盛韧｜东北大学｜学者主页

2026

Novel SIRT1 Up-regulator F1462 Attenuates Endothelial Cell Senescence and Vascular Aging by Promoting Mitochondrial Biogenesis via Activating the SIRT1/PGC-1α/TFAM Pathway.

Shun-Wang Li, X. Zuo, Chao Liu, Jiangxue Han, Yu-Hao Zhang, Jing Zhang, Jingshuai Wu, Guijun Yang, Ren Sheng, Jing-Rui Wang, Xinwei Wei, Weiliang Jiang, Chuanjia Ju, Yu-Yan Zhang, Lijuan Lei, Yan-Ni Xu, Shu-Yi Si

European Journal of Pharmacology

DOI

2026

Novel aromatic amide Pan-PPAR agonists for dual amelioration of hepatic steatosis and islet dysfunction by promoting cholesterol efflux in the KKAy diabetic mice.

Ren Sheng, Yu-Yan Zhang, Jing-Rui Wang, Guijun Yang, Weiliang Jiang, Chuanjia Ju, Shun-Wang Li, Chen-Yin Wang, Jing Zhang, Lijuan Lei, Xinwei Wei, Tao Liu, Chao Liu, Yan-Ni Xu, Shu-Yi Si

European journal of medicinal chemistry

DOI

2026

Discovery of potent and orally bioavailable benzothiazole-benzenesulfonamide derivatives as ABCA1 upregulators for the management of dyslipidemia.

Wenyan Li, Lijuan Lei, Guosheng Zhang, Yun-Jin Zhang, Yujie Wang, Yexiang Wu, Ren Sheng, Guijun Yang, Yan-Ni Xu, Hong-Tao Liu

European journal of medicinal chemistry

DOI

2025

A Novel RANKL/RANK Inhibitor IMB-R38 Inhibits Osteoporosis Through Regulating Bone Metabolism

Yu-Yan Zhang, Xinwei Wei, Ren Sheng, Guijun Yang, Xiao-Wan Han, Jing-Rui Wang, Chao Liu, Shun-Wang Li, Lijuan Lei, Weiliang Jiang, Lun Yang, Shu-Yi Si, Jing Zhang, Yan-Ni Xu

International Journal of Molecular Sciences

DOI

2025

[Research advances in ferroptosis in the regulation of metabolic dysfunction-associated steatotic liver disease].

Jing-Rui Wang, Ren Sheng, Shun-Wang Li, Yu-Hao Zhang, Xinwei Wei, Yan-Ni Xu, Shu-Yi Si

Sheng wu gong cheng xue bao = Chinese journal of biotechnology

DOI

2025

Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL

Dong Luo, Jing Zheng, Shuning Lv, Ren Sheng, Maorong Chen, Xi He, Xinjun Zhang

eLife

DOI

2025

Correction: Chemoresistance mechanisms to 5-Fluorouracil and reversal strategies in lung and breast cancer

Chunge Zhong, Shengnan Wang, Wenjie Jiang, Zexu Li, Xiaofeng Wang, Shuangshuang Fan, Jun Huang, Hua‐Jun Wu, Ren Sheng, Teng Fei

Scientific Reports

DOI

2025

CDKL3, a versatile kinase with increasing recognition

Lanjing Ma, Haijiao Zhang, Zhongqiu Pang, Ren Sheng

Biochemical and Biophysical Research Communications

DOI

2025

The deubiquitination-PARylation positive feedback loop of the USP10-PARP1 axis promotes DNA damage repair and affects therapeutic efficacy of PARP1 inhibitor

Jingwei Liu, Siyi Zhang, Liangzi Cao, Liangzi Cao, Naijin Zhang, Qiqiang Guo, Yu Feng Zou, Ruohan Yang, Shiyuan Dong, Lixia Zheng, Yutong Xiao, Yubang Wang, Songming Lu, Pengcheng Jiang, Keshen Zhou, Di Chen, Di Chen, Hao Li, Ying Zhang, Ren Sheng, Chengzhong Xing, Xiaoyu Song, Zhenning Wang, Liu Cao, Liu Cao

Oncogene

DOI

2025

Comprehensive analysis of multi‐omics single‐cell data using the single‐cell analyst

Lu Pan, Bufu Tang, Xuan Zhang, Paolo Parini, Roman Tremmel, Joseph Loscalzo, Volker Martin Lauschke, Bradley A. Maron, Paola Paci, Ingemar T. Ernberg, Nguan Soon Tan, Ákos Végvári, Zehuan Liao, Sundararaman Rengarajan, Roman A. Zubarev, Yuxuan Fan, Zheng Xu, Xinyue Jian, Ren Sheng, Zhenning Wang, Xuexin Li

iMeta

DOI

2025

NSP6 of SARS-CoV-2 Dually Regulates Autophagic–Lysosomal Degradation

Haijiao Zhang, Jianying Chang, Ren Sheng

International Journal of Molecular Sciences

DOI

2025

Deciphering immune predictors of immunotherapy response: A multiomics approach at the pan-cancer level

Xuexin Li, Lu Pan, Weiyuan Li, Bingyang Liu, Chunjie Xiao, Valerie Chew, Xuan Zhang, Xuan Zhang, Long Wang, Florent Ginhoux, Joseph Loscalzo, Marcus Buggert, Xiaolu Zhang, Xiaolu Zhang, Ren Sheng, Zhenning Wang

Cell Reports Medicine

DOI

2025

Chemoresistance mechanisms to 5-Fluorouracil and reversal strategies in lung and breast cancer

Chunge Zhong, Shengnan Wang, Wenjie Jiang, Zexu Li, Xiaofeng Wang, Shuangshuang Fan, Jun Huang, Hua‐Jun Wu, Ren Sheng, Fei Teng

Scientific Reports

DOI

2025

Clear cell renal carcinoma essentially requires CDKL3 for oncogenesis

Lanjing Ma, Zhongqiu Pang, Haijiao Zhang, Xueling Yang, Shaoqin Zheng, Yi Chen, Weijie Ding, Qing Han, Xi Zhang, Liu Cao, Teng Fei, Qiang Wang, Daming Gao, Aina He, Kebang Hu, Xuexin Li, Ren Sheng

Proceedings of the National Academy of Sciences

DOI

2025

Author Correction: CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

Chunge Zhong, Wenjie Jiang, Yingjia Yao, Zexu Li, You Li, Shengnan Wang, Xiaofeng Wang, Wenjuan Zhu, Siqi Wu, Jing Wang, Shuangshuang Fan, Shixin Ma, Yeshu Liu, Han Zhang, Wenchang Zhao, Lu Zhao, Yi Feng, Zihan Li, Ruifang Guo, Yu Li, Fengyun Pei, Jun Hu, Xingzhi Feng, Zihuan Yang, Zhengjia Yang, Xueying Yang, Yue Hou, Danni Zhang, Dake Xu, Ren Sheng, Yihao Li, Lijun Liu, Hua‐Jun Wu, Jun Huang, Fei Teng

Nature Communications

DOI

2025

Author response: Wnt specifically induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL

Dong Luo, Jing Zheng, Shuning Lv, Ren Sheng, Maorong Chen, Xi He, Xinjun Zhang

DOI

2024

Antirheumatic drug leflunomide attenuates atherosclerosis by regulating lipid metabolism and endothelial dysfunction via DHODH/AMPK signaling pathway

Xin-Hai Jiang, Weizhi Wang, Lijuan Lei, Tingting Feng, Yang Hu, Peng Liu, Yi-Ning Li, Ren Sheng, Yu-Yan Zhang, Shun-Wang Li, Jing Zhang, Yu-Hao Zhang, Zheng-Gen Jin, Zhuang Tian, Jian-Dong Jiang, Yan-Ni Xu, Shu-Yi Si

International Journal on Biological Sciences

DOI

2024

A pan-PPAR agonist E17241 ameliorates hyperglycaemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in the key target organs

Ren Sheng, Yan-Ni Xu, Shu-Yi Si

Atherosclerosis

DOI

2024

The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPARδ signaling pathway to prevent bone loss in ovariectomized rats and senile mice.

Yi-Ning Li, Chao Liu, Xiao-Wan Han, Ren Sheng, Li Bao, Lijuan Lei, Yexiang Wu, Quanjie Li, Yu-Yan Zhang, Jing Zhang, Weizhi Wang, Yu-Hao Zhang, Shun-Wang Li, Chen-Yin Wang, Xinwei Wei, Jing-Rui Wang, Zong-Gen Peng, Yan-Ni Xu, Shu-Yi Si

Bioorganic chemistry (Print)

DOI

2024

ASGR1 Deficiency Inhibits Atherosclerosis in Western Diet–Fed ApoE −/− Mice by Regulating Lipoprotein Metabolism and Promoting Cholesterol Efflux

Yu-Yan Zhang, Xin-Hai Jiang, Weizhi Wang, Lijuan Lei, Ren Sheng, Shun-Wang Li, Jin-Que Luo, Huan Liu, Jing Zhang, Xiao-Wan Han, Yi-Ning Li, Yu-Hao Zhang, Chen-Yin Wang, Shu-Yi Si, Zheng-Gen Jin, Yan-Ni Xu

Arteriosclerosis, Thrombosis and Vascular Biology

DOI

2024

A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis

Weizhi Wang, Chao Liu, Jing Luo, Lijuan Lei, Ming-hua Chen, Yu-Yan Zhang, Ren Sheng, Yi-Ning Li, Li Wang, Xin-Hai Jiang, Tong Xiao, Yu-Hao Zhang, Shun Li, Yexiang Wu, Yang Xu, Yan-Ni Xu, Shu-Yi Si

Acta Pharmacologica Sinica

DOI

2024

A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue.

Ren Sheng, Yi-Ning Li, Ye-Xiang Wu, Chang Liu, Weizhi Wang, Xiao-Wan Han, Ying-Hong Li, Lijuan Lei, Xin-Hai Jiang, Yu-Yan Zhang, Yu-Hao Zhang, Shun-Wang Li, Bin Hong, Chao Liu, Yan-Ni Xu, Shu-Yi Si

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

DOI

2024

HNF4α-CDKL3 axis restricts MASLD progression by targeting FoxO1 via noncanonical phosphorylation

Zhongqiu Pang, Hui Zhang, Shaoqin Zheng, Xueling Yang, Chang Liu, Qing Quan Han, Yi Chen, Zexu Li, Xi Zhang, Liu Cao, Qiang Wang, Yanli Cao, Xun Sun, Pu Zhao, Xuexin Li, Qianqian Zheng, Ren Sheng

Hepatology

DOI

2024

CDKL3 is a targetable regulator of cell cycle progression in cancers

Haijiao Zhang, Jiahui Lin, Shaoqin Zheng, Lanjing Ma, Zhongqiu Pang, Hongyi Yin, Chengcheng Meng, Yinuo Wang, Qing Quan Han, Xi Zhang, Zexu Li, Liu Cao, Lijun Liu, Fei Teng, Daming Gao, Liang Yang, Xueqiang Peng, Chen Ding, Shixue Wang, Ren Sheng

Journal of Clinical Investigation

DOI

2024

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

Chunge Zhong, Wenjie Jiang, Yingjia Yao, Zexu Li, You Li, Shengnan Wang, Xiaofeng Wang, Wenjuan Zhu, Siqi Wu, Jing Wang, Shuangshuang Fan, Shixin Ma, Yeshu Liu, Han Zhang, Wenchang Zhao, Lu Zhao, Yi Feng, Zihan Li, Ruifang Guo, Yu Li, Fengyun Pei, Jun X. Hu, Xingzhi Feng, Zihuan Yang, Zhengjia Yang, Xueying Yang, Yue Hou, Danni Zhang, Dake Xu, Ren Sheng, Yihao Li, Lijun Liu, Hua‐Jun Wu, Jun Huang, Fei Teng

Nature Communications

DOI

2024

The emerging understanding of Frizzled receptors

Shaoqin Zheng, Ren Sheng

FEBS Letters

DOI

2023

SIRT1 Activator E1231 Alleviates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism

Jiangxue Han, Shun-Wang Li, Weizhi Wang, Xin-Hai Jiang, Chao Liu, Lijuan Lei, Yi-Ning Li, Ren Sheng, Yu-Yan Zhang, Ye-Xiang Wu, Jing Zhang, Yu-Hao Zhang, Yan-Ni Xu, S. Si

Current Issues in Molecular Biology

DOI

2023

The deubiquitinase USP10 mediates crosstalk between the LKB1/AMPK axis and Wnt/β‐catenin signaling in cancer

Yinuo Wang, Jingwei Liu, Shaoqin Zheng, Liu Cao, Yiwei Li, Ren Sheng

FEBS Letters

DOI

2023

USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential

Yinuo Wang, Aihua Mao, Jingwei Liu, Pengjie Li, Shaoqin Zheng, Tong Tong, Zexu Li, Haijiao Zhang, Lanjing Ma, Jiahui Lin, Zhongqiu Pang, Qing Han, Fukang Qi, Xinjun Zhang, Maorong Chen, Xi He, Xi Zhang, Fei Teng, Bi‐Feng Liu, Daming Gao, Liu Cao, Qiang Wang, Yiwei Li, Ren Sheng

Cell chemical biology

DOI

2023

Anti‐Pan‐Rspo Chimeric Protein‐Conjugated Albumin Nanoparticle Provides Promising Opportunities in Cancer Targeted Therapy

Shaoqin Zheng, Xi Zhang, Zhongqiu Pang, Jidong Liu, Siyu Liu, Ren Sheng

Advanced Healthcare Materials

DOI

2023

Frizzled receptors facilitate Tiki inhibition of Wnt signaling at the cell surface

Mingyi Li, Jing Zheng, Dong Luo, Kai Xu, Ren Sheng, Bryan T. MacDonald, Xi He, Xinjun Zhang

EMBO Reports

DOI

2022

Trichostatin D as a Novel KLF2 Activator Attenuates TNFα-Induced Endothelial Inflammation

Lijuan Lei, Minghua Chen, Chen-Yin Wang, Xin-Hai Jiang, Ying-Hong Li, Weizhi Wang, Shun-Wang Li, Liping Zhao, Ren Sheng, Jiangxue Han, Yuyan Zhang, Yu-Chien Chen, Biying Yan, Ye-Xiang Wu, Li-Yan Yu, S. Si, Yan-Ni Xu

International Journal of Molecular Sciences

DOI

2022

Correction: CDKL3 promotes osteosarcoma progression by activating Akt/PKB

Aina He, Lanjing Ma, Yujing Huang, Haijiao Zhang, Wei Duan, Zexu Li, Fei Teng, Junqing Yuan, Hao Wu, Liguo Liu, Yueqing Bai, Wentao Dai, Yonggang Wang, Hongtao Li, Yong Sun, Yaling Wang, Chunyan Wang, Ting Yuan, Qingcheng Yang, Songhai Tian, Min Dong, Ren Sheng, Dongxi Xiang

Life Science Alliance

DOI

2022

Aberrant Cholesterol Metabolism and Wnt/ β ‐Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth

Shaoqin Zheng, Jiahui Lin, Zhongqiu Pang, Hui Zhang, Yinuo Wang, Lanjing Ma, Haijiao Zhang, Xi Zhang, Maorong Chen, Xinjun Zhang, Chao Zhao, Jun Qi, Liu Cao, Min Wang, Xi He, Ren Sheng

Advanced Science

DOI

2021

Synthesis of N-methylpyridine-chlorofuranformamide analogs as novel OPG up-regulators and inhibitors of RANKL-induced osteoclastogenesis.

Chao Liu, Yi-Ning Li, Ren Sheng, Xiao-Wan Han, Li Bao, Chen-Yin Wang, Weizhi Wang, Xin-Hai Jiang, Jiangxue Han, Lijuan Lei, Ni Li, Jing Zhang, Minghua Chen, Yan Li, Ye-Xiang Wu, Shun-Wang Li, Yu Ren, Yan-Ni Xu, S. Si

Bioorganic chemistry (Print)

DOI

2020

Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling

Yiwei Li, Maorong Chen, Jiliang Hu, Ren Sheng, Qirong Lin, Xi He, Ming Guo

Cell stem cell

DOI

2020

CDKL3 promotes osteosarcoma progression by activating Akt/PKB

Life Science Alliance

DOI

2018

Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design.

Ren Sheng, Liu Yang, Yan-Chun Zhang, En-Ming Xing, Rui Shi, X. Wen, He-Yao Wang, Hongbin Sun

Bioorganic & Medicinal Chemistry Letters

DOI

精选作品

期刊论文

Novel SIRT1 Up-regulator F1462 Attenuates Endothelial Cell Senescence and Vascular Aging by Promoting Mitochondrial Biogenesis via Activating the SIRT1/PGC-1α/TFAM Pathway.

Novel aromatic amide Pan-PPAR agonists for dual amelioration of hepatic steatosis and islet dysfunction by promoting cholesterol efflux in the KKAy diabetic mice.

Discovery of potent and orally bioavailable benzothiazole-benzenesulfonamide derivatives as ABCA1 upregulators for the management of dyslipidemia.

A Novel RANKL/RANK Inhibitor IMB-R38 Inhibits Osteoporosis Through Regulating Bone Metabolism

[Research advances in ferroptosis in the regulation of metabolic dysfunction-associated steatotic liver disease].

Wnt induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL

Correction: Chemoresistance mechanisms to 5-Fluorouracil and reversal strategies in lung and breast cancer

CDKL3, a versatile kinase with increasing recognition

The deubiquitination-PARylation positive feedback loop of the USP10-PARP1 axis promotes DNA damage repair and affects therapeutic efficacy of PARP1 inhibitor

Comprehensive analysis of multi‐omics single‐cell data using the single‐cell analyst

NSP6 of SARS-CoV-2 Dually Regulates Autophagic–Lysosomal Degradation

Deciphering immune predictors of immunotherapy response: A multiomics approach at the pan-cancer level

Chemoresistance mechanisms to 5-Fluorouracil and reversal strategies in lung and breast cancer

Clear cell renal carcinoma essentially requires CDKL3 for oncogenesis

Author Correction: CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

Author response: Wnt specifically induces FZD5/8 endocytosis and degradation and the involvement of RSPO-ZNRF3/RNF43 and DVL

Antirheumatic drug leflunomide attenuates atherosclerosis by regulating lipid metabolism and endothelial dysfunction via DHODH/AMPK signaling pathway

A pan-PPAR agonist E17241 ameliorates hyperglycaemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in the key target organs

The novel small molecule E0924G dually regulates bone formation and bone resorption through activating the PPARδ signaling pathway to prevent bone loss in ovariectomized rats and senile mice.

ASGR1 Deficiency Inhibits Atherosclerosis in Western Diet–Fed ApoE −/− Mice by Regulating Lipoprotein Metabolism and Promoting Cholesterol Efflux

A novel small-molecule PCSK9 inhibitor E28362 ameliorates hyperlipidemia and atherosclerosis

A pan-PPAR agonist E17241 ameliorates hyperglycemia and diabetic dyslipidemia in KKAy mice via up-regulating ABCA1 in islet, liver, and white adipose tissue.

HNF4α-CDKL3 axis restricts MASLD progression by targeting FoxO1 via noncanonical phosphorylation

CDKL3 is a targetable regulator of cell cycle progression in cancers

CRISPR screens reveal convergent targeting strategies against evolutionarily distinct chemoresistance in cancer

The emerging understanding of Frizzled receptors

SIRT1 Activator E1231 Alleviates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism

The deubiquitinase USP10 mediates crosstalk between the LKB1/AMPK axis and Wnt/β‐catenin signaling in cancer

USP10 strikes down β-catenin by dual-wielding deubiquitinase activity and phase separation potential

Anti‐Pan‐Rspo Chimeric Protein‐Conjugated Albumin Nanoparticle Provides Promising Opportunities in Cancer Targeted Therapy

Frizzled receptors facilitate Tiki inhibition of Wnt signaling at the cell surface

Trichostatin D as a Novel KLF2 Activator Attenuates TNFα-Induced Endothelial Inflammation

Correction: CDKL3 promotes osteosarcoma progression by activating Akt/PKB

Aberrant Cholesterol Metabolism and Wnt/ β ‐Catenin Signaling Coalesce via Frizzled5 in Supporting Cancer Growth

Synthesis of N-methylpyridine-chlorofuranformamide analogs as novel OPG up-regulators and inhibitors of RANKL-induced osteoclastogenesis.

Volumetric Compression Induces Intracellular Crowding to Control Intestinal Organoid Growth via Wnt/β-Catenin Signaling

CDKL3 promotes osteosarcoma progression by activating Akt/PKB

Discovery of novel selective GPR120 agonists with potent anti-diabetic activity by hybrid design.