huang

The CRISPR Journal

DOI

2022

A Gene Transfer-Positive Cell Sorting System Utilizing Membrane-Anchoring Affinity Tag

Lele Yang, Lifang Cui, Shumin Ma, Qingqing Zuo, Qilai Huang

Frontiers in Bioengineering and Biotechnology

DOI

2022

GPI-anchored glutathione S-transferase as marker allows affinity sorting of transfection-positive cells

Shumin Ma, Lele Yang, Qingqing Zuo, Qilai Huang

Frontiers in Molecular Biosciences

DOI

2022

Increasing Genome Editing Efficiency of Cas9 Nucleases by the Simultaneous Use of Transcriptional Activators and Histone Acetyltransferase Activator

Junhao Liu, Bo Li, Lele Yang, Naixia Ren, Meichen Xu, Qilai Huang

The CRISPR Journal

DOI

2021

Dinucleotide tag‐based parallel reporter gene assay method enables efficient identification of regulatory mutations

Naixia Ren, Bo Li, Qingqing Liu, Lele Yang, Xiaodan Liu, Qilai Huang

Biotechnology Journal

DOI

2021

Functional Screenings Identify Regulatory Variants Associated with Breast Cancer Susceptibility

Naixia Ren, Ying-Ying Li, Yulong Xiong, Panfeng Li, Yutian Ren, Qilai Huang

Current Issues in Molecular Biology

DOI

2021

Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC

Xiaoming Dong, Qin Zhang, Jinglan Hao, Qianwen Xie, B. Xu, Peng Zhang, H. Lu, Qilai Huang, Tie-Lin Yang, Gong-Hong Wei, R. Na, P. Gao

Frontiers in Oncology

DOI

2021

Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition

Naixia Ren, Qingqing Liu, Lingjie Yan, Qilai Huang

International Journal of Molecular Sciences

DOI

2021

rs10514231 Leads to Breast Cancer Predisposition by Altering ATP6AP1L Gene Expression

Shumin Ma, Naixia Ren, Qilai Huang

Cancers

DOI

2020

Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner

Weiwei Jiang, Fangfang Cai, Huangru Xu, Yanyan Lu, Jia Chen, Jia Liu, Nini Cao, Xiangyu Zhang, Xiao Chen, Qilai Huang, Hongqin Zhuang, Zi-Chun Hua

Protein & Cell

2019

The Role of HOX Transcription Factors in Cancer Predisposition and Progression

Bo Li, Qilai Huang, Gong-Hong Wei

Cancers

DOI

2019

A qPCR method for genome editing efficiency determination and single-cell clone screening in human cells

Bo Li, Naixia Ren, Lele Yang, Junhao Liu, Qilai Huang

Scientific Reports

DOI

2018

Biology and clinical implications of the 19q13 aggressive prostate cancer susceptibility locus

P. Gao, Jihan Xia, C. Sipeky, Xiao-Ming Dong, Q. Zhang, Yue-Hong Yang, Peng Zhang, S. Cruz, Kai Zhang, Jing Zhu, Hang-Mao Lee, Sufyan Suleman, Nikolaos Giannareas, Song Liu, T. Tammela, Anssi Auvinen, Xiao-Yue Wang, Qilai Huang, Li-Guo Wang, A. Manninen, M. Vaarala, Liang Wang, J. Schleutker, Gong-Hong Wei

Cell

DOI

2014

A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding

Qilai Huang, Thomas Whitington, P. Gao, J. Lindberg, Yue-Hong Yang, Jie-Lin Sun, Marja-Riitta Väisänen, R. Szulkin, Matti Annala, Jian Yan, L. Egevad, Kai Zhang, Ruizhu Lin, A. Jolma, M. Nykter, A. Manninen, F. Wiklund, M. Vaarala, T. Visakorpi, Jian-Feng Xu, J. Taipale, Gong-Hong Wei

Nature Genetics

DOI

2013

木犀草素的药理作用研究进展

王继双，何焱，张文静，张鹏，黄启来，华子春

《生命科学》

2013

薯蓣皂苷元联合TRAIL对非小细胞肺癌A549细胞的协同作用及其中效原理评价

何焱，王继双，张鹏，张文静，黄启来，华子春

《药学学报》

2013

胸腺肽α1的研究进展

张鹏，黄启来，华子春

《东南大学学报(医学版)》

2012

高良姜素的生物学活性研究进展

张文静，黄启来，华子春

《中国医药生物技术》

2012

木犀草素抑制人肺腺癌A549细胞株的运动及其机制研究

张文静，黄启来，华子春

《东南大学学报(医学版)》

2011

局部黏着斑激酶作为肿瘤治疗靶点的研究进展

张文静，黄启来，华子春

《生命科学》

2010

冬凌草甲素抗肿瘤作用的研究进展

张文静，黄启来，华子春

《生命科学》

2010

《基因工程》在中药学专业中的教学实践与探索

殷武，黄启来，华子春

《药物生物技术》

2002

真核基因转录激活的多位点协同调控

薛文，王进，黄启来，郑伟娟，华子春

《生物化学与生物物理进展》

黄启来

精选作品

期刊论文

VSTM2L protects prostate cancer cells against ferroptosis via inhibiting VDAC1 oligomerization and maintaining mitochondria homeostasis

Temperature regulates negative supercoils to modulate meiotic crossovers and chromosome organization

A Digital PCR Method Based on Highly Specific Taq for Detecting Gene Editing and Mutations

Dna2 removes toxic ssDNA-RPA filaments generated from meiotic recombination-associated DNA synthesis

Enhanced Taq Variant Enables Efficient Genome Editing Testing and Mutation Detection

A Gene Transfer-Positive Cell Sorting System Utilizing Membrane-Anchoring Affinity Tag

GPI-anchored glutathione S-transferase as marker allows affinity sorting of transfection-positive cells

Increasing Genome Editing Efficiency of Cas9 Nucleases by the Simultaneous Use of Transcriptional Activators and Histone Acetyltransferase Activator

Dinucleotide tag‐based parallel reporter gene assay method enables efficient identification of regulatory mutations

Functional Screenings Identify Regulatory Variants Associated with Breast Cancer Susceptibility

Large Multicohort Study Reveals a Prostate Cancer Susceptibility Allele at 5p15 Regulating TERT via Androgen Signaling-Orchestrated Chromatin Binding of E2F1 and MYC

Parallel Reporter Assays Identify Altered Regulatory Role of rs684232 in Leading to Prostate Cancer Predisposition

rs10514231 Leads to Breast Cancer Predisposition by Altering ATP6AP1L Gene Expression

Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner

The Role of HOX Transcription Factors in Cancer Predisposition and Progression

A qPCR method for genome editing efficiency determination and single-cell clone screening in human cells

Biology and clinical implications of the 19q13 aggressive prostate cancer susceptibility locus

A prostate cancer susceptibility allele at 6q22 increases RFX6 expression by modulating HOXB13 chromatin binding

木犀草素的药理作用研究进展

薯蓣皂苷元联合TRAIL对非小细胞肺癌A549细胞的协同作用及其中效原理评价

胸腺肽α1的研究进展

高良姜素的生物学活性研究进展

木犀草素抑制人肺腺癌A549细胞株的运动及其机制研究

局部黏着斑激酶作为肿瘤治疗靶点的研究进展

冬凌草甲素抗肿瘤作用的研究进展

《基因工程》在中药学专业中的教学实践与探索

真核基因转录激活的多位点协同调控

会议论文

FAK基因的表达调控及在肿瘤治疗中的应用