张在军｜暨南大学｜学者主页

2026

基于数据挖掘及网络药理学探讨益气活血中药治疗卒中后认知障碍的用药规律及作用机制

陈继祥，高坤，李娜，景梅，宋秀豹，张在军

《广东药科大学学报》

2026

The multifunctional memantine nitrate MN-08 ameliorates neuropathology and motor deficits in Huntington’s disease models

Chunhui Huang, Wen Jin, Zheng Xiao, Ou Zhanchao, Yingqi Lin, Wu Jiaxi, Li Caijuan, Li Jiawei, Jianhao Wu, Yizhi Chen, Wang Wei, Jiale Gao, Chunxiang Shi, Junzhu Song, Fang Shenzhe, Zhang Gaoxiao, Li Shihua, Li Xiaojiang, Li Wei, Zaijun Zhang, Yan Sen

《动物学研究》

精选作品

期刊论文

基于数据挖掘及网络药理学探讨益气活血中药治疗卒中后认知障碍的用药规律及作用机制

The multifunctional memantine nitrate MN-08 ameliorates neuropathology and motor deficits in Huntington’s disease models

Cul4B up‐regulation attenuates sepsis‐induced acute lung injury by promoting NLRP3 ubiquitination and inhibiting NLRP3 inflammasome activation

Unraveling the Pathological Mechanisms and Biomarkers of Amyotrophic Lateral Sclerosis: A Comprehensive Review

A novel arctigenin derivative attenuates nonalcoholic fatty liver disease by activating adiponectin receptor 1-mediated AMPK signaling pathway

Retraction Note: Xanthohumol Attenuates Lipopolysaccharide-Induced Depressive Like Behavior in Mice: Involvement of NF-κB/Nrf2 Signaling Pathways

ARC-18 Alleviates Alzheimer-like Pathology and Cognitive Deficits via AdipoR1-Mediated Activation of Autophagy and Modulation of APP Processing

Multi-functional memantine nitrate attenuated cognitive impairment in models of vascular dementia and Alzheimer's disease through neuroprotection and increased cerebral blood flow

Anti-neuroinflammatory and Neuroprotective Effects of T-006 on Alzheimer’s Disease Models by Modulating TLR4-Mediated MyD88/ NF-κB Signaling

Neuroprotective and intraocular pressure lowering effects of dual-functional memantine nitrate MN-08 on the experimental models of glaucoma

Long-term oral glucocerebrosidase activator reduces soluble α-synuclein oligomer accumulation in Parkinsonian LRRK2 mutant mouse brain

A Novel Genetic TDP‐43 Pig Model Mimics Multiple Key ALS‐Like Features

Endothelial Dysfunctions in Blood–Brain Barrier Breakdown in Alzheimer's Disease: From Mechanisms to Potential Therapies

Tetramethylpyrazine Analogue T-006 Protects Neuronal and Endothelial Cells Against Oxidative Stress via PI3K/AKT/mTOR and Nrf2 Signaling

Tetramethylpyrazine Nitrone (TBN) Reduces Amyloid β Deposition in Alzheimer’s Disease Models by Modulating APP Expression, BACE1 Activity, and Autophagy Pathways

Insights into the transcriptomic heterogeneity of brain endothelial cells in normal aging and Alzheimer’s disease

Abnormal outer and inner retina in a mouse model of Huntington’s disease with age

Advances in Clinical Therapies for Huntington's Disease and the Promise of Multi‐Targeted/Functional Drugs Based on Clinicaltrials.gov

Tetramethylpyrazine nitrone delays the aging process of C. elegans by improving mitochondrial function through the AMPK/mTORC1 signaling pathway

Arctigenin derivative A‐1 ameliorates motor dysfunction and pathological manifestations in SOD1 G93A transgenic mice via the AMPK / SIRT1 / PGC ‐1α and AMPK / SIRT1 / IL ‐1β/ NF‐κB pathways

Tetramethylpyrazine Nitrone Promotes the Clearance of Alpha-Synuclein via Nrf2-Mediated Ubiquitin–Proteasome System Activation

Safety and efficacy of tetramethylpyrazine nitrone in patients with amyotropic lateral sclerosis: A randomized, double-blind, placebo-controlled trial

Tetramethylpyrazine nitrone exerts neuroprotection via activation of PGC-1α/Nrf2 pathway in Parkinson’s disease models

Strategies targeting endoplasmic reticulum stress to improve Parkinson’s disease

Correction to: Xanthohumol Attenuates Lipopolysaccharide-Induced Depressive Like Behavior in Mice: Involvement of NF-κB/Nrf2 Signaling Pathways

Chrysin prevents inflammation-coinciding liver steatosis via AMPK signalling

Acetylated tau exacerbates learning and memory impairment by disturbing with mitochondrial homeostasis

Adiponectin deficiency accelerates brain aging via mitochondria-associated neuroinflammation

Evaluation of therapeutic effects of tetramethylpyrazine nitrone in Alzheimer’s disease mouse model and proteomics analysis

激活AMPK/SIRT1/PGC-1α信号通路调控线粒体能量代谢在肌萎缩性侧索硬化症治疗中的潜力

Memantine nitrate MN-08 suppresses NLRP3 inflammasome activation to protect against sepsis-induced acute lung injury in mice

Tetramethylpyrazine nitrone activates hypoxia-inducible factor and regulates iron homeostasis to improve renal anemia

Harmol promotes α-synuclein degradation and improves motor impairment in Parkinson’s models via regulating autophagy-lysosome pathway

Tetramethylpyrazine nitrone TBN extends the lifespan of C. elegans by activating the Nrf2/SKN-1 signaling pathway

Murine Beta-Amyloid (1–42) Oligomers Disrupt Endothelial Barrier Integrity and VEGFR Signaling via Activating Astrocytes to Release Deleterious Soluble Factors

T-006改善APP/PS1/Tau转基因小鼠学习记忆功能及调控突触相关蛋白表达

Dual-Functional MN-08 Attenuated Pulmonary Arterial Hypertension Through Vasodilation and Inhibition of Pulmonary Arterial Remodeling

Mitochondriomics reveals the underlying neuroprotective mechanism of TrkB receptor agonist R13 in the 5×FAD mice

Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer’s disease

RETRACTED ARTICLE: Xanthohumol Attenuates Lipopolysaccharide-Induced Depressive Like Behavior in Mice: Involvement of NF-κB/Nrf2 Signaling Pathways

Neuroprotection against 1-Methyl-4-phenylpyridinium-induced cytotoxicity by naturally occurring polydatin through activation of transcription factor MEF2D

Nephroprotective Effects of Tetramethylpyrazine Nitrone TBN in Diabetic Kidney Disease

Therapeutic efficacy of novel memantine nitrate MN‐08 in animal models of Alzheimer’s disease

TBN improves motor function and prolongs survival in a TDP-43M337V mouse model of ALS

Tetramethylpyrazine Improves Cognitive Impairment and Modifies the Hippocampal Proteome in Two Mouse Models of Alzheimer's Disease

Dauricine Attenuates Spatial Memory Impairment and Alzheimer-Like Pathologies by Enhancing Mitochondrial Function in a Mouse Model of Alzheimer's Disease

The Tetramethylpyrazine Analogue T-006 Alleviates Cognitive Deficits by Inhibition of Tau Expression and Phosphorylation in Transgenic Mice Modeling Alzheimer’s Disease

R13 preserves motor performance in SOD1 G93A mice by improving mitochondrial function

3-取代吲哚酮类抗癌药物对抗神经退行性疾病之进展

Transcription factor EB agonists from natural products for treating human diseases with impaired autophagy-lysosome pathway

Tetramethylpyrazine nitrone improves motor dysfunction and pathological manifestations by activating the PGC-1α/Nrf2/HO-1 pathway in ALS mice

Maintaining the balance of TDP-43, mitochondria, and autophagy: a promising therapeutic strategy for neurodegenerative diseases

Proteomic Profile of Mouse Brain Aging Contributions to Mitochondrial Dysfunction, DNA Oxidative Damage, Loss of Neurotrophic Factor, and Synaptic and Ribosomal Proteins

Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation

Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease

Tetramethylpyrazine Analogue T-006 Exerts Neuroprotective Effects against 6-Hydroxydopamine-Induced Parkinson’s Disease In Vitro and In Vivo

Tetramethylpyrazine Analogue T-006 Promotes the Clearance of Alpha-synuclein by Enhancing Proteasome Activity in Parkinson's Disease Models

Memantine Improves Cognitive Function and Alters Hippocampal and Cortical Proteome in Triple Transgenic Mouse Model of Alzheimer's Disease

The dual‐functional memantine nitrate MN‐08 alleviates cerebral vasospasm and brain injury in experimental subarachnoid haemorrhage models

Tetramethylpyrazine Nitrone Reduces Oxidative Stress to Alleviate Cerebral Vasospasm in Experimental Subarachnoid Hemorrhage Models

Marine-Derived Natural Compounds for the Treatment of Parkinson’s Disease

Novel neuroprotective tetramethylpyrazine analog T-006 promotes neurogenesis and neurological restoration in a rat model of stroke

Dysregulation of Myosin Complex and Striated Muscle Contraction Pathway in the Brains of ALS–SOD1 Model Mice

Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer's disease

Neuroprotective and Neurogenic Effects of Novel Tetramethylpyrazine Derivative T-006 in Parkinson's Disease Models Through Activating the MEF2-PGC1α and BDNF/CREB Pathways

Proteomic analysis reveals the potential neuroprotective effects of tetramethylpyrazine dimer in neuro2a/APPswe cells

The novel N-methyl-d-aspartate receptor antagonist MN-08 ameliorates lipopolysaccharide-induced acute lung injury in mice

Memantine Nitrate Ester Derivatives MN-08 Improves Cognitive and Attenuates Alzheimer's Disease-Like Neuropathology in Transgenic mice

Hippocampal Proteomic Alteration in Triple Transgenic Mouse Model of Alzheimer’s Disease and Implication of PINK 1 Regulation in Donepezil Treatment

Miconazole stimulates post-ischemic neurogenesis and promotes functional restoration in rats

A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways

Inhibition of non-NMDA ionotropic glutamate receptors delays the retinal degeneration in rd10 mouse

The Prenylflavonoid Xanthohumol Reduces Alzheimer-Like Changes and Modulates Multiple Pathogenic Molecular Pathways in the Neuro2a/APPswe Cell Model of AD

Hippocampal Subcellular Organelle Proteomic Alteration of Copper-Treated Mice

TRPC1 Deletion Causes Striatal Neuronal Cell Apoptosis and Proteomic Alterations in Mice

Mitochondrial Molecular Abnormalities Revealed by Proteomic Analysis of Hippocampal Organelles of Mice Triple Transgenic for Alzheimer Disease

Neuroprotective Effect and Mechanism of Action of Tetramethylpyrazine Nitrone for Ischemic Stroke Therapy

Proteomic alterations of brain subcellular organelles caused by low-dose copper exposure: implication for Alzheimer’s disease