杨爱红｜天津中医药大学｜学者主页

2026

基于网络药理、分子对接及实验验证探究补骨脂总黄酮治疗类风湿关节炎的机制研究

向雨虹，李亚萍，刘艳，郭丛，刘安，杨爱红，许青霞

《现代药物与临床》

2026

Cu2+-selective porphyrin probes with multifunctional anti-AD activities and the structural-activity insights from X-ray single crystal analysis

Jie Zhi, Huixin Feng, Qingyang Xue, Zi Pang, Rui Shen, Ai‐Hong Yang, Xiaodi Kou

European Journal of Medicinal Chemistry

DOI

2026

Restoring Homeostatic Balance: Advances in Traditional Chinese Medicine for Rheumatoid Arthritis

Yuhong Xiang, Ai‐Hong Yang, Cong Guo, Jintang Cheng, Jun Zhang, C Chen, Sha Chen, Jinzhu Jiang, Jipeng Di, Xianju Liu, S Y Li, An Liu, Yan Liu, Qingxia Xu

The American Journal of Chinese Medicine

DOI

2026

A simple LC-MS/MS method for the simultaneous determination of 18 free fatty acids in human serum

Zhimin Gong, Ling Luo, Meng Liu, Jingyi Fan, Yujing Zhai, Li Ning, Aihong Yang, Jinxia Wei, Yubo Li

Journal of Chromatography B

DOI

2026

A Multifunctional coumarin-derived probe for metal chelation, radical scavenging, and Aβ1-42 aggregation inhibition in Alzheimer’s disease

Ken Chen, Huixin Feng, Quanzhen Chen, Jianzhong Cui, Aihong Yang

Journal of Molecular Structure

DOI

2026

Construction and anti-Alzheimer’s disease potential of gallic acid-mediated berberine-metal self-assemblies

Lijun Zhang, Xiang Zhou, Jianhua Wu, Huiyan Wang, Aolin Zhang, Rui Shen, Aihong Yang, Xiaodi Kou

Journal of Molecular Structure

DOI

2026

Zinc-porphyrin complex as multifunctional anti-AD agent: Synthesis, X-ray single crystal analysis and activity study

Xiang Zhou, Lijun Zhang, Jie Zhi, Lihua Zhao, Rui Shen, Aihong Yang, Xiaodi Kou

Journal of Inorganic Biochemistry

DOI

2025

Study on the structure–activity relationships of natural γ-pyranone products and their derivatives with anti-AD activities focusing on metal chelation

Junyi Mao, Caiyun Wang, Xiangyu Li, Ruihao Du, Xiangyu Zhang, Rui Shen, Ai‐Hong Yang, Xiaodi Kou

Molecular Diversity

DOI

2025

Identification of Chemical Constituents and Metabolites of YinChen WuLing Powder In Vitro and In Vivo Based on UHPLC‐Q‐Orbitrap HRMS

Ling Luo, Jia Shao, Jia Shao, Rongrong Zheng, Rongrong Zheng, Chenlei Geng, Chenlei Geng, Lingxin Jiang, Lingxin Jiang, Yubo Li, Yanpu Liu, Lihua Zuo, Lihua Zuo, Ai‐Hong Yang, Ai‐Hong Yang, Jinxia Wei, Jinxia Wei, Yubo Li, Yubo Li

Separation Science Plus

DOI

2025

Novel Biochanin A Carbamate Derivatives as Multifunctional Anti‐Alzheimer's Disease Metal Chelators: Design, Synthesis, and Activity Evaluation

Yiyi Sun, Xinjie Jiang, Xiaoyue Yi, Caiyun Wang, Xiangyu Zhang, Rui Shen, Ai‐Hong Yang, Xiaodi Kou

Chemistry & Biodiversity

DOI

2025

From natural isoflavone to multitarget ligand: biochanin A derivatives with multifunctional activities against Alzheimer's Disease

Xinjie Jiang, Yiyi Sun, Xiaoyue Yi, Tong liu, Yunhua Wang, Rui Shen, Ai‐Hong Yang, Xiaodi Kou

Journal of Molecular Structure

DOI

2025

An insight into porphyrin carbamate derivatives and a Cu(II) metalloporphyrin as G-quadruplex binder: Synthesis, single crystal characterization, binding ability and anti-tumor potential

Xinyan Zou, Wenting Xiao, Xiang Yu Zhou, Rui Shen, Ai‐Hong Yang, Xiaodi Kou

Journal of Inorganic Biochemistry

DOI

2025

Design, synthesis, biological evaluation, and X‐ray single crystal structure of novel computer‐aided‐drug‐designbased α‐mangostin derivatives: Multifunctional ligands against Alzheimer's disease

Quanzhen Chen, Xiangyu Li, Wenting Xiao, Yiyi Sun, Rui Shen, Xiaodi Kou, Ai‐Hong Yang

Archiv der Pharmazie

DOI

2025

Carrier-free nanoparticles—new strategy of improving druggability of natural products

Yaqi Yao, Zhenghu Xu, Haoran Ding, Shenshen Yang, Bohan Chen, Mengjiao Zhou, Yehan Zhu, Ai‐Hong Yang, Xingxu Yan, Chenrui Liang, Xiaodi Kou, Bo Chen, Wei Huang, Yubo Li

Journal of Nanobiotechnology

DOI

2024

基于细胞因子TNF-α、IL-6变化研究小续命汤加减治疗痛性糖尿病周围神经病变阳虚寒凝证疗效

邹彦，李骧，杨爱红

《陕西中医》

2024

The new multidrug crystal of berberine and naringenin based on the couplet medicine of TCM: Crystal structure, physicochemical property, and synergistic anti-AD effect

Wenting Xiao, Xinyan Zou, Lijun Zhang, Rui Shen, Ai‐Hong Yang, Xiaodi Kou

Journal of Molecular Structure

DOI

2024

Study of multifunctional anti-AD ligands: design, synthesis, X-ray crystal structure and biological evaluation of diosmetin derivatives

Ai‐Hong Yang, Xiaoyue Yi, Hongwei Zhang, Quanzhen Chen, Rui Shen, Xiaodi Kou

Molecular Diversity

DOI

2024

Diosmetin derivatives as multifunctional anti‐AD ligands: Design, synthesis, and biological evaluation

Ai‐Hong Yang, Xiaoyue Yi, Hongwei Zhang, Rui Shen, Xiaodi Kou

Chemical Biology & Drug Design

DOI

2023

Emodin derivatives as promising multi-aspect intervention agents for amyloid aggregation: molecular docking/dynamics simulation, bioactivities evaluation, and cytoprotection

Rui Shen, Wenshuang Zhao, Xiangyu Li, Juanjuan Liu, Ai‐Hong Yang, Xiaodi Kou

Molecular Diversity

DOI

2023

A coumarin-based multifunctional chemosensor for Cu2+/Al3+ as an AD theranostic agent: Synthesis, X-ray single crystal analysis and activity study

Xiaodi Kou, Chengting Hu, Zi Pang, Xinyu Zhang, Huiyan Wang, Rui Shen, Ai‐Hong Yang

Analytica Chimica Acta

DOI

2023

A Review on the Natural Components Applied as Lead Compounds for Potential Multi-target Anti-AD Theranostic Agents

Xiaodi Kou, Xuli Shi, Zi Pang, Ai‐Hong Yang, Rui Shen, Lihua Zhao

Current Medicinal Chemistry

DOI

2022

Synthesis, single crystal characterization and anti-AD activities of a novel complex of Cu(II) with in situ formed protonated chrysin derivative ligand

Chang Liu, Jianhua Wu, Chengting Hu, Ai‐Hong Yang, Rui Shen, Xiaodi Kou

Journal of Inorganic Biochemistry

DOI

2022

Design, Synthesis, Calculation and Biological Activity Studies Based on Privileged Coumarin Derivatives as Multifunctional Anti‐AD Lead Compound

Huiyan Wang, Mengyang Su, Xuli Shi, Xiangyu Li, Xinyu Zhang, Ai‐Hong Yang, Rui Shen

Chemistry & Biodiversity

DOI

2022

Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal framework as a synergistic anti-AD agent

Rui Shen, Yuhong Chen, Xiangyu Li, Xi Wang, Ai‐Hong Yang, Xiaodi Kou

International Journal of Pharmaceutics

DOI

2022

Study on Multi-Target Synergistic Treatment of Alzheimer’s Disease Based on Metal Chelators

Rui Shen, Xiaodi Kou, Ai‐Hong Yang, Jianhua Wu, Yuhong Chen

Current Drug Targets

DOI

2022

Xanthone derivatives as potential telomeric G-quadruplex stabilizing and cytotoxic agents: Effects of substitution on quadruplex binding affinity and cytotoxicity

Rui Shen, Xiangyu Li, Yuhong Chen, Ai‐Hong Yang, Xiaodi Kou

Journal of Molecular Structure

DOI

2022

Study on the novel usnic acid derivatives: Design, synthesis, X-Ray crystal structure of Cu(II) complex and anti-AD activities

Ai‐Hong Yang, Wenjing Liu, Xiangyu Li, Wanru Wu, Xiaodi Kou, Rui Shen

Journal of Molecular Structure

DOI

2022

Effect of Bis‐Dimethylamine Substitution on DNA Binding Property and Cytotoxic Activity of Polyhydroxyxanthone

Rui Shen, Yuhong Chen, Jianhua Wu, Lihua Zhao, Ai‐Hong Yang, Xiaodi Kou

Chemistry & Biodiversity

DOI

2022

Corrigendum to “Multifunctional fluorescence sensor as a potential theranostic agent against Alzheimer's disease” [Spectrochim. Acta Part A: Molec. Biomolec. Spectrosc. 267 (2022) 120587]

Xiaodi Kou, Xingying Li, Chengting Hu, Juanjuan Liu, Yuhong Chen, Yang Zhang, Ai‐Hong Yang, Rui Shen

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy

DOI

2022

A multifunctional metal regulator as the potential theranostic agent: Design, synthesis, anti-AD activities and metallic ion sensing properties

Xiaodi Kou, Chengting Hu, Xuli Shi, Xingying Li, Ai‐Hong Yang, Rui Shen

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy

DOI

2022

A multifunctional anti-AD approach: Design, synthesis, X-ray crystal structure, biological evaluation and molecular docking of chrysin derivatives

Ai‐Hong Yang, Chang Liu, Hongwei Zhang, Jianhua Wu, Rui Shen, Xiaodi Kou

European Journal of Medicinal Chemistry

DOI

2021

苓萆四妙汤联合西药治疗脾肾两虚、浊毒内阻证2型糖尿病合并高尿酸血症临床疗效观察

谢小超，龚敏，陈文文，杨爱红，刘敏

《中华中医药杂志》

2021

Multifunctional fluorescence sensor as a potential theranostic agent against Alzheimer's disease

Xiaodi Kou, Xingying Li, Chengting Hu, Juanjuan Liu, Yuhong Chen, Yang Zhang, Ai‐Hong Yang, Rui Shen

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy

DOI

2021

Novel chrysin derivatives as hidden multifunctional agents for anti-Alzheimer's disease: design, synthesis and in vitro evaluation

Chang Liu, Xiaodi Kou, Xi Wang, Jianhua Wu, Ai‐Hong Yang, Rui Shen

European Journal of Pharmaceutical Sciences

DOI

2021

Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease

Jiarui Wu, Xiaodi Kou, Hui Ju, Hongwei Zhang, Ai‐Hong Yang, Rui Shen

Bioorganic & Medicinal Chemistry Letters

DOI

2021

Emodin derivatives with multi-factor anti-AD activities: AChE inhibitor, anti-oxidant and metal chelator

Xiaodi Kou, Juanjuan Liu, Yuhong Chen, Ai‐Hong Yang, Rui Shen

Journal of Molecular Structure

DOI

2021

A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease

Ai‐Hong Yang, Chang Liu, Jiarui Wu, Xiaodi Kou, Rui Shen

European Journal of Pharmacology

DOI

2020

Design, Synthesis and Biological Evaluation of Xanthone Derivatives for Possible Treatment of Alzheimer's Disease Based on Multi‐Target Strategy

Ai‐Hong Yang, Qiao Yu, Hui Ju, Lulu Song, Xiaodi Kou, Rui Shen

Chemistry & Biodiversity

DOI

2019

远志活性成分优呫吨酮铜(Ⅱ)配合物的抗肿瘤活性研究

宋路路，于俏，齐学洁，杨爱红，张昕阳，申蕊，寇晓娣，赵利花

《天津中医药》

2019

Anti-depressant effect of curcumin-loaded guanidine-chitosan thermo-sensitive hydrogel by nasal delivery

Xue‐Jie Qi, Xiangyun Liu, Leimengyuan Tang, Pan-Feng Li, Feng Qiu, Ai‐Hong Yang

Pharmaceutical Development and Technology

DOI

2019

An important mechanism of herb-induced hepatotoxicity: To produce RMs based on active functional groups-containing ingredients from phytomedicine by binding CYP450s

Xin He, Zijun Wu, Lili Wang, Xue Gao, Yue Hai, Wenli Liu, Lemei Du, Lei Zhang, Ai‐Hong Yang, Nan-nan Huang

Chinese Herbal Medicines

DOI

2019

Synthesis, characterization and properties of lanthanide complexes with different ancillary ligands

Li-Hua Zhao, Hong-Man Chen, Ai‐Hong Yang, Dong-Fang Wu, Jian Gou, Jian‐Zhong Cui, Hong‐Ling Gao

Inorganica Chimica Acta

DOI

2017

Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole

Ai‐Hong Yang, Lei Justan Zhang, Dexian Zhi, Wenli Liu, Xue Gao, Xin He

Xenobiotica

DOI

2017

Studies on the metabolites difference of psoralen/isopsoralen in human and six mammalian liver microsomes in vitro by UHPLC–MS/MS

Ai‐Hong Yang, Jun-Xiu Chen, Yetao Ma, Lili Wang, Yao-Wen Fan, Xin He

Journal of Pharmaceutical and Biomedical Analysis

DOI

2015

Identification and characterization of reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2

Ai‐Hong Yang, Xin He, Jun-Xiu Chen, Li-Na He, Chunhuan Jin, Lili Wang, Fangliang Zhang, Lijun An

Chemico-Biological Interactions

DOI

2014

PBL教学法在无机化学实验中对学生自主学习能力的培养

杨爱红，齐学洁，张师愚，张毅，赵培莉

《天津中医药大学学报》

2014

Reactive metabolite activation by CYP2C19-mediated rhein hepatotoxicity

Li-Na He, Ai‐Hong Yang, Tianyi Cui, Yiran Zhai, Fangliang Zhang, Jun-Xiu Chen, Chunhuan Jin, Yao-Wen Fan, Zijun Wu, Lili Wang, Xin He

Xenobiotica

DOI

2014

Syntheses, Structures, and Properties of the 3D Lanthanide Organic Frameworks with N‐Heterocyclic Polycarboxylic Acids

Ai‐Hong Yang, Li‐Hua Zhao, Xue‐Jie Qi, Yiwei Lu

Zeitschrift für anorganische und allgemeine Chemie

DOI

2014

Two Three-Dimensional Lanthanide Frameworks Exhibiting Luminescence Increases upon Dehydration and Novel Water Layer Involving in Situ Decarboxylation

Ai‐Hong Yang, Ji‐Yong Zou, Wen‐Min Wang, Xueying Shi, Hong‐Ling Gao, Jian‐Zhong Cui, Bin Zhao

Inorganic Chemistry

DOI

2014

Spectroscopic and electrochemical studies on the evaluation of the radical scavenging activities of luteolin by chelating iron

Ai‐Hong Yang, Xueying Shi, Xue Li, Fangfang Li, Qinqin Zhang, Shuxin Jiang, Jian‐Zhong Cui, Hong‐Ling Gao

RSC Advances

DOI

精选作品

期刊论文

基于网络药理、分子对接及实验验证探究补骨脂总黄酮治疗类风湿关节炎的机制研究

Cu2+-selective porphyrin probes with multifunctional anti-AD activities and the structural-activity insights from X-ray single crystal analysis

Restoring Homeostatic Balance: Advances in Traditional Chinese Medicine for Rheumatoid Arthritis

A simple LC-MS/MS method for the simultaneous determination of 18 free fatty acids in human serum

A Multifunctional coumarin-derived probe for metal chelation, radical scavenging, and Aβ1-42 aggregation inhibition in Alzheimer’s disease

Construction and anti-Alzheimer’s disease potential of gallic acid-mediated berberine-metal self-assemblies

Zinc-porphyrin complex as multifunctional anti-AD agent: Synthesis, X-ray single crystal analysis and activity study

Study on the structure–activity relationships of natural γ-pyranone products and their derivatives with anti-AD activities focusing on metal chelation

Identification of Chemical Constituents and Metabolites of YinChen WuLing Powder In Vitro and In Vivo Based on UHPLC‐Q‐Orbitrap HRMS

Novel Biochanin A Carbamate Derivatives as Multifunctional Anti‐Alzheimer's Disease Metal Chelators: Design, Synthesis, and Activity Evaluation

From natural isoflavone to multitarget ligand: biochanin A derivatives with multifunctional activities against Alzheimer's Disease

An insight into porphyrin carbamate derivatives and a Cu(II) metalloporphyrin as G-quadruplex binder: Synthesis, single crystal characterization, binding ability and anti-tumor potential

Design, synthesis, biological evaluation, and X‐ray single crystal structure of novel computer‐aided‐drug‐designbased α‐mangostin derivatives: Multifunctional ligands against Alzheimer's disease

Carrier-free nanoparticles—new strategy of improving druggability of natural products

基于细胞因子TNF-α、IL-6变化研究小续命汤加减治疗痛性糖尿病周围神经病变阳虚寒凝证疗效

The new multidrug crystal of berberine and naringenin based on the couplet medicine of TCM: Crystal structure, physicochemical property, and synergistic anti-AD effect

Study of multifunctional anti-AD ligands: design, synthesis, X-ray crystal structure and biological evaluation of diosmetin derivatives

Diosmetin derivatives as multifunctional anti‐AD ligands: Design, synthesis, and biological evaluation

Emodin derivatives as promising multi-aspect intervention agents for amyloid aggregation: molecular docking/dynamics simulation, bioactivities evaluation, and cytoprotection

A coumarin-based multifunctional chemosensor for Cu2+/Al3+ as an AD theranostic agent: Synthesis, X-ray single crystal analysis and activity study

A Review on the Natural Components Applied as Lead Compounds for Potential Multi-target Anti-AD Theranostic Agents

Synthesis, single crystal characterization and anti-AD activities of a novel complex of Cu(II) with in situ formed protonated chrysin derivative ligand

Design, Synthesis, Calculation and Biological Activity Studies Based on Privileged Coumarin Derivatives as Multifunctional Anti‐AD Lead Compound

Carrier-free Chinese herbal small molecules self-assembly with 3D-porous crystal framework as a synergistic anti-AD agent

Study on Multi-Target Synergistic Treatment of Alzheimer’s Disease Based on Metal Chelators

Xanthone derivatives as potential telomeric G-quadruplex stabilizing and cytotoxic agents: Effects of substitution on quadruplex binding affinity and cytotoxicity

Study on the novel usnic acid derivatives: Design, synthesis, X-Ray crystal structure of Cu(II) complex and anti-AD activities

Effect of Bis‐Dimethylamine Substitution on DNA Binding Property and Cytotoxic Activity of Polyhydroxyxanthone

Corrigendum to “Multifunctional fluorescence sensor as a potential theranostic agent against Alzheimer's disease” [Spectrochim. Acta Part A: Molec. Biomolec. Spectrosc. 267 (2022) 120587]

A multifunctional metal regulator as the potential theranostic agent: Design, synthesis, anti-AD activities and metallic ion sensing properties

A multifunctional anti-AD approach: Design, synthesis, X-ray crystal structure, biological evaluation and molecular docking of chrysin derivatives

苓萆四妙汤联合西药治疗脾肾两虚、浊毒内阻证2型糖尿病合并高尿酸血症临床疗效观察

Multifunctional fluorescence sensor as a potential theranostic agent against Alzheimer's disease

Novel chrysin derivatives as hidden multifunctional agents for anti-Alzheimer's disease: design, synthesis and in vitro evaluation

Design, synthesis and biological evaluation of naringenin carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease

Emodin derivatives with multi-factor anti-AD activities: AChE inhibitor, anti-oxidant and metal chelator

A review on α-mangostin as a potential multi-target-directed ligand for Alzheimer's disease

Design, Synthesis and Biological Evaluation of Xanthone Derivatives for Possible Treatment of Alzheimer's Disease Based on Multi‐Target Strategy

远志活性成分优呫吨酮铜(Ⅱ)配合物的抗肿瘤活性研究

Anti-depressant effect of curcumin-loaded guanidine-chitosan thermo-sensitive hydrogel by nasal delivery

An important mechanism of herb-induced hepatotoxicity: To produce RMs based on active functional groups-containing ingredients from phytomedicine by binding CYP450s

Synthesis, characterization and properties of lanthanide complexes with different ancillary ligands

Identification and analysis of the reactive metabolites related to the hepatotoxicity of safrole

Studies on the metabolites difference of psoralen/isopsoralen in human and six mammalian liver microsomes in vitro by UHPLC–MS/MS

Identification and characterization of reactive metabolites in myristicin-mediated mechanism-based inhibition of CYP1A2

PBL教学法在无机化学实验中对学生自主学习能力的培养

Reactive metabolite activation by CYP2C19-mediated rhein hepatotoxicity

Syntheses, Structures, and Properties of the 3D Lanthanide Organic Frameworks with N‐Heterocyclic Polycarboxylic Acids

Two Three-Dimensional Lanthanide Frameworks Exhibiting Luminescence Increases upon Dehydration and Novel Water Layer Involving in Situ Decarboxylation

Spectroscopic and electrochemical studies on the evaluation of the radical scavenging activities of luteolin by chelating iron

会议论文

以异优散酮为先导物的多靶点抗AD配体设计、合成及生物活性研究

香豆素衍生物的设计合成及抗AD活性研究

中药学专业无机化学自主学习能力培养方法研究