王君

2026

红松不同器官非结构性碳水化合物和化学计量特征对疏伐的响应

《植物研究》

2026

间伐对红松人工林土壤胞外酶活性及其化学计量比的影响

《应用生态学报》

DOI

2025

红松优树子代生长变异分析及优良材料选择

《植物研究》

2025

Exploring polycyclic scaffolds as adamantane replacements in M2 channel inhibitors of Influenza A virus

bioRxiv

DOI

2024

3种商品茶多酚的表征、抗氧化性及其抑菌效果比较研究

《扬州大学学报(农业与生命科学版)》

2024

花椒精油成分分析及其对四种植物病原真菌的抗菌作用

《湖北农业科学》

2023

植物黄酮类化合物的生物学功能及其在水产动物生产中的应用研究进展

《饲料研究》

2023

杨树派间远缘杂种小胡杨(Populus simonii×P.euphratica)组培快繁体系的构建

《分子植物育种》

2023

大运河（沧州段）浮游植物群落特征与水体营养状况分析

《水产学杂志》

2023

Antiviral effects and mechanisms against EV71 of the novel 2-Benzoxyl-Phenylpyridine Derivatives.

European Journal of Pharmaceutical Sciences

DOI

2023

A Study of the Activity of Adamantyl Amines against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple Blocker, Explored by Molecular Dynamics Simulations and Solid‐State NMR **

ChemMedChem

DOI

2023

FlipGFP protease assay for evaluating in vitro inhibitory activity against SARS-CoV-2 Mpro and PLpro

STAR Protocols

DOI

2022

响应面法优化超声辅助提取金丝皇菊多糖工艺及生理活性研究

《中国食品添加剂》

2022

响应面法优化超声辅助提取金丝皇菊总黄酮工艺及抗氧化活性研究

《粮食与油脂》

2022

Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor

Medicinal Chemistry Research

DOI

2022

Current scenario on non-nucleoside reverse transcriptase inhibitors (2018-present)

Arabian Journal of Chemistry

DOI

2022

Progress and challenges in targeting the SARS-CoV-2 papain-like protease

Journal of Medicinal Chemistry

DOI

2022

SARS-CoV-2 main protease drug design, assay development, and drug resistance studies

Accounts of Chemical Research

DOI

2022

Cytopathic Effect Assay and Plaque Assay to Evaluate in vitro Activity of Antiviral Compounds Against Human Coronaviruses 229E, OC43, and NL63.

Bio-protocol

DOI

2022

Drug repurposing screening identified tropifexor as a SARS-CoV-2 papain-like protease inhibitor

ACS Infectious Diseases

DOI

2022

Amantadine Variant – Aryl Conjugates that Inhibit Multiple M2 Mutant – Amantadine Resistant Influenza A Viruses

Social Science Research Network

DOI

2022

Point-of-care SARS-CoV-2 sensing using lens-free imaging and a deep learning-assisted quantitative agglutination assay

Lab on a Chip

DOI

2022

AG1478 Elicits a Novel Anti-Influenza Function via an EGFR-Independent, GBF1-Dependent Pathway

International Journal of Molecular Sciences

DOI

2022

Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays

Acta Pharmaceutica Sinica B

2021

低温胁迫下红松与西伯利亚红松光合与气孔特性

《植物研究》

2021

Efficacy of GC-376 against SARS-CoV-2 virus infection in the K18 hACE2 transgenic mouse model

Scientific Reports

DOI

2021

Rimantadine Binds to and Inhibits the Influenza A M2 Proton Channel without Enantiomeric Specificity

Biochemistry

DOI

2021

Discovery of SARS-CoV-2 Papain-like Protease Inhibitors through a Combination of High-Throughput Screening and a FlipGFP-Based Reporter Assay

ACS Central Science

DOI

2021

Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir

ACS Pharmacology & Translational Science

DOI

2021

Amantadine Variants Activity Against Multiple Influenza A Viruses

DOI

2021

Expedited approach toward the rational design of non-covalent SARS-CoV-2 main protease inhibitors

Journal of Medicinal Chemistry

DOI

2021

Preclinical characterization of an intravenous coronavirus 3CL protease inhibitor for the potential treatment of COVID19

Nature Communications

DOI

2021

Brilacidin, a COVID-19 Drug Candidate, demonstrates broad-spectrum antiviral activity against human coronaviruses OC43, 229E and NL63 through targeting both the virus and the host cell

bioRxiv

DOI

2021

Boceprevir, calpain inhibitors II and XII, and GC-376 have broad-spectrum antiviral activity against coronaviruses

ACS Infectious Diseases

DOI

2021

The in vitro antiviral activity of lactoferrin against common human coronaviruses and SARS-CoV-2 is mediated by targeting the heparan sulfate co-receptor

Emerging Microbes and Infections

DOI

2021

Discovery of di- and trihaloacetamides as covalent SARS-CoV-2 main protease inhibitors with high target specificity

Journal of the American Chemical Society

DOI

2021

Discovery of hydrazide-containing oseltamivir analogues as potent inhibitors of influenza A neuraminidase.

European journal of medicinal chemistry

DOI

2021

Influenza A M2 Channel Oligomerization is Sensitive to its Chemical Environment

bioRxiv

DOI

2021

Enterovirus A71 antivirals: Past, present, and future

Acta Pharmaceutica Sinica B

DOI

2021

Dipyridamole, chloroquine, montelukast sodium, candesartan, oxytetracycline, and atazanavir are not SARS-CoV-2 main protease inhibitors

Proceedings of the National Academy of Sciences of the United States of America

DOI

2021

Rational design of a deuterium-containing M2-S31N channel blocker UAWJ280 with in vivo antiviral efficacy against both oseltamivir sensitive and -resistant influenza A viruses

Emerging Microbes and Infections

DOI

2021

Amantadine Variant - Aryl Conjugates that Inhibit Multiple Amantadine Resistant M2 Mutant Influenza A Viruses

DOI

2021

Discovery of potent and broad-spectrum pyrazolopyridine-containing antivirals against enterovirus D68, A71, and coxsackievirus B3 by targeting the viral 2C protein

Journal of Medicinal Chemistry

DOI

2021

Validation and Invalidation of SARS-CoV-2 Papain-like Protease Inhibitors

bioRxiv

DOI

2021

Enzyme-deep eutectic solvent pre-treatment for extraction of essential oil from Mentha haplocalyx Briq. leaves: Kinetic, chemical composition and inhibitory enzyme activity

Industrial Crops and Products

DOI

2020

金丝小枣多酚的提取及抗氧化性和抑菌活性研究

《中国调味品》

2020

Discovery of a Novel Inhibitor of Coronavirus 3CL Protease as a Clinical Candidate for the Potential Treatment of COVID-19

bioRxiv

DOI

2020

Chemical Probes for Blocking of Influenza A M2 WT and S31N Channels

ACS Chemical Biology

DOI

2020

Pharmacological characterization of the mechanism of action of R523062, a promising antiviral for enterovirus D68.

ACS Infectious Diseases

DOI

2020

X-ray crystal structures of the influenza M2 proton channel drug-resistant V27A mutant bound to a spiro-adamantyl amine inhibitor reveal the mechanism of adamantane resistance

Biochemistry

DOI

2020

Investigation of the Drug Resistance Mechanism of M2-S31N Channel Blockers through Biomolecular Simulations and Viral Passage Experiments.

ACS Pharmacology & Translational Science

DOI

2020

Put a cork in it: Plugging the M2 viral ion channel to sink influenza

Antiviral Research

DOI

2020

Enterovirus D68 antivirals: past, present and future

ACS Infectious Diseases

DOI

2020

(2-Hydroxy-4-methoxy)benzyl Aminoadamantane Conjugates as Probes to Investigate Specificity Determinants in Blocking Influenza M2 S31N and M2 WT Channels with Binding Kinetics and Simulations

DOI

2020

Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L

Science Advances

DOI

2020

Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease

Cell Research

DOI

2020

Development of Broad-Spectrum Enterovirus Antivirals Based on Quinoline scaffold

Bioorganic chemistry (Print)

DOI

2020

Ebselen, Disulfiram, Carmofur, PX-12, Tideglusib, and Shikonin Are Nonspecific Promiscuous SARS-CoV-2 Main Protease Inhibitors

ACS Pharmacology & Translational Science

DOI

2019

微波辅助提取火龙果果皮红色素及其稳定性的研究

《中国调味品》

2019

二色补血草生物活性成分提取及抗氧化功能研究

《植物生理学报》

DOI

2019

双酶法提取红松籽油及其抗氧化分析

《食品研究与开发》

2019

二色补血草生物活性成分及抗氧化功能研究进展

《现代农村科技》

2019

干旱胁迫对不同土壤基质下核桃楸幼苗的生理特性的影响

《植物研究》

2019

Structural basis of adamantane resistance in the influenza A M2 proton channel

Acta Crystallographica Section A: Foundations and Advances

DOI

2019

X-ray Crystal Structure of the Influenza A M2 Proton Channel S31N Mutant in Two Conformational States: An Open and Shut Case

Journal of the American Chemical Society

DOI

2019

Discovery of quinoline analogs as potent antivirals against enterovirus D68 (EV-D68)

Journal of Medicinal Chemistry

DOI

2019

The L46P Mutant Confers a Novel Allosteric Mechanism of Resistance Toward the Influenza A Virus M2 S31N Proton Channel Blockers

Molecular Pharmacology

DOI

2019

A novel capsid binding inhibitor displays potent antiviral activity against Enterovirus D68

ACS Infectious Diseases

DOI

2019

Focusing on the influenza virus polymerase complex: recent progress in drug discovery and assay development

Current Medicinal Chemistry

DOI

2019

Validating Enterovirus D68-2Apro as an Antiviral Drug Target and the Discovery of Telaprevir as a Potent D68-2Apro Inhibitor

Journal of Virology

DOI

2019

Discovery of M2 channel blockers targeting the drug-resistant double mutants M2-S31N/L26I and M2-S31N/V27A from the influenza A viruses

European Journal of Pharmaceutical Sciences

DOI

2019

Identification of NMS-873, an allosteric and specific p97 inhibitor, as a broad antiviral against both influenza A and B viruses

European Journal of Pharmaceutical Sciences

DOI

2019

Discovery of Influenza polymerase PA-PB1 Interaction Inhibitors Using an In Vitro Split-Luciferase Complementation-based Assay

ACS Chemical Biology

DOI

2018

不同林分红松生长与结实性状比较研究

《植物研究》

2018

金丝小枣中黄酮抗氧化性和稳定性的研究

《中国园艺文摘》

2018

Exploring Ugi-Azide Four-Component Reaction Products for Broad-Spectrum Influenza Antivirals with a High Genetic Barrier to Drug Resistance

Scientific Reports

DOI

2018

Symmetric dimeric adamantanes for exploring the structure of two viroporins: influenza virus M2 and hepatitis C virus p7

Drug Design, Development and Therapy

DOI

2018

Structure-Property Relationship Studies of Influenza A Virus AM2-S31N Proton Channel Blockers.

ACS Medicinal Chemistry Letters

DOI

2018

Profiling the in vitro drug-resistance mechanism of influenza A viruses towards the AM2-S31N proton channel blockers

Antiviral Research

DOI

2018

Unraveling the Binding, Proton Blockage, and Inhibition of Influenza M2 WT and S31N by Rimantadine Variants.

ACS Medicinal Chemistry Letters

DOI

2018

In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses

Journal of Medicinal Chemistry

DOI

2018

Discovery of Highly Potent Pinanamine-Based Inhibitors Against Amantadine- and Oseltamivir- resistant Influenza A Viruses

Journal of Medicinal Chemistry

DOI

2018

Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters

Journal of the American Chemical Society

DOI

2017

Slow but steady wins the race: dissimilarities among new dual inhibitors of the wild-type and the V27A mutant M2 channels of influenza A virus

Journal of Medicinal Chemistry

DOI

2017

Protonation equilibria and pore-opening structure of the dual-histidine influenza B virus M2 transmembrane proton channel from solid-state NMR

Journal of Biological Chemistry

DOI

2017

Influenza BM2 Proton Channel Structure from SSNMR

2017

Affinity of Rimantadine Enantiomers against Influenza A/M2 Protein Revisited.

ACS Medicinal Chemistry Letters

DOI

2017

Expeditious Lead Optimization of Isoxazole-Containing Influenza A Virus M2-S31N Inhibitors Using the Suzuki–Miyaura Cross-Coupling Reaction

Journal of Medicinal Chemistry

DOI

2017

Discovery of dapivirine, a Nonnucleoside HIV-1 Reverse Transcriptase Inhibitor, as a Broad-Spectrum Antiviral against Both Influenza A and B Viruses

Antiviral Research

DOI

2017

Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses

European journal of medicinal chemistry

DOI

2017

An M2-V27A channel blocker demonstrates potent in vitro and in vivo antiviral activities against amantadine-sensitive and -resistant influenza A viruses

Antiviral Research

DOI

2017

Chemical Genomics Approach Leads to the Identification of Hesperadin, an Aurora B Kinase Inhibitor, as a Broad-Spectrum Influenza Antiviral

International Journal of Molecular Sciences

DOI

2017

Functional studies reveal the similarities and differences between AM2 and BM2 proton channels from influenza viruses

Biochimica et Biophysica Acta - Biomembranes

DOI

2017

Influenza A virus nucleoprotein: a highly conserved multi-functional viral protein as a hot antiviral drug target

Current Topics in Medicinal Chemistry

DOI

2016

槭树属植物种子休眠因素及打破种子休眠方法研究进展

《种子》

2016

M2 as a target to combat influenza drug resistance: what does the evidence say?

DOI

2016

Solid-State NMR Investigation of the Conformation, Proton Conduction, and Hydration of the Influenza B Virus M2 Transmembrane Proton Channel

Journal of the American Chemical Society

DOI

2016

Discovery of potent antivirals against amantadine-resistant influenza A viruses by targeting the M2-S31N proton channel

ACS Infectious Diseases

DOI

2016

Targeting the influenza A virus M2 proton channel to combat drug resistance

DOI

2016

Discovery of cyclosporine A and its analogs as broad-spectrum anti-influenza drugs with a high in vitro genetic barrier of drug resistance

Antiviral Research

DOI

2016

Pharmacological Characterization of the Spectrum of Antiviral Activity and Genetic Barrier to Drug Resistance of M2-S31N Channel Blockers

Molecular Pharmacology

DOI

2016

Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

Journal of Medicinal Chemistry

DOI

2015

三倍体‘银中杨’叶肉原生质体制备的优化

《西北植物学报》

2015

冬枣黄酮的提取及其抗氧化作用探讨

《山东工业技术》

2015

Recent progress in designing inhibitors that target the drug‐resistant M2 proton channels from the influenza A viruses

Biopolymers

DOI

2015

Inhibitors targeting the influenza virus hemagglutinin.

Current Medicinal Chemistry

DOI

2014

杜仲花粉离体萌发特征及花粉管微丝骨架分布

《西北植物学报》

2014

Flipping in the Pore: Discovery of Dual Inhibitors That Bind in Different Orientations to the Wild-Type versus the Amantadine-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel

Journal of the American Chemical Society

DOI

2014

2D IR spectroscopy reveals the role of water in the binding of channel-blocking drugs to the influenza M2 channel.

Journal of Chemical Physics

DOI

2014

Structure and Inhibition of the M2 Proton Channel from the Influenza a Virus

DOI

2013

小钻‘白城杨2号’小孢子发生及花粉大小变异

《西北植物学报》

2013

Discovery of Novel Dual Inhibitors of the Wild-Type and the Most Prevalent Drug-Resistant Mutant, S31N, of the M2 Proton Channel from Influenza A Virus

Journal of Medicinal Chemistry

DOI

2013

Influenza virus A M2 protein generates negative Gaussian membrane curvature necessary for budding and scission

Journal of the American Chemical Society

DOI

2013

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

Proceedings of the National Academy of Sciences of the United States of America

DOI

2013

Asp44 Stabilizes the Trp41 Gate of the M2 Proton Channel of Influenza A Virus

Structure

DOI

2013

Drug-Induced Conformational and Dynamical Changes of the S31N Mutant of the Influenza M2 Proton Channel Investigated by Solid-State NMR

Journal of the American Chemical Society

DOI

2013

An Assay Suitable for High Throughput Screening of Anti-Influenza Drugs

PLoS ONE

DOI

2013

3-Azatetracyclo[5.2.1.15,8.01,5]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant

Journal of Medicinal Chemistry

DOI

2013

Inhibitors of the Influenza A Virus M2 Proton Channel Discovered Using a High-Throughput Yeast Growth Restoration Assay

PLoS ONE

DOI

2013

Detection of drug‐induced conformational change of a transmembrane protein in lipid bilayers using site‐directed spin labeling

Protein Science

DOI

2012

Mapping Water Density to Design New Blockers Against a Viral Proton Channel

DOI

2011

响叶杨小孢子母细胞减数分裂及染色体行为的研究

《植物科学学报》

2011

白杨杂种三倍体小孢子母细胞减数分裂及花粉形态观察

《西北植物学报》

2011

Exploring the Size Limit of Templates for Inhibitors of the M2 Ion Channel of Influenza A Virus

Journal of Medicinal Chemistry

DOI

2011

Structural and Dynamic Mechanisms for the Function and Inhibition of the M2 Proton Channel From Influenza A Virus

Current Opinion in Structural Biology

DOI

2011

Exploring Organosilane Amines as Potent Inhibitors and Structural Probes of Influenza A Virus M2 Proton Channel

Journal of the American Chemical Society

DOI

2011

Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus

ACS Medicinal Chemistry Letters

DOI

2011

Specific Binding of Adamantane Drugs and Direction of their Polar Amines in the Pore of the Influenza M2 Transmembrane Domain in Lipid Bilayers and Dodecylphosphocholine Micelles Determined by NMR Spectroscopy

Journal of the American Chemical Society

DOI

2011

Molecular Dynamics (MD) Simulation Directed Rational Design of Inhibitors Targeting Drug-Resistant Mutants of Influenza A Virus M2

Journal of the American Chemical Society

DOI

2010

小胡杨花粉母细胞减数分裂染色体行为研究

《西北植物学报》

2010

Proton and cation transport activity of the M2 proton channel from influenza A virus

Proceedings of the National Academy of Sciences of the United States of America

DOI

2010

Structure of the Amantadine Binding Site of Influenza M2 Proton Channels In Lipid Bilayers

Nature

DOI

2010

Solid-state NMR structure of the M2 transmembrane peptide of the influenza A virus in DMPC lipid bilayers bound to deuterated amantadine

DOI

2010

Structure-based design of inhibitors targeting influenza A virus M2 proton channel (A/M2)

2009

Reversibility of Amantadine Inhibition in the M2 Proton Channel of Influenza A Virus

DOI

2009

Discovery of Spiro-Piperidine Inhibitors and Their Modulation of the Dynamics of the M2 Proton Channel from Influenza A Virus

Journal of the American Chemical Society

DOI

2009

Design and Pharmacological Characterization of Inhibitors of Amantadine-Resistant Mutants of the M2 Ion Channel of Influenza A Virus

Biochemistry

DOI

2009

Solid-supported membrane technology for the investigation of the influenza A virus M2 channel activity

Pflügers Archiv: European Journal of Physiology

DOI

2008

杨树染色中心数目及其与倍性水平关系研究

《西北植物学报》

2007

新疆杨叶肉原生质体游离和纯化的研究

《西北植物学报》

2006

通辽杨花粉母细胞减数分裂及其染色体行为研究

《西北植物学报》