付玉华｜复旦大学｜学者主页

2026

Expanded Polyglycine Protein Aggregates Alter the RNA Splicing Profile into a Premature State Partially via Sequestering SF3B4

Jiaxin Yang, Youqi Zheng, Jianyi Hu, Yanzhen Wu, Xin Yang, Peihan Chai, Zhaolin Zhang, Shiping Zhang, Qiong Liu, Yongcheng Pan, Yimin Sun, Jian Wang, Beisha Tang, Boxun Lu, Huijuan Feng, Yuhua Fu

Neuroscience Bulletin

DOI

2025

脂滴清除通过代谢重编程抑制食管癌增殖（英文）

蒲艳，万怡，付玉华，李恺，陈伊教，王云之，李斌，李玲玲，秦兆宇，徐婧妍，蒋冬先，李艳，余国营，孙刚，鲁伯埙，杨雯隽，丁琛

Science Bulletin

2025

Lipid droplet clearance inhibits esophageal cancer growth via metabolic reprogramming

Yan Pu, Yi Wan, Yuhua Fu, Kai Li, Yijiao Chen, Yunzhi Wang, Бин Ли, Lingling Li, Zhaoyu Qin, Jingyan Xu, Dongxian Jiang, Yan Li, Guoying Karen Yu, Sun Gang, Boxun Lu, Wenjun Yang, Chen Ding

《中国科学通报：英文版》

DOI

2024

DDHD2, whose mutations cause spastic paraplegia type 54, enhances lipophagy via engaging ATG8 family proteins

Fei Jia, Xiaoman Wang, Yuhua Fu, Shimin Zhao, Boxun Lu, Chenji Wang

Cell Death and Differentiation

DOI

2023

自噬小体绑定化合物(ATTEC)靶向降解线粒体及其潜在治疗效果（英文）

谭水霞，王达，付玉华，郑惠文，刘妍，鲁伯埙

Science Bulletin

2023

Clearance of lipid droplets by chimeric autophagy-tethering compound ameliorates the age-related macular degeneration phenotype in mice lacking APOE

Yuelu Zhang, Jiancheng Huang, Yu Liang, Jiaqiu Huang, Yuhua Fu, Ningxie Chen, Boxun Lu, Chen Zhao

Autophagy

DOI

2023

Targeted clearance of mitochondria by an autophagy-tethering compound (ATTEC) and its potential therapeutic effects

Shuixia Tan, Da Wang, Yuhua Fu, Huiwen Zheng, Yan Liu, Boxun Lu

《中国科学通报：英文版》

DOI

2022

Autophagic Clearance of Lipid Droplets Alters Metabolic Phenotypes in a Genetic Obesity–Diabetes Mouse Model

Ningxie Chen, Boxun Lu, Yuhua Fu

Phenomics

DOI

2021

Targeting lipid droplets for autophagic degradation by ATTEC

Yuhua Fu, Boxun Lu

Autophagy

DOI

2021

Degradation of lipid droplets by chimeric autophagy-tethering compounds

Yuhua Fu, Ningxie Chen, Ziying Wang, Shouqing Luo, Yu Ding, Boxun Lu

Cell Research

DOI

2021

Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex

Xiaojing Li, Yuanyuan Zhang, Yuhua Fu, Hao Zhang, He-xuan Li, Quanfu Li, Hailing Li, Renke Tan, Chen-xiao Jiang, Wei Jiang, Zeng-xia Li, Cheng Luo, Boxun Lu, Yongjun Dang

Acta Pharmacologica Sinica

DOI

2021

Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy

Xiaodan Zhang, Xue Wen, Ismael Al‐Ramahi, Juan Botas, Boxun Lu, Yuhua Fu

Neuroscience Bulletin

DOI

2019

Bim contributes to the progression of Huntington’s disease-associated phenotypes

Sheridan L. Roberts, Tracey Evans, Yi Yang, Yuhua Fu, Robert W. Button, Rebecca J. Sipthorpe, Katrina Cowan, Evelina Valionyte, Oleg V. Anichtchik, Huiliang Li, Boxun Lu, Shouqing Luo

Human Molecular Genetics

DOI

2018

Targeting Gpr52 lowers mutant HTT levels and rescues Huntington’s disease-associated phenotypes

Haikun Song, Hexuan Li, Shimeng Guo, Yuyin Pan, Yuhua Fu, Zijian Zhou, Zhaoyang Li, Xue Wen, Xiaoli Sun, Bingqing He, Haifeng Gu, Quan Zhao, Cen Wang, Ping An, Shouqing Luo, Youhong Hu, Xin Xie, Boxun Lu

Brain

DOI

2017

HIPK3 modulates autophagy and HTT protein levels in neuronal and mouse models of Huntington disease

Yuhua Fu, Xiaoli Sun, Boxun Lu

Autophagy

DOI

2017

Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models

Meng Yu, Yuhua Fu, Yijian Liang, Haikun Song, Yao Yao, Peng Wu, Yuwei Yao, Yuyin Pan, Xue Wen, Lixiang Ma, Hexige Saiyin, Yu Ding, Shouqing Luo, Boxun Lu

Cell Research

DOI

2017

Conformation-dependent recognition of mutant HTT (huntingtin) proteins by selective autophagy

Xiaoli Sun, Yuhua Fu, Yuyin Pan, Boxun Lu

Autophagy

DOI

2017

A toxic mutant huntingtin species is resistant to selective autophagy

Yuhua Fu, Peng Wu, Yuyin Pan, Xiaoli Sun, Huiya Yang, Marian DiFiglia, Boxun Lu

Nature Chemical Biology

DOI

2016

神经退行性疾病制药新思路:致病变异蛋白的降解

付玉华，鲁伯埙

《中国科学:生命科学》

付玉华

精选作品

期刊论文

Expanded Polyglycine Protein Aggregates Alter the RNA Splicing Profile into a Premature State Partially via Sequestering SF3B4

脂滴清除通过代谢重编程抑制食管癌增殖（英文）

Lipid droplet clearance inhibits esophageal cancer growth via metabolic reprogramming

DDHD2, whose mutations cause spastic paraplegia type 54, enhances lipophagy via engaging ATG8 family proteins

自噬小体绑定化合物(ATTEC)靶向降解线粒体及其潜在治疗效果（英文）

Clearance of lipid droplets by chimeric autophagy-tethering compound ameliorates the age-related macular degeneration phenotype in mice lacking APOE

Targeted clearance of mitochondria by an autophagy-tethering compound (ATTEC) and its potential therapeutic effects

Autophagic Clearance of Lipid Droplets Alters Metabolic Phenotypes in a Genetic Obesity–Diabetes Mouse Model

Targeting lipid droplets for autophagic degradation by ATTEC

Degradation of lipid droplets by chimeric autophagy-tethering compounds

Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex

Inhibition of HIPK3 by AST487 Ameliorates Mutant HTT-Induced Neurotoxicity and Apoptosis via Enhanced Autophagy

Bim contributes to the progression of Huntington’s disease-associated phenotypes

Targeting Gpr52 lowers mutant HTT levels and rescues Huntington’s disease-associated phenotypes

HIPK3 modulates autophagy and HTT protein levels in neuronal and mouse models of Huntington disease

Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models

Conformation-dependent recognition of mutant HTT (huntingtin) proteins by selective autophagy

A toxic mutant huntingtin species is resistant to selective autophagy

神经退行性疾病制药新思路:致病变异蛋白的降解

研究方向