黄龙江｜青岛科技大学｜学者主页

2026

Novel 5,7-Diazaindole-based ERK5 inhibitor induces endoplasmic reticulum stress and mitochondrial apoptosis in non-small cell lung Cancer.

Bin-Bin Tian, Yun-Jie Li, Pengyu Xue, Renhao Chen, Shuo Lv, Luqian He, Gaoyang Lin, Jun Xiao, Lin Long, Guo-Rui Cao, Chuanlong Guo, Longjiang Huang

Bioorganic chemistry (Print)

DOI

2026

A Base-Promoted Annulation Cascade: One-Pot Construction of C2-Spiropseudoindoxyls from 2-Nitrobenzaldehydes and Sulfonyl Hydrazones.

Renhao Chen, Lidan Cheng, Feifei Xin, Luqian He, Bin-Bin Tian, Yu-Xin Zhou, Cui Lv, Shuo Lv, Bin Lou, Xu‐Jie Wang, Longjiang Huang

Journal of Organic Chemistry

DOI

2026

Novel 7-Substituted-1,2,4-Triazolopyrimidines targeting Nav1.2 channels as low-neurotoxicity antiepileptic agents.

Yu-Xi Zhou, Weina Wang, Cui Lv, Jiaqi. Wu, Shuo Lv, Luqian He, Xin-Yu Zhao, X. Qin, Bin-Bin Tian, Renhao Chen, Chuanlong Guo, Longjiang Huang, Haibo Yu

Bioorganic & Medicinal Chemistry

DOI

2026

Modular synthesis of AIE-active naphthalimide-triazolopyrimidine hybrids: Color tunable emission and multi-stimuli responsiveness

Jia-Jia Yan, Yi-Cheng Sun, Renhao Chen, Shuo Lv, Ye Yuan, Zhongxuan Qiu, Feifei Xin, Longjiang Huang

Dyes and pigments

DOI

2025

NaI‐promoted Synthesis of Dihydroquinolines via an Unusual Azetine Intermediate

Futong Li, Zhongxuan Qiu, Daoshan Yang, Longjiang Huang, Feifei Xin

Annalen der Pharmacie

DOI

2025

Discovery of novel 4-azaindole derivatives as selective Nav1.2 Inhibitor with potent antiepileptic activity and low neurotoxicity.

Bin Lou, Wenhui Liang, N. Jiang, Yuhan Guo, Tianhao Zhang, Chuan-Long Guo, Tongtong Du, Longjiang Huang, Haibo Yu

European journal of medicinal chemistry

DOI

2025

Pharmacokinetics and Tissue Distribution Study for 2‐(2‐Fluorophenyl)‐5‐Phenyl‐7‐Alkoxy‐ [1,2,4]Triazole[1,5‐a]Pyrimidine Antiepileptic Compounds in Rats

Han Liang, Ranran Guo, Yuxi Zhou, Cui Lv, Chuanlong Guo, Feng Su, Qingkun Dong, Longjiang Huang, Wen Xu

Biomedical Chromatography

DOI

2025

Design, synthesis and structure-activity relationship of novel 1,2,4-triazolopyrimidin-5-one derivatives targeting GABAA1 and Nav1.2 with antiepileptic activity

Tongtong Du, Jun Wu, Weina Wang, Wenhui Liang, Yunjie Li, Chuanlong Guo, Xiufen Li, Longjiang Huang, Haibo Yu

European Journal of Medicinal Chemistry

DOI

2024

The Potential of PARP Inhibitors as Antitumor Drugs and the Perspective of Molecular Design.

Yinghan Wang, Jingtao Zhang, Xiao-Chen Wu, Longjiang Huang, Wenjing Xiao, Chuan-Long Guo

Journal of Medicinal Chemistry

DOI

2024

A novel [1, 2, 4]triazolo[5,1-b]quinazoline derivative as a fluorescent probe for highly selective detection of Fe 3+ ions

Zhenpeng Li, Han Zhao, Zi‐Han Zhang, Zhongxuan Qiu, Xiufen Li, Longjiang Huang

Journal of Asian Natural Products Research

DOI

2023

Design, synthesis and SAR of novel 7-azaindole derivatives as potential Erk5 kinase inhibitor with anticancer activity.

Qin Zhang, Xintao Gao, Xiyu Duan, Han Liang, M. Gao, Dian-Quan Dong, Chuan-Long Guo, Longjiang Huang

Bioorganic & Medicinal Chemistry

DOI

2023

A New Pathway for the Synthesis of Ketones from Aldehydes and Sulfonylhydrazones: Is Diazo the Key Intermediate?

Yue-Xing Wang, Li‐ping Chen, Feng‐de Cao, Bin Zhao, Zhenpeng Li, Xiu‐fen Li, Longjiang Huang

Chemistry - A European Journal

DOI

2023

Design, synthesis, anticonvulsant activity and structure-activity relationships of novel 7-Azaindole derivatives

Qingfei Meng, Xue Ren, Rui Wang, Yu Kyeong Han, Xiufen Li, Qin Zhang, Zhenpeng Li, Yuexing Wang, Longjiang Huang, Haibo Yu

Bioorganic Chemistry

DOI

2022

Suzuki-Miyaura偶联反应在沙丁胺醇合成中的应用

陈丽平，仇中选，李振鹏，王跃兴，黄龙江

《精细化工》

2022

马来酸氟伏沙明-D3的合成

仇中选，王东，黄龙江

《合成化学》

2022

Synthesis of 19-hydroxyprogesterone and insights into the ring-opening mechanism of the 6,19-epoxy bridge

Yan Wang, Wei Dong, Qin Zhang, Zhenpeng Li, Yue-Xing Wang, Xiufen Li, Longjiang Huang

Journal of Asian Natural Products Research

DOI

2022

Oxidative coupling of primary amines to imines catalyzed by CoCl2·6H2O

Chengxi Lian, Chaoying Zhang, Yingchun Zhao, Hui Wang, Xiu‐fen Li, Longjiang Huang

Applied Organometallic Chemistry

DOI

2021

Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABAA1 and GABAA4 receptors with potent antiepileptic activity

Jun Wu, Zhipeng Hou, Yan Wang, Liping Chen, Chengxi Lian, Qingfei Meng, Chaoying Zhang, Xiufen Li, Longjiang Huang, Haibo Yu

Bioorganic Chemistry

DOI

2021

A novel [1,2,4]triazolo[1,5-a]pyrimidine derivative as a fluorescence probe for specific detection of Fe3+ ions and application in cell imaging

Yanru Geng, Liping Chen, Qinglan Wan, Chengxi Lian, Yu Kyeong Han, Yan Wang, Chaoying Zhang, Longjiang Huang, Han Zhao, Xingshen Sun, Hongwei He

Analytica Chimica Acta

DOI

2020

The importance of indole and azaindole scaffold in the development of antitumor agents

Yu Kyeong Han, Wei Dong, Qunqun Guo, Xiufen Li, Longjiang Huang

European Journal of Medicinal Chemistry

DOI

2020

Synthesis of the impurity F of salbutamol

Shu-Lian Song, Cheng-Xi Lian, Liping Chen, Longjiang Huang

Journal of Asian Natural Products Research

DOI

2020

Direct amidation of non‐activated carboxylic acid and amine derivatives catalyzed by TiCp2Cl2

Hui Wang, Dong Wei, Zhipeng Hou, Lidan Cheng, Xiufen Li, Longjiang Huang

Applied Organometallic Chemistry

DOI

2019

金属催化剂催化醇和胺直接偶联制备亚胺的研究进展

王辉，黄龙江

《有机化学》

2019

抗癫痫1,2,4-三氮唑类衍生物研究进展

耿延汝，丁静，黄龙江

《精细化工》

DOI

2019

Discovery of [1,2,4]-triazolo [1,5-a]pyrimidine-7(4H)-one derivatives as positive modulators of GABAA1 receptor with potent anticonvulsant activity and low toxicity

Longjiang Huang, Jing Ding, Min Li, Zhipeng Hou, Yanru Geng, Xiufen Li, Haibo Yu

European Journal of Medicinal Chemistry

DOI

2018

染料木素的结构修饰及活性研究进展

黄龙江，丁静

《精细化工》

2018

Synthesis and in vitro anti-epileptic activities of novel [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one derivatives

Jing Ding, Feng‐de Cao, Yanru Geng, Yuan Tian, Peng Li, Xiu-Fen Li, Longjiang Huang

Journal of Asian Natural Products Research

DOI

2018

Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl 2

Lidan Cheng, Xiaoping Ge, Longjiang Huang

Royal Society Open Science

DOI

2017

2-Boc-6-氧代八氢[2,7]萘啶的合成

王佩，黄龙江

《化学试剂》

2017

催化直接酰胺化反应研究进展

成丽丹，马定娜，黄龙江

《精细石油化工》

2017

3-氰基-4-哌啶酮盐酸盐的合成与表征

王赛，杨明，王佩，黄龙江

《化学与生物工程》

2017

2-苄基-6-对甲苯磺酰基-2,6-二氮杂螺[3,3]庚烷的合成

李秀芬，黄龙江，滕大为

《青岛科技大学学报(自然科学版)》

2016

(3R,4S)-(3-乙烯基-4-叔丁氧羰基甲基)-哌啶的合成

王佩，黄龙江

《精细石油化工》

2016

An efficient synthesis of 1′,4′-dihydro-2′H-spiro[azetidin-2,3′-quinolin]-2′-one

Longjiang Huang, Yuan Tian, Dawei Teng

Research on Chemical Intermediates

DOI

2016

ChemInform Abstract: Synthesis of 3,4,5‐Trisubstituted Isoxazoles via 1,3‐Dipolar Cycloaddition/SO2 Extrusion of Benzoisothiazole‐2,2‐dioxide‐3‐ylidenes with Nitrile Oxides.

Guorui Cao, Yu Wang, Tao Cui, Longjiang Huang, Dawei Teng

ChemInform

DOI

2016

Synthetic Strategy and Anti-Tumor Activities of Macrocyclic Scaffolds Based on 4-Hydroxyproline

Guorui Cao, Kun Yang, Yue Li, Longjiang Huang, Dawei Teng

Molecules

DOI

2016

Synthesis of 3,4,5-trisubstituted isoxazoles via 1,3-dipolar cycloaddition/SO 2 extrusion of benzoisothiazole-2,2-dioxide-3-ylidenes with nitrile oxides

Guorui Cao, Yu Wang, Tao Cui, Longjiang Huang, Dawei Teng

RSC Advances

DOI

2015

螺[二氢吲哚-3,3′-吡咯烷]-2,5-二酮的合成

晏桂刚，张茜，黄龙江

《化学与生物工程》

2015

三唑酮类化合物的合成

吴燕天，黄龙江，滕大为

《化学与生物工程》

2015

ChemInform Abstract: Synthesis of Spiropyrrolidinyl‐Benzoisothiazoline Derivatives by 1,3‐Dipolar Cycloaddition of Benzoisothiazole‐2,2‐dioxide‐3‐ylidenes and Azomethine Ylide.

Guorui Cao, Feifei Long, Yingchun Zhao, Yu Wang, Longjiang Huang, Dawei Teng

ChemInform

DOI

2014

6-氯-7-氮杂吲哚合成工艺研究

施海风，龙飞飞，黄龙江

《精细化工中间体》

2014

1-叔丁基氧羰基-4-(2-吡啶基)哌啶的合成研究

王丽丽，黄龙江

《化学与生物工程》

2014

间甲磺酰基苯甲酸的合成工艺研究

桑伟，李铮铮，黄龙江，滕大为

《应用化工》

2014

1-叔丁基氧羰基-2'-氧-螺-[氮杂环丁烷-3,3'-二氢吲哚]的合成

王丽丽，邓鹏朋，黄龙江，滕大为

《应用化工》

2014

9-Boc-1-氧-4,9-二氮杂螺[5,5]十一烷的合成

施海风，黄龙江

《化学与生物工程》

2014

N-Boc-6-氨基-3-苄基-3-氮杂双环[3.2.1]辛烷的合成

邓鹏朋，王丽丽，黄龙江，滕大为

《化学与生物工程》

2014

Synthesis of spiropyrrolidinyl-benzoisothiazoline derivatives by 1,3-dipolar cycloaddition of benzoisothiazole-2,2-dioxide-3-ylidenes and azomethine ylide

Guorui Cao, Feifei Long, Yingchun Zhao, Yu Wang, Longjiang Huang, Dawei Teng

Tetrahedron

DOI

2013

高效液相色谱法测定硫酸二甲酯中的甲醛含量

陈辉，黄龙江，滕大为

《青岛科技大学学报(自然科学版)》

2013

手性记忆策略在α-氨基酸不对称烷基化反应中的研究进展

刘洋，黄龙江，滕大为

《化学与生物工程》

2013

5-苄基-4,5,6,7-四氢吡唑并[1,5-a]哌嗪的合成

张学楷，刘志达，黄龙江，滕大为

《应用化工》

2013

喹诺酮类抗菌药主环化合物的合成研究进展

崔涛，黄龙江

《应用化工》

2013

6-碘-1-四氢萘酮的合成

边华东，崔涛，黄龙江，滕大为

《化学与生物工程》

2013

光活环二肽环(L-脯-L-丙)和环(L-脯-L-缬)的合成

张晓晓，黄龙江，滕大为

《化学与生物工程》

2013

氧化重排法合成2-吲哚酮和2,2'-吲哚啉螺环化合物的研究进展

马强，黄龙江，滕大为

《应用化工》

2013

5-(2-羟乙基)-2,2-二甲基-1,3-二恶烷的合成研究

马强，张学楷，黄龙江，滕大为

《应用化工》

2013

1-Boc-3-氰基-4-吡咯烷酮的合成工艺研究

崔涛，刘志达，黄龙江

《应用化工》

2013

Study on the synthesis of 1-Boc-3-cyano-4-oxopyrrolidine

Longjiang Huang

Applied Chemical Industry

2012

6-2-氨丙基-2,3-二氢苯并呋喃的合成

孙得艳，黄龙江，滕大为

《精细化工》

2011

4-氯-2-羟基苯乙酮的合成

王晓静，刘静，黄龙江，滕大为

《中国医药工业杂志》

2010

吲哚啉螺环化合物的生物活性及合成研究进展

洪卉，黄龙江，滕大为

《化学试剂》

2010

2-氨基色满的合成

黄龙江，洪卉，滕大为

《化学试剂》

2010

无机物负载型钯催化剂的研究进展

焦建丽，黄龙江，滕大为

《化学与生物工程》

2010

1,2,3,4-四氢-2,6-萘啶的合成

刘静，黄龙江，滕大为

《科学技术与工程》

2009

合成肽在不对称催化反应中的应用

于燕，黄龙江，滕大为

《化学与生物工程》

2009

醇腈酶在不对称催化合成氰醇中的应用

郭帅，黄龙江，滕大为

《化学与生物工程》

精选作品

期刊论文

Novel 5,7-Diazaindole-based ERK5 inhibitor induces endoplasmic reticulum stress and mitochondrial apoptosis in non-small cell lung Cancer.

A Base-Promoted Annulation Cascade: One-Pot Construction of C2-Spiropseudoindoxyls from 2-Nitrobenzaldehydes and Sulfonyl Hydrazones.

Novel 7-Substituted-1,2,4-Triazolopyrimidines targeting Nav1.2 channels as low-neurotoxicity antiepileptic agents.

Modular synthesis of AIE-active naphthalimide-triazolopyrimidine hybrids: Color tunable emission and multi-stimuli responsiveness

NaI‐promoted Synthesis of Dihydroquinolines via an Unusual Azetine Intermediate

Discovery of novel 4-azaindole derivatives as selective Nav1.2 Inhibitor with potent antiepileptic activity and low neurotoxicity.

Pharmacokinetics and Tissue Distribution Study for 2‐(2‐Fluorophenyl)‐5‐Phenyl‐7‐Alkoxy‐ [1,2,4]Triazole[1,5‐a]Pyrimidine Antiepileptic Compounds in Rats

Design, synthesis and structure-activity relationship of novel 1,2,4-triazolopyrimidin-5-one derivatives targeting GABAA1 and Nav1.2 with antiepileptic activity

The Potential of PARP Inhibitors as Antitumor Drugs and the Perspective of Molecular Design.

A novel [1, 2, 4]triazolo[5,1-b]quinazoline derivative as a fluorescent probe for highly selective detection of Fe 3+ ions

Design, synthesis and SAR of novel 7-azaindole derivatives as potential Erk5 kinase inhibitor with anticancer activity.

A New Pathway for the Synthesis of Ketones from Aldehydes and Sulfonylhydrazones: Is Diazo the Key Intermediate?

Design, synthesis, anticonvulsant activity and structure-activity relationships of novel 7-Azaindole derivatives

Suzuki-Miyaura偶联反应在沙丁胺醇合成中的应用

马来酸氟伏沙明-D3的合成

Synthesis of 19-hydroxyprogesterone and insights into the ring-opening mechanism of the 6,19-epoxy bridge

Oxidative coupling of primary amines to imines catalyzed by CoCl2·6H2O

Discovery of 7-alkyloxy- [1,2,4] triazolo[1,5-a] pyrimidine derivatives as selective positive modulators of GABAA1 and GABAA4 receptors with potent antiepileptic activity

A novel [1,2,4]triazolo[1,5-a]pyrimidine derivative as a fluorescence probe for specific detection of Fe3+ ions and application in cell imaging

The importance of indole and azaindole scaffold in the development of antitumor agents

Synthesis of the impurity F of salbutamol

Direct amidation of non‐activated carboxylic acid and amine derivatives catalyzed by TiCp2Cl2

金属催化剂催化醇和胺直接偶联制备亚胺的研究进展

抗癫痫1,2,4-三氮唑类衍生物研究进展

Discovery of [1,2,4]-triazolo [1,5-a]pyrimidine-7(4H)-one derivatives as positive modulators of GABAA1 receptor with potent anticonvulsant activity and low toxicity

染料木素的结构修饰及活性研究进展

Synthesis and in vitro anti-epileptic activities of novel [1,2,4]-triazolo[1,5-a]pyrimidin-7(4H)-one derivatives

Direct amidation of non-activated phenylacetic acid and benzylamine derivatives catalysed by NiCl 2

2-Boc-6-氧代八氢[2,7]萘啶的合成

催化直接酰胺化反应研究进展

3-氰基-4-哌啶酮盐酸盐的合成与表征

2-苄基-6-对甲苯磺酰基-2,6-二氮杂螺[3,3]庚烷的合成

(3R,4S)-(3-乙烯基-4-叔丁氧羰基甲基)-哌啶的合成

An efficient synthesis of 1′,4′-dihydro-2′H-spiro[azetidin-2,3′-quinolin]-2′-one

ChemInform Abstract: Synthesis of 3,4,5‐Trisubstituted Isoxazoles via 1,3‐Dipolar Cycloaddition/SO2 Extrusion of Benzoisothiazole‐2,2‐dioxide‐3‐ylidenes with Nitrile Oxides.

Synthetic Strategy and Anti-Tumor Activities of Macrocyclic Scaffolds Based on 4-Hydroxyproline

Synthesis of 3,4,5-trisubstituted isoxazoles via 1,3-dipolar cycloaddition/SO 2 extrusion of benzoisothiazole-2,2-dioxide-3-ylidenes with nitrile oxides

螺[二氢吲哚-3,3′-吡咯烷]-2,5-二酮的合成

三唑酮类化合物的合成

ChemInform Abstract: Synthesis of Spiropyrrolidinyl‐Benzoisothiazoline Derivatives by 1,3‐Dipolar Cycloaddition of Benzoisothiazole‐2,2‐dioxide‐3‐ylidenes and Azomethine Ylide.

6-氯-7-氮杂吲哚合成工艺研究

1-叔丁基氧羰基-4-(2-吡啶基)哌啶的合成研究

间甲磺酰基苯甲酸的合成工艺研究

1-叔丁基氧羰基-2'-氧-螺-[氮杂环丁烷-3,3'-二氢吲哚]的合成

9-Boc-1-氧-4,9-二氮杂螺[5,5]十一烷的合成

N-Boc-6-氨基-3-苄基-3-氮杂双环[3.2.1]辛烷的合成

Synthesis of spiropyrrolidinyl-benzoisothiazoline derivatives by 1,3-dipolar cycloaddition of benzoisothiazole-2,2-dioxide-3-ylidenes and azomethine ylide

高效液相色谱法测定硫酸二甲酯中的甲醛含量

手性记忆策略在α-氨基酸不对称烷基化反应中的研究进展

5-苄基-4,5,6,7-四氢吡唑并[1,5-a]哌嗪的合成

喹诺酮类抗菌药主环化合物的合成研究进展

6-碘-1-四氢萘酮的合成

光活环二肽环(L-脯-L-丙)和环(L-脯-L-缬)的合成

氧化重排法合成2-吲哚酮和2,2'-吲哚啉螺环化合物的研究进展

5-(2-羟乙基)-2,2-二甲基-1,3-二恶烷的合成研究

1-Boc-3-氰基-4-吡咯烷酮的合成工艺研究

Study on the synthesis of 1-Boc-3-cyano-4-oxopyrrolidine

6-2-氨丙基-2,3-二氢苯并呋喃的合成

4-氯-2-羟基苯乙酮的合成

吲哚啉螺环化合物的生物活性及合成研究进展

2-氨基色满的合成

无机物负载型钯催化剂的研究进展

1,2,3,4-四氢-2,6-萘啶的合成

合成肽在不对称催化反应中的应用

醇腈酶在不对称催化合成氰醇中的应用

研究方向